Spk400

Species: Sea Urchin
Alias: Spk400
External Links:
Annotation:

Classification

Group: Other
Family: urch
Subfamily: urchC

Sequence

Name Sequence Type Origin Length Description Download
Spk400.AA Protein None 508 None Fasta, JSON
Spk400.kin_dom Protein Kinase Domain None 102 None Fasta, JSON

Protein domain

Protein domains of Spk400.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Spk400.AA urchC 218-436 55 2.4e-155 506.74 In-house 1-223 (223) Show / Hide
Range on Protein: 218-436
Range on HMM: 1-223/223
Sequence Identity: 55% (125 aa)

KLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWKANQGRTRKESLCLQLLKGXCPYFAQMVGTITIGRELCXCNRVRGSGQTGRPY
...|.|||.||.|.|.||.|.|...||||||||||.|...|..|.|||.|.||..||.. .|.... ||||..|.||..|....|      |..|.|..|
QTILEMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQHFTPEKEESEWKQNNGRCEKEARVGQMMST-CPYFPRMYGTVMIDENMCIVTEFIGDKQQGKVY

RLHDALQ---EIDPILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTTMAYT-EQRSFSDLIPESQRLK-FPHIA
.||||..   ..|||.|...|||||||||..|||...|||||||||||.||.|||||.|||||.|||||.|.||||. .||.|.|..|..|.|. |.|||
MLHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFIHIA

PELLDVVGSQVSASTDIFAVGVQL
||.||..|.|||...||..||| |
PEVLDIDGCQVSVASDIYSVGVIL

Kinase Spk400.AA urch 224-433 39 2.4e-96 326.39 In-house 1-217 (217) Show / Hide
Range on Protein: 224-433
Range on HMM: 1-217/217
Sequence Identity: 39% (86 aa)

IGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLK--GEAAENEWKANQGRTRKESLCLQLLKGXCPYFAQMVGTITIGRELCXCNRVRGSGQTGRPYRLHD
||.|..| |.|..... ..|||||.|..| ...  .|....|||||..|..||.. .||. | .||| .. |...|...||      |. .||..|.||.
IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSG-HPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHW

ALQ---EIDPILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGE-RWHGVIIDMGLVTTMAYT-EQRSF-SDLIPESQRLK-FPHIAPE
...    ..|....|.||...|||| |.|.. .||.|.||||.|.||.|||.||. |||.||||.|.|.||... ....| .....|..... ..|||||
CIHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPE

LLDVVGSQVSASTDIFAVG
...  |...|...|...||
CVL-DGQPCSIASDVYSVG

Kinase Spk400.AA urch-unclassified 224-433 29 1.2e-34 120.74 In-house 1-215 (215) Show / Hide
Range on Protein: 224-433
Range on HMM: 1-215/215
Sequence Identity: 29% (66 aa)

IGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWK---ANQGRTRKESLCLQLLKGXCPYFAQMVGTITIGRELCXCNRVRGSGQTGRPYRLH
|| |.|| | .. . .   ||..|  ... | . .  | . .   ..  |. ||..  .|. .  |||  . |  ...  .|      |  ||.. | | 
IGKGTFGKVFMMRHQREAVPVKVK--MIHEHHNDYDYEMRMQNKLLMHERIMKEAMVHRLF-ADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLC

DALQEID---PILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGE--RWHGVIIDMGLVTTMAY-TEQRSFSDLIPESQRL--KFPHIA
... |     | |  |. ..  |..| . |    |. .|||||.|..||||. ...  |||  |||.|...||..   ||.|||   .  ..     |.|
QWIHERHKSNPAL--SKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMA

PELLDVVGSQVSASTDIFAVG
||     |   |  .||.  |
PEIV-LYGQPTSVYSDIYSLG

Kinase Spk400.AA urchB 219-387 40 4.2e-33 116.06 In-house 2-164 (212) Show / Hide
Range on Protein: 219-387
Range on HMM: 2-164/212
Sequence Identity: 40% (69 aa)

LELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPA--HLKGEAAENEWK-ANQGRTRKESLCLQLLKGXCPYFAQMVGTITIGRELCXCNRVRGSGQTGR
 .|  || |..| |..        | ||| |       . .|  . | . |   | .|| .  ||. .  ||| .  ||  |...||      |   || 
NDLQEIGRGTYGRVVIARHRQTKVPLAIKQPCWSDNYQSPNEMVD-ELHDATRTRVTKEAMIHQLMSD-SPYFPKFWGTLDIDNDLCQAQEFVGCKKTGI

PYRLHDALQEIDPILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTT
 | ||       | |  |. | | |||| |.|.  .|| |||||| | ||.||| || |.| |||| |.| |
GYPLHEP-----PPL--SMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVST

Kinase Spk400.AA urchA 337-384 34 4e-10 28.93 In-house 110-158 (208) Show / Hide
Range on Protein: 337-384
Range on HMM: 110-158/208
Sequence Identity: 34% (17 aa)

MVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEH-RGERWHGVIIDMGL
. ... |   |   .|. | | || | ||.|.    . || ..|||.|.
WMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFGRWRAKIIDFGW

Kinase Spk400.AA S_TKc 218-475 16 8.3e-09 -47.74 SMART 1-231 (231) Show / Hide
Range on Protein: 218-475
Range on HMM: 1-231/231
Sequence Identity: 16% (47 aa)

KLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWKANQGRTRKESLCLQLLKGXCPYFAQMVGTITIGRELCXCNRVRGSGQTGRP-
   |. || |.|| | ...  .  . ||||.                     ..|.|  .|.     .|.  .. ...    .|. .             
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMV------MEYCDGD

