Gene ULK4 (Sea Urchin)

ULK4

Species: Sea Urchin
Alias: SPU_008621, Spk200, ULK4
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
ULK4.AA Protein None 1334 None Fasta, JSON
ULK4.kin_dom Protein Kinase Domain None 225 None Fasta, JSON

Protein domain

Protein domains of ULK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ULK4.AA ULK 39-289 23 4.2e-58 199.35 In-house 15-324 (324) Show / Hide 
Range on Protein: 39-289
Range on HMM: 15-324/324
Sequence Identity: 23% (79 aa)

TMYKGRRKGS---VNFVAIHCVDKARRSEVTNR----------------VRLTHELSHSN--IVEFYEWYETT--NHLWLIVELCTGGSLELILSQDGHF
. |||| | .     .||. ..||   ..  |.                ..  .||.| |  ||..|.|.||.  |....|.|.| || || .. .....
KVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKL

PETA----------VRGFGLDLI---------------------LVDS------------SGSLKYDDFSLARLEEENLDDIFDMTSAEGTSDQTKQGGE
||            ...|  ...                     |.              .| ||  || .|.  ..|  . ...... .   . |    
PE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVN---E-K----

GTATSTLVIILYLLIVGCPNYLAPEVLQ----GQPHS-IATDLWSLGCLLYEMYTGNPPFQADEFPKLVE------------QILTKDYPTPKVKGPRLA
             .|.| | | ||..||    ..|.. . .|.|||||..||| .| .||... | ....            ||. |. | .. |.|  .
-------------RIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPP-KD

TKPTPDFCSLIKVLLTKDPARRATWHELVIHPFW
 |  |.. .||. .|..|.  | .|.|.  ||..
PKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase ULK4.AA ULK 39-289 22 5.4e-57 195.67 In-house 14-329 (329) Show / Hide 
Range on Protein: 39-289
Range on HMM: 14-329/329
Sequence Identity: 22% (77 aa)

TMYKGRRKGS----VNFVAIHCVDKA--RRSE-----------VTNRVRLTHELS--------HSNIVEFYEWYETT--NHLWLIVELCTGGSLELILSQ
. |||| | .    .  ||.  .||   ....           ..| ... ..|         | |||..|.|.||.  |....|.|.| || || ....
KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKK

DGHFPETA----------VRGFGLDLI---------------------LVDSS------------GSLKYDDFSLARLEEENLDDIFDMTSAEGTSDQTK
....||.           .. |  ...                     |..              | ||  || .|.  .........|... .   . |
NKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVN---E-K

QGGEGTATSTLVIILYLLIVGCPNYLAPEVLQ----GQPHS-IATDLWSLGCLLYEMYTGNPPFQADEFPKLVEQILTKDYPTPKVKGP---RLATK---
                 .. | | | ||..||    ..|..   .|.|||||..||| .| |||.|  | ....||..| .  |.. ..      ..   
-----------------RLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPK

------PTPDFCSLIKVLLTKDPARRATWHELVIHPFW
        |.. .||. .|..|.  | .|.||  ||..
DGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
S_TKc ULK4.AA S_TKc 26-289 22 2e-32 114.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 26-289
Range on HMM: 1-231/231
Sequence Identity: 22% (67 aa)

FVLYDEIRQTETSTMYKGRRKGSVNFVAIHCVDKARRSEVTNRVRLTHELSHSNIVEFYEWYETTNHLWLIVELCTG--GSLELILSQDGH------FPE
. . ..| .   .. ||.| |..   ||| ...      . . ... ..  | ||| .|..... .||... |.| |  |.|  .. . |.      |||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

TAVRGFGLDL---------------------ILVDSSGSLKYDDFSLARLEEENLDDIFDMTSAEGTSDQTKQGGEGTATSTLVIILYLLIVGCPNYLAP
  .| .   .                     ||.|.   .|  || |||.                                        ..| |.|.||
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------TTFCGTPWYMAP

EVLQGQPHSI-ATDLWSLGCLLYEMYTGNPPFQADEFPKLVEQILTKDYPTPKVKGPRLATKPTPDFCSLIKVLLTKDPARRATWHELVI-------HPF
|||   ...  . | ||.||.||||..| |||.  .  .. ..|.                  .|.....|. .|.|||..| |  |.         ||.
EVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

W
 
F
Kinase ULK4.AA AGC 191-289 32 1.2e-31 77.82 In-house 271-395 (395) Show / Hide 
Range on Protein: 191-289
Range on HMM: 271-395/395
Sequence Identity: 32% (42 aa)

PNYLAPEVLQGQPHSIATDLWS--LGCLLYEMYTGNPPFQADE----------FPKLVEQILTKDYPTP-KVKGPRLA-------TKPTPDFCSLIKVLL
|.|.|||.|    .. | | ||  ||||.||| || |||..|.            .. ..|.  .|  . ||| |.          . .|.  .||| ||
PEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLL

TKDPARRAT----------WHELVIHPFW
.|||..| .            |.  ||. 
CKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase ULK4.AA Pkinase 187-289 26 6.7e-29 103.27 Pfam 171-293 (293) Show / Hide 
Range on Protein: 187-289
Range on HMM: 171-293/293
Sequence Identity: 26% (33 aa)

IVGCPNYLAPEVLQ-GQPHSIATDLWSLGCLLYEMYTGNPPFQAD------EFPKLVEQILTKDYPTPKVKGPR--------------LATKPTPDFCSL
..| |.|.||||.. ||... . | ||.||.||||..|.|||. .      .  .....|. .... .  .  .              . .. .......
FCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDF

IKVLLTKDPARRATWHELVIHPFW
|| .|.|||..| |..... ||..
IKWCLCKDPKKRPTAEQILQHPWF
Kinase ULK4.AA CAMK 188-289 24 5.1e-26 80.24 In-house 280-425 (425) Show / Hide 
Range on Protein: 188-289
Range on HMM: 280-425/425
Sequence Identity: 24% (36 aa)

VGCPNYLA-PEVLQG--------------QPHSIATDLWSLGCLLYEMYTGNPPFQAD-------------EFPKLVEQILTKDY--PTPKVKGPR----
.|.| | | ||||.|              .... ..| ||.|..|| | .| |||..|             . ..| |.|.. .|  | |.....     
CGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYG

-----------LATKPTPDFCSLIKVLLTKDPARRATWHELVIHPFW
              . ...  .||. .|..|| .|.| ..   ||. 
PEWWDDISDEFHH-FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase ULK4.AA STE 187-289 26 4.5e-24 81.96 In-house 223-359 (359) Show / Hide 
Range on Protein: 187-289
Range on HMM: 223-359/359
Sequence Identity: 26% (37 aa)

IVGCPNYLAPEVLQG------QPHSIATDLWSLGCLLYEMYTGNPPFQADEFPKLVEQILTK-------------DYPTPKVKGPRL-------------
.||.| . ||||.|.      .....  | |||||.. || ||.||.     ..   .|...             . | |. . .               
FVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTT

-ATKPTPDFCSLIKVLLTKDPARRATWHELVI--HPFW
  .| .|.|.  |.  |.|||  |.| ..|    ||| 
YPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase ULK4.AA Fused 187-289 41 1.2e-21 70.97 In-house 157-251 (251) Show / Hide 
Range on Protein: 187-289
Range on HMM: 157-251/251
Sequence Identity: 41% (43 aa)

IVGCPNYLAPEVLQGQPHSIATDLWSLGCLLYEMYTGNPPFQADEFPKLVEQILTKDYPTPKVKGPRLATKPTPDFCSLIKVLLTKDPARRATWHELVIH
| | | |.||| .  ||     |.||||| |||   | ||| |    .||  |.  |     || |      |. . .    ||||||  | .| .|  |
IKGTPLYMAPELVEEQPYDHHADMWSLGCILYELMVGQPPFCANSIFHLVSMIKHDD-----VKWPSTI---TSCCRNFLQGLLTKDPRHRISWPQLLCH

PFW
|| 
PFV
Kinase ULK4.AA Ciliate-E2-Unclassified 187-289 30 2.3e-21 70.89 In-house 222-352 (352) Show / Hide 
Range on Protein: 187-289
Range on HMM: 222-352/352
Sequence Identity: 30% (40 aa)

IVGCPNYL----APEVLQGQPHS----IATDLWSLGCLLYEMYTGNPPFQADEFPK----------------LVEQILTKDYPTPKVK---GPRLATKPT
..| |||.    |||||||| ..    .. | ||||..|||| .|..||..    .                | ..|. |..  || .    |    .  
FCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEA

PDFCS-LIKVLLTKDPARRATWHELVIHPFW
 ||.. |.. .| |.|  | |. ..  ||. 
KDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase ULK4.AA RSK 188-289 29 7e-21 73.3 In-house 169-278 (278) Show / Hide 
Range on Protein: 188-289
Range on HMM: 169-278/278
Sequence Identity: 29% (34 aa)

VGCPNYLAPEVLQ---GQP-HSIATDLWSLGCLLYEMYTGNPPFQA---DEFPKLVEQILTKDYPTPKVKGP--RLATKPTPDFCSLIKVLLTKDPARRA
..  .|.|||.|    .|  |. | |.||||.|.||| ||.||||.   .   .. ..|.....    ...|        .... .||. .|..||..| 
CYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKF---SLTMPNWQYL---SQEAKDLIRKMLHRDPHKRL

T-----WHELVIHPFW
.       |.  ||..
GCGPQDAEEIKQHPWF
Kinase ULK4.AA Ciliate-E2 187-289 29 1.6e-20 67.18 In-house 247-365 (365) Show / Hide 
Range on Protein: 187-289
Range on HMM: 247-365/365
Sequence Identity: 29% (38 aa)

IVGCPNYLAPEVLQGQP---------HSIATDLWSLGCLLYEMYTGNPPFQADEFPKLVEQILTKDYPTPKVKGPRLATK-----------PTPDFCSLI
|.| |.|.|||.|.|..         .. . |.||||..|||| .|.|||         .||. ...  |. .     |.            ...   ||
ICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKD-TQCIQCKWKSWKKWSQECKDLI

KV----LLTKDPARRAT-WHELVIHPFW
|     .| |||  | | | ..  ||. 
KKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase ULK4.AA PLK1 189-289 33 2.6e-20 63.26 In-house 161-253 (253) Show / Hide 
Range on Protein: 189-289
Range on HMM: 161-253/253
Sequence Identity: 33% (34 aa)

GCPNYLAPEVLQGQPHSIATDLWSLGCLLYEMYTGNPPFQADEFPKLVEQILTKDYPTPKVKGPRLATKPTPDFCSLIKVLLTKDPARRATWHELVIHPF
| |||.|||||. . ||   |.||.||..| .  |.||| .        .|   .|  |.   .  |        .||...| .|| || | ....   |
GTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLFGQPPFETKCLKETYSRIKKNEYRIPSHISQPAA--------QLIRKMLDPDPTRRPTIEQVLNDEF

W
.
F
Kinase ULK4.AA Pkinase 41-121 26 1.7e-12 45.27 Pfam 16-111 (293) Show / Hide 
Range on Protein: 41-121
Range on HMM: 16-111/293
Sequence Identity: 26% (25 aa)

YKGRRKGSVNFVAIHCVDKARRSEVTNR-------VRLTHELSHSNIVEFYEWYETTNHLWLIVELCTGG----SLELILS--QDGHF--PETAVR
||...||.   ||. ...| ....  ..       ... ..|.| |||..|.|.|. .|.... |.| ||    .|  ..|  ..| |  .|  ..
YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECK
Kinase ULK4.AA CAMK 74-123 21 5.8e-12 34.12 In-house 94-184 (425) Show / Hide 
Range on Protein: 74-123
Range on HMM: 94-184/425
Sequence Identity: 21% (20 aa)

ELSHSNIVEFYEWYE------------TTNH--------LWLIV---ELCTGGSL--EL------------------ILSQDGHFPETAVRGF
.|.| ||. .||.||            | ..        ....    |.|.|| |  .|                  |. ..|.|.|  .| .
KLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRY
Kinase ULK4.AA Ciliate-E2 74-106 37 1.3e-08 25.62 In-house 88-122 (365) Show / Hide 
Range on Protein: 74-106
Range on HMM: 88-122/365
Sequence Identity: 37% (13 aa)

ELSHSNIVEFYEWYE--TTNHLWLIVELCTGGSLE
.|.| ||...||...  ..|.. |. |.| ||.|.
QLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLF
Kinase ULK4.AA STE 26-118 15 3.9e-08 24.95 In-house 1-151 (359) Show / Hide 
Range on Protein: 26-118
Range on HMM: 1-151/359
Sequence Identity: 15% (23 aa)

FVLYDEIRQTETSTMYKGRRKG---------------SVNFVAIHCVD--------------------KARRSEVTNRVRLTHELS--HSNIVEFYEWYE
. . ..| .  . | ||....                .....||  ..                    .  . .. . ... ....  | |||..|  |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TT-------NHLWLIVELCTGGSLELILS------QD--------GHFPET
         ..||.. |.. ||||. |.       ..        ..|||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPES
Kinase ULK4.AA TyrKc 26-289 16 3.1e-07 -105.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 26-289
Range on HMM: 1-280/280
Sequence Identity: 16% (52 aa)

