Gene Spk372 (Sea Urchin)

Spk372

Species: Sea Urchin
Alias: SPU_011168, Spk372
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: urch
Subfamily: urch-unclassified

Sequence

Name Sequence Type Origin Length Description Download
Spk372.AA Protein None 530 None Fasta, JSON
Spk372.kin_dom Protein Kinase Domain None 207 None Fasta, JSON

Protein domain

Protein domains of Spk372.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Spk372.AA urch-unclassified 275-481 53 1.2e-149 503.5 In-house 1-215 (215) Show / Hide 
Range on Protein: 275-481
Range on HMM: 1-215/215
Sequence Identity: 53% (114 aa)

IGKGAFGKVNLMRYLPTNIPVAVK-VQEKKNRGISEDEMKNKLVS--RSMKEAVMHHVMSDNPSFPGLLGVVEIEDNLGVVLEFIGDKQFVIIHPLCDVL
||||.||||..||......||.|| ..|..|....|..|.|||..  |.||||..|....|.|.||...|.|..||....|.||.||||.....|||...
IGKGTFGKVFMMRHQREAVPVKVKMIHEHHNDYDYEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLCQWI

LERR---PGLSRLEWIDIAFDIIQGLASLHDKRLLHNDLKKNNILLQRSGE--RWRAYIIDFGHGSTVTMPLKFPTFSLEEEREYMEGLLYHHLAPEIVR
.||.   |.||...||.|..||..|....|...|||||||.||||||....  ||.|||||||..||.|||.|...||..|.||||.|..|||.|||||.
HERHKSNPALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMAPEIVL

DQQPTSVYSDIYSLG
..|||||||||||||
YGQPTSVYSDIYSLG
Kinase Spk372.AA urch 275-481 44 5.4e-121 408.26 In-house 1-217 (217) Show / Hide 
Range on Protein: 275-481
Range on HMM: 1-217/217
Sequence Identity: 44% (96 aa)

IGKGAFGKVNLMRYLPTNIPVAVKVQEKKNRGI--SEDEMKNKLVS--RSMKEAVMHHVMSDNPSFPGLLGVVEIEDNLGVVLEFIGDKQFVIIHPLCDV
||.|..|.|.|.|. .|..|||.|... ....   .|.||......  | .|||..|..||..|.|| ..|.|.|.|.|..|.||||||.. ...||...
IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHWC

LLE-----RRPGLSRLEWIDIAFDIIQGLASLHDKRLLHNDLKKNNILLQRSGE-RWRAYIIDFGHGSTVTMPLKFPTFSLEEEREYMEGLLYHHLAPEI
..      . | ||. .|..||.||..|.  .||...||||||..|.||...|. ||.|.|||||. .|.|||.|...|. ||.||||.|  |.|.|||.
IHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPEC

VRDQQPTSVYSDIYSLG
|.|.||.|..||.||.|
VLDGQPCSIASDVYSVG
Kinase Spk372.AA urchA 275-478 34 1.3e-45 145.18 In-house 1-208 (208) Show / Hide 
Range on Protein: 275-478
Range on HMM: 1-208/208
Sequence Identity: 34% (73 aa)

IGKGAFGKVNLMRYLPTNIPVAVKVQEKKNRGISEDEMKNKLVSRSMKEAVMHHVMSDNPSFPGLLGVVEI-EDNLGVVLEFIGDKQ----FVIIHPLCD
 | |. | | | |   |..|||.|| |  . . .        ..   .|.  | | .  | || ..|  || ||  |   ||.||      . |.  |  
LGRGVYGTVHLYRHRQTDHPVALKVIELPKEYKKMRR----KIECFQNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDK

VLLERRPGLSRLEWIDIAFDIIQGLASLHDKRLLHNDLKKNNILLQR-SGERWRAYIIDFGHGSTVTMPL---KFPTFSLEEEREYMEGLLYHHLAPEIV
 .. | | |.| .| ... || .||  .|.|  | ||||  |.|.   .. |||| |||||  . . ||     .. |. .. ..|  .  . | ||| .
AMEMRQPALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFGRWRAKIIDFGWACPCQMPFPACRMH-FDQRQKQFYRYCHRCCHIAPECA

RDQQPTSVYSDIY
 | || |  ||.|
LDAQPCSTSSDVY
Kinase Spk372.AA urchC 271-485 37 2.7e-39 124.79 In-house 1-223 (223) Show / Hide 
Range on Protein: 271-485
Range on HMM: 1-223/223
Sequence Identity: 37% (86 aa)

EEIL--IGKGAFGKVNLMRYLPTNIPVAVK---VQEKKNRGISEDEMKNKLVSRSMKEAVMHHVMSDNPSFPGLLGVVEIEDNLGVVLEFIGDKQFVIIH
  ||  ||||..|.| | |      |||.|   |         | | | . . |  |||.   .||  | || ..| | |. |. .| |||||||     
QTILEMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQHFTPEKEESEWKQNNG-RCEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVTEFIGDKQQGKVY

PLCDVLL-----ERRPGLSRLEWIDIAFDIIQGLASLHDKRLLHNDLKKNNILLQRSGERWRAYIIDFGHGSTVTMPLKFPTF-SLEEEREYMEGLLYHH
.| |..      .  | ..    ..|| ||| |   .||  ||||| |  |.||   .||| . ||| |  ||.. |  .  | .. ..     |.   |
MLHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFI--H

LAPEIVR-DQQPTSVYSDIYSLGKVLL
 |||..  |   .|| ||||| | |.|
IAPEVLDIDGCQVSVASDIYSVG-VIL
Kinase Spk372.AA urchB 275-481 39 9.1e-38 131.79 In-house 7-212 (212) Show / Hide 
Range on Protein: 275-481
Range on HMM: 7-212/212
Sequence Identity: 39% (84 aa)

IGKGAFGKVNLMRYLPTNIPVAVKVQEKKNRGISEDEMKNKLV----SRSMKEAVMHHVMSDNPSFPGLLGVVEIEDNLGVVLEFIGDKQFVIIHPLCDV
|| | .| | . |   | .| |.|   . .   |  || . |      |  |||  |  ||| | ||  .|   |. .|    ||.| |   |  |    
IGRGTYGRVVIARHRQTKVPLAIKQPCWSDNYQSPNEMVDELHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDIDNDLCQAQEFVGCKKTGIGYP----

LLERRPGLSRLEWIDIAFDIIQGLASLHDKRLLHNDLKKNNILLQRSGERWRAYIIDFGHGSTVTMPLKFPTFSLEEEREYMEGLLYHHLAPEIVRDQQP
|.|  | ||    .||| ||..|.  .||  |||||||  |.|| . | |. | |||||  ||.| |||      |    |  |      |||.. . |.
LHE-PPPLSMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVSTITAPLKMVEVPKELKMAYVHGEEADYIAPEVILHGQS

TSVYSDIYSLG
||. ||..| |
TSISSDVFSVG
Kinase Spk372.AA TKL 275-481 16 3.9e-15 50.94 In-house 1-276 (364) Show / Hide 
Range on Protein: 275-481
Range on HMM: 1-276/364
Sequence Identity: 16% (47 aa)

IGKGAFGKVNLMRYLPTN--------IPVAVKVQEKKNRGISED-----------------EMKNKLVSRSMKEAVMHHVMSDNPSFPGLLGVVEIEDN-
||.|.||.|   ..  ..         .||||.  ..|   ...                 .....      .| .|.. . . |    ..|..  ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LGVVLEFI--GDKQFVIIHPLCDVLLERRPGLSRLEWIDIAFDIIQGLASLHDKR--------LLHNDLKKNNILLQRSGE-------
            |. | |..  |.   ...                   ...| || .|.. || ..        ..| ||| .|||. . ..       
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMY

----RWRAYIIDFGHGSTVTMPLKFPTFS-----------LEEEREYMEGLLYHHLAPEIVRDQQPTSVYS---------------DIYSLG
     |.. | |||  |..  . .  . .           . ... ....  . ..|||. |.|.... ..               |.|| |
NPNADWCCKICDFGL-SRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG
S_TKc Spk372.AA S_TKc 269-522 18 1.6e-12 6.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 269-522
Range on HMM: 1-231/231
Sequence Identity: 18% (52 aa)

AAEEILIGKGAFGKVNLMRYLPTNIPVAVKVQEKKNRGISEDEMKNKLVSRSMKEAVMHHVMSDNPSFPGLLGVVEIEDNLGVVLEFIGDKQFVIIH---
     .||||||||| . |   |.  ||.|.                   . ..|  ...   . |    |..| .  |.| .|.|...       .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCD-------GDLG

PLCDVLLERRPG-----LSRLEWIDIAFDIIQGLASLHDKRLLHNDLKKNNILLQRSGERWRAYIIDFGHGSTVTMPLKFPTFSLEEEREYMEGLLYHHL
 | |.. .|...     ..  .   ..  |...|. .|... .| |||  |||| .     .  |.|||    .              . .   . |  .
DLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWY--M

APEIVRDQQPTSV-YSDIYSLG----------------KVLLDIGRVSGDRDLRLVAEMCTRVKPYRRPTMSNVEL--------SVM
|||..    . .   .|..|.|                ...... .   .....   . | .. | .|||   .            .
APEVL----GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Spk372.AA Pkinase 275-481 24 1.4e-11 42.08 Pfam 7-199 (293) Show / Hide 
Range on Protein: 275-481
Range on HMM: 7-199/293
Sequence Identity: 24% (52 aa)

IGKGAFGKVNLMRYLPTNIPVAVKVQEKKNRGISEDEMKNKLVSRSMKEAVMHHVMSDNPSFPGLLGVVEIEDNLGVVLEFIGDK-QFVIIHPLCDVLL-
||.|.||.| . .   |.. ||||. .|...  ..|. . .|    .  ..|... ..|     |....| .|.. .|.|. .     |.   |.|..  
IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRLNHPN--IVRLYDWFEDKDHIYMVMEYCEGGLY-VM--DLFDYIST

ERRPGL--SRLEWIDIAFDIIQGLASLHDKRLLHNDLKKNNILLQRSGER-WRAYIIDFGHGSTVTMPLKFPTFSLEEEREYMEGLL--YHHLAPEIVRD
.|. ..  |  | ....  |..||. .|... .| |||  |||. . |.   .  |.|||    .           .   . | ..   .. .|||..|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----------Y-NNS-MTTFCGTPWYMAPEVIRG

QQPTSVYSDIYSLG
.|. .  .|..|.|
GQYYGPKVDMWSCG
Kinase Spk372.AA Ciliate-E2 390-485 24 1.7e-11 35.74 In-house 169-286 (365) Show / Hide 
Range on Protein: 390-485
Range on HMM: 169-286/365
Sequence Identity: 24% (32 aa)

IIQGLASLHDKR-LLHNDLKKNNILLQRSGERWRAYIIDFGHGSTVTMPLKFPTFSLEEEREYMEGL------------------------LYHHLAPEI
||..| .|| |   .| |.| .|||.          |||||    .. . .  |  . .  .||.                           .. .||||
IILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEI

VR--------DQQPTSVYSDIYSLGKVLL
..        .|.. .  .||.||| |.|
LNGKKYDNQQKQKGYDYKCDIWSLG-VIL
Kinase Spk372.AA Ciliate-E2-Unclassified 390-481 24 1.6e-09 29.24 In-house 152-257 (352) Show / Hide 
Range on Protein: 390-481
Range on HMM: 152-257/352
Sequence Identity: 24% (31 aa)

IIQGLASLHDK-RLLHNDLKKNNILLQRSGERWRAYIIDFGH------------------------------GSTVTMPLKFPTFSLEEEREYMEGLLYH
|.||| .|| |   .| |.| .|||.. .|.. .  |||||                               |.  .|| .                   
ILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q-------------------

HLAPEIVRDQQPTS---VYSDIYSLG
 .|||. . |..       .||.|||
YTAPEVLQGQNYDHSKAYKCDIWSLG
Kinase Spk372.AA LISK 384-429 38 3.6e-08 22.44 In-house 104-150 (296) Show / Hide 
Range on Protein: 384-429
Range on HMM: 104-150/296
Sequence Identity: 38% (18 aa)

IDIAFDIIQGLASLHDKRLLHNDLKKNNILLQRS-GERWRAYIIDFG
..|| || .|.. ||..  .| ||| .|.|. ..  ..||. ..|||
VKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFG
TyrKc Spk372.AA TyrKc 269-521 18 6.9e-07 -111.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 269-521
Range on HMM: 1-280/280
Sequence Identity: 18% (58 aa)

AAEEILIGKGAFGKVNLMRYLPTNIPVAVKVQEKKNRGISEDEMKNKLVSRSMKEAVMHHVM-SDNPSFPGLLGVVEIE-------DNLGVVLEFI--GD
   .  .| ||||.| . ..    |.||||.  .              .   |.|| . .    ..|    |.||.  .       . | .|.|.   ||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD

KQFVIIHPLCDVLLERRPGLSRLEWIDIAFDIIQGLASLHDKRLLHNDLKKNNILLQRSGERWRAYIIDFG----HGST--------VTMP-----LK--
        | | | ..|| |.  . ......| .| . ||.|.. | ||   |.|. . .   .. | |||    ...         . ..      |  
--------LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTM

FP-----------------------------TFSLEEEREY------MEGLLYHHLAPEIVRDQQPTSVYSDIYSLGKVLLDIGRVSGDRDLRLVAEMCT
.|                              |.. ..  .      |.    ...  .  |  || ..|  . .          |    ..  . ..| 
LPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSF----------VCCPDEMYQIMKQCW

RVKPYRRPTMSNVELSV
. .|  |||.|..    
HEDPEDRPTFSEIHECF
Kinase Spk372.AA Ciliate-E3 384-429 39 3e-06 15.91 In-house 106-151 (202) Show / Hide 
Range on Protein: 384-429
Range on HMM: 106-151/202
Sequence Identity: 39% (18 aa)

IDIAFDIIQGLASLHDKRLLHNDLKKNNILLQRSGERWRAYIIDFG
.||.  ||||.  .| | . | |.|  |||.  .  .  . | |||
YDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFG
Kinase Spk372.AA Ciliate-E3 461-488 42 4e-06 15.6 In-house 176-202 (202) Show / Hide 
Range on Protein: 461-488
Range on HMM: 176-202/202
Sequence Identity: 42% (12 aa)

APEIVRDQQPTSVYSDIYSLGKVLLDIG
|||..  ||. |  ||.||.| |.... 
APEQNDQQQI-SKESDYYSVGAVFCQLC
Kinase Spk372.AA LISK 274-298 44 5e-06 15.5 In-house 1-25 (296) Show / Hide 
Range on Protein: 274-298
Range on HMM: 1-25/296
Sequence Identity: 44% (11 aa)

LIGKGAFGKVNLMRYLPTNIPVAVK
 ||||.||||   ... |. ..|.|
EIGKGFFGKVYKGTHRQTGQVMAIK
Kinase Spk372.AA Ciliate-E2-Unclassified 275-315 27 0.06334 2.49 In-house 7-59 (352) Show / Hide 
Range on Protein: 275-315
Range on HMM: 7-59/352
Sequence Identity: 27% (15 aa)

IGKGAFGKVNLMRYLPTNIPV-----AVKVQEKKNRGISE--------DEMKNK
||.|.|||| ...   ..  .     . |.|..| . | .        .||.||
IGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNK