Gene WNK (Sea Urchin)

WNK

Species: Sea Urchin
Alias: WNK, SPU_022200, Spk212
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: WNK

Sequence

Name Sequence Type Origin Length Description Download
WNK.AA Protein None 2593 None Fasta, JSON
WNK.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of WNK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase WNK.AA WNK 248-507 79 1.1e-226 739.46 In-house 1-261 (261) Show / Hide 
Range on Protein: 248-507
Range on HMM: 1-261/261
Sequence Identity: 79% (207 aa)

MKYDVAVGQGSFKTVFRGLDTETGVAVAWCELQERKLSRSERQRFKEEAEMLKGLSHPNIVSFYDYWEEVSPRGKKHIVLVTELMTSGTLKTYLKRFKGV
||.|..||.||||||.|||||||.|.|||||||..|||..|||||||||||||.|.|||||.||||||.| ..|||.|||||||||||||||||||||..
MKFDEEVGRGSFKTVYRGLDTETWVEVAWCELQDQKLSKNERQRFKEEAEMLKKLQHPNIVRFYDYWESV-LCGKKCIVLVTELMTSGTLKTYLKRFKKM

KNRVLRSWCRQILKGLHFLHTRQP-PIIHRDLKCDNIFITGTSGAVKIGDLGLA-TLKKSSFAKSVIGTPEFMAPEMYEEHYDEAVDVYAFGMCLLEMAT
|..||||||||||||||||||||| |||||||||||||||||.|.||||||||| |||.|||||||||||||||||||||||||.|||||||||.|||||
KPKVLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIGDLGLAVTLKNSSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMAT

SEYPYAECSNAAQIYRRVTTGVKPQSFEKVNDNKIKEIIDGCTKTNNTERYLIQELLKHTFF
|||||.||.|||||||.||.|.||.||.|......||||..|...|..||. ||.||.|.||
SEYPYSECQNAAQIYRKVTQGIKPNSFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF
Kinase WNK.AA S_TKc 248-507 24 8.8e-62 212.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 248-507
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

MKYDVAVGQGSFKTVFRGLDTETGVAVAWCELQERKLSRSERQRFKEEAEMLKGLSHPNIVSFYDYWEEVSPRGKKHIVLVTELMTS--GTLKTYLKRFK
 .    .|.|.| .|... ...||  ||  ..          .... | ..||   ||||| .||....      .|. .|.|..    |.|..|.|. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

G------VKNRVLRSWCRQILKGLHFLHTRQPPIIHRDLKCDNIFITGTSGAVKIGDLGLATLKKSSFAKSVIGTPEFMAPEMYEEHYDE-AVDVYAFGM
.          . |....||...| ..| .   ||||||| .||...     .||.| |||..      ....|||..||||.   .|.  ..|....| 
RHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGC

CLLEMATSEYPYAECSNAAQIYRRVTTGVKPQSFEKVNDNKIKEIIDGCTKTNNTERYLIQELLK-------HTFF
.| ||.. . |.    . .......             .   |..|..| . . ..|. . |.|.       | .|
ILYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase WNK.AA Pkinase 248-507 26 2.4e-56 198.3 Pfam 1-293 (293) Show / Hide 
Range on Protein: 248-507
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

MKYDVAVGQGSFKTVFRGLDTETGVAVAWCELQERKLSRSERQRFKE--EAEMLKGLSHPNIVSFYDYWEEVSPRGKKHIVLVTELMTSG----TLKTYL
 .    .|.||| .|... .  ||  ||  ..  |. . ...|.     |....| |.||||| .||..|.     |.|| .|.|..  |     |..|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

K--RFKGV--KNRVLRSWCRQILKGLHFLHTRQPPIIHRDLKCDNIFITGTSGAV----KIGDLGLAT---LKKSSFAKSVIGTPEFMAPEM--YEEHYD
.  | ...    ........|||.|| ..| .   ||||||| .||.|    | .    ||.| |||    . ..| .... |||..||||     ..|.
STWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

EAVDVYAFGMCLLEMATSEYPYAEC-----SNAAQIYRRVTTGVKPQSFEKVND-------------------NKIKEIIDGCTKTNNTERYLIQELLKH
 .||....|  | ||.. . |. ..      .  |...|.  .  . .... ..                      |..|..| . . ..|. ....|.|
PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

TFF
 .|
PWF
Kinase WNK.AA STE 248-507 20 1.8e-54 187.29 In-house 1-359 (359) Show / Hide 
Range on Protein: 248-507
Range on HMM: 1-359/359
Sequence Identity: 20% (74 aa)