FVLYDEIRQTETSTMYKGRRKGSVNFVAIHCVDKARRSEVTNRVRLTHEL--SHSNIVEFYEWYETT-------NHLWLIVELCTGGSLELILSQDGH-F
 .| ...   .  . |||. |     ||. .. .  | .  .  |. ..|  .| ||| .|    .          |....|.. .|.|   |   .. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

PETAVRGFGLDL---------------------ILVDSSGSLKYDDFSLARLEEEN-LDDIFDMTSAEGTSDQTKQGGEGTATSTLVIILYLLIVGCPNY
.      | ..                      .||.. .  |  || |.|  ..               |....   |.  . |.. |           
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---------ESKDYYRKKEHKGGKTMLPI---------RW

LAPEVLQGQPHSIATDLWSLGCLLYEMYT-GNPPFQA-----DEFPKLVEQILTKDYPTPKVK-----GPRLATKPTPDFCSLIKVLLTKDPARRATWHE
.|||...    ....| || | ...|..| | .|         .   ..|.. . ... .             . |.  .  ..|     ||. | |  |
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQ-IMKQCWHEDPEDRPTFSE

LVIHPFW
.  | ..
I--HECF
Kinase ULK4.AA PLK1 57-105 26 3.1e-07 19.54 In-house 38-86 (253) Show / Hide 
Range on Protein: 57-105
Range on HMM: 38-86/253
Sequence Identity: 26% (13 aa)

VDKARRSEVTNRVRLTHELSHSNIVEFYEWYETTNHLWLIVELCTGGSL
. . .|  .|  ... ..|.| .||.|....|  . .....|||   ||
IKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSL
Kinase ULK4.AA RSK 76-121 32 2e-06 20.26 In-house 59-107 (278) Show / Hide 
Range on Protein: 76-121
Range on HMM: 59-107/278
Sequence Identity: 32% (16 aa)

SHSNIVEFYEWYETTNHLWLIVELCTGGSLELILSQDGH---FPETAVR
.| .||. .. ..|  .|.|| |.| || |   |.. .|   | |. ..
QHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEAC
Kinase ULK4.AA AGC 76-121 24 3.3e-05 7.84 In-house 88-149 (395) Show / Hide 
Range on Protein: 76-121
Range on HMM: 88-149/395
Sequence Identity: 24% (15 aa)

SHSNIVE-FYEWYETTNH--LWLIVELCT---------GG-SLELILS---QDGHFPETAVR
.| .||   .  ... .|  | .. |..          ||  | |.|    . |.|.| ..|
HHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERAR
Kinase ULK4.AA Fused 41-121 26 0.000129 11.54 In-house 16-100 (251) Show / Hide 
Range on Protein: 41-121
Range on HMM: 16-100/251
Sequence Identity: 26% (23 aa)

YKGRRKGSVNFVAIHCVDKARRSE-----VTNRVRLTHELSHSNIVEFYEWYETTNHLWLIVELCTGGSLELILSQDGHFPETAVR
||.||| .   |||  . |  ||.         .    .. | .|..  . .||   .  . .    . |  .|. ||  ||  ||
YKARRKYDSKVVAIKFIPKRGRSDKELKNLRRECEIMRRMHHPHIIHMIDSFETDKEVVVVTDYAE-MELHQYLEYDGKMPEEQVR
Kinase ULK4.AA Ciliate-E2-Unclassified 75-121 15 0.000805 9.16 In-house 78-141 (352) Show / Hide 
Range on Protein: 75-121
Range on HMM: 78-141/352
Sequence Identity: 15% (10 aa)

LSHSNIVEFYEWYETTNHLWLIVELCTGGSLELILSQDGH-----------------FPETAVR
. | .|| .... ...... .. |.| ||.|. .... ..                 |.| ...
HPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAK
Kinase ULK4.AA Pkinase_Tyr 194-228 32 0.001448 12.7 Pfam 181-217 (270) Show / Hide 
Range on Protein: 194-228
Range on HMM: 181-217/270
Sequence Identity: 32% (12 aa)

LAPEVLQGQPHSIATDLWSLGCLLYEMYT-GNPP-FQ
.|||...    ....| || | |..|..| |  | ..
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYP
Kinase ULK4.AA Pkinase_Tyr 73-105 24 0.060489 7.21 Pfam 58-94 (270) Show / Hide 
Range on Protein: 73-105
Range on HMM: 58-94/270
Sequence Identity: 24% (9 aa)

HEL-SHSNIVEFYEWYE-TTNH--LWLIVELCTGGSL
..| .| ||| .|        .  .....|.. .|.|
KQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL