Gene TTK (Sea Urchin)

TTK

Species: Sea Urchin
Alias: TTK, SPU_010530, Spk197
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: TTK

Sequence

Name Sequence Type Origin Length Description Download
TTK.AA Protein None 1042 None Fasta, JSON
TTK.kin_dom Protein Kinase Domain None 332 None Fasta, JSON

Protein domain

Protein domains of TTK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TTK.AA TTK 559-890 69 8.10000000001e-280 935.87 In-house 1-344 (344) Show / Hide 
Range on Protein: 559-890
Range on HMM: 1-344/344
Sequence Identity: 69% (240 aa)

YSIIRLIGKGGSSKVFQVLSEDSKKLWALKYVKLDFADEMAMQSYMNEITLLARLKTFK-RIIHLHDYELT--EDYIYLVMECGSIDLATFLKKNKD--N
||||..||.||||||||||||||||..|||||.|||||....|.|||||..|..|...| .||.|.|||.|  |.|||.|||||..||...|.|.|.  |
YSIIKQIGCGGSSKVFQVLSEDSKKIYALKYVCLDFADPQTIQGYMNEIEMLNKLQQQKDCIIQLYDYEMTMEEQYIYMVMECGDCDLNKWLQKYKTPMN

LSPHHMWCYWQEMLEAVDVIHKEGIVHSDLKPANFIFVEASLKLIDFGIANAIQN-DHTSVVKESQVGTLNYMSPEAIQDTSPVNEVNEYGHKKPRLKIN
|.|..||||||.||..|.|||..||||||||||||..|...|||||||||||||| |.|..|||||.||.||||||||||.|..||.....|||||||||
LNPWFMWCYWQQMLQCVHVIHQHGIVHSDLKPANFVMVQGMLKLIDFGIANAIQNDDTTNIVKESQIGTFNYMSPEAIQDMSYGNENMCMHHKKPRLKIN

CKSDVWSLGCILYSMVYGRTPFQHIVHRLLKMQAICNPDHFIDFQPIENELLLDVMKINCKSDVWSLGCILYSMVYGRTPFQHIVHRLLKMQAICNPDHF
||||||||||||||||||||.||||||||||||||||||||||||||||||||||.||.|||||||.|||||.|.||.||||||.....||.|||||.|.
CKSDVWSLGCILYSMVYGRTKFQHIVHRLLKMQAICNPDHFIDFQPIENELLLDVWKISCKSDVWSCGCILYYMIYGKTPFQHIQNQYSKMHAICNPHHK

IDFQPIE------NELLLDVMKKCLTRDVKRRPSIEELLNHPYV
|.|....      |..|..|||.||.|..|.|.||.||||||..
IEFPEHPPYYEKINKMLIHVMKCCLYRNPKKRWSIPELLNHPFH
Kinase TTK.AA S_TKc 559-890 21 3.4e-74 253.73 SMART 1-231 (231) Show / Hide 
Range on Protein: 559-890
Range on HMM: 1-231/231
Sequence Identity: 21% (76 aa)

YSIIRLIGKGGSSKVFQVLSEDSKKLWALKYVKLDFADEMAMQSYMNEITLLARLKTFKRIIHLHDYELTEDYIYLVMECGSI---DLATFLKKNKDN--
| |.|.||||. .||...   ..... |.| .|         .. ..|| .| .    . |..|.|.  . |..|.|||. .    || ...||.. .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LSPHHMWCYWQEMLEAVDVIHKEGIVHSDLKPANFIFVEASLKLIDFGIANAIQNDHTSVVKESQVGTLNYMSPEAIQDTSPVNEVNEYGHKKPRLK
   ... | ..| .....|.. .|. ||.| ||||.|  . |  .|..|||.|  .          ...||..||.|| .                   .
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL---------TTFCGTPWYMAPEVL-------------------G

INC-KSDVWSLGCILYSMVYGRTPFQHIVHRLLKMQAICNPDHFIDFQPIENELLLDVMKINCKSDVWSLGCILYSMVYGRTPFQHIVHRLLKMQAICNP
 .. |.|.||.||||| |..|..||.   .  . .. |.                                                             
YGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-------------------------------------------------------------

DHFIDFQPIENELLLDVMKKCLTRDVKRRPSIEELLN-------HPYV
           . ..| ..|||..| ..||.. |.|.       ||..
----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TTK.AA Pkinase 559-776 28 2.2e-53 188.44 Pfam 1-214 (293) Show / Hide 
Range on Protein: 559-776
Range on HMM: 1-214/293
Sequence Identity: 28% (67 aa)

YSIIRLIGKGGSSKVFQVLSEDSKKLWALKYVKLDFADEMAMQSYMN--EITLLARLKTFKRIIHLHDYELTEDYIYLVMECGSI-----DLATFLK-KN
| |.| ||.|....|..    .. |..|.| .|.. ...   |.  .  || ...||   . |. |.|.  ..|.||.|||.        ||..... ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

KDNL--SPHHMWCYWQEMLEAVDVIHKEGIVHSDLKPANFIFV-EASL----KLIDFGIANAIQNDHTSVVKESQVGTLNYMSPEAIQDTSPVNEVNEYG
. ..  |...  .|. ..|.... .|..||.| ||||.|. .. .  .    |..|||.|  ..    ..   . .||..||.|| |.      . ..||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR------GGQYYG

HKKPRLKINCKSDVWSLGCILYSMVYGRTPFQH
.         |.|.||.||||| |. ||.||..
P---------KVDMWSCGCILYEMLCGRPPFPG
Kinase TTK.AA AGC 559-776 20 2.8e-44 111.2 In-house 1-307 (395) Show / Hide 
Range on Protein: 559-776
Range on HMM: 1-307/395
Sequence Identity: 20% (66 aa)

YSIIRLIGKGGSSKVFQVLSE------DSKKLWALKYVKLDF---ADEMAMQSY-MNE------------ITLLARLKT---------FKRIIH-LHDYE
. ....||||. .||..|         |..|. |.| .| .     ..  |. . |.|               |....             |.. ||   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

LTEDY--IYLVME-----------CGSIDLATFLKK--NKDNLSPHHMWCYWQE-------MLEAVDVIHK-EGIVHSD-LKPANFIFVE-ASLKLIDFG
 ..|.  .|.|||           .|  .| . |..  ..  ..  .   |  |       .. |.. .|.  ||.| | ||| |  . |   .|| |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

IANAIQNDHTSVVKESQ-------------------------------------------------VG--TLNYMSPEAIQDTSPVNEVNEYGHKKPRLK
 .  . ||.. ... ||                                                 .|  | .||.|| .                    
LCKEGMNDGEKGQQ-SQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL--------------------

INCKSDVWS--LGCILYSMVYGRTPFQH
 .   | ||  |||..| |..|..||..
YGKACDWWSFGLGCLMYEMLTGYPPFYG
Kinase TTK.AA CAMK 564-784 15 1.6e-36 114.72 In-house 1-358 (425) Show / Hide 
Range on Protein: 564-784
Range on HMM: 1-358/425
Sequence Identity: 15% (57 aa)

LIGKGGSSKVFQVLSEDSK------------KLWALKYVKLDFAD--------------------------EMAMQSYMNEITLLARLKT------FKRI
 .|.|. .||. .    ..            . .| | .. . ..                          .  ... ..|| .. .|.        . |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IHLHDYELT-------------------EDYIYLVM------ECGSI--DLATFLKKNKDN--------------LSPHHMWCYWQEMLEAVDVIHKEGI
|.|...  .                   ....|.||      . |    ||  ........              .. .    | . ...||. .|. .|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHSDLKPANFIFVEAS------------------LKLIDFGIANAIQNDHTSV---------------------VKESQVGTLNYMS-PEAIQD------
|| |||| |  ... .                  .|.|||| || .. .. .                        . ..||. ||. || ..       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

---TSPVNEVNEYGHKKPRLKINCKSDVWSLGCILYSMVYGRTPFQHI--------------VHRLLKM
   |              .  .. |.|.||.|.||| |. |. ||..                ..|...
QNAT-----------DEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEK
Kinase TTK.AA ULK 559-775 25 2.3e-34 117.39 In-house 1-257 (329) Show / Hide 
Range on Protein: 559-775
Range on HMM: 1-257/329
Sequence Identity: 25% (70 aa)

YSIIRLIGKGGSSKVFQVLSEDSK----KLWALKYVK----LDFAD----EMAMQSYMNEITLLARLK-------TFKRIIHLHDYELTE--DYIYLVME
|.... .|||   ||..   ...|    ...| | .       . .    . ..|. .||| .. .||       . . |. |.|.  |   ..||..||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

CGSI-DLATFLKKNKD---------NLSPHHMWCYWQEMLEAVDVIHKEGIVHSDLKPANFIFVEAS--------------LKLIDFGIANAIQND-HTS
     || ...||||          .||      . .  |..   .||..|.| |.||.| | .                 ||. ||| |  ..||    
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQN-ILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQ

VVKESQV------GTLNYMSPEAIQDT-SPVNEVNEYGHKKPRLKIN-CKSDVWSLGCILYSMVYGRTPFQ
 .  ..|      ||  ||.|. .|.                . . .  |.|.||||||.| |.||..||.
QMMMTCVNEKRLCGTPLYMAPQILQGQGE-------------QKPYYDYKCDIWSLGCIFYEMLYGKPPFY
Kinase TTK.AA CMGC 559-774 16 6.7e-34 108.08 In-house 1-342 (513) Show / Hide 
Range on Protein: 559-774
Range on HMM: 1-342/513
Sequence Identity: 16% (59 aa)

YSIIRLIGKGGSSKVFQVLS--------------EDSKKLWALKYVKLDFADEMAMQ----------SYMNEITLLARLK---------------TFKR-
| ||. ||.|  ..|..                  ..... |.| .|..| .|  ..          .   || .| .|.                 .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIHLHDYELTED-----------------YIYLVMECGSIDLATFLKKNKD--------NLSPHH------------MWCYW------QEMLEAVD--VI
|..|.|.  ...                 ..|||.|.   ||. ..|.|..        .||. |              ..       . .|....   .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HKEG--IVHSDLKPANFIFVEA---------------------SLKLIDFGIANAIQND-------------------HTSVVKESQVGTLNYMSPEAIQ
|. .  |.| ||||.|  . .                       ||..||| | .. .                    ...    ..| |. | .|| . 
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

DT------SPVNEVNEYGHKKPRLKINCKSDVWSLGCILYSMVYG-------RTPF
                        . ... |.||.|||.. |. |       . |.
GWKHYTNHN------------YSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPL
Kinase TTK.AA ULK 559-775 25 3.1e-33 115.32 In-house 1-253 (324) Show / Hide 
Range on Protein: 559-775
Range on HMM: 1-253/324
Sequence Identity: 25% (67 aa)

YSIIRLIGKGGSS-KVFQVLSEDS---KKLWALKYVKLD-FAD-------EMAMQSYMNEITLLARLKT-----FKRIIHLHDYELTE--DYIYLVMECG
|.... .|||    ||..   ...   ....| | . .. . .       . ..|. .||| ..  ||         |. |.|.  |   ..||..||  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYC

SI-DLATFLKKNKD--------NLSPHHMWCYWQEMLEAVDVIHKEGIVHSDLKPANFIFVEAS--------------LKLIDFGIANAIQND-HTSVVK
   || ...||||         .||      . .  ...   .||..|.| |.||.| | .                 ||. ||| |  ..|.     . 
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQN-ILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMC

ESQV------GTLNYMSPEAIQDT-SPVNEVNEYGHKKPRLKIN-CKSDVWSLGCILYSMVYGRTPFQ
 ..|      ||  ||.|. .|.                . . .  |.|.||||||.| |.||..||.
QTCVNEKRIKGTPLYMAPQILQGQGE-------------QKPYYDYKCDIWSLGCIFYEMLYGKYPFF
Kinase TTK.AA STE 559-774 19 1.4e-31 108.87 In-house 1-268 (359) Show / Hide 
Range on Protein: 559-774
Range on HMM: 1-268/359
Sequence Identity: 19% (54 aa)

YSIIRLIGKGGSSKVFQVLSE------DSKKL---------WALKYVKLDFAD---------------EMAMQSYMNEITLLARLKT-FKRIIHLHDYEL
. .|. ||||.. .|.. .        .....          | | ..|.  .               .. ||....|| .. ...   . |.. .....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TE-------DYIYLVMECGS-IDLATFLKKNK---DNLS----------PHHMWCYWQEMLEA-VDVIHKEGIVHSDLKPANFIFVEASLKLIDFGIANA
 |       |.....||  .   |  ..|...   ..|.           .   .. .. |..  . .|. .|.| |.||||  .     ||.|||..  
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

IQNDH-------------TSV-VKESQVGTLNYMSPEAIQD-TSPVNEVNEYGHKKPRLKINCKSDVWSLGCILYSMVYGRTPF
.....             |..    . |||  .|.|| ||  ... .          . . ..|.|.||||| .  |. |. |.
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R----------DKGYDTKCDIWSLGCTIIEMATGKPPW
Kinase TTK.AA Ciliate-E2 559-802 19 2e-31 105.11 In-house 1-332 (365) Show / Hide 
Range on Protein: 559-802
Range on HMM: 1-332/365
Sequence Identity: 19% (69 aa)

YSIIRLIGKGGSSKVFQV--LSE---------------------DSKKLWALKYV-KLDFADEMAMQSYMNEIT----------LLARLKTFKRIIHLHD
| .|..||.|. ..|...   ..                     . .|. |.|.. | .    . ... |.||           .| .|. .. || ...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLN-HPNIIKMYE

YEL--TEDYIYLVME-CGSIDLATFLKKNKDN----------LSPHHMWCYWQEMLE---------------AVDVIHKEG-IVHSDLKPANFIFVEASL
.    ....|||||| |   ||  ..|.|| .          ..  ..  . .. |.               |.  .|... |.| |.|| | .|    .
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----I

KLIDFGIANAIQNDHT-----SVVK------------------------ESQVGTLNYMSPEAIQDTSPVNEVNEYGHKKPRLK--INCKSDVWSLGCIL
|.||||..  ...|.      .  |                         ...||..||.|| ..  .  |.          ..   . |.|.||||.||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ---------QKQKGYDYKCDIWSLGVIL

YSMVYGRTPFQHIVHRLLKMQAICNPDHFID-----------------FQPIENE
| |..|..||         .| |.. .  ..                 .. ...|
YEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQE
Kinase TTK.AA Ciliate-E2-Unclassified 559-775 22 4.8e-30 101.41 In-house 1-271 (352) Show / Hide 
Range on Protein: 559-775
Range on HMM: 1-271/352
Sequence Identity: 22% (64 aa)

YSIIRLIGKGGSSKVFQVLSEDSKKLWALKYVKLDFADEMAMQSYMNEITLLARLKTFKR-----------------------IIHLHDYELTEDYIYLV
| ||. ||.|| .||...  .. |.. |.|| |    . .  . ... . ..  .  ...                       |....... ....||.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

ME-CGSIDLATFLKKNKD----------------NLSPHHMW-----CYWQEMLEAVDVIHKEG-IVHSDLKPANFIFVEA----SLKLIDFGIANAIQN
|| |   ||  ..||.|                  ..  ..       |  . |.. . .|... |.| |.|| | .| .      .|.|||||.  .|.
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

DHTSVVKE--------------SQVGTLNYM----SPEAIQDTSPVNEVNEYGHKKPRLKINCKSDVWSLGCILYSMVYGRTPFQ
.  .  ..              ...||.|||    .|| .|   . ..               |.|.||||.||| |..|. ||.
NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA------------YKCDIWSLGVILYEMLFGYYPFY
Kinase TTK.AA NEK 559-732 27 2e-23 79.67 In-house 1-198 (286) Show / Hide 
Range on Protein: 559-732
Range on HMM: 1-198/286
Sequence Identity: 27% (56 aa)

YSIIRLIGKGGSSKVFQVLSEDSKKL-----WALKYVKLDFADEMAMQSYM-NEITLLARLK-----TFKRIIHLHDYELTED--YIYLVMECGSI--DL
| ||. ||.|  .||. | .   .|      ...| ....  .|   |  . ||. .|..||     ...  .      . |.  ... |||      ||
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSF------IEEQNNCLCIVMEYCEGGGDL

ATF---LKKNKD---NLSPHHMWCYWQEMLEAVDVIHKE-----GIVHSDLKPANFIFVEAS------LKLIDFGIANAIQNDHTSVVKES-QVGTLNYM
. .   .||.|.   ...    | . . |. |.. .|..      |.| |.||.| ||  ..      .|. ||||.  ..|. |.  . . ||||  ||
YQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQN-IFLTKNNNDYHNVKIGDFGIS-KVLNHTTDMAY-TTQVGTPYYM

SPEAIQD
||| .|.
SPEVCQN
Kinase TTK.AA Pkinase 813-890 29 1.3e-22 81.01 Pfam 192-293 (293) Show / Hide 
Range on Protein: 813-890
Range on HMM: 192-293/293
Sequence Identity: 29% (30 aa)

KSDVWSLGCILYSMVYGRTPFQHI-----VHRLLKMQAICNPDHFIDFQPIEN-------------------ELLLDVMKKCLTRDVKRRPSIEELLNHP
|.|.||.||||| |. ||.||..      .  . ... |  |.   |..   .                   | ..|..|.||..| |.||..|..|.||
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

YV
..
WF
Kinase TTK.AA CAMK 802-890 22 1.1e-19 59.48 In-house 290-425 (425) Show / Hide 
Range on Protein: 802-890
Range on HMM: 290-425/425
Sequence Identity: 22% (31 aa)

ELLLD-------------VMKINCKSDVWSLGCILYSMVYGRTPFQHI--------------VHRLLKMQAICNPD-HFIDFQP------------IENE
|.|.                 .. |.|.||.|.||| |. |. ||..                ..|...   .. |     | |            | .|
EVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDE

-------LLLDVMKKCLTRDVKRRPSIEELLNHPYV
          |  .|.|..| ..|..||. |||| .
FHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase TTK.AA Ciliate-E2 811-890 25 3.5e-19 62.46 In-house 274-365 (365) Show / Hide 
Range on Protein: 811-890
Range on HMM: 274-365/365
Sequence Identity: 25% (26 aa)

NCKSDVWSLGCILYSMVYGRTPFQHIVHRLLKMQAICNPDHFIDFQPIENELLL-----------------DVMKK----CLTRDVKRRPS-IEELLNHP
. |.|.||||.||| |..|..||         .| |.. .  ....  ... ..                 | .||    .| .| . |.. .|..||||
DYKCDIWSLGVILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQKD-TQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHP

YV
. 
WF
Kinase TTK.AA ULK 808-890 28 1.2e-18 61.77 In-house 230-329 (329) Show / Hide 
Range on Protein: 808-890
Range on HMM: 230-329/329
Sequence Identity: 28% (29 aa)

MKIN-CKSDVWSLGCILYSMVYGRTP----FQHIV----HRLLKMQAICNP---DHFIDFQ-----PIENELLLDVMKKCLTRDVKRRPSIEELLNHPYV
.. .  |.|.||||||.| |.||..|    |.  .     .|.. .  ...   .. ..|.     |.  . . |  ...|..| | | |.|||.||| .
KPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase TTK.AA AGC 815-890 24 1.8e-18 42.93 In-house 285-395 (395) Show / Hide 
Range on Protein: 815-890
Range on HMM: 285-395/395
Sequence Identity: 24% (27 aa)

DVWS--LGCILYSMVYGRTPFQHI---------VHRLLKMQAICNPDHFIDFQPIEN--------------ELLLDVMKKCLTRDVKRRPS---------
| ||  |||..| |..|..||..           ..  ..| |.|.. || ...  .              . . | .||.|..| ..|.          
DWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDK

-IEELLNHPYV
 .||. |||. 
GAEEIKNHPWF
Kinase TTK.AA ULK 808-890 31 1.6e-17 58.8 In-house 226-324 (324) Show / Hide 
Range on Protein: 808-890
Range on HMM: 226-324/324
Sequence Identity: 31% (31 aa)

MKIN-CKSDVWSLGCILYSMVYGRTP----FQHIVH---RLLK-----MQAICN-PDHFID--FQPIENELLLDVMKKCLTRDVKRRPSIEELLNHPYV
.. .  |.|.||||||.| |.||..|    |.  ..   .|..     .  |.| |  | .   .|.  . . |  ...|..| | | |.||..||| .
KPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase TTK.AA Ciliate-E2-Unclassified 813-890 25 1.8e-16 53.7 In-house 250-352 (352) Show / Hide 
Range on Protein: 813-890
Range on HMM: 250-352/352
Sequence Identity: 25% (26 aa)

KSDVWSLGCILYSMVYGRTPFQH--------------------IVHRLLKMQAICNPDHFI-----DFQPIENELLLDVMKKCLTRDVKRRPSIEELLNH
|.|.||||.||| |..|. ||.                     ....  | . |..| .       . .|   ... | ..|.|  . . |...|..|||
KCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNH

PYV
|. 
PWF
Kinase TTK.AA CMGC 802-890 11 4.2e-15 45.19 In-house 295-513 (513) Show / Hide 
Range on Protein: 802-890
Range on HMM: 295-513/513
Sequence Identity: 11% (26 aa)

ELLLDV---------MKINCKSDVWSLGCILYSMVYG--------RTPFQ-------------HIVHRLLKMQAICN------------------PD---
|.||           |. ... |.||.|||.. |. |        .. |.             . .. | |.  ..                   ..   
EILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWP

-----------------------------------------HFIDFQPI--------------------------------------ENELLLDVMKKCL
                                         ........                                      ......| .||.|
NMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKML

TRDVKRRPSIEELLNHPYV
. | ..|...|. |.||| 
QYDPDKRITAEQALQHPYF
Kinase TTK.AA STE 809-890 23 2.5e-13 43.52 In-house 244-359 (359) Show / Hide 
Range on Protein: 809-890
Range on HMM: 244-359/359
Sequence Identity: 23% (27 aa)

KINCKSDVWSLGCILYSMVYGRTPFQHIVHRLLKMQAICNPDHFI-----------DFQPIEN----------------------ELLLDVMKKCLTRDV
. ..|.|.||||| .  |. |. |. |  | .  | .| .  |             .  |...                      . . | ..|||..| 
GYDTKCDIWSLGCTIIEMATGKPPW-HDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDP

KRRPSIEELLN--HPYV
. ||. ..||.  || .
NKRPTASQLLKSEHPFI
Kinase TTK.AA TyrKc 559-890 15 8.3e-09 -80.29 SMART 1-280 (280) Show / Hide 
Range on Protein: 559-890
Range on HMM: 1-280/280
Sequence Identity: 15% (56 aa)

YSIIRLIGKGGSSKVFQ-VLSEDSKKLWALKYVKLDFADEMAMQSYMNEITLLARL-KTFKRIIHLHDYELTE-------DYIYLVME-CGSIDLATFLK
 . .. .| |   .|.. ...       | | .| |      ..  |.|. .. .| .  . |. |. . ...       . ...||| .   ||  .|.
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KNKDNLSPHHMWCYWQEMLEAVDVIHKEGIVHSDLKPANFIFVEASL--KLIDFGIANAIQND------HTSVVK----ESQ-VGTLNYMSPEAIQDTSP
|....|.. ..  .     .  . .|. ...| ||   | . | . .  |  ||| . .| .|      .   .|     .  .  .  |.||.|..   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARN-CLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY---

VNEVNEYGHKKPRLKINCKSDVWSLGCILY------SMVYGR-----TPFQHIVHRLLKMQAICNPDH----FIDFQPIENELLLDVMKINCKSDVWSLG
    ... .         |||||| |  ..       . |        . |...... .      |..                                
----GKFTT---------KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------

CILYSMVYGRTPFQHIVHRLLKMQAICNPDHFIDFQPIENELLLDVMKKCLTRDVKRRPSIEELLNHPYV
                                  | ..  . . ..||.|  .| . ||. .|.  | . 
----------------------------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase TTK.AA NEK 865-890 26 5.5e-07 21.06 In-house 261-286 (286) Show / Hide 
Range on Protein: 865-890
Range on HMM: 261-286/286
Sequence Identity: 26% (7 aa)

DVMKKCLTRDVKRRPSIEELLNHPYV
... ..|..| . |||....|..|..
NLISQMLQKDPEQRPSCNQILEMPFI
Kinase TTK.AA NEK 754-765 83 3.9e-05 14.48 In-house 204-215 (286) Show / Hide 
Range on Protein: 754-765
Range on HMM: 204-215/286
Sequence Identity: 83% (10 aa)

KSDVWSLGCILY
|||.|||||.||
KSDIWSLGCVLY
Kinase TTK.AA NEK 813-824 83 3.9e-05 14.48 In-house 204-215 (286) Show / Hide 
Range on Protein: 813-824
Range on HMM: 204-215/286
Sequence Identity: 83% (10 aa)

KSDVWSLGCILY
|||.|||||.||
KSDIWSLGCVLY