Spk017

Species: Sea Urchin
Alias: SPU_027765, Spk017
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: urch
Subfamily: urchB

Sequence

Name Sequence Type Origin Length Description Download
Spk017.AA Protein None 441 None Fasta, JSON
Spk017.kin_dom Protein Kinase Domain None 212 None Fasta, JSON

Protein domain

Protein domains of Spk017.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Spk017.AA urchB 179-390 78 2.1e-195 655.47 In-house 1-212 (212) Show / Hide
Range on Protein: 179-390
Range on HMM: 1-212/212
Sequence Identity: 78% (166 aa)

INDLQEIGRGTYGRVLLARHVQTKTPLAIKQSCRSENYQLLNEMVDEAHDATRARVKKEALVHQLLSDSPFFPRFLGTLDIDKDLCLAQEFVGNRKSGIA
|||||||||||||||..|||.|||.||||||.|.|.|||..||||||.|||||.||.|||..|||.||||.||.|.||||||.|||.||||||..|.||.
INDLQEIGRGTYGRVVIARHRQTKVPLAIKQPCWSDNYQSPNEMVDELHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDIDNDLCQAQEFVGCKKTGIG

FPLLEPPPLSVANGLDIAEDVVRGLMEIHDHGLLHNDLKTDNVLLEKRGHRYHAVIIDFGMVSTISSPLRMTELPEALKVAYIHGEEGDYVAPEVILHGQ
.||.||||||..|..|||||.|.|.||.|||||||||||.|||||||||||||||||||||||||..||.|.|.|..||.||.||||.||.|||||||||
YPLHEPPPLSMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVSTITAPLKMVEVPKELKMAYVHGEEADYIAPEVILHGQ

STSISSDVFSVG
||||||||||||
STSISSDVFSVG

Kinase Spk017.AA urch 185-390 53 4.1e-127 428.59 In-house 1-217 (217) Show / Hide
Range on Protein: 185-390
Range on HMM: 1-217/217
Sequence Identity: 53% (117 aa)

IGRGTYGRVLLARHVQTKTPLAIKQSCRSENYQLLNEMVDEAHDATRARVKKEALVHQLLSDSPFFPRFLGTLDIDKDLCLAQEFVGNRKSGIAFPLLEP
|||||||||.|.|| |||.|.|||. | ..||. .|||..|...|...|..|||.||||.|..|.||.|.|..|||.||||..||.|..| |. .||...
IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHWC

PP----------LSVANGLDIAEDVVRGLMEIHDHGLLHNDLKTDNVLLEKRGH-RYHAVIIDFGMVSTISSPLRMTELPEALKVAYIHGEEGDYVAPEV
.           ||  | |.||||.|.|.|..||||.|||||| |||||||||| |.||||||||.|.|.  |..|...|. .. .|.||.. ...|||.
IHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPEC

ILHGQSTSISSDVFSVG
.|.||..||.|||.|||
VLDGQPCSIASDVYSVG

Kinase Spk017.AA urchC 180-393 38 7e-72 232.02 In-house 2-223 (223) Show / Hide
Range on Protein: 180-393
Range on HMM: 2-223/223
Sequence Identity: 38% (88 aa)

NDLQEIGRGTYGRVLLARHVQTKTPLAIKQSCRSENYQLLNEMVDEAHDATRARVKKEALVHQLLSDSPFFPRFLGTLDIDKDLCLAQEFVGNRKSGIAF
. | .||.| ||.|.|.|    | | |||      .  .  |       .   |..|||.| |..| .|.|||..||. ||...|. .||.|  . |  .
TILEMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQH--FTPEKEESEWKQNNGRCEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVTEFIGDKQQGKVY

PL---LE-------PPPLSVANGLDIAEDVVRGLMEIHDHGLLHNDLKTDNVLLEKRGHRYHAVIIDFGMVSTISSP----LRMTELPEALKVA-YIHGE
.|   ..        | ..  | ..||||..|| . .|| |||||| | |||||| |. | |..||| |||||.  |         .|.  |   .||  
MLHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFIH--

EGDYVAPEVIL-HGQSTSISSDVFSVGKIL
    .||||.   |  .| .||..||| ||
----IAPEVLDIDGCQVSVASDIYSVGVIL

Kinase Spk017.AA urch-unclassified 185-390 35 1.1e-65 224.52 In-house 1-215 (215) Show / Hide
Range on Protein: 185-390
Range on HMM: 1-215/215
Sequence Identity: 35% (76 aa)

IGRGTYGRVLLARHVQTKTPLAIK-QSCRSENYQLLNEMVDEAHDATRARVKKEALVHQLLSDSPFFPRFLGTLDIDKDLCLAQEFVGNRKSGIAFPLL-
|| ||.|.| . ||  .  | ..| ..  .  |    ||      .  .|  |||.||.|..|.| ||| .|  ..  ..|.. || |. . ..  ||  
IGKGTFGKVFMMRHQREAVPVKVKMIHEHHNDYD--YEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLCQ

----EP---PPLSVANGLDIAEDVVRGLMEIHDHGLLHNDLKTDNVLLEKRGH--RYHAVIIDFGMVSTISSPLRMTELPEALKVAYIHGEEGDYVAPEV
    .    | ||  . ..|..|.. |... |. .||||||| .|.||....|  | || ||||||.||.  |.    ..   .  |  |    . |||.
WIHERHKSNPALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMAPEI

ILHGQSTSISSDVFSVG
.| || ||. ||..| |
VLYGQPTSVYSDIYSLG

Kinase Spk017.AA urchA 185-387 32 5e-47 149.76 In-house 1-208 (208) Show / Hide
Range on Protein: 185-387
Range on HMM: 1-208/208
Sequence Identity: 32% (71 aa)

IGRGTYGRVLLARHVQTKTPLAIKQSCRSENYQLLNEMVDEAHDATRARVKKEALVHQLLSDSPFFPRFLGTLDIDKD-LCLAQEFVGNRKSGIA----F
 |||.|| | | || ||. | |.|         | .|...     .    ..|. .||.|. .|.|| |.| ..|..|   .| ||.|    |       
LGRGVYGTVHLYRHRQTDHPVALKV------IELPKEYKKMRR--KIECFQNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITW

PLLE-----PPPLSVANGLDIAEDVVRGLMEIHDHGLLHNDLKTDNVLLEK-RGHRYHAVIIDFGMVSTISSPL---RMTELPEALKVAYIHGEEGDYVA
 |.       | |.    .... |.  ||  .|. | | |||| ||.|. |  . |  |.|||||  . .  |    ||  . .  |  |  .    ..|
CLDKAMEMRQPALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFGRWRAKIIDFGWACPCQMPFPACRM-HFDQRQKQFYRYCHRCCHIA

PEVILHGQSTSISSDVF
|| .| .|. |.||||.
PECALDAQPCSTSSDVY

Kinase Spk017.AA S_TKc 179-437 16 2.4e-15 48.13 SMART 1-231 (231) Show / Hide
Range on Protein: 179-437
Range on HMM: 1-231/231
Sequence Identity: 16% (48 aa)

INDLQEIGRGTYGRVLLARHVQTKTPLAIKQSCRSENYQLLNEMVDEAHDATRARVKKEALVHQLLSDSPFFPRFLGTLDIDKDLCLAQEFVGNRKSGIA
   |..||.|..|.| ..||. |.   |||.                       ....|  ...   . |.  ..... .  ..|..  |....      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLF

FPLLEPPP------LSVANGLDIAEDVVRGLMEIHDHGLLHNDLKTDNVLLEKRGHRYHAVIIDFGMVSTISSPLRMTELPEALKVAYIHGEEG--DYVA
  . . ..      ..      ..  ....|  .|.|| .| ||| .|.|| .     |  |.|||.   .                  .   |  .|.|
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------------------TTFCGTPWYMA

PEVILHGQSTSI-SSDVFSVG---------KI----LEDITQVVEEGSPLLKALTALANKCMKRNPESRPDLPSLLR-------ASST
|||.    . .  ..|. |.|         .     .. . ...       . .  . .||....|| ||    .|.           
PEVL----GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase Spk017.AA Pkinase 179-393 20 2.4e-14 51.8 Pfam 1-202 (293) Show / Hide
Range on Protein: 179-393
Range on HMM: 1-202/293
Sequence Identity: 20% (47 aa)

INDLQEIGRGTYGRVLLARHVQTKTPLAIKQSCRSENYQLLNEM---VDEAHDATRARVKKEALVHQLLSDSPFFPRFLGTLDIDKDLCLAQEFVGNRKS
.  .. ||.|..|.| ...|. |    |.|. .....    ..                  |. ... | ..|.  |....   ...... .|....  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL------------SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY

GIAFPLL------EPPPL--SVANGLDIAEDVVRGLMEIHDHGLLHNDLKTDNVLLEKRGHR-YHAVIIDFGMVSTISSPLRMTELPEALKVAYIHGEEG
   . |       .  ..  |     ...  ..|||  .|..| .| ||| .|.|. ..||   .  |.|||    ..            .    ..  |
--VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----------Y-NNS-MTTFCG

--DYVAPEVILHGQSTSISSDVFSVGKIL
  .|.|||||..||  . ..|..|.| ||
TPWYMAPEVIRGGQYYGPKVDMWSCGCIL

Kinase Spk017.AA STE 295-390 21 1e-09 30.62 In-house 156-255 (359) Show / Hide
Range on Protein: 295-390
Range on HMM: 156-255/359
Sequence Identity: 21% (24 aa)

IAEDVVRG-LMEIHDHGLLHNDLKTDNVLLEKRGHRYHAVIIDFGMVSTISSPLRMTELPE----------ALKVAYIHGEEGDYVAPEVILHG-----Q
|. ....| |  .|.|.  | |.| .|.||        . ..|||  . ... ..   . .          . |   . |    . |||||. .     .
ICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP--WMAPEVIQQNGQGRDK

STSISSDVFSVG
  ....|. |.|
GYDTKCDIWSLG

Kinase Spk017.AA Ciliate-C7 287-339 37 6.5e-09 25.22 In-house 99-148 (164) Show / Hide
Range on Protein: 287-339
Range on HMM: 99-148/164
Sequence Identity: 37% (20 aa)

LSVANGLDIAEDVVRGLMEIHDHGLLHNDLKTDNVLLEKRGHRYHAVIIDFGM
|.  . . .|.|.  || .||. ... |||| || |    |    ||..|||.
LNEISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGN---AVVCDFGL

Kinase Spk017.AA NKF1 180-209 36 1.1e-08 26.1 In-house 2-31 (269) Show / Hide
Range on Protein: 180-209
Range on HMM: 2-31/269
Sequence Identity: 36% (11 aa)

NDLQEIGRGTYGRVLLARHVQTKTPLAIKQ
.  .. | |.||..||..| |..|..|.|.
EIIRQLGEGCYGKILLCEHRQSGTRMALKF

Kinase Spk017.AA TyrKc 179-435 17 2.1e-08 -86.85 SMART 1-280 (280) Show / Hide
Range on Protein: 179-435
Range on HMM: 1-280/280
Sequence Identity: 17% (55 aa)

INDLQEIGRGTYGRVLLARHVQTKTPLAIKQSCRSENYQLLNEMVDEAHDATRARVKKEALVHQLL-SDSPFFPRFLGTLDID-------KDLCLAQEFV
|  ....|.| .|.| ...     .. |.|    .                 |.   .|| .   |  . |   |..|    .       . |..  |..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM

GN-------RKSGIAFPLLEPPPLSVANGLDIAEDVVRGLMEIHDHGLLHNDLKTDNVLLEKRGHRYHAVIIDFGMVSTISSP-LRMTELPEALKVAYIH
 .       ||..          |...  |... .. .|   .|.... | || . |.|. ...   .. | |||.   | .   .      . |  | .
PHGDLKDYLRKHRPK--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG-----ESKDYYRK

GE--EGD------YVAPEVILHGQSTSISSDVFS----------------VG-----KILEDITQVVEEG----SPLL----------KALTALANKCMK
 |   |.        |||.| .|  |.  |||.|                 |     .  ... . |..|     |            ...  .  .| .
KEHKGGKTMLPIRWMAPECINYGKFTT-KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWH

RNPESRPDLPSLLRAS
..||.||    . .  
EDPEDRPTFSEIHECF

Kinase Spk017.AA TKL 293-390 19 6.6e-08 24.58 In-house 135-276 (364) Show / Hide
Range on Protein: 293-390
Range on HMM: 135-276/364
Sequence Identity: 19% (27 aa)

LDIAEDVVRGLMEIHDHG--------LLHNDLKTDNVLLEKRGH-----------RYHAVIIDFGMVSTISSPLRMTELPEALK-------VAYIHGEEG
...| |. ||.   | ..        ..| |||..|.|. . ..            ... | |||   ..|    |.    . .        .  .. ..
CRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQC

---DYVAPEVIL---------------HGQSTSISSDVFSVG
    . ||||.                .| . | ..||.| |
GTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG

Kinase Spk017.AA Ciliate-E2-Unclassified 293-393 21 7.7e-07 19.78 In-house 146-260 (352) Show / Hide
Range on Protein: 293-393
Range on HMM: 146-260/352
Sequence Identity: 21% (28 aa)

LDIAEDVVRGLMEIHDHG-LLHNDLKTDNVLLEKRGHRYHAVIIDFGMVS---------------------TISSPLRMTEL--PEALKVAYIHGEEGDY
....  .. ||  .|  .  .| |.| .|.|. . | .|.  |||||  .                      ...    |    |              |
KFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q------------Y

VAPEVILH-GQSTS--ISSDVFSVGKIL
 ||||.   ....|  ...|..|.| ||
TAPEVLQGQNYDHSKAYKCDIWSLGVIL

Kinase Spk017.AA STE 179-209 23 1.4e-05 15.76 In-house 1-46 (359) Show / Hide
Range on Protein: 179-209
Range on HMM: 1-46/359
Sequence Identity: 23% (11 aa)

INDLQEIGRGTYGRVLLARHV------QTKTP---------LAIKQ
  ....||.|..| | .|...      .|.            ||||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQ

Kinase Spk017.AA Ciliate-E2-Unclassified 179-216 26 4.8e-05 13.48 In-house 1-38 (352) Show / Hide
Range on Protein: 179-216
Range on HMM: 1-38/352
Sequence Identity: 26% (10 aa)

INDLQEIGRGTYGRVLLARHVQTKTPLAIKQSCRSENY
 . .. ||.| .| | ...| ..|   |.|. . . .|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIY

Kinase Spk017.AA TKL 185-209 21 0.000556 10.24 In-house 1-33 (364) Show / Hide
Range on Protein: 185-209
Range on HMM: 1-33/364
Sequence Identity: 21% (7 aa)

IGRGTYGRVLLARHVQTK--------TPLAIKQ
||.|..| |  ... ..         .. |.|.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKK

Kinase Spk017.AA NKF1 306-323 44 0.00414 6.82 In-house 117-134 (269) Show / Hide
Range on Protein: 306-323
Range on HMM: 117-134/269
Sequence Identity: 44% (8 aa)

IHDHGLLHNDLKTDNVLL
.|...| | |.| .|||.
MHSRNLVHRDIKPENVLV

Kinase Spk017.AA Ciliate-C7 182-208 40 0.005131 6.05 In-house 1-27 (164) Show / Hide
Range on Protein: 182-208
Range on HMM: 1-27/164
Sequence Identity: 40% (11 aa)

LQEIGRGTYGRVLLARHVQTKTPLAIK
.  .|.| .| ||||.  .|.   |||
FRFLGQGQQGLVLLAKDQKTNMRYAIK

Kinase Spk017.AA STE 396-433 17 0.06601 2.67 In-house 293-353 (359) Show / Hide
Range on Protein: 396-433
Range on HMM: 293-353/359
Sequence Identity: 17% (11 aa)

ITQVVEEGSPLL------------------------KALTALANKCMKRNPESRPDLPSLLR
. ..|....| |                        . .    ||| ...|. ||.   ||.
L-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLK