Gene Spk369 (Sea Urchin)
Spk369
Sequence
Protein domains of Spk369.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Spk369.AA | urchC | 247-464 | 58 | 1.4e-168 | 550.25 | In-house | 1-223 (223) | Show / Hide |
Range on Protein: 247-464 Range on HMM: 1-223/223 Sequence Identity: 58% (130 aa) KLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVGTITIGRELCVVTEFVGSGQTGRPYR ...|.|||.||.|.|.||.|.|...||||||||||.|...|..|.|||.|.||..||..|......||||..|.||..|....|.||||.|..|.|..|. QTILEMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQHFTPEKEESEWKQNNGRCEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVTEFIGDKQQGKVYM LHDALQ---EIDPILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTTMAYT-EQRSFSDLIPESQRLK-FPHIAP ||||.. ..|||.|...|||||||||..|||...|||||||||||.||.|||||.|||||.|||||.|.||||. .||.|.|..|..|.|. |.|||| LHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFIHIAP ELLDIAGSQVSASTDIFAVGVQL |.|||.|.|||...||..||| | EVLDIDGCQVSVASDIYSVGVIL |
|||||||||
| Kinase | Spk369.AA | urch | 253-461 | 40 | 2e-112 | 379.77 | In-house | 1-217 (217) | Show / Hide |
Range on Protein: 253-461 Range on HMM: 1-217/217 Sequence Identity: 40% (89 aa) IGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLK--GEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVGTITIGRELCVVTEFVGSGQTGRPYRLHDA ||.|..| |.|..... ..|||||.|..| ... .|....|||||..|..||..|..|. |.||| .. |...|...||.|.||.|. .||..|.||.. IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHWC LQ---EIDPILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGE-RWHGVIIDMGLVTTMAYT-EQRSF-SDLIPESQRLK-FPHIAPEL .. ..|....|.||...|||| |.|.. .||.|.||||.|.||.|||.||. |||.||||.|.|.||... ....| .....|..... ..|||||. IHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPEC LDIAGSQVSASTDIFAVG .. .|...|...|...|| VL-DGQPCSIASDVYSVG |
|||||||||
| Kinase | Spk369.AA | urch-unclassified | 253-461 | 31 | 3.1e-46 | 159.92 | In-house | 1-215 (215) | Show / Hide |
Range on Protein: 253-461 Range on HMM: 1-215/215 Sequence Identity: 31% (70 aa) IGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWK---ANQGRTRKESLVLELLKGCPYFAQMVGTITIGRELCVVTEFVGSGQTGRPYRLHD || |.|| | .. . . ||..| ... | . . | . . .. |. ||..| |. . ||| . | ... .|.| || | ||.. | | . IGKGTFGKVFMMRHQREAVPVKVK--MIHEHHNDYDYEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLCQ ALQEID---PILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGE--RWHGVIIDMGLVTTMAY-TEQRSFSDLIPESQRL--KFPHIAP .. | | | |. .. |..| . | |. .|||||.|..||||. ... ||| |||.|...||.. ||.||| . .. |.|| WIHERHKSNPAL--SKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMAP ELLDIAGSQVSASTDIFAVG | | | .||. | EIV-LYGQPTSVYSDIYSLG |
|||||||||
| Kinase | Spk369.AA | urchB | 248-415 | 41 | 7.3e-40 | 138.75 | In-house | 2-164 (212) | Show / Hide |
Range on Protein: 248-415 Range on HMM: 2-164/212 Sequence Identity: 41% (71 aa) LELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPA--HLKGEAAENEWK-ANQGRTRKESLVLELLKGCPYFAQMVGTITIGRELCVVTEFVGSGQTGRP .| || |..| |.. | ||| | . .| . | . | | .|| .. |. . ||| . || |...|| |||| || NDLQEIGRGTYGRVVIARHRQTKVPLAIKQPCWSDNYQSPNEMVD-ELHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDIDNDLCQAQEFVGCKKTGIG YRLHDALQEIDPILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTT | || | | |. | | |||| |.|. .|| |||||| | ||.||| || |.| |||| |.| | YPLHEP-----PPL--SMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVST |
|||||||||
| Kinase | Spk369.AA | TKL | 253-462 | 16 | 1e-14 | 49.46 | In-house | 1-277 (364) | Show / Hide |
Range on Protein: 253-462
Range on HMM: 1-277/364
Sequence Identity: 16% (49 aa)
IGNGSFGIVLLGHLDGLS--------KPVAIKRPYVPAHLKGEAAENE-------------WKANQGRTRKESLVLELLKG--CPYFAQMVGTITIGRE-
|| |.||.| |.. | . |.||.|. . . . ..| .. .. .| .. ... .| |..| . ..
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------LCVVTEFVGSGQ-TGRPYRLHDALQEIDPILYPSIWNM-VAIAEDLVRGVSTIHDFG--------LLHNDIKGDNILLEHRGE-----
|| |.|.. | . |. . .| | ||.. | . ..| |.| .|||. ..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNY
------RWHGVIIDMGLVTTMAYTEQRSFSDL-------------IPESQRLKFPHIAPELLD--------------IAGSQVSASTDIFAVGV
|. | |.|| ..| ... . . .|. . . |||.|. . |.. | ..|... |.
MYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGI
|
|||||||||
| Kinase | Spk369.AA | urchA | 301-412 | 27 | 1.8e-13 | 39.87 | In-house | 43-158 (208) | Show / Hide |
Range on Protein: 301-412 Range on HMM: 43-158/208 Sequence Identity: 27% (32 aa) RKESLVLELLKGCPYFAQMVGTITIGRELCVVT-EFVGSGQTGRPYRLHDALQE----IDPILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNIL ..| ....| . |.| .. | | . ||.|. ||. | . . |. | | . . ... | | .|. | | || | ||.| QNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDKAMEMRQPAL--TRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCL LEH-RGERWHGVIIDMGL . . || ..|||.|. VRKTEFGRWRAKIIDFGW |
|||||||||
| Kinase | Spk369.AA | S_TKc | 247-503 | 17 | 2.1e-11 | -9.54 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 247-503 Range on HMM: 1-231/231 Sequence Identity: 17% (50 aa) KLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVGTITIGRELCVVTEFVGS--GQTGRP |. || |.|| | ... . . ||||. ..|.| .|. ..|. .. ... .|..|.|... | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGD---- YRLHDALQEIDPILYP---SIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTTMAYTEQRSFSDLIPESQRLKFPHIAP |.| ... . .. . .. ..... .|. | .| |.| .|||| . | |.| || . . .. .|| --LFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAP ELLDIAGSQVSA-STDIFAVGV-------------QLNMIGQFIDDDELVTVGEHCCENEPHLRPKALDDIV-------PKLV |.| . . . |. ..|. |..|. . | ..|. ..|.. .| || | . . EVL-----GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | Spk369.AA | Pkinase | 253-401 | 23 | 3e-11 | 40.86 | Pfam | 7-146 (293) | Show / Hide |
Range on Protein: 253-401 Range on HMM: 7-146/293 Sequence Identity: 23% (36 aa) IGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVGTITIGRELCVVTEFVGSGQTGRPYRLHDALQ || |||| | ..| | .| ||.|. .. | | . .. ... | .. | ..|. .. .. . ......|.|... | . |.| .. IGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL------SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY--VMDLFDYIS --EIDPILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGE . ... | | .. ..||. .|. | .| |.| .|||. ..|. TWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGH |
|||||||||
| Kinase | Spk369.AA | TKL-ciliate1 | 371-462 | 28 | 4.7e-07 | 20.18 | In-house | 111-207 (279) | Show / Hide |
Range on Protein: 371-462 Range on HMM: 111-207/279 Sequence Identity: 28% (28 aa) DLVRGVSTIHDFG--LLHNDIKGDNILLEHRGERWHGVIIDMGLVTT--MAYTEQRSFSDLIPESQRLKFPH-IAPELLD---IAGSQVSASTDIFAVGV |. .|.. .| | | |.| |||. .| | . . |.. . || |. |.||. .| ||| .| . ... ||.|.|. DIAQGMQYLHMRQNPLIHRDLKMQNILY---DEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYAYGI |
|||||||||
| Kinase | Spk369.AA | TyrKc | 247-502 | 16 | 1e-06 | -114.86 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 247-502 Range on HMM: 1-280/280 Sequence Identity: 16% (51 aa) KLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWKANQGRTRKESLVLELL-KGCPYFAQMVGTITIG-------RELCVVTEFVGS ....|.| ||.| .|... .||.| | . ..| .. | . | ...| .| . |..|.|.. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH GQTGRPYRLHDALQEIDPILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTTMAYT-EQRSFSDLIPESQ--RLK | |.| |.. | . .. .. . .| . .|. .. | |. |.|. ... . | | || .| .| . .. | G------DLKDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK --FP--HIAPELLDIA---------------------GSQVSAS--------TDIFAVGVQLNMIGQFID---------DDELVTVGEHCCENEPHLRPK .| ||| .. | | ..... | .. | . ||. .. . |.. .|. || TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT ALDDIVPKL .|. .. FS-EIHECF |
|||||||||
| Kinase | Spk369.AA | Dicty3 | 368-396 | 46 | 4e-06 | 16.08 | In-house | 116-145 (351) | Show / Hide |
Range on Protein: 368-396 Range on HMM: 116-145/351 Sequence Identity: 46% (14 aa) IAEDLVRGVSTIHDFG-LLHNDIKGDNILL |..||| . . ||. . ..| |||.|||.| IICDLVKTLNYIHKNCHIIHRDIKCDNIML |
|||||||||
| Kinase | Spk369.AA | FNIPK | 368-396 | 41 | 5e-06 | 15.7 | In-house | 126-156 (425) | Show / Hide |
Range on Protein: 368-396 Range on HMM: 126-156/425 Sequence Identity: 41% (13 aa) IAEDLVRGVSTIHDFG--LLHNDIKGDNILL ...||| . ||. | | |||.|||.. CMCDLVKSLNCIHENGRHIIHRDIKCDNIMI |
|||||||||
| Kinase | Spk369.AA | Ciliate-E1 | 345-401 | 23 | 1.1e-05 | 14.99 | In-house | 81-147 (202) | Show / Hide |
Range on Protein: 345-401 Range on HMM: 81-147/202 Sequence Identity: 23% (16 aa) YRLHDALQ---------EID-PILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGE ..|.| || .. . .......|. .|. |.. .|.....| ||| .||| .. |. CSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGN |
|||||||||
| Kinase | Spk369.AA | urchA | 438-458 | 38 | 0.008342 | 4.96 | In-house | 189-208 (208) | Show / Hide |
Range on Protein: 438-458 Range on HMM: 189-208/208 Sequence Identity: 38% (8 aa) HIAPELLDIAGSQVSASTDIF |||||. . .. | | |.. HIAPECA-LDAQPCSTSSDVY |
|||||||||
| Kinase | Spk369.AA | urchB | 439-461 | 47 | 0.05021 | 3.46 | In-house | 191-212 (212) | Show / Hide |
Range on Protein: 439-461 Range on HMM: 191-212/212 Sequence Identity: 47% (11 aa) IAPELLDIAGSQVSASTDIFAVG |||| . . | | | |.| || IAPEVI-LHGQSTSISSDVFSVG |
|||||||||
| Kinase | Spk369.AA | Ciliate-E1 | 253-264 | 66 | 0.216423 | 0.87 | In-house | 1-12 (202) | Show / Hide |
Range on Protein: 253-264 Range on HMM: 1-12/202 Sequence Identity: 66% (8 aa) IGNGSFGIVLLG ||||||.||. . IGNGSFSIVFKA |
|||||||||