MKYDVAVGQGSFKTVFRGLDT------ETG-----------VAVAWCELQE--------RKLSRS-------ERQRFKEEAEMLKGLS--HPNIVSFYDY
 .    .|.|.| ||.....       .||           .|.   .|..         . . .       |.|....| ...| ..  ||||| .|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

WEEVS--PRGKKHIVLVTELMTSGTLKTYLK-RFKGVK-------------NRVLRSWCRQILKG-LHFLHTRQPPIIHRDLKCDNIFITGTSGAVKIGD
 .  .     . .. .. |.|  |.|   .| ...  |               ...  ||||||| |..||  .  |||||.|..||..      ||. |
YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------VKLCD

LGLATLKKSS------------------FAKSVIGTPEFMAPEMYEE-------HYDEAVDVYAFGMCLLEMATSEYPYAECSNAAQIYRRVTTG-----
 |...   .|                    ....||| .||||. .        .||. .|.. .| ...|||| ..|... ..   ...  . .     
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQ

--------VKPQSFEK-------------------VNDNKIKEIIDGCTKTNNTERYLIQELLK--HTFF
         .| ...                        . |. |. | . .  .|   ..|||  | |.
FEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase WNK.AA CAMK 253-507 16 1.9e-47 150.56 In-house 1-425 (425) Show / Hide 
Range on Protein: 253-507
Range on HMM: 1-425/425
Sequence Identity: 16% (71 aa)

AVGQGSFKTVFRGLDTETG------------VAVAWCELQERKLS--------------------------RSERQRFKEEAEMLKGLS-------HPNI
  |.||| .|... ...|.            . ||   .  .||.                           . |.... | |..| |.       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSFYDYWEE-----------VSPRG----KKHIVLVT---ELMTSG----TLKTYLKRFKG---------------VKNRVLRSWCRQILKGLHFLHTRQ
...|...|               ..    .||...|.   |... |     |  |... ..               .. |  | . |||. ..|..| . 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

PPIIHRDLKCDNIFITGTS----------------GAVKIGDLGLATLKKSS-------------------------FAKSVIGTPEFMA-PEMYE----
  |.|||||..|| ..  .                . .|| | |.|. ....                           | . ||||.|| ||. .    
--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-----------EHYDEAVDVYAFGMCLLEMATSEYPYAECS------------NAAQIYRRVTTGVKPQSFEKVND----------------------NK
           . |....|. . |  |  | . ..|. . .            |  ........|      ... .                        
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

IKEIIDGCTKTNNTERYLIQELLKHTFF
 |  | .. ... ..|. |.. |.| ..
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase WNK.AA TKL 254-505 20 9.5e-47 161.62 In-house 1-364 (364) Show / Hide 
Range on Protein: 254-505
Range on HMM: 1-364/364
Sequence Identity: 20% (76 aa)

VGQGSFKTVFRGLDTETG----------VAV--------AWCELQERK---------------LSRSERQRFKEEAEMLKGLSHPNIVSFYDYWEEVSPR
.|.|.| .|..|    .|          |||          .......                .. .|....||. |.. |.|||||.|. |  . ...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

G--------KKHIVLVTELMTSGT-LKTYLKRFKGVKNRVLRSWCRQILKGLHFLHTRQ------PPIIHRDLKCDNIFITG-------------TSGAV
.        .... .|.|..  |. | ...         .. .|...| .|...||...      ||||||||| .||..                 . .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDLGLATLKKSSF---------------------AKSVIGTPEFMAPEMYE-----------------EHYDEAVDVYAFGMCLLEMATSEYPYAECS
||.|.||.. .. |.                       ...||| .||||. .                 . |.|..|||.||..| |..| . ||..  
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

NAAQI---------YRRVTTGVKPQSFEKVN--------DNK---IKEIIDGCTKTNNTERYLIQELLKHT
.  .|         . ..  | .|   .  .        ..    .|...  | ... ..|   ||.||. 
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase WNK.AA Ciliate-E2 248-507 17 4.2e-46 156.25 In-house 1-365 (365) Show / Hide 
Range on Protein: 248-507
Range on HMM: 1-365/365
Sequence Identity: 17% (69 aa)

MKYDVAVGQGSFKTVFRGLDTETGVAVAWCELQERKLSRSE---------------------RQRFKEEAEM---------------LKGLSHPNIVSFY
 |     |||.| .|... . ...  .|    . .|. ..                      .| ..|. .|               |. |.||||. .|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

