Gene ULK3 (Sea Urchin)
ULK3
Sequence
Protein domains of ULK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | ULK3.AA | ULK | 8-183 | 29 | 3.9e-71 | 242.62 | In-house | 88-329 (329) | Show / Hide |
Range on Protein: 8-183
Range on HMM: 88-329/329
Sequence Identity: 29% (73 aa)
WDQHY--IYLIMEFCSGGDLSQTIHKRIALPEAT----------VKTFLRQLASALMFLNSRNITHMDLKPQNLLLSN-----------SYNPVLKVADF
..... ||.|||.| ||||.| |.|. ||| | .. |..|.......|...|| | |.|||| |..| . |.|||.|||
ETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADF
GFAQHITED------IQADM----LRGSPLYMAPEIITDR----IYN-AKADLWSVGVIMFVHLILICCFSCGLHQIPT------FVE------------
|||.|...| ... |.|.||||||.|. .. |. .|.|.||.|.|.. | . |.. . ..
GFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQ
------------SSGACRDLLSRLLKRDPGERIEFEDFFHHPFI
| |.||..|.|..|. .||..|..|.||..
PLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
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| Kinase | ULK3.AA | ULK | 11-183 | 30 | 6.8e-71 | 241.83 | In-house | 89-324 (324) | Show / Hide |
Range on Protein: 11-183
Range on HMM: 89-324/324
Sequence Identity: 30% (73 aa)
H-YIYLIMEFCSGGDLSQTIHKRIALPEAT----------VKTFLRQLASALMFLNSRNITHMDLKPQNLLLSN-----------SYNPVLKVADFGFAQ
| .||.|||.| ||||.| |.|. ||| | .. |..|.......|...|| | |.||||.|..| . |.|||.||||||.
HNNIYIIMEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAK
HITEDIQADMLR----------GSPLYMAPEIITDR----IYN-AKADLWSVGVIMFVHLILICCFSCGLHQIPT-----------------------FV
|. .. ...... |.||||||.|. .. |. .|.|.||.|.|.. | . |.. . |
HVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFP
------ESSGACRDLLSRLLKRDPGERIEFEDFFHHPFI
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KPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
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| Kinase | ULK3.AA | CAMK | 9-131 | 22 | 4.1e-43 | 136.3 | In-house | 117-326 (425) | Show / Hide |
Range on Protein: 9-131 Range on HMM: 117-326/425 Sequence Identity: 22% (48 aa) DQHY------------IYLIM---EFCSGG----DLSQTIHKR---------------IALPEATVKTFLRQLASALMFLNSRNITHMDLKPQNLLLSNS .. | .|..| |.|||| || . | .. ..|. .... ||..||. .. |.|| | |||| |.||... ND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDN YNP---------------VLKVADFGFAQHITE------------------------DIQADMLRGSPLYMA-PEIITD--------------RIYNAKA .. .|..|||||..... . |.| ||| ||.. . |. |. NDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKC DLWSVGVIMFV | ||.|||... DMWSCGVILYI |
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| Kinase | ULK3.AA | Ciliate-E2 | 9-183 | 24 | 4.6e-42 | 142.18 | In-house | 105-365 (365) | Show / Hide |
Range on Protein: 9-183 Range on HMM: 105-365/365 Sequence Identity: 24% (67 aa) DQHYIYLIMEFCSGGDLSQTIHKRI-----------ALPEATVKTFLRQLAS---------------ALMFLNSRN-ITHMDLKPQNLLLSNSYNPVLKV |...|||.||.|.|||| . | .. . | .|.. .|... || .| |.| | | |.||.|.|. .|. DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-------IKI ADFGFAQHITED-----------------------------IQADM---LRGSPLYMAPEIIT---------DRIYNAKADLWSVGVIMFVHLILICCFS .|||... ...| || .| . |.| ||||||. |. |.|.||.|||.. | | IDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF- CGLHQIPT-----------------------FVESSGACRDLLSR----LLKRDPGERIE-FEDFFHHPFI . || . . | | ||... .|..|| .|| .|. . ||.. --QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | ULK3.AA | Ciliate-E2-Unclassified | 9-183 | 24 | 5.6e-39 | 132.85 | In-house | 92-352 (352) | Show / Hide |
Range on Protein: 9-183 Range on HMM: 92-352/352 Sequence Identity: 24% (64 aa) DQHYIYLIMEFCSGGDLSQTIHKR-----------------IALPEATVK-----TFLRQLASALMFLNSRN-ITHMDLKPQNLLLSNSY-NPVLKVADF |. .||..||.| ||||.| | || ..| .| ....|. ..| .| . | | | |.||.|.|..|. | .|..|| DKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDF GFAQHITEDIQADMLR-----------------GSPLYM----APEIITDRIYN----AKADLWSVGVIMFVHLILICCFSC------------------ |.. .. .... | . |.| || |||.. |. |.| ||.|||.. | ..|.. GISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAY --GLHQIP-TF-------------VESSGACRDLLS----RLLKRDPGERIEFEDFFHHPFI |.|. .| . |... ..|| .|..|| ||. . ||.. RKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | ULK3.AA | CAMKL | 12-131 | 37 | 2.7e-38 | 119.71 | In-house | 95-228 (297) | Show / Hide |
Range on Protein: 12-131 Range on HMM: 95-228/297 Sequence Identity: 37% (50 aa) YIYLIMEFCSGGD--LSQTI--HKRIA--LPEATVKTFLRQLASALMFLNSRNITHMDLKPQNLLLSNSYNPVLKVADFGFAQHITE-----DIQADMLR .|||.|| ||||. | . | |.. .|| . . ||. ||. .. |..| | |.|| |.||... | ..|..||||. .... . .. KIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFC GSPLYMAPEIITD--RIYN-AKADLWSVGVIMFV ||| ||||||. . . |. |.| || |||... GSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYA |
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| Kinase | ULK3.AA | Ciliate-E2a | 9-130 | 34 | 2.9e-34 | 98.29 | In-house | 70-207 (275) | Show / Hide |
Range on Protein: 9-130 Range on HMM: 70-207/275 Sequence Identity: 34% (48 aa) DQHYIYLIMEFCSGGDLSQTIHKRIALPEA--TVKTFLRQLAS-ALMFLNSRNITHMDLKPQNLLL----SNS-YNPVLKVADFGFAQHITEDIQ--ADM | ...||.||.|.||.| . | . . | .. ...|| . .| . .||| | ||||.|.|. .|| .| .|..|||.|. | |.. DENNYYLVMEYCEGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQ LRGSPLYMAPEIITDRI------YNAKADLWSVGVIMF |.| |.|||.. . | | |.||.|||.. KCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFY |
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| Kinase | ULK3.AA | Pkinase | 12-130 | 33 | 1.4e-33 | 119.82 | Pfam | 74-203 (293) | Show / Hide |
Range on Protein: 12-130 Range on HMM: 74-203/293 Sequence Identity: 33% (44 aa) YIYLIMEFCSGG----DLSQTIH--KRIAL--PEATVKTFLRQLASALMFLNSRNITHMDLKPQNLLLSNSYNP--VLKVADFGFAQH--ITEDIQADML .||..||.| || ||. |. .. .. .| ..| ...|....| .. |..| | ||||.|.|..| ... .|..|||.| . . . .. . HIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTF RGSPLYMAPEIIT-DRIYNAKADLWSVGVIMF |.| |||||.| .. | |.| ||.|.|.. CGTPWYMAPEVIRGGQYYGPKVDMWSCGCILY |
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| Kinase | ULK3.AA | STE | 9-129 | 25 | 7.7e-33 | 113.33 | In-house | 108-258 (359) | Show / Hide |
Range on Protein: 9-129 Range on HMM: 108-258/359 Sequence Identity: 25% (40 aa) DQHYIYLIMEFCSGGDLSQTIH-KRIA-------------LPEATVKTFLRQLASA-LMFLNSRNITHMDLKPQNLLLSNSYNPVLKVADFGFAQHITED . ......||...|| |.. |. | . .|| .....||. . | .| | .| | |.||.| || | .|||.. .|.. NDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-------VKLCDFGVCGQLTDS I-----------------QADMLRGSPLYMAPEIITDRI------YNAKADLWSVGVIM . . . . |.| .||||.|. . |..|.| ||.| . MANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI |
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| Kinase | ULK3.AA | MAPKAPK | 14-131 | 35 | 3.7e-30 | 90.2 | In-house | 77-210 (292) | Show / Hide |
Range on Protein: 14-131 Range on HMM: 77-210/292 Sequence Identity: 35% (48 aa) YLIMEFCSGGDLSQTIHK--RIALPEATVKTFLRQLASALMFLNSRNITHMDLKPQNLLL-SNSYNPVLKVADFGFAQH------ITEDIQADMLR---G ||.||. ||.| | |.. ... | . .. .||..|| |.|| | |||| |.| ... | ..| ||||| .|. |. | . YLVMECMEGGELFQHIQQRGHKHFTEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCY SPLYMAPEIITDRI----YNAKADLWSVGVIMFV .| |||||.. . |. . |.|| |||| . TPYYMAPEVVGAFKEAHTYDKSCDMWSLGVIMYI |
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| S_TKc | ULK3.AA | S_TKc | 3-183 | 24 | 6.2e-29 | 103.37 | SMART | 17-231 (231) | Show / Hide |
Range on Protein: 3-183 Range on HMM: 17-231/231 Sequence Identity: 24% (57 aa) LCQYPW------------------------------------DQHYIYLIMEFCSG--GDLSQTIHKRIA------LPEATVKTFLRQLASALMFLNSRN .|. | ...|..||.|.| ||| . |.|| .|| ... ...|...|| .. |.. KCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG ITHMDLKPQNLLLSNSYNPVLKVADFGFAQHITEDIQADMLRGSPLYMAPEIITDRIYNA-KADLWSVGVIMFVHLILICCFSCGLHQIPTFVESSGACR | | ||||.|.||.. ..|..|||.| .. . . |.| |||||.. |. |.| ||.|.|.. | |. .... . | .. IIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-SPEAK DLLSRLLKRDPGERIEFEDFFH-------HPFI |.....|..|| .|. . .. ||.. DFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | ULK3.AA | RSK | 9-130 | 29 | 7.6e-27 | 95.34 | In-house | 72-203 (278) | Show / Hide |
Range on Protein: 9-130 Range on HMM: 72-203/278 Sequence Identity: 29% (39 aa) DQHYIYLIMEFCSGGDLSQTIHKRIA---LPEATVKTFLRQLASALMFLNSRNITHMDLKPQNLLLSN-SYN-PVLKVADFGFAQH-ITE-DIQADMLRG .. ..|||||.|.||.| . |. . | ... ......|. .| .. | | |||| | |. . | | .|. ||||. . ... .. TEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCY SPLYMAPEIIT----DRIYNAKADLWSVGVIMF . |||||... .. ... .|.|| ||.|. TIEYMAPEMLKRANQQGGHDKACDWWSLGVLMY |
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| Kinase | ULK3.AA | Pkinase_Tyr | 12-130 | 31 | 1.2e-11 | 40.11 | Pfam | 81-205 (270) | Show / Hide |
Range on Protein: 12-130 Range on HMM: 81-205/270 Sequence Identity: 31% (40 aa) YIYLIMEFCSGGDLSQTIHK----RIALPEATVKTFLRQLASALMFLNSRNITHMDLKPQNLLLSNSYNPVLKVADFGFAQHI-TED---IQADMLRGSP .||..||.. .||| .| . .|. . . .| |... .| |.|. | || | |... | | |..||| | | .| ... . QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE--NNVVKICDFGLARDIYNDDYYYRKRGGGKLPI LYMAPEIITDRIYNAKADLWSVGVIMF |||| | ..... | | || || |. KWMAPECINYGKFTTKSDVWSFGVLMW |
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| Kinase | ULK3.AA | MAPKAPK | 153-183 | 41 | 6.7e-09 | 23.21 | In-house | 262-292 (292) | Show / Hide |
Range on Protein: 153-183 Range on HMM: 262-292/292 Sequence Identity: 41% (13 aa) SGACRDLLSRLLKRDPGERIEFEDFFHHPFI | . || ..||.||| .|. |.. ||.| SEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI |
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| Kinase | ULK3.AA | CAMKL | 141-183 | 30 | 1.6e-08 | 23.16 | In-house | 257-297 (297) | Show / Hide |
Range on Protein: 141-183 Range on HMM: 257-297/297 Sequence Identity: 30% (13 aa) CGLHQIPTFVESSGACRDLLSRLLKRDPGERIEFEDFFHHPFI || ...| ... | ||||....|...| .|. .. ||. CG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| TyrKc | ULK3.AA | TyrKc | 1-183 | 17 | 2.1e-08 | -86.73 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-183
Range on HMM: 1-280/280
Sequence Identity: 17% (50 aa)
M-----------------------------------------ALCQY-P------------WDQ-------HYIYLIMEFCSGGDLSQTIHKRIA-LPEA
.|.. . .| . ....||....||| . ..|. |. .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK
TVKTFLRQLASALMFLNSRNITHMDLKPQNLLLSNSYNPVLKVADFGFAQHITED--------IQAD----MLRG-SPL-YMAPEIITDRIYNAKADLWS
. | | |. .| |.|. | || | |... . . |..||| . |..| .. |. |||| | ..... | | ||
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWS
VGVIM------------------FVHLILICCFSCG--LHQIPT-----FVESSGACRDLLSRLLKRDPGERIEFEDFFHHPFI
|| | .| . | . | | ||. . . .. .. ..|| .| |.. | ..
FGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
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| Kinase | ULK3.AA | CAMK | 156-183 | 35 | 3.1e-07 | 18.59 | In-house | 398-425 (425) | Show / Hide |
Range on Protein: 156-183 Range on HMM: 398-425/425 Sequence Identity: 35% (10 aa) CRDLLSRLLKRDPGERIEFEDFFHHPFI |.||....|..|| .|. |. ||.. CKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | ULK3.AA | Ciliate-E2a | 155-183 | 34 | 7e-06 | 13.34 | In-house | 247-275 (275) | Show / Hide |
Range on Protein: 155-183 Range on HMM: 247-275/275 Sequence Identity: 34% (10 aa) ACRDLLSRLLKRDPGERIEFEDFFHHPFI .| ||....|. || .|| .. ||. ECKDLMKKMLEKDPKKRITAQQALNHPWF |
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| Kinase | ULK3.AA | Pkinase | 155-183 | 31 | 1.1e-05 | 21.14 | Pfam | 265-293 (293) | Show / Hide |
Range on Protein: 155-183 Range on HMM: 265-293/293 Sequence Identity: 31% (9 aa) ACRDLLSRLLKRDPGERIEFEDFFHHPFI .|.|.....|..|| .|. .|. ..||.. ECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | ULK3.AA | RSK | 153-183 | 30 | 1.3e-05 | 16.92 | In-house | 243-278 (278) | Show / Hide |
Range on Protein: 153-183 Range on HMM: 243-278/278 Sequence Identity: 30% (11 aa) SGACRDLLSRLLKRDPGERIE-----FEDFFHHPFI | ...||....|.||| |. |. ||.. SQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | ULK3.AA | STE | 156-183 | 30 | 6.1e-05 | 13.52 | In-house | 330-359 (359) | Show / Hide |
Range on Protein: 156-183 Range on HMM: 330-359/359 Sequence Identity: 30% (9 aa) CRDLLSRLLKRDPGERIEFEDFFH--HPFI ..| ... |..|| .| .. . |||| FKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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| MIT | ULK3.AA | MIT | 193-261 | 43 | 3.5e-21 | 76.7 | Pfam | 1-71 (71) | Show / Hide |
Range on Protein: 193-261 Range on HMM: 1-71/71 Sequence Identity: 43% (31 aa) SLDKARTTVMEAVKSDQ-KGEWKEAIRLYLKAMEYFIPAIQYERDATKKEA-LKVRGMEYMRRAEELKGLL .|.||. | .||. |. .|. |||..| .| |||..||.||......|| |. . .||| |||..| .| YLQKAIELVKKAVEADEDAGNYEEAIQCYQEAIEYFMQAIKYEPNPKWREARLRQKMQEYMDRAEQIKEHL |
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| MIT | ULK3.AA | MIT | 190-265 | 28 | 4e-14 | 54.16 | SMART | 1-81 (81) | Show / Hide |
Range on Protein: 190-265 Range on HMM: 1-81/81 Sequence Identity: 28% (23 aa) CSESLDKARTTVMEAVKSDQ--KGEWKEAIRLYLKAMEYFIPAIQYE-RDATKKEALKVRGMEYMRRAEELKGLL--KPKK . ..|| . . ||| |. .| . .|| .| |. .|. .|.|| | ....|.. . ||..|.||.| . . . QRDYYQKAIEYITQAVKADEDEWGDYEQAIEHYQKGIDYLMQGIKYEKPDEKRRHAIWAKCREYLDRMEEIKNCHDWRLCP |
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| MIT | ULK3.AA | MIT | 310-374 | 26 | 1.3e-15 | 57.28 | Pfam | 5-71 (71) | Show / Hide |
Range on Protein: 310-374 Range on HMM: 5-71/71 Sequence Identity: 26% (18 aa) AVKLAKDASREDN-NEEYHIALDLYEQALSHLMPILQVEQKGKRKDL-LLKETEKCMTRAEVLKQYI |..|.| | ..|. . .| |...| .|. ..|.....|. |.... | . ....|.||| .|... AIELVKKAVEADEDAGNYEEAIQCYQEAIEYFMQAIKYEPNPKWREARLRQKMQEYMDRAEQIKEHL |
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| MIT | ULK3.AA | MIT | 304-378 | 18 | 6.6e-05 | 23.54 | SMART | 1-81 (81) | Show / Hide |
Range on Protein: 304-378 Range on HMM: 1-81/81 Sequence Identity: 18% (15 aa) NPEMKV-AVKLAKDASREDN--NEEYHIALDLYEQALSHLMPILQVE-QKGKRKDLLLKETEKCMTRAEVLKQYI--EVCQ . | .... | ..|. .. | |...|.... .|| ....| .. ||.. . . . ..|.| .|... | QRDYYQKAIEYITQAVKADEDEWGDYEQAIEHYQKGIDYLMQGIKYEKPDEKRRHAIWAKCREYLDRMEEIKNCHDWRLCP |
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