Gene Myt1 (Sea Urchin)
Myt1
Sequence
Protein domains of Myt1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Myt1.AA | WEE | 3-168 | 40 | 1.8e-95 | 320.64 | In-house | 91-297 (297) | Show / Hide |
Range on Protein: 3-168 Range on HMM: 91-297/297 Sequence Identity: 40% (83 aa) S-----LQAYAE-QNHKIPENILWGFLVDLIQGLAHMHSH-GLLHLDVKPENIFISFHQ--------------------VCKLGDFGLSVDMD--EHDVT | .... . ||..||. .|..|||..|||.|.||. |..|.|.||||||||... .||.||||...||. ..... SNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMNSNNNNPH DTQEGDPKYLAPELLQG--HFGMH--ADVYSLGITILELASDLELPRNGDSWHDLRQG-------RIP-WQLTAGISSELKGLIRSMMDPDFRKRPSLAS ..||||..|.|||.||| |.... ||..||||||.|||....||.|||.||..||| .|| ......||.|||.||..||.||...||. .. QEQEGDSRYMAPEILQGYYHYTHLYKADIFSLGITIYELACNMDLPKNGDWWHQIRQGDLSFDKNQIPFPEFDNIISQELKQLIKWMMHPDPEQRPTCQQ LMETSLV |...... LLQHPVL |
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| Kinase | Myt1.AA | Pkinase | 26-168 | 22 | 8.3e-30 | 106.48 | Pfam | 117-293 (293) | Show / Hide |
Range on Protein: 26-168
Range on HMM: 117-293/293
Sequence Identity: 22% (41 aa)
LIQGLAHMHSHGLLHLDVKPENIFISFHQVC----KLGDFGLSVD--MDEHDVTDTQEGDPKYLAPELLQ--GHFGMHADVYSLGITILELASDLELPRN
...||...||.| .| |.|||||.|. . .. |..||||. ..| | | |.|||... . | .|..|.|... |... . ..
ILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPG
G------DSWHDLRQGRI-----PWQLTAGIS-----------------SELKGLIRSMMDPDFRKRPSLASLMETSLV
| . ... . .|. . || .|.| .|... ..| |||. . ... .
HCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| Kinase | Myt1.AA | STE | 11-109 | 27 | 3.6e-24 | 82.31 | In-house | 145-262 (359) | Show / Hide |
Range on Protein: 11-109
Range on HMM: 145-262/359
Sequence Identity: 27% (34 aa)
NHKIPENILWGFLVDLIQG-LAHMHSHGLLHLDVKPENIFISFHQVCKLGDFGLSVDMDEH-----------------DVTDTQEGDPKYLAPELLQG--
.|..||... .......| |.. |||. | |.|| ||.. .|| |||.. .... ..| | | . ||| .|.
QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNG
-----HFGMHADVYSLGITILELA
. . .|..|||.||.|.|
QGRDKGYDTKCDIWSLGCTIIEMA
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| Kinase | Myt1.AA | ULK | 4-103 | 26 | 2.5e-22 | 74.83 | In-house | 107-244 (329) | Show / Hide |
Range on Protein: 4-103
Range on HMM: 107-244/329
Sequence Identity: 26% (36 aa)
LQAYAEQNHK----------IPENILWGFLVDLIQGLAHMHSHGLLHLDVKPENIFISFHQ------------VCKLGDFGLSVDMDEH----DVTDTQE
|. | ..|.| ..|.. |. ....|. ..|.|. | | ||.|| |. .| |.|..|||.. .|. ... |.
LEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCV
------GDPKYLAPELLQGH-----FG-MHADVYSLGI
| | | ||..|||. .. .|..|||.
NEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGC
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| Kinase | Myt1.AA | ULK | 4-103 | 26 | 1.2e-21 | 73.68 | In-house | 104-240 (324) | Show / Hide |
Range on Protein: 4-103
Range on HMM: 104-240/324
Sequence Identity: 26% (36 aa)
LQAYAEQNHK---------IPENILWGFLVDLIQGLAHMHSHGLLHLDVKPENIFISFHQ------------VCKLGDFGLSVDMDE----HDVTDTQE-
|. | ..|.| ..|.. .|. ....|. ..|.|. | | ||.|| |. .| |.|..|||.. |. ... |.
LEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVN
-----GDPKYLAPELLQGH-----FGMH-ADVYSLGI
| | | ||..|||. .... .|..|||.
EKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGC
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| Kinase | Myt1.AA | Ciliate-E2 | 9-168 | 20 | 1.2e-20 | 67.57 | In-house | 145-365 (365) | Show / Hide |
Range on Protein: 9-168 Range on HMM: 145-365/365 Sequence Identity: 20% (48 aa) EQNHKIPENILWGF-------LVDLIQGLAHMHSHG-LLHLDVKPENIFISFHQVCKLGDFGLSVDMDEH------------------------------ .. .| . || || .. .|..| ..|| . .| | |||||.. .|. ||||| . |. KEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQII --DVTDTQEGDPKYLAPELLQG----------HFGMHADVYSLGITILELASDLELPRNGDSWHDLRQGRI-PWQLT------------------AGISS ....|. | | |.||| |.| . . .|..|||... |. . ..| ..| .... .| QQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF-GKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQ ELKGLIRS----MMDPDFRKRPS-LASLMETSLV | | ||. |.. | ||.. ... ECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | Myt1.AA | TKL | 22-166 | 18 | 1.4e-19 | 67.16 | In-house | 137-364 (364) | Show / Hide |
Range on Protein: 22-166 Range on HMM: 137-364/364 Sequence Identity: 18% (43 aa) FLVDLIQGLAHMHSHG--------LLHLDVKPENIFIS--FHQV------------CKLGDFGLSVDMDEHD--------------------VTDTQEGD . | .|....||.. ..| | |..||.. .. | ||..||||| .|... | || | WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT PKYLAPELLQGH-----------------FGMHADVYSLGITILELASDLELPRNGDSW------------HDLRQGRIPWQLT------------AGIS | ..|||.|.|. . .|||| || . |... . .. .. . . . . . PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCP SELKGLIRSMMDPDFRKRPSLASLMETS ..| |. .|.| .|||| .... PSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | Myt1.AA | Ciliate-E2-Unclassified | 3-168 | 18 | 2.8e-19 | 63.57 | In-house | 107-352 (352) | Show / Hide |
Range on Protein: 3-168 Range on HMM: 107-352/352 Sequence Identity: 18% (45 aa) SLQAYAEQNHK-----------------IPENILW-----GFLVDLIQGLAHMHSHG-LLHLDVKPENIFISFHQ---VCKLGDFGLSV--------DMD .|. | ....| ..|. .. ..||| ..|. . .| | |||||... . .|. |||.| | . DLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-T E---------HDVTDTQEGDPKYL----APELLQG-HFG----MHADVYSLGITILELASDLELPRNGDS-------------------WHDLRQGR--- . .. ..|. | | |. |||.||| . . .|..|||. . |. .| .. . .. . . NQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY-YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQ IPWQLT----AGISSELK----GLIRSMMDPDFRKRPSLASLMETSLV .|.. ..| | | |...|.. . ||... ... . FPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | Myt1.AA | CAMK | 26-103 | 20 | 5.1e-18 | 53.98 | In-house | 188-322 (425) | Show / Hide |
Range on Protein: 26-103 Range on HMM: 188-322/425 Sequence Identity: 20% (28 aa) LIQGLAHMHSHGLLHLDVKPENIFISFHQ-----------------VCKLGDFGLSVDMDE------------------------HDVTDTQEGDPKYLA ........|||. |.| ||||| .. . |. |||.. .|. . |. | | | | ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMA -PELLQGH---------------FGMHADVYSLGI ||.|.| | .|. |.|. APEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGV |
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| Kinase | Myt1.AA | MEK5 | 13-109 | 38 | 6.2e-17 | 58.51 | In-house | 89-185 (254) | Show / Hide |
Range on Protein: 13-109 Range on HMM: 89-185/254 Sequence Identity: 38% (38 aa) KIPENILWGFLVDLIQGLAHMHSHGLLHLDVKPENIFISFHQVCKLGDFGLSVDMDEHDVTDTQEGDPKYLAPELLQG-HFGMHADVYSLGITILELA .||| || | ...|| . . ..| |||| |. . . || ||| | . . .| | | |.||| . | ..|.|.||.|||| ..|.| CIPEHILGRMTVAIVKGLNYLWNLKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNS-ITRTYIGTNAYMAPERISGDQYGIHSDVWSLGIFFMEMA |
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| Kinase | Myt1.AA | NEK | 9-90 | 30 | 4.5e-15 | 49.88 | In-house | 106-198 (286) | Show / Hide |
Range on Protein: 9-90 Range on HMM: 106-198/286 Sequence Identity: 30% (28 aa) EQNHKIPENILWGFLVDLIQGLAHMHSH-----GLLHLDVKPENIFIS-FHQ---VCKLGDFGLSVDMDEH-DVTDT-QEGDPKYLAPELLQG .... ..|.. | ... .. .| .||.. || | || |||.. . . |.||||.| .. | | | | | |..||..|. QKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQN |
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| S_TKc | Myt1.AA | S_TKc | 2-168 | 17 | 5.1e-12 | -0.72 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 2-168 Range on HMM: 1-231/231 Sequence Identity: 17% (44 aa) F-------------------------------------------------------------------------SLQAYAEQNHK------IPENILWGF . .| | ... . .|| . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY LVDLIQGLAHMHSHGLLHLDVKPENIFISFHQVCKLGDFGLSVDMDEHDVTDTQEGDPKYLAPELLQGHFGM-HADVYSLGITILELASDLELPRNGDSW . ....|...|||| .| |.|||||... . |..||||. . .|. | | |.|||.| ..| .|..|.|... |... . | MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLC-GYPPFP---- HDLRQGRIPWQLTAGISSELKGLIRSMMDPDFRKRPSLASLME-------TSLV .. . .. |.|.| .|| ... | .|||. ... . QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | Myt1.AA | NEK | 138-168 | 32 | 1.1e-07 | 23.51 | In-house | 256-286 (286) | Show / Hide |
Range on Protein: 138-168 Range on HMM: 256-286/286 Sequence Identity: 32% (10 aa) SSELKGLIRSMMDPDFRKRPSLASLMETSLV |..|. ||..| .| .||| ...|.... SQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| TyrKc | Myt1.AA | TyrKc | 2-167 | 14 | 2e-06 | -117.76 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 2-167 Range on HMM: 1-280/280 Sequence Identity: 14% (41 aa) FSLQ-----------------------------------------AY--------------AEQ---------------------------NHK--IPEN .| . .| .|. .. ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK ILWGFLVDLIQGLAHMHSHGLLHLDVKPENIFISFHQVCKLGDFGLSVDMDEH-------DVTDTQE--GDP-----KYLAPELL-QGHFGMHADVYSLG | | .. .| .. ||... | | |. .. ...| .||||| | ... |. ...| | . .||| . | | ||.| | DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFG ITILELASDLELPRNG-----DSWHD----LRQGRIPWQLTAG-------ISSELKGLIRSMMDPDFRKRPSLASLMETSL ... |. .. . | | |. . ..||. . | . ..|. .... . | .||. . . . VCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF |
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| Kinase | Myt1.AA | CAMK | 136-168 | 26 | 9.8e-05 | 10.4 | In-house | 385-425 (425) | Show / Hide |
Range on Protein: 136-168 Range on HMM: 385-425/425 Sequence Identity: 26% (11 aa) GISSE--------LKGLIRSMMDPDFRKRPSLASLMETSLV .|| | | |||.|. .| ||.... .. . DISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | Myt1.AA | ULK | 136-168 | 35 | 0.011823 | 5.19 | In-house | 293-329 (329) | Show / Hide |
Range on Protein: 136-168 Range on HMM: 293-329/329 Sequence Identity: 35% (13 aa) G----ISSELKGLIRSMMDPDFRKRPSLASLMETSLV | ||.|.| ||| |. | ..| | | . .. GNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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| Kinase | Myt1.AA | ULK | 137-168 | 34 | 0.018537 | 4.61 | In-house | 293-324 (324) | Show / Hide |
Range on Protein: 137-168 Range on HMM: 293-324/324 Sequence Identity: 34% (11 aa) ISSELKGLIRSMMDPDFRKRPSLASLMETSLV ||.|.| ||| |. | ..| | . . .. ISPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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| Kinase | Myt1.AA | STE | 138-168 | 27 | 0.079044 | 2.39 | In-house | 327-359 (359) | Show / Hide |
Range on Protein: 138-168 Range on HMM: 327-359/359 Sequence Identity: 27% (9 aa) SSELKGLIRSMMDPDFRKRPSLASLME--TSLV |.|.| |. . | .|||. |.. . . SPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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