DYWEEVSPRGKKHIVLVTELMTSGTLKTYLK--RFKGVKN---------RVLRSWCRQILK---------------GLHFLHTRQPPIIHRDLKCDNIFI
....|     ...| ||.|.   |.|. |.|  . |  ..         .  .   .|||.               .|..|| . . |||||.| .||..
ECFQE---KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF

TGTSGAVKIGDLGLAT----------------LKKSSF------------------AKSVIGTPEFMAPEMYE----------EHYDEAVDVYAFGMCLL
      .|| |.||..                ...  .                  .....|||..||||...          ..||...|....|..| 
------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY

EMATSEYPYAECSNAAQIYRRVTTGVKPQSFEKVNDNKIK----------------------------EIIDG----CTKTNNTERYL-IQELLKHTFF
|| . ..|.                     ...  ..||.                             .|      . . .  .|.  ....|.| .|
EMLFGKPPF---------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase WNK.AA NRBP 254-508 31 1.6e-42 147.3 In-house 2-261 (261) Show / Hide 
Range on Protein: 254-508
Range on HMM: 2-261/261
Sequence Identity: 31% (84 aa)

VGQGSFKTVFRGLDTETGVAVAWCELQ--ERKLSRSERQRFKEEAEMLKGLSHPNIVSFYDYWEEVSPRGKKHIVLVTELMTSGTLKTYLKRFK----GV
      ....  .|||.|| | | |.|  |||  ...  . ..  . |  | |.||| |  || ...   |  .. .|| | || .| .||. |     .
RDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEE-KPRVIFITEYMSSGSMKQFLKKTKKNHKNM

KNRVLRSWCRQILKGLHFLHTRQPPIIHRDLKCDNIFITGTSGAVKIGDLGLATLKKS-SFAKSVIGTPEFMAPEMY---EEHYDEAVDVYAFGMCLLEM
. .  . || |||  | .||. .|||||  | || |||    | .|||     .....   ..       |.|||      ..   |||.|.|||| |||
NEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQ-HNGLIKIGCVWPDAIHHHVRTCREEMRNMHFFAPEYGILEVTDLTTAVDIYSFGMCALEM

ATSEYPYAECSNAAQIYRRVTTGVKPQSFEKVNDNKIKEIIDGCTKTNNTERYLIQELLKHTFFE
|  |   . |.|.   |  ||  .  .. . ..|.  ...|  | . .  .|   .||| |    
AVLEI-QSGCQNGESEY--VTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF
Kinase WNK.AA STE11 248-507 23 1.1e-40 141.53 In-house 1-303 (303) Show / Hide 
Range on Protein: 248-507
Range on HMM: 1-303/303
Sequence Identity: 23% (72 aa)

MKYDVAVGQGSFKTVFRGLDTETGVAVAWCELQERKLS------RSERQR------FKEEAEMLKGLSHPNIVSFYDYWEEVSPRG-KKHIVLVTELMTS
 .     |.|.| ||...... ||. .|  . .... .      . | |       ..|| ...|.|.|.||| .|.   .    . ..|.    | .  
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLH---DNQNDHVNIFMEYCPG

GTLKTYLK-RFKG--VKNRVLRSWCRQILKGLHFLHTRQPPIIHRDLKCDNIFITGTSGAVKIGDLGLATLKKSS------------FAKSVIGTPE---
|.|.  |. ..        | |   .|||.||..||  .  |||||.| .||..  ... .|..| | |.  ...            . ||. |||    
GSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHG--IIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSM

-----FMAPEMYE-EH---YDEAVDVYAFGMCLLEMATSEYPYAECSN--AAQIYRRVTT-GVKPQSFEKVND-----NKIKEIIDGCTKTNNTERYLIQ
     .||||..  |    |. ..|. ..| . .||||   |......  .|.... ... .  |.  |..        . ..... | . .  .|.  .
MGTPMWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTAN

ELLKHTFF
.||.| |.
QLLQHPFI
Kinase WNK.AA Ciliate-E2-Unclassified 255-507 18 5e-38 129.5 In-house 8-352 (352) Show / Hide 
Range on Protein: 255-507
Range on HMM: 8-352/352
Sequence Identity: 18% (66 aa)

GQGSFKTVFRGLDTETGVAVAWCELQERKLSRSERQR-------FKEEAEMLKG---------------LSHPNIVSFYDYWEEVSPRGKKHIVLVTELM
|||.| .|..  . ...  ..  .    . ... .|        ....... |                |.||...  ...... .   |..| .|.|..
GQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQD---KQNIYIVMEYC

TSGTLKTYLKRFKG-----------------VKNRVLR-----SWCRQILKGLHFLHTRQPPIIHRDLKCDNIFITGTSG--AVKIGDLGLAT-------
  |.|. |.| .|.                 .  .  .      ...|||.|| .||  .  |||||.|..||...   .   .|| |.|..        
EGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNN

----------LKKSSFAKSVIGTPEFM----APEMYEE-HYD----EAVDVYAFGMCLLEMATSEYPY-AECSNA--------------AQIYRRVTTG-
            |.  .....|||..|    |||.... .||    ...|....|..| || . .||. .....                |.|.    . 
CDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKN

VKPQSFEK-----VNDNKIKEIID----GCTKTNNTERYLIQELLKHTFF
.. ..|..       ... |..|      . | |  .|. ....|.| .|
IQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase WNK.AA ULK 255-507 21 3.6e-37 127.35 In-house 8-329 (329) Show / Hide 
Range on Protein: 255-507
Range on HMM: 8-329/329
Sequence Identity: 21% (72 aa)

GQGSFKTVFRGLDTET----GVAVAWCELQERKLSRSERQR--------FKEEAEMLKGLS--------HPNIVSFYDYWEEVSPRGK--KHIVLVTELM
|.||| .|..| . .|    ...||   ..  |..... ..        .| | . .| |         ||||| .||. |.     .  ..| ...|. 
GKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFET-----SNHNNIYIIMEYC

TSGTLKTYLKRFKG----------VKNRVLRSWCRQILKGLHFLHTRQPPIIHRDLKCDNIFITGT-----------SGAVKIGDLGLATLKKSS-----
  |.|..|.|. |.                .. ..||| |. .|| ..  |||||.| .|| |.             .| .||.| |.|    ..     
NGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

FAKSVI------GTPEFMAPEMYEEH-----YDEA-VDVYAFGMCLLEMATSEYPYAECSNAAQI----YRRVTTG--------VKPQSFE-----KVND
 ...        ||| .|||.  ...     |... .|.. .|. . || . ..|. .. .  |.    .. .  .         .|  |.     ..  
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

NKIKEIIDGCTKTNNTERYLIQELLKHTFF
...|..| .. . . ..|  ..||..| .|
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase WNK.AA ULK 255-507 22 6.7e-36 124.88 In-house 8-324 (324) Show / Hide 
Range on Protein: 255-507
Range on HMM: 8-324/324
Sequence Identity: 22% (74 aa)

GQGSFK-TVFRGLDTET---GVAVAWCELQERKLSRSERQ--------RFKEEAEMLKGLS---HPN--IVSFYDYWEEVSPRGK--KHIVLVTELMTSG
|.|||  .|..| . .|   ...||    .  |.. .. .         .| | . .| |    |||  || .||. |.     .  ..| ...|.   |
GKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFET-----SNHNNIYIIMEYCNGG

TLKTYLKRFKGVKNRV----------LRSWCRQILKGLHFLHTRQPPIIHRDLKCDNIFITGT-----------SGAVKIGDLGLATLKKS-SFAKSVI-
.|..|.|. |. .  .           .. ..||. |. .|| ..  |||||.| .|| |.             .| .||.| |.|    . .... .. 
DLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

---------GTPEFMAPEMYEEH-----YDEA-VDVYAFGMCLLEMATSEYPYAECSNAAQI------------YRRVTTGVKPQSFEKV---NDNKI--
         ||| .|||.  ...     |... .|.. .|. . || . .||. .. .  |.            .    . .| | ...    .|.||  
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQ---QIYIKNQPIQFPKPPKDPKISP

--KEIIDGCTKTNNTERYLIQELLKHTFF
  |..| .. . . ..|  ..|...| .|
ECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase WNK.AA FRWNK_Wnk1 508-596 47 4.1e-28 99.32 In-house 2-92 (92) Show / Hide 
Range on Protein: 508-596
Range on HMM: 2-92/92
Sequence Identity: 47% (43 aa)

EDTAFRVDIVHDDN--KDQIQLQLRVEDPKKRRERHRDNEALQFEIDLNKDEPDQVAKEMVRIGFVSEEDSKAVTKVIRDRIGTVWKNREK
|||  ||.   .|.  |. | | |..||||| . ...||||..|  ||.|| |..||.||| .||. |.|.|.| | ||||.  ....||.
EDTGVRVELAEEDDGEKSAIKLWLWMEDPKKLKGKYKDNEAIEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER
Kinase WNK.AA Pkinase_Tyr 285-400 33 6.3e-20 68.12 Pfam 41-158 (270) Show / Hide 
Range on Protein: 285-400
Range on HMM: 41-158/270
Sequence Identity: 33% (41 aa)

SRSE--RQRFKEEAEMLKGL-SHPNIVSFYDYWEEVSPRGKKHIVLVTELMTSGTLKTYLKR----FKGVKNRVLRSWCRQILKGLHFLHTRQPPIIHRD
. ..  |. | .||...| | .|||||..|    . .  .  .| .|.|.|  | |..||..     . ..   | ..|.|| ||. .|. ..  .||||
MHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRD

LKCDNIFITGTSGAVKIGDLGLA
| . |. .| .   |||.| |||
LAARNCLVTENN-VVKICDFGLA
Kinase WNK.AA TyrKc 248-507 23 2.1e-16 42.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 248-507
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

MKYDVAVGQGSFKTVFRGLDTETGVAVAWCELQERKLSRSERQRFKEEAEMLKGL--SHPNIVSFYDYWEEVSPRGK---KHIVLVTELMTSGTLKTYLK
 . .   | | | .|..|  .   . ||   |.| .     |. | .||.... |  .||||| .| .  . . .     . . .|.|.|  | || ||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLR

RFKG-VKNRVLRSWCRQILKGLHFLHTRQPPIIHRDLKCDNIFITGTSGAVKIGDLGLATLKKSS----FAKSVIGT-----PEF------MAPEMYEEH
. .. .... | |.| || .|  .|| .  ..||||| . |. ..     |||.| ||.   ..      .|... .       .      ||||   ..
KHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

-YDEAVDVYAFGMCLLEMATSEYPYAEC-----SNAAQIYRRVTTGVKPQSFEKV-------NDNKIKEIIDGCTKTNNTERYLIQELLKHTFF
 . .. ||..|| |. |. |   .  .       ........| .|  .   . .          .. .|.  | . .  .|   .|.  | .|
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase WNK.AA OSR1_C 525-562 57 4.7e-16 61.92 Pfam 1-38 (38) Show / Hide 
Range on Protein: 525-562
Range on HMM: 1-38/38
Sequence Identity: 57% (22 aa)

IQLQLRVEDPKKRRERHRDNEALQFEIDLNKDEPDQVA
|.|.||..||||| ..|..|||.||| |..||.|..||
INLWLRMRDPKKRKGKHKENEAIQFEFDIEKDTPEEVA
Kinase WNK.AA FRWNK_Wnk2.hmm 549-594 28 0.000917 10.13 In-house 18-63 (63) Show / Hide 
Range on Protein: 549-594
Range on HMM: 18-63/63
Sequence Identity: 28% (13 aa)

FEIDLNKDEPDQVAKEMVRIGFVSEEDSKAVTKVIRDRIGTVWKNR
|  ||. |.|...|. ||.  |. |.. ..  . .|| |  . .  
FKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRDIIQKAEEMM
Kinase WNK.AA Pkinase_Tyr 418-466 29 0.005197 10.82 Pfam 181-232 (270) Show / Hide 
Range on Protein: 418-466
Range on HMM: 181-232/270
Sequence Identity: 29% (16 aa)

MAPE--MYEEHYDEAVDVYAFGMCLLEMAT-SEYP-YAECSNAAQIYRRV-TTG
||||  .| . . .. ||..|| .. |. |  | | |...   ...|...   |
MAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDG
FRWNK_Wnk2.hmm WNK.AA FRWNK_Wnk2.hmm 1214-1275 26 1.2e-09 29.88 In-house 1-63 (63) Show / Hide 
Range on Protein: 1214-1275
Range on HMM: 1-63/63
Sequence Identity: 26% (17 aa)

DQVIECSLETHRGDTIVFKFS-EDDQLDGIVSNLTVAKWVHEQHAGLFKEQLLKVMEDAKRLG
|...|| ||||   .. |||  . |. . | . .  . .. |..   | ||. .... |. ..
DRMVECQLETHNHKMVTFKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRDIIQKAEEMM
OSR1_C WNK.AA OSR1_C 2045-2053 55 41.490473 0.54 Pfam 30-38 (38) Show / Hide 
Range on Protein: 2045-2053
Range on HMM: 30-38/38
Sequence Identity: 55% (5 aa)

ERDTPDSIA
|.|||. .|
EKDTPEEVA