-YRLHDALQEIDPILYP---SIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTTMAYTEQRSFSDLIPESQRLKFPHIA
   |.| ...  .  ..   .      ..  .....  .|. | .| |.| .|||| .     |  |.| || . .              ..      .|
LGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMA

PELLDVVGSQVSA-STDIFAVGV-------------QLNMIGQFIDDDELVTVGEHCCENEPHLRPKALDDIV-------PKLV
||.|     . .  . |. ..|.             |..|. . | ..|.    ..|.. .|  || | .             .
PEVL-----GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase Spk400.AA TKL 340-434 18 1.8e-07 23.02 In-house 137-277 (364) Show / Hide
Range on Protein: 340-434
Range on HMM: 137-277/364
Sequence Identity: 18% (26 aa)

IAEDLVRGVSTIHDFG--------LLHNDIKGDNILLEHRGE-----------RWHGVIIDMGLVTTMAYTEQRSFSDL-------------IPESQRLK
.| |  ||..  |  .        ..| |.| .|||.   ..            |.  | |.|| ..|  ... . .                  .|.  
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

FPHIAPELLDVV--------------GSQVSASTDIFAVGV
. . |||.|.                |.. | ..|... |.
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGI

Kinase Spk400.AA TKL-ciliate1 343-434 28 1e-06 18.77 In-house 111-207 (279) Show / Hide
Range on Protein: 343-434
Range on HMM: 111-207/279
Sequence Identity: 28% (28 aa)

DLVRGVSTIHDFG--LLHNDIKGDNILLEHRGERWHGVIIDMGLVTT--MAYTEQRSFSDLIPESQRLKFPH-IAPELLD---VVGSQVSASTDIFAVGV
|. .|.. .|     | | |.|  |||.   .|     | . . |..     .   || |.  |.||.  .|  ||| .|     . ...   ||.|.|.
DIAQGMQYLHMRQNPLIHRDLKMQNILY---DEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYAYGI





Kinase Spk400.AA Dicty3 340-368 46 4e-06 16.08 In-house 116-145 (351) Show / Hide
Range on Protein: 340-368
Range on HMM: 116-145/351
Sequence Identity: 46% (14 aa)

IAEDLVRGVSTIHDFG-LLHNDIKGDNILL
|..||| . . ||. . ..| |||.|||.|
IICDLVKTLNYIHKNCHIIHRDIKCDNIML

Kinase Spk400.AA FNIPK 340-368 41 5e-06 15.7 In-house 126-156 (425) Show / Hide
Range on Protein: 340-368
Range on HMM: 126-156/425
Sequence Identity: 41% (13 aa)

IAEDLVRGVSTIHDFG--LLHNDIKGDNILL
...|||   . ||. |    | |||.|||..
CMCDLVKSLNCIHENGRHIIHRDIKCDNIMI

Kinase Spk400.AA Ciliate-E1 317-373 23 1.1e-05 14.99 In-house 81-147 (202) Show / Hide
Range on Protein: 317-373
Range on HMM: 81-147/202
Sequence Identity: 23% (16 aa)

YRLHDALQ---------EID-PILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGE
..|.| ||         ..     . .......|. .|. |.. .|.....| ||| .||| .. |.
CSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGN

Kinase Spk400.AA TKL 224-248 36 2.4e-05 15.21 In-house 1-33 (364) Show / Hide
Range on Protein: 224-248
Range on HMM: 1-33/364
Sequence Identity: 36% (12 aa)

IGNGSFGIVLLGHLDGLS--------KPVAIKR
|| |.||.|  |.. | .        |.||.|.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKK

Kinase Spk400.AA Pkinase 319-373 26 6.8e-05 18.39 Pfam 91-146 (293) Show / Hide
Range on Protein: 319-373
Range on HMM: 91-146/293
Sequence Identity: 26% (15 aa)

LHDALQ--EIDPILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGE
|.| ..  .  ...  | |    ..  ..||.  .|. | .| |.| .|||. ..|.
LFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGH

Kinase Spk400.AA urchA 410-430 38 0.077496 1.79 In-house 189-208 (208) Show / Hide
Range on Protein: 410-430
Range on HMM: 189-208/208
Sequence Identity: 38% (8 aa)

HIAPELLDVVGSQVSASTDIF
|||||.  . ..  | | |..
HIAPECA-LDAQPCSTSSDVY

Kinase Spk400.AA Pkinase 224-248 52 0.082045 7.49 Pfam 7-31 (293) Show / Hide
Range on Protein: 224-248
Range on HMM: 7-31/293
Sequence Identity: 52% (13 aa)

IGNGSFGIVLLGHLDGLSKPVAIKR
|| |||| | ..|  | .| ||.|.
IGSGSFGCVYKCHHKGTGKIVAVKI

Kinase Spk400.AA urchB 411-433 47 0.167897 1.56 In-house 191-212 (212) Show / Hide
Range on Protein: 411-433
Range on HMM: 191-212/212
Sequence Identity: 47% (11 aa)

IAPELLDVVGSQVSASTDIFAVG
|||| .   |   | | |.| ||
IAPEVI-LHGQSTSISSDVFSVG

Kinase Spk400.AA Ciliate-E1 224-235 66 0.216423 0.87 In-house 1-12 (202) Show / Hide
Range on Protein: 224-235
Range on HMM: 1-12/202
Sequence Identity: 66% (8 aa)

IGNGSFGIVLLG
||||||.||. .
IGNGSFSIVFKA