Gene Spk374 (Sea Urchin)

Spk374

Species: Sea Urchin
Alias: Spk374, SPU_011808
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: urch
Subfamily: urchA

Sequence

Name Sequence Type Origin Length Description Download
Spk374.AA Protein None 792 None Fasta, JSON
Spk374.kin_dom Protein Kinase Domain None 206 None Fasta, JSON

Protein domain

Protein domains of Spk374.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Spk374.AA urchA 538-737 55 3e-153 497.62 In-house 1-208 (208) Show / Hide 
Range on Protein: 538-737
Range on HMM: 1-208/208
Sequence Identity: 55% (115 aa)

LGRGVYGAVHLYSHKQTGQAVAVKVITLPKEYTKRRATISLFKKEVQFQELVSKSPYFPKLYGCFRLDEDKVGMAMEFVGDEVTGKS----TTLLKALEV
|||||||.||||.|.||...||.|||.|||||.|.|..|..|..|.|........|.||..|||....||||||||||.|||.||.|    ..|.||.|.
LGRGVYGTVHLYRHRQTDHPVALKVIELPKEYKKMRRKIECFQNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDKAMEM

RQPALTRYQMLLIAVDVAEGLRVLHDQGILINDLKNDNILIRK-EFGRWRGVLIDLGYACILQDPV---RFHFSQREKQEYLTIGRYGHIAPELAISEQP
|||||||.|......|.||||.|.|..|.|.||||.||.|.|| ||||||...||.|.||..|.|.   |.||.||.||.|....|..|||||.|...||
RQPALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFGRWRAKIIDFGWACPCQMPFPACRMHFDQRQKQFYRYCHRCCHIAPECALDAQP

ATIASDVF
....|||.
CSTSSDVY
Kinase Spk374.AA urch 538-740 42 7.79999999999e-113 381.16 In-house 1-217 (217) Show / Hide 
Range on Protein: 538-740
Range on HMM: 1-217/217
Sequence Identity: 42% (92 aa)

LGRGVYGAVHLYSHKQTGQAVAVKVITLPKEYTKRRA--------TISLFKKEVQFQELVSKSPYFPKLYGCFRLDEDKVGMAMEFVGDEVTGKS----T
.|||.||.|||| |.||.|.||.|....|..||....        ... |.||.....|.|..|||||.|||...| |.....|||.||. ||||    .
IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDID-DDLCLVMEFIGDKKTGKSYPLHW

TLLKA-LEVRQPALTRYQMLLIAVDVAEGLRVLHDQGILINDLKNDNILIRK-EFGRWRGVLIDLGYACILQDPV-RFHFSQREKQEYLTIGRYGHIAPE
...|. .....|.|.....|.||.|...|....||.|.|.||||.||.|..| ..|||..|.||.|..|....|. ..||...|..|| ....|.|||||
CIHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPE

LAISEQPATIASDVFQVG
.....||..|||||. ||
CVLDGQPCSIASDVYSVG
Kinase Spk374.AA urch-unclassified 538-740 30 1.7e-46 160.8 In-house 1-215 (215) Show / Hide 
Range on Protein: 538-740
Range on HMM: 1-215/215
Sequence Identity: 30% (66 aa)

LGRGVYGAVHLYSHKQTGQAVAVK-VITLPKEYTK--RRATISLF----KKEVQFQELVSKSPYFPKLYGCFRLDEDKVGMAMEFVGDEVTGKSTTLLKA
.| | .| | .. |. . ..|.|| .. . . |    |.  ..|      ||.  . | . .||||..||   . ||  . .||| ||  |..  .| ..
IGKGTFGKVFMMRHQREAVPVKVKMIHEHHNDYDYEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKH-EDCPCIVMEFLGDKQTYTVYPLCQW

LEVRQ---PALTRYQMLLIAVDVAEGLRVLHDQGILINDLKNDNILIRKEFG--RWRGVLIDLGYACILQDPVR-FHFSQREKQEYLTIGRYGHIAPELA
.  |    ||| .  ...|..|. .|.  .|. ..| |||| .||| ..     ||.   ||.| .  .  |   . ||  |..||     | |.|||  
IHERHKSNPALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMAPEIV

ISEQPATIASDVFQVG
   ||  ..||..  |
LYGQPTSVYSDIYSLG
Kinase Spk374.AA urchC 566-689 35 7.1e-27 83.88 In-house 41-168 (223) Show / Hide 
Range on Protein: 566-689
Range on HMM: 41-168/223
Sequence Identity: 35% (46 aa)

PKEYTKRRATISLFKKEVQFQELVSKSPYFPKLYGCFRLDEDKVGMAMEFVGDEVTGKSTTLLKALE---VRQPA--LTRYQMLLIAVDVAEGLRVLHDQ
.||   ...    ..||    .. | .||||..||   .||.   .  ||.||  .||.  |. |..   .  |   .    |. || |. .|  ..|| 
EKEESEWKQNNGRCEKEARVGQMMSTCPYFPRMYGTVMIDEN-MCIVTEFIGDKQQGKVYMLHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDF

GILINDLKNDNILI--RKEFGRWRGVLIDLG
| | || | ||.|   |||  || |. ||.|
GLLHNDIKDDNVLLEHRKE--RWHGCIIDMG
Kinase Spk374.AA urchB 536-740 35 1.2e-26 92.73 In-house 5-212 (212) Show / Hide 
Range on Protein: 536-740
Range on HMM: 5-212/212
Sequence Identity: 35% (75 aa)

SELGRGVYGAVHLYSHKQTGQAVAVKVITLPKEYTKR-------R-ATISLFKKEVQFQELVSKSPYFPKLYGCFRLDEDKVGMAMEFVGDEVTGKSTTL
 | ||| || | .  |.||.   |.|      .|          . ||    .||   . | | |||||| .|   .| |   .| ||||   ||    |
QEIGRGTYGRVVIARHRQTKVPLAIKQPCWSDNYQSPNEMVDELHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDIDND-LCQAQEFVGCKKTGIGYPL

LKALEVRQPALTRYQMLLIAVDVAEGLRVLHDQGILINDLKNDNILIRKEFGRWRGVLIDLGYACILQDPVRF-HFSQREKQEYLTIGRYGHIAPELAIS
.       | |     . || |.  |.  .|| | | |||||||.|  |   |.  | || | .     | .     .  |  |   .    ||||  . 
HEP-----PPLSMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVSTITAPLKMVEVPKELKMAYVHGEEADYIAPEVILH

EQPATIASDVFQVG
.|.  |.|||| ||
GQSTSISSDVFSVG
Kinase Spk374.AA S_TKc 532-788 19 6.8e-13 12.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 532-788
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)

GHGGSELGRGVYGAVHLYSHKQTGQAVAVKVITLPKEYTKRRATISLFKKEVQFQELVSKSPYFPKLYGCFRLDEDKVGMAMEFVGDEVTGKST---TLL
 . . ..|.| .| |..  || ||. ||.|.|               ...|.|  .   . |.  |||..|.   |.. | ||..       ..   .|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYC-------DGDLGDLF

KALEVRQPA-----LTRYQMLLIAVDVAEGLRVLHDQGILINDLKNDNILIRKEFGRWRGVLIDLGYACILQDPVRFHFSQREKQEYLTIGRYGHIAPEL
. .. |..      ..  .   ..  ....|  .|..||.  ||| .|||. .     .  ..| | |..|               .  .|    .|||.
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------------TTFCGTPWYMAPEV

AISEQPATI-ASDVFQVGAVYIGLGQ-----CFQMNELHQLG---------CICCSIAPSQRPTLDAILQ-CLGEIMKKYY
     . .  ..|.  .| . . .       . ||... ..          . |.   |..|||   .|| ..   .  . 
L----GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Spk374.AA Ciliate-E2 538-742 14 1.8e-11 35.65 In-house 7-285 (365) Show / Hide 
Range on Protein: 538-742
Range on HMM: 7-285/365
Sequence Identity: 14% (43 aa)

LGRGVYGAVHLYSHKQTGQAVA----------------VKVITLPKEYTKRRATISLFKKEVQFQELV--------------SKSPYFPKLYGCFRL-DE
.|.| .| | . ....... .|                ||.    ... | .  ....... ...|.                ..|.  |.| ||   |.
IGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDD

DKVGMAMEFVGD--------EVTGKSTTLLKALEVRQPALTRYQMLLIAVDVAE---------------GLRVLHDQG-ILINDLKNDNILIRKEFGRWR
... . ||..          .   |..  ..  .     .| .... |   ...               .|. || .. |.  |.| .|||.        
NNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE--K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------

GVLIDLGYACILQDP--VRFHFSQREKQEYLT----------------------IGRYGHIAPELAIS--------EQPATIASDVFQVGAV
  .||.|.. ...|.   |.|..|...  .                        .| .|  |||   .        ... . ..|.. .| .
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVI
Kinase Spk374.AA TKL 538-737 15 4.5e-11 36.14 In-house 1-273 (364) Show / Hide 
Range on Protein: 538-737
Range on HMM: 1-273/364
Sequence Identity: 15% (44 aa)

LGRGVYGAVHLYSHKQ--------TGQAVAVKVITLP--KEYTK-----------------RRATISLFKKEVQFQELVSK--SPYFPKLYG-CFRLDED
.|.| .| |.   ...        ||. ||||..     .| ||                  . .  ....|..   . |.   |   ...| |.. . .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------KVGMAMEFV-----GDEVTGKSTTLLKALEVRQPALTRYQMLLIAVDVAEGLRVLHDQG--------ILINDLKNDNILIRKEF-----
           . .. ||..      . ..                    |.. .| |.| |.  || ..        |.  ||| .|||. . .     
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSN

------GRWRGVLIDLGYACILQDPVRFHFS-----------QREKQEYLTIGRYGHIAPELAISEQ---------------PATIASDVF
        |.  . |.| .  ..       .           ...|. .  .| ... |||.   ..               ... ..||.
YMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVY
Pkinase Spk374.AA Pkinase 532-674 28 2e-10 37.98 Pfam 1-141 (293) Show / Hide 
Range on Protein: 532-674
Range on HMM: 1-141/293
Sequence Identity: 28% (42 aa)

GHGGSELGRGVYGAVHLYSHKQTGQAVAVKVITLPKEYT-KRRATISLFKKEVQFQELVSKSPYFPKLYGCFRLDEDKVGMAMEFVGDEVTGKSTTLLKA
 | |. .|.| .| | .  || ||. ||||.| ...|   |... . |   |.|    . ..|.  .||..|.  .|.. | ||...  ..     |   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFED-KDHIYMVMEYCEGGLY--VMDLFDY

LE-VRQPAL--TRYQMLLIAVDVAEGLRVLHDQGILINDLKNDNILI
..  |. ..  .  .   ..  ...||  .|..||.  ||| .||||
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI
Kinase Spk374.AA LISK 537-584 33 1.4e-09 27.12 In-house 1-48 (296) Show / Hide 
Range on Protein: 537-584
Range on HMM: 1-48/296
Sequence Identity: 33% (16 aa)

ELGRGVYGAVHLYSHKQTGQAVAVKVITLPKEYTKRRATISLFKKEVQ
|.|.| .| |   .|.|||| .|.| |.   .  ......  ...|||
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQ
Kinase Spk374.AA STE 532-617 18 1.5e-09 30.01 In-house 1-120 (359) Show / Hide 
Range on Protein: 532-617
Range on HMM: 1-120/359
Sequence Identity: 18% (22 aa)

GHGGSELGRGVYG-AVHLYSHK-----QTGQA---------VAVKVITLPKE------------YTKRRATISLFKKEVQFQELVSK-SPYFPKLYGCFR
  | ...|.| .|  .  . ||     .||.          .|.|.. | ..             .|    .  ..||...    .. .|.  | |||. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LD------EDKVGMAMEFVG
 .      .|.. ..||...
KEGHNHKNDDELWICMEYMD
Kinase Spk374.AA LISK 646-691 40 4e-09 25.58 In-house 106-152 (296) Show / Hide 
Range on Protein: 646-691
Range on HMM: 106-152/296
Sequence Identity: 40% (19 aa)

IAVDVAEGLRVLHDQGILINDLKNDNILIR-KEFGRWRGVLIDLGYA
||.|.|.|.. ||...|.  |||  |.|.| .. ..|| ...|.| |
IALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFA
Kinase Spk374.AA TESK 637-697 30 6e-08 20.72 In-house 90-155 (292) Show / Hide 
Range on Protein: 637-697
Range on HMM: 90-155/292
Sequence Identity: 30% (20 aa)

ALTRYQMLLIAVDVAEGLRVLHDQGILINDLKNDNILIR-KEFGRWRGVLIDLGYA----CILQDP
.|   | .  |.|.| |.. ||..|.   ||   |.|.| ..   .  |. | | |    |.   |
HLSWTQKIHLAYDIARGMSYLHSKGVFHRDLTSKNCLVRQRDNNQYEAVVGDFGLARVLGCMPDPP
Kinase Spk374.AA TyrKc 535-780 17 1e-06 -114.9 SMART 4-280 (280) Show / Hide 
Range on Protein: 535-780
Range on HMM: 4-280/280
Sequence Identity: 17% (53 aa)

GSELGRGVYGAVHLYSHKQTGQAVAVKVITLPKEYTKRRATISLFKKEVQFQELV-SKSPYFPKLYGCFRLDE------DKVGMAMEFVGDEVTGKSTTL
| .||.| .| |..   |   . ||||..   .        .  | .| .    .  . |   .|||. . ..      . . . ||..      .   |
GKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM------PHGDL

LKALEVRQPALTRYQMLLIAVDVAEGLRVLHDQGILINDLKNDNILIRKEFGRWRGVLI-DLGYACILQDP-------VRFHFSQ--REKQ---------
.. |  ..| |.  ..| .....|.| . ||....   ||   |.|. ...     | | | | .  . |           . ..   .|          
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EYLTIGRYGH-------------IAPELAISEQPA-----TIASDVFQVGAVYIGLGQCFQ---------MNELHQLGCICCSIAPSQRPTLDAILQCL
| .  |.. .             |   .  .  |        ...|..       . |              |..|.   |.   |..|||  .| .|.
ECINYGKFTTKSDVWSFGVCMWEIF-TYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Spk374.AA LISK 754-780 33 0.000494 8.77 In-house 270-296 (296) Show / Hide 
Range on Protein: 754-780
Range on HMM: 270-296/296
Sequence Identity: 33% (9 aa)

ELHQLGCICCSIAPSQRPTLDAILQCL
....|   ||.  |. ||. . |.| |
PFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase Spk374.AA TESK 757-782 34 0.003636 5.34 In-house 267-292 (292) Show / Hide 
Range on Protein: 757-782
Range on HMM: 267-292/292
Sequence Identity: 34% (9 aa)

QLGCICCSIAPSQRPTLDAILQCLGE
||   ||.. |..||.   | . |  
QLAFHCCNMDPKDRPVFHEITKHLEW
Kinase Spk374.AA TKL 752-780 27 0.011919 5.38 In-house 336-364 (364) Show / Hide 
Range on Protein: 752-780
Range on HMM: 336-364/364
Sequence Identity: 27% (8 aa)

MNELHQLGCICCSIAPSQRPTLDAILQCL
. .. .|   |..  |..||. . ||. |
PPSMKKLMQDCWDHDPEKRPSFQEILKRL