Gene Spk387 (Sea Urchin)

Spk387

Species: Sea Urchin
Alias: Spk387, SPU_023236
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: urch
Subfamily: urch-unclassified

Sequence

Name Sequence Type Origin Length Description Download
Spk387.AA Protein None 588 None Fasta, JSON
Spk387.kin_dom Protein Kinase Domain None 145 None Fasta, JSON

Protein domain

Protein domains of Spk387.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Spk387.AA urch-unclassified 345-545 37 3.4e-95 322.56 In-house 1-215 (215) Show / Hide 
Range on Protein: 345-545
Range on HMM: 1-215/215
Sequence Identity: 37% (80 aa)

LGGGAFGRVFAYRQKRGRQGKTVAMKILHSNADDYEVRRQ-------EIILEARLIRLFAGTGVFPRTYGVGSLGNDTAIAMEFLGDDSTYKVKTLNTWT
.|.|.||.||..|..|......|.|...|.|..|||.|.|       .|..||...||||....|||.||.........|.||||||..||.|..|..|.
IGKGTFGKVFMMRHQREAVPVKVKMIHEHHNDYDYEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLCQWI

HEEH-----VSIHHAKTVLLDVLSAMKALHSMDILHNDIKGDNVIVKQSDHDL-FSGYLIDLGNASTTFL-SAIYDFGQTERDYYDDDPLSIHYAPELIF
||.|     .|.||......|....|.|.|.||.||||.|..|......|||.    | ||.|..||         |   |.  |    .  | ||| . 
HERHKSNPALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMAPEIVL

DNAATTRASDVYQIG
. . |  .||.|  |
YGQPTSVYSDIYSLG
Kinase Spk387.AA urch 345-545 28 1.3e-76 260.78 In-house 1-217 (217) Show / Hide 
Range on Protein: 345-545
Range on HMM: 1-217/217
Sequence Identity: 28% (62 aa)

LGGGAFGRVFAYRQKRGRQGKTVAMKILHSNADDYEV--------RRQEIILEARLIRLFAGTGVFPRTYGVGSLGNDTAIAMEFLGDDSTYKVKTLNTW
.|.|..|||..||.....|.....|.....|..|...        ...... ||....|..|...||..||......|....|||.||..|.|...|...
IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHWC

TH-------EEHVSIHHAKTVLLDVLSAMKALHSMDILHNDIKGDNVIVKQSDHDLFSGYLIDLGNASTTFLSA-IYDFGQTERDYYDDDPLSIHYAPEL
.|       ..|.|.........|....|.|.|....||||.|.|||......|.   ...||.|...|    .  . | . |.. |      .| |||.
IHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPEC

IFDNAATTRASDVYQIG
. | .... |||||  |
VLDGQPCSIASDVYSVG
Kinase Spk387.AA urchA 345-542 26 7.7e-20 60.75 In-house 1-208 (208) Show / Hide 
Range on Protein: 345-542
Range on HMM: 1-208/208
Sequence Identity: 26% (55 aa)

LGGGAFGRVFAYRQKRGRQGKTVAMKILHSNADDYEVRRQEIIL---EARLIRLFAGTGVFPRTYGVGSLGNDTA-IAMEFLGDDSTYKV----KTLNT-
|| |. | |. || .    .. ||.|.    ...|  .|. | .   |..   .  ..  ||  ||   .  | . .|||| || .| .      .|   
LGRGVYGTVHLYRHR--QTDHPVALKVIE-LPKEYKKMRRKIECFQNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDKA

-WTHEEHVSIHHAKTVLLDVLSAMKALHSMDILHNDIKGDNVIVKQSDHDLFSGYLIDLGNASTTFLSA---IYDFGQTERDYYDDDPLSIHYAPELIFD
    .   . .    |.||.    |..|.. .| || | ||. |      .  . .||.| |.          . | | . . |       | |||.. |
MEMRQPALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFGRWRAKIIDFGWACPCQMPFPACRMHFDQRQKQFYRYCHRCCHIAPECALD

NAATTRASDVY
    . .||||
AQPCSTSSDVY
Kinase Spk387.AA S_TKc 339-584 16 1.4e-11 -7.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 339-584
Range on HMM: 1-231/231
Sequence Identity: 16% (45 aa)

NKSIITLGGGAFGRVFAYRQKRGRQGKTVAMKILHSNADDYEVRRQEIILEARLIRLFAGTGVFPRTYGVGSLGNDTAIAMEFLGD---DSTYKVKTLNT
 . . ..| ||||.|.  | |.   |. ||.||..          . |. | .. .   .     . |.|    ..  . ||...    |     |  ..
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

WTHEEHVSIHHAKTVLLDVLSAMKALHSMDILHNDIKGDNVIVKQSDHDLFSGYLIDLGNASTTFLSAIYDFGQTERDYYDDDPLSIHY-APELIFDNAA
       .  ||. ..  ...|.. .||. |.| |.| .|. . .         ..| | |                   .    . .| |||..     
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----------------TTFCGTPWYMAPEVL---GY

TTRASDVY-----------------QIGQLIYIMGNDMGNEDLRDIGERCVYREPLSRIRLLDLIE----------L
.....|..                 |. ... ..|     ....|. ..|  ..|  |.   .. .          .
GKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Spk387.AA TKL 345-496 17 6.8e-10 31.81 In-house 1-201 (364) Show / Hide 
Range on Protein: 345-496
Range on HMM: 1-201/364
Sequence Identity: 17% (37 aa)

LGGGAFGRVFAYRQKR------GRQGKTVAMKILHS------------------------NADDYEVRRQEIILEARLIRL--------FAGTGVFPRT-
.| |.|| |.  . .       .. ||.||.|...|                        |.....  |.... |.....         | |    |.  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-YGVG--SLGNDTAIAMEFL--GD-DSTYKVKTLNTWTHEEHVSIHHAKTVLLDVLSAMKALHSMD--------ILHNDIKGDNVIVKQSDH--------
 . .   .  .. .| ||.   |.  ...               .|.     ||. ..|  ||||.        |.| |.| .|. |..  .        
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYN

--DLFSGYLIDLGNA
  .     . |.| .
PNADWCCKICDFGLS
Kinase Spk387.AA Pkinase 344-483 19 1.7e-07 27.59 Pfam 6-146 (293) Show / Hide 
Range on Protein: 344-483
Range on HMM: 6-146/293
Sequence Identity: 19% (30 aa)

TLGGGAFGRVFAYRQKRGRQGKTVAMKILHSNADDYEVRRQEIIL--EARLIRLFAGTGVFPRTYGVGSLGNDTAIAMEFLGD-----DSTYKVKTLNTW
..| |.||.|.  . |  ..  .||.||.    .. .  .|. ..  |... . . .     |.|..   ...  . ||...      |    ..|    
KIGSGSFGCVYKCHHKGTGK--IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST----

THEEHVSI----HHAKTVLLDVLSAMKALHSMDILHNDIKGDNVIVKQSDH
  ..| ..    ...| ... .|.... .||| |.| |.| .|. ... .|
--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGH
Kinase Spk387.AA Ciliate-B3 447-495 36 3.2e-07 22.71 In-house 2-50 (69) Show / Hide 
Range on Protein: 447-495
Range on HMM: 2-50/69
Sequence Identity: 36% (18 aa)

AKTVLLDVLSAMKALHSMDILHNDIKGDNVIVKQSDHDLFSGYLIDLGN
|   .  |.  .| ||.. | | ||| ||..|.| |.. .   .|| |.
ALKHFHQVVEKIKILHEKNICHCDIKVDNILVNQQDKENYKVIIIDFGH
Kinase Spk387.AA TyrKc 339-585 16 1e-06 -114.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 339-585
Range on HMM: 1-280/280
Sequence Identity: 16% (54 aa)

NKSIITLGGGAFGRVFAYRQKRGRQGKTVAMKILHSNADDYEVRRQEIILEARLIRLF--AGTGVFPRTYGVGSLG-------NDTAIAME---------
 . . .|| ||||.|.  . |      .|| | |...|      |.... |||. . .      .  | ||| . .           | ||         
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIV-RLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLGDDSTYKVKTLNTWTHEEHVSIHHAKTVLLDVLSAMKALHSMDILHNDIKGDNVIVKQSDHDLFSGYLIDLGNASTTFLSAIYDFG----QTER----
.| .                 ..  .     ... . |  |||. . | |.   |. |.                        | |||     ..     
YLRKHRPK-------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------------------TVKISDFGLSRDIYDDDQQG

---DYYD-----DDP--LSIH-YAPELIFDN---------------------------------AATTRASDVYQIGQLIYIMGNDM------GNEDLRD
   |||.     .    | |  .||| |...                                    ...    . |    .. ||         ... .
ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ

IGERCVYREPLSRIRLLDLIELV
| ..|  ..| .| .  ...|. 
IMKQCWHEDPEDRPTFSEIHECF
Kinase Spk387.AA AGC 340-372 36 3e-06 10.63 In-house 1-38 (395) Show / Hide 
Range on Protein: 340-372
Range on HMM: 1-38/395
Sequence Identity: 36% (14 aa)

KSII-TLGGGAFGRVFAYRQKRGR----QGKTVAMKIL
  .. ..| |.||.|.  | | |      ||  |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVL
Kinase Spk387.AA urchC 453-476 45 3e-06 16.19 In-house 128-151 (223) Show / Hide 
Range on Protein: 453-476
Range on HMM: 128-151/223
Sequence Identity: 45% (11 aa)

DVLSAMKALHSMDILHNDIKGDNV
|..    ..|.   ||||||.|||
DIIRGVHFMHDFGLLHNDIKDDNV
Kinase Spk387.AA CAMK 344-383 21 5e-06 14.66 In-house 1-80 (425) Show / Hide 
Range on Protein: 344-383
Range on HMM: 1-80/425
Sequence Identity: 21% (17 aa)

TLGGGAFGRVFAYRQKRGRQ----------GKTVAMKILH------------------------------SNADDYEVRR
||| |.|| |.  ..|.  .          |. ||.||.                               .  |  .|||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRR
Kinase Spk387.AA ASK 454-478 56 1.2e-05 14.51 In-house 103-127 (254) Show / Hide 
Range on Protein: 454-478
Range on HMM: 103-127/254
Sequence Identity: 56% (14 aa)

VLSAMKALHSMDILHNDIKGDNVIV
.|  .| ||  .| | |||||||.|
ILEGLKYLHENQIVHRDIKGDNVLV
Kinase Spk387.AA STE 339-394 21 0.000308 11.01 In-house 1-83 (359) Show / Hide 
Range on Protein: 339-394
Range on HMM: 1-83/359
Sequence Identity: 21% (18 aa)

NKSIITLGGGAFG-RVFAYRQ------KRGRQ------GKTVAMKILH---SNADDYE------------VRRQEIILEARLIR
 . |  .| ||||  . |..       | |..      |. .|.|...   .|. | |              .|.|. | .. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMK
Kinase Spk387.AA urchC 522-548 39 0.000364 9.14 In-house 196-223 (223) Show / Hide 
Range on Protein: 522-548
Range on HMM: 196-223/223
Sequence Identity: 39% (11 aa)

IHYAPELIF-DNAATTRASDVYQIGQLI
|| |||..  |  ..  |||.| .| . 
IHIAPEVLDIDGCQVSVASDIYSVGVIL
Kinase Spk387.AA STE 445-476 30 0.001277 8.8 In-house 151-183 (359) Show / Hide 
Range on Protein: 445-476
Range on HMM: 151-183/359
Sequence Identity: 30% (10 aa)

HHAKTVLLDVLSA-MKALHSMDILHNDIKGDNV
.  .... ..| . .. |||. | | |||..|.
SQIAYICRQILKGLLYYLHSHHIIHRDIKPANI
Kinase Spk387.AA CAMK 439-484 23 0.039845 1.84 In-house 173-218 (425) Show / Hide 
Range on Protein: 439-484
Range on HMM: 173-218/425
Sequence Identity: 23% (11 aa)

EEHVSIHHAKTVLLDVLSAMKALHSMDILHNDIKGDNVIVKQSDHD
. ... . |...   ..||.. .||..| | |.| .|. . ... |
RGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDD