Spk366

Species: Sea Urchin
Alias: SPU_007056, Spk366
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: urch
Subfamily: urch-unclassified

Sequence

Name Sequence Type Origin Length Description Download
Spk366.AA Protein None 367 None Fasta, JSON
Spk366.kin_dom Protein Kinase Domain None 99 None Fasta, JSON

Protein domain

Protein domains of Spk366.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Spk366.AA urch 110-314 37 2.4e-79 269.89 In-house 1-217 (217) Show / Hide
Range on Protein: 110-314
Range on HMM: 1-217/217
Sequence Identity: 37% (82 aa)

IGNGSYGQVNVLRYRKTLQPIAVKNFVFGSGISSSHAL--------PCLIQHEAHELAAMVGSDFFPRFYGLIRLSRNHFKLAMEFVGDQKTGRTCSVSR
||.|.|| |.  |.|.| ||.|.| ..  . ...  ..           .. ||  . .| |...||.||| .... .   |.|||.|| |||.. . ..
IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDID-DDLCLVMEFIGDKKTGKSYPLHW

ALVY-----HDLVEGEETWINITIDVCHGMNELHSRKRLHNDLKSDNIMLFRCPRRLRWAAKIIDFGMISTFDR-GKLFSFPDEEKTLYMMGDDYLHIAP
..         .    . |.||..|..|||...|....||||||.||..|...... || |.|||||...|...  |...|||||.. ||.|..| ||||
CIHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHG-RWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAP

EIVLGGAPTSKATDVFSLG
|.||.|.|.|.|.||.|.|
ECVLDGQPCSIASDVYSVG

Kinase Spk366.AA urch-unclassified 167-314 44 3.3e-79 269.46 In-house 65-215 (215) Show / Hide
Range on Protein: 167-314
Range on HMM: 65-215/215
Sequence Identity: 44% (69 aa)

FPRFYGLIRLSRNHFKLAMEFVGDQKTGRTCSVSRALVYHD-----LVEGEETWINITIDVCHGMNELHSRKRLHNDLKSDNIMLFRCPRRLRWAAKIID
||| ||   .  .   ..||| || .|... . ....         |  . . ||||..|.||||...|....|||||||.||.|..|....||.|.|||
FPRCYGMVKHE-DCPCIVMEFLGDKQTYTVYPLCQWIHERHKSNPAL--SKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIID

FGMISTFDR-GKLFSFPDEEKTLYMMGDDYLHIAPEIVLGGAPTSKATDVFSLG
||||||... .|...|.|.|...||||..|.|.||||||.|.|||...|..|||
FGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMAPEIVLYGQPTSVYSDIYSLG

Kinase Spk366.AA urchA 110-311 29 4.3e-44 140.18 In-house 1-208 (208) Show / Hide
Range on Protein: 110-311
Range on HMM: 1-208/208
Sequence Identity: 29% (61 aa)

IGNGSYGQVNVLRYRKTLQPIAVKNFVFGSGISSSHALPCLIQHEAHELAAMVGSDFFPRFYGLIRLSRNHFKLAMEFVGDQKTGRT----CSVSRALVY
 | | || |   | |.| .|.|.| . .   . .  .   ..| |.  . .  ....|| |||  ...     .||||.||  ||.        ..|.  
LGRGVYGTVHLYRHRQTDHPVALKVIELPKEYKKMRRKIECFQNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDKAMEM

HDLVEGEETWINITIDVCHGMNELHSRKRLHNDLKSDNIMLFRCPRRLRWAAKIIDFGMISTFDRGK---LFSFPDEEKTLYMMGDDYLHIAPEIVLGGA
  .    . | |. .|.  |   .|..  | |||| ||. .   .   || |||||||  .  ..      . |  ..|  |  .  . ||||| .| . 
RQPALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFG-RWRAKIIDFGWACPCQMPFPACRMHFDQRQKQFYRYCHRCCHIAPECALDAQ

PTSKATDVF
| | . ||.
PCSTSSDVY

Kinase Spk366.AA urchC 154-317 31 1.8e-25 79.3 In-house 57-223 (223) Show / Hide
Range on Protein: 154-317
Range on HMM: 57-223/223
Sequence Identity: 31% (55 aa)

EAHELAAMVGSDFFPRFYGLIRLSRNHFKLAMEFVGDQKTGRTCSVSRALV---YHDLVEGEETW--INITIDVCHGMNELHSRKRLHNDLKSDNIMLFR
||  .  | .. .|||.|| . . .|.  .  ||.|| ..|..     |.      | .     |  . |  |.  |   .|..  |||| | ||. |  
EARVGQMMSTCPYFPRMYGTVMIDENMC-IVTEFIGDKQQGKVYMLHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEH

CPRRLRWAAKIIDFGMIST--FD---RGKLFSFPDEEKTLYMMGDDYLHIAPEIVL-GGAPTSKATDVFSLGYLM
  |  || . ||| ||.||  .    ||.  . ||  |     .  . |||||..   |  .|.|.|..| | ..
--RKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQK-----LYGFIHIAPEVLDIDGCQVSVASDIYSVGVIL

Kinase Spk366.AA urchB 216-314 45 9.3e-21 71.35 In-house 115-212 (212) Show / Hide
Range on Protein: 216-314
Range on HMM: 115-212/212
Sequence Identity: 45% (45 aa)

INITIDVCHGMNELHSRKRLHNDLKSDNIMLFRCPRRLRWAAKIIDFGMISTFDR-GKLFSFPDEEKTLYMMGDDYLHIAPEIVLGGAPTSKATDVFSLG
. |  |.  || |.|    |||||| ||..| .  |  |. | ||||||.||     |.   | | |  |  |.    ||||..| | .|| . |||| |
VDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEK--RGHRYHAVIIDFGMVSTITAPLKMVEVPKELKMAYVHGEEADYIAPEVILHGQSTSISSDVFSVG





Kinase Spk366.AA Ciliate-E2 222-314 21 2.8e-12 38.44 In-house 169-283 (365) Show / Hide
Range on Protein: 222-314
Range on HMM: 169-283/365
Sequence Identity: 21% (28 aa)

VCHGMNELHSRK-RLHNDLKSDNIMLFRCPRRLRWAAKIIDFGMISTFD------------RGKLFSFPDEEKTLYMMGDDYL---------------HI
.......|||..  .| |.| .||..           ||||||.   .|              ..| . |...|   |.   .                 
IILALEYLHSKNNIIHRDIKPENILF----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD---QIIQQNMFNTICGTPGYM

APEIVLG--------GAPTSKATDVFSLG
||||. |        . . ... |..|||
APEILNGKKYDNQQKQKGYDYKCDIWSLG

Kinase Spk366.AA TKL 205-314 20 4.4e-10 32.51 In-house 126-276 (364) Show / Hide
Range on Protein: 205-314
Range on HMM: 126-276/364
Sequence Identity: 20% (32 aa)

YHDLVEGEETWINITIDVCHGMNELHSRK--------RLHNDLKSDNIMLFRC---------PRRLRWAAKIIDFGMISTFDRGKLFSFP----------
.|.|    .  ... .|.. ||| |||..         .| ||||.||....          ..   | .|| |||   .... .  .            
LHYLH--WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEH

-DEEKTLYMMGDDYLHIAPEIVLGGAPTSKAT---------------DVFSLG
 . .||... .  . . |||.  |  .....                ||.| |
QNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG

Kinase Spk366.AA S_TKc 104-354 17 6.2e-10 -31.21 SMART 1-231 (231) Show / Hide
Range on Protein: 104-354
Range on HMM: 1-231/231
Sequence Identity: 17% (49 aa)

KIESLFIGNGSYGQVNVLRYRKTLQPIAVKNFVFGSGISSSHALPCLIQHEAHELAAMVGSDFFPRFYGLIRLSRNHFKLAMEFVGDQKTGRTCSVSRAL
      || |..|.|   | .|| .  |.|               . |. |   |    . ..  ..|. ..   .|. . ||...    | . .. . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCD----GDLGDLFDYI

VYHDLV-----EGEETWINITIDVCHGMNELHSRKRLHNDLKSDNIMLFRCPRRLRWAAKIIDFGMISTFDRGKLFSFPDEEKTLYMMGDDYLH----IA
. .          | .   ..  .| ... .||.. .| ||| .||.| .         ||.|||.   .                   . .      .|
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-------------------TTFCGTPWYMA

PEIVLGGAPTSK-ATDVFSLG----------------YLMRDIAQRKAVVSLDFISRLCLNVEAMHRPAMDVVKK---------YV
||..    . .| . |. |.|                ..| ..        .|||.. ||...  .||    . .         ..
PEVL----GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG--SPEAKDFIRK-CLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase Spk366.AA STE 218-263 31 1.3e-09 30.27 In-house 156-192 (359) Show / Hide
Range on Protein: 218-263
Range on HMM: 156-192/359
Sequence Identity: 31% (15 aa)

ITIDVCHG-MNELHSRKRLHNDLKSDNIMLFRCPRRLRWAAKIIDFG
|. ....| .. ||| .. | |.|..||.|          .|..|||
ICRQILKGLLYYLHSHHIIHRDIKPANILL----------VKLCDFG

Kinase Spk366.AA urchB 105-194 33 4e-07 21.93 In-house 1-98 (212) Show / Hide
Range on Protein: 105-194
Range on HMM: 1-98/212
Sequence Identity: 33% (34 aa)

IESLF-IGNGSYGQVNVLRYRKTLQPIAVKNFVFGSGISSSHALPCLIQHEAH-------ELAAMV-----GSDFFPRFYGLIRLSRNHFKLAMEFVGDQ
|  |  || |.|| | . | | |  | |.|     .  |   ..|     |.|          ||.     .| .||.|.|   .  |   .| |||| .
INDLQEIGRGTYGRVVIARHRQTKVPLAIKQ----PCWSDNYQSPNEMVDELHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDID-NDLCQAQEFVGCK

KTG
|||
KTG

Kinase Spk366.AA RAF 216-246 51 7e-07 18.02 In-house 106-136 (282) Show / Hide
Range on Protein: 216-246
Range on HMM: 106-136/282
Sequence Identity: 51% (16 aa)

INITIDVCHGMNELHSRKRLHNDLKSDNIML
|.|   || ||. ||... .| |||| ||.|
IDISRQVCQGMDYLHAKNIIHRDLKSNNIFL

Kinase Spk366.AA CAMK 222-314 20 7.5e-07 17.34 In-house 188-321 (425) Show / Hide
Range on Protein: 222-314
Range on HMM: 188-321/425
Sequence Identity: 20% (28 aa)

VCHGMNELHSRKRLHNDLKSDNIMLFRCPRRLR------------WAAKIIDFGMISTFDRGKL---------------FSFPDEEKTLYMMGDDYLHIA
.| ... .||..  | ||| .||.|    .               .  ||||||.   ||.|.                .. |.| . .. .      .|
ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMA

-PEIVLG-------------GAPTSKATDVFSLG
 ||...|               . ....|. |.|
APEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCG

Kinase Spk366.AA urch-unclassified 110-133 37 4e-06 18.25 In-house 1-24 (215) Show / Hide
Range on Protein: 110-133
Range on HMM: 1-24/215
Sequence Identity: 37% (9 aa)

IGNGSYGQVNVLRYRKTLQPIAVK
|| |..| |.  |.  ...| .||
IGKGTFGKVFMMRHQREAVPVKVK

Kinase Spk366.AA TyrKc 104-354 15 5.4e-05 -141.91 SMART 1-280 (280) Show / Hide
Range on Protein: 104-354
Range on HMM: 1-280/280
Sequence Identity: 15% (49 aa)

KIESLFIGNGSYGQVNVLRYRKTLQPIAVKNFVFGSGISSSHALPCLIQHEAHELAAM-------VGSDFFPRFYGLIRLSR------NHFKLAMEFVGD
      .|.| .|.|   ...   .. |||    ..           . .||  .          |      |.|| .. .           . ||..  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIV------RLYGVCTQQGRNFMYIEPLMIVMEYMPH

-------QKTGRTCSVSRALVYHDLVEGEETWINITIDVCHGMNELHSRKRLHNDLKSDNIMLFRCPRRLRWAAKIIDFGM-ISTFDR---GKLFSFPDE
       .|....                .. ... .... ||. |||..  | ||   |... .        .|| |||.     |    |       |
GDLKDYLRKHRPK-------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQG-------E

EKTLYMM----GDDY-LHI---APEIVLGGAPTSKATDVFS----------------LG-----YLMRDIAQRKAVV-SLDFISR---------------
.|  |..    | .. | |   |||    |   . ..||.|                 |        ... ..      ..                   
SKDYYRKKEHKGGKTMLPIRWMAPECINYGK-FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ

---LCLNVEAMHRPAMDVVKKYV
    | . ..  || .  .... 
IMKQCWHEDPEDRPTFSEIHECF

Kinase Spk366.AA urchC 104-118 46 0.011952 4.15 In-house 1-15 (223) Show / Hide
Range on Protein: 104-118
Range on HMM: 1-15/223
Sequence Identity: 46% (7 aa)

KIESLFIGNGSYGQV
. .  .||.||||.|
QTILEMIGKGSYGEV

Kinase Spk366.AA TKL 110-133 31 0.033537 3.74 In-house 1-32 (364) Show / Hide
Range on Protein: 110-133
Range on HMM: 1-32/364
Sequence Identity: 31% (10 aa)

IGNGSYGQVNVLRYRK--------TLQPIAVK
|| |..|.|   ..|         | ...|||
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVK

Kinase Spk366.AA CAMK 109-133 24 0.03929 1.86 In-house 1-37 (425) Show / Hide
Range on Protein: 109-133
Range on HMM: 1-37/425
Sequence Identity: 24% (9 aa)

FIGNGSYGQVNVLRYRKTL------------QPIAVK
 .| ||.|.|   . ..|             |  |.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIK

Kinase Spk366.AA STE 105-133 22 0.082156 2.33 In-house 1-45 (359) Show / Hide
Range on Protein: 105-133
Range on HMM: 1-45/359
Sequence Identity: 22% (10 aa)

IES-LFIGNGSYGQVNVLRYRK---------------TLQPIAVK
 |   .||.|..|.|   ...|               | . .|.|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIK