Gene Npr3 (Sea Urchin)

Npr3

Species: Sea Urchin
Alias: Spk219, Npr3, SPU_012848
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
Npr3.AA Protein None 988 None Fasta, JSON
Npr3.kin_dom Protein Kinase Domain None 213 None Fasta, JSON

Protein domain

Protein domains of Npr3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor Npr3.AA ANF_receptor 21-373 19 2.1e-58 205.11 Pfam 1-364 (364) Show / Hide 
Range on Protein: 21-373
Range on HMM: 1-364/364
Sequence Identity: 19% (76 aa)

HLRPAIDIAFEKVNNGAA-RGLYLNFSMSYVFRETGPDCGRPVMEAPAIAAELYRRYSLDGILGSPCSYETVGIADLAAYWNLPVVTGVSTSAVLDD--K
.. ||...| | .|.     .  ... . .   ..          | | |....     ..|.|  |||..  .| .|..||.|...  .|.  |.|  |
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCY----CSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLTDKAK

SRYRTLTRTSFKTGVL-AKAVVAFFEE-YEWRQFALVWQYPGY--SSLI---AIAMKELMETQ----ENV---TMYEFDLRDYGSIKDALDA-AAAVSRI
.|| ...||     .. ..|.|....  . |...|..     |  .  .   . |......       ..   .|.. . .|. ..   ..   .  .|.
NRYPYFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYDDDDYYYWRGGCYFMEAFQDELREHGGNCVYYAYVSMVIPWDDDFMDYLKKIKDIIKMKARV

IILSAQGELV----REAMLHAFDTGLVDGEYAFVSIEPFSNTLVFGDDNWKQNDGRDDDAKKAYESLLIFRLFKPQTDEYRAFQRELERREILDYNWTRP
|.. ......    |. |. | . |. .|.|... ......... . . |  .|  .|....|... |.|..  | . |.. | ... .           
IVMCCYPDDMGLLQRQIMQQAHELGMMSGGYVWIYTDWWMHSYDMQ-W-WYDDDMDNDKFREAMKGVLGFTMH-P-SPEFQEFMQRWKK-----------

DPDHNNYFASAFHDAVILYSLAVNETLAEGGNISDGY---------VITRKMWG-RSFQGISGTVTINENGDRSGDYSLWDMTNT
...  ||.|  ..||| ||  |....| ...|...|           ... ||  ..|.|..|.|....||.|  ||..|.|. .
TDTEMNYYAAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPDYMYWIMNWD
Kinase Npr3.AA RGC 514-729 37 4.5e-110 371.98 In-house 30-300 (300) Show / Hide 
Range on Protein: 514-729
Range on HMM: 30-300/300
Sequence Identity: 37% (101 aa)

YKMRNLEHTNVVRFVGACVDPP------DQAILTEYCPRGSLQDILENDQLKLDLMFRQSLLMDAVRGLNYIHDSVIGVHGRLTSSNCVVDGRFVLKITD
..||.|.| |...|.|.|.|||      . .|..|||.|||||||||||..|.| ||. |...| |.|..|.|.| |..||.|.|.|||||.|.|.||||
KQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQYLHHSPIRYHGNLKSWNCVVDSRWVVKITD

FGI-----PSFRNS------------NKYED----NNYKLLWRAPERLR----DPFSPP-------SKEGDLYALGIIMLEIGTRCGPFDEE--------
||.      .|...            ....     . .|.||.||| ||    .. ..|       ...|| |..|||| || ||.||.|.|        
FGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGE

--RKVMDTNGILEILKSTSSQPPFRPSVPEA------VWNPVIKDLMKRCWAENPGDRPT-ASALQTALKK
  .  |. . .. ..... .|.|||||..|        .|| .  ||..||||.| .||. .. ....||.
YELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase Npr3.AA RGC 514-729 37 4.5e-110 371.98 In-house 30-300 (300) Show / Hide 
Range on Protein: 514-729
Range on HMM: 30-300/300
Sequence Identity: 37% (101 aa)

YKMRNLEHTNVVRFVGACVDPP------DQAILTEYCPRGSLQDILENDQLKLDLMFRQSLLMDAVRGLNYIHDSVIGVHGRLTSSNCVVDGRFVLKITD
..||.|.| |...|.|.|.|||      . .|..|||.|||||||||||..|.| ||. |...| |.|..|.|.| |..||.|.|.|||||.|.|.||||
KQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQYLHHSPIRYHGNLKSWNCVVDSRWVVKITD

FGI-----PSFRNS------------NKYED----NNYKLLWRAPERLR----DPFSPP-------SKEGDLYALGIIMLEIGTRCGPFDEE--------
||.      .|...            ....     . .|.||.||| ||    .. ..|       ...|| |..|||| || ||.||.|.|        
FGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGE

--RKVMDTNGILEILKSTSSQPPFRPSVPEA------VWNPVIKDLMKRCWAENPGDRPT-ASALQTALKK
  .  |. . .. ..... .|.|||||..|        .|| .  ||..||||.| .||. .. ....||.
YELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase Npr3.AA TKL-Unique 516-730 28 7.6e-45 155.31 In-house 49-290 (290) Show / Hide 
Range on Protein: 516-730
Range on HMM: 49-290/290
Sequence Identity: 28% (73 aa)

MRNLE-HTNVVRFVGACV----DPPDQAILTEYCPRGSLQDILE---------NDQLKLDLMFRQSLLMDAVRGLNYIHDSV--IGVHGRLTSSNCVVDG
| .|. | |.|...|.|.    .||.  | .||||.||| | |          |. .||..  | ..  |...|..|.| .   |  |. |.|||  || 
MKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPI-IHRDLKSSNFLVDN

R-----FVLKITDFGIPSFRNSNKYEDNNYK-----------LLWRAPERLRDPFSPPSKEGDLYALGIIMLEIGTRCG------PFDEERKVMDTNGIL
.     .  || |||.. |....  . || .           ..|.||| ||..|.  |.  | |. ||.. || ||.       |...    || ....
NSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQG----MDQEQWC

EILKSTSSQPPFRPSVPEAVWNPVIKDLMKRCWAENPGDRPTASALQTALKKI
|.....     .|| .|.  ... ..||...||. .| .||.   ... ....
EMVHYM--EENYRPPIPNH-CPKEYRDLIQQCWHHDPSQRPS---FDEIIHRL
Kinase Npr3.AA TKL 516-727 23 5.5e-38 132.53 In-house 79-364 (364) Show / Hide 
Range on Protein: 516-727
Range on HMM: 79-364/364
Sequence Identity: 23% (70 aa)

MRNLEHTNVVRFVGACVDPPD-------------QAILTEYCPRGSLQDILENDQLKLDLMFRQSLLMDAVRGLNYIHDSVI-------GVHGRLTSSNC
|..| | |.|.|.|.| .||.              .| .||||.||| ..|        .  | .. .|. ||.|| | .          .|  |.|.|.
MSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNI

VVDGRFV--------------LKITDFGIPSF---------------------RNSNKYEDNNYKLLWRAPERLRDP--------------FSPPSKEGD
 ||  .               .||.|||.  |                     .|...       . | ||| ||.               ... |.  |
LVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCD

LYALGIIMLEIGTRCGPFDEER----KVMDTNGILEILKSTS--SQPPFRPSVPE--------AVWNPVIKDLMKRCWAENPGDRPTASALQTAL
 |. ||.. || ||| |....     ...|   . |...  .  ...| .|....            | .|.||..||...| .||... .   |
VYSFGIVLWEILTRCRPYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Npr3.AA TK 515-727 16 1.7e-29 95.4 In-house 94-486 (486) Show / Hide 
Range on Protein: 515-727
Range on HMM: 94-486/486
Sequence Identity: 16% (66 aa)

KMRN--LEHTNVVRFVGACVDP------------PDQAILTEYCPRGS----LQDILENDQLK-------------------------------------
.|..  ..| |.||..|.|...            .   |..||.| |.    |.| | .   |                                     
MMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSP

--------------------------------------LDLMFRQSLLMDAVRGLNYIHDS--VIG----VHGRLTSSNCVVDGRFV-----------LK
                                      |..  .    ... .|. |.|.     .    ||. |   || |. . |            |
CPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCK

ITDFG----------IPSFRNSNKYEDNNYKLL--------------------------WRAPERLRDP-------FSPPSKEGDLYALGIIMLEIGTRC
|.|||              .... | ...|.                            | ||| |.|        .   . . | ...|. | || |..
IADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYG

-GPFDEE---RKVMD---TNGILEILKS-------------TSSQPPFRPSVPEAVWN----------PVIKDLMKRCWAENPGDRPTASALQTAL
 .|. ..   ..|.       ..| |..                ..|  |  |. .            ... |||..||...| |||| |.|. .|
QEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWM-RYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Npr3.AA DRK 516-609 37 3.9e-23 75.22 In-house 51-145 (258) Show / Hide 
Range on Protein: 516-609
Range on HMM: 51-145/258
Sequence Identity: 37% (36 aa)

MRNLEHTNVVRFVGACVDPPDQAILTEYCPRGSLQDILENDQLKLDLMFRQSLLMDAVRGLNYIHDSV-IGVHGRLTSSNCVVDGRFVLKITDFG
| .| | |.. | |.|  |||  | .|| |||||  || .. ...|   . .. .|. .|..| | .  | .|  | | |  ||  .  |. |||
MCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFG
Kinase Npr3.AA MLK 517-727 23 5.1e-20 66.24 In-house 60-291 (291) Show / Hide 
Range on Protein: 517-727
Range on HMM: 60-291/291
Sequence Identity: 23% (57 aa)

RNLEHTN----VVRFVGACVDPPDQ-AILTEYCPRGSLQDIL--ENDQLK-----------LDLMFRQSLLMDAVRGLNYIHDSVIG--VHGRLTSSNCV
| | | |    ...|.|.| .|| . .|..|||. ||| ..|  ....              |. .  .  ..  ||..| |       .|  | |.| .
RILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNIL

VD------GRFVLKITDFGIPSFRNSNKYE---DNNYKLLWRAPERLRD-PFSPPSKEGDLYALGIIMLEIGTRCGPFDEERKVMDTNGILEILKSTSSQ
.|      .  .|||.|||.  . .... .   .| . . |.||| .   . .. |.  | .  |... |. ||  |..      . ...  . . .   
IDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYK-----QHYDPMAIAWWVAYNG

--PPFRPSVPEAVWNPVIKDLMKRCWAENPGDRPTASALQTAL
  || ...      .. .| |||.|| ..|..||. .  .. |
LRPPIPST-----CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase Npr3.AA Dicty4 516-610 33 1.2e-19 62.37 In-house 52-160 (277) Show / Hide 
Range on Protein: 516-610
Range on HMM: 52-160/277
Sequence Identity: 33% (37 aa)

MRNLEHTNVVRFVGACV----DPPDQAILTEYCPRGSLQDILEN------DQLKLDLMFRQS---LLMDAVRGLNYIHD--SVIGVHGRLTSSNCVVDGR
| .. | |.. | |||      |..  | |||.|.|.|  .| .      .  |||.  . .   .  ||.||.|. |   .|| .|  | |.|  ||  
MCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVI-IHRDLKSHNLLVDKN

FVLKITDFGI
.. |..|||.
WRVKVCDFGL
Kinase Npr3.AA LRRK 516-729 24 2.4e-19 65.1 In-house 111-351 (351) Show / Hide 
Range on Protein: 516-729
Range on HMM: 111-351/351
Sequence Identity: 24% (61 aa)

MRNLEHTNVVRFVGACVDPPDQAILTEYCPRGSLQDILE---NDQL-----KLDLMFRQSLLMDAVRGLNYIHDSV--IGVHGRLTSSNCVV---D----
|..|.| |.|  .| | .|.  .. .|| | |.|.. |.   .|..     ... |... . ..  .|..| |..   | .|  |.| |  .   .    
MSHLNHPNIVSLKGFCIHPL--CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPI-IHRDLKSPNILLWSSPQNHS

-----GRFVLKITDFGIPS----FRN--SNKYEDNNYKLLWRAPERLRD----PFSPPSKEGDLYALGIIMLEIGTRC-GPFDE-E-RKVMDTNGILEIL
        . || |||| .    |..   .....|    .|.||| .|.     .. ..   | |. |.|. |. ||   |||| . ...|  . ..| .
PNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGN---PGWMAPEIMRYNGEEEYTEKV---DCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDK

KSTSSQPPFRPS-VPEAVWNPVIKDLMKRCWAENPGDRPTASALQTALKK
 .    |.. ..  |. .  .  .||.. ||...| .||..|     |. 
IIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase Npr3.AA TK-Unique 516-657 22 1.7e-16 53.5 In-house 57-232 (294) Show / Hide 
Range on Protein: 516-657
Range on HMM: 57-232/294
Sequence Identity: 22% (40 aa)

MRNLE-HTNVVRFVGACVDPP-DQAILTEYCPRGSLQDILENDQ---------------------------LKLDLMFRQSLLMDAVRGLNYIHD--SVI
|..|  | |.|...|.|...  .. |. ||||.|.||. | . .                           ... ....   . .  .|..|..     |
MKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYH--FAWQIACGMEYLASQRKKI

GVHGRLTSSNCVVDGRFVLKITDFGIPS-----FRNSNKYEDNNYKLLWRAPERLR-DPFSPP-SKEGDLYALGIIMLEI
 ||..| ..|. . ...|.||.|||.         .|.. . .   . | |||.|. .   .  . ..| ...|..| ||
-VHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCY-HGMYHTTKSDVWSFGVLMWEI
S_TKc Npr3.AA S_TKc 471-728 18 1.1e-13 23.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 471-728
Range on HMM: 1-231/231
Sequence Identity: 18% (53 aa)

ELIFEEIGK----SVATATSGS--RALSSKRSMNEEIQDGGQIFATVARYKMRNLEHTNVVRFVGACVDPPDQAILTEYCPR--GSLQDILENDQLK---
  | ..|||    .|  ..  .  |    |.           . .   .  ...  | |.|.. ....|  .  . .|||.   |.| |.... . .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDLMFRQSLLMDAVRGLNYIHDSVIGVHGRLTSSNCVVDGRFVLKITDFGIPSFRNSNKYEDNNYK--LLWRAPERLRDPFSPPSK-EGDLYALGIIM
  ..    ....   ...|.|.|.  | .|  |  .|  .|   ..||.|||.  .        . .   . ..||| |     . .| . | ...|.|.
FPFPE-HARFYMYQICCALEYCHSHGI-IHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCIL

LEIGTRCGPFDEERKVMDTNGILEILKSTSSQPPFRPSVPEAVWNPVIKDLMKRCWAENPGDRPTASALQ-------TALK
 |  ... ||.      . . ......                  |  ||....|.  .| .|||| |||           
YEMLCGYPPFP------QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
TyrKc Npr3.AA TyrKc 495-727 21 3.6e-12 -25.82 SMART 1-280 (280) Show / Hide 
Range on Protein: 495-727
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

RSMNEEIQDG--GQIFATVAR--------------------YKMRNL--EHTNVVRFVGACVDP-------PDQAILTEYCPRGSLQDILENDQLKLDLM
 ......  |  |...  ...                      |..|  .| |.||..|.|...       .   |..||.| |.|.| | . . || . 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

FRQSLLMDAVRGLNYIHDSVIGVHGRLTSSNCVVDGRFVLKITDFGIPSFRNSNKY-----EDNNYKL----LWR--------APERLRDP-FSPPSKEG
   |   .. .| .|.|.  . .|  |   || |. ... ||.|||    |.   .     ..  |.       .        ||| ...  |.. |   
DLLSFCWQIACGMEYLHSKNC-IHRDLAARNCLVGENHTVKISDFGLS--RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS---

DLYALGIIMLEIGTRCGPFDEE---RKVMDTNGILEILKSTSSQPPFRPSVPEAV----WNPVIKDLMKRCWAENPGDRPTASALQTAL
| .. |. | || |....  ..   . .|.   ..| .|.    |.      . .      . . ..||.||.|.| |||| |..   .
DVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Npr3.AA Pkinase 592-727 17 2.8e-11 40.94 Pfam 136-293 (293) Show / Hide 
Range on Protein: 592-727
Range on HMM: 136-293/293
Sequence Identity: 17% (29 aa)

SSNCVVDGRFVL----KITDFGIPS---FRNSNKYEDNNYKLLWRAPERLRDPFSPPSKEGDLYALGIIMLEIGTRCGPFDEE---RKVMDTNGILEILK
..|. .| . ..    ||.|||.       |.  . .    . ..||| .|   .. ... | ...|.|. |  ..  ||...    . .| . ...  .
PENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIM

STSSQPPFRPSVPEA--------------VWNPVIKDLMKRCWAENPGDRPTASALQTA--L
..    ..  . ..                |..  ||..|.|.. .| .||||  .     .
GPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Npr3.AA Pkinase_Tyr 516-609 30 9.6e-09 30.24 Pfam 57-156 (270) Show / Hide 
Range on Protein: 516-609
Range on HMM: 57-156/270
Sequence Identity: 30% (31 aa)

MRNL-EHTNVVRFVGACV--DPP-DQAILTEYCPRGSLQDILEND---QLKLDLMFRQSLLMDAVRGLNYIHDSVIGVHGRLTSSNCVVDGRFVLKITDF
|..|  | |.||..|.|.  . |    | .||.| |.| | | .    . .|..    .  ..  .|..| ..  . .|  |   || |.  .| ||.||
MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNC-IHRDLAARNCLVTENNVVKICDF

G
|
G
Kinase Npr3.AA Pkinase_Tyr 702-727 53 1.1e-08 30.02 Pfam 245-270 (270) Show / Hide 
Range on Protein: 702-727
Range on HMM: 245-270/270
Sequence Identity: 53% (14 aa)

IKDLMKRCWAENPGDRPTASALQTAL
| ||||.||...| |||| |...  |
IYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Npr3.AA Pkinase 516-581 24 3e-06 23.24 Pfam 54-126 (293) Show / Hide 
Range on Protein: 516-581
Range on HMM: 54-126/293
Sequence Identity: 24% (18 aa)

MRNLEHTNVVRFVGACVDPPDQAILTEYCPRG----SLQDILE-NDQLKL--DLMFRQSLLMDAVRGLNYIHD
|..| | |.||. ... |...  . .|||. |    .| |...  .. ..  .    .. .   .|||.|.|.
MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS
Kinase Npr3.AA TK-Unique 689-727 30 1.6e-05 15.19 In-house 256-294 (294) Show / Hide 
Range on Protein: 689-727
Range on HMM: 256-294/294
Sequence Identity: 30% (12 aa)

FRPSVPEAVWNPVIKDLMKRCWAENPGDRPTASALQTAL
.|. .|| . .. .  |||.|| ..| .||. ...   |
YRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase Npr3.AA Dicty4 690-719 36 8.3e-05 12.16 In-house 237-265 (277) Show / Hide 
Range on Protein: 690-719
Range on HMM: 237-265/277
Sequence Identity: 36% (11 aa)

RPSVPEAVWNPVIKDLMKRCWAENPGDRPT
||..|  .  | .|.|...|| ..|  ||.
RPPIPDWC-PPSWKHLIQWCWDHDPQHRPS
Kinase Npr3.AA DRK 690-732 32 8.7e-05 12.19 In-house 220-258 (258) Show / Hide 
Range on Protein: 690-732
Range on HMM: 220-258/258
Sequence Identity: 32% (14 aa)

RPSVPEAVWNPVIKDLMKRCWAENPGDRPTASALQTALKKINK
|| .|. .  . |. ||..|| |.|  ||.   .|  |. .  
RPPMPQWCPPKYIQ-LMNDCWNEDPQHRPS---MQECLERLEA
CYCc Npr3.AA CYCc 768-962 44 1.3e-104 354.74 SMART 1-231 (231) Show / Hide 
Range on Protein: 768-962
Range on HMM: 1-231/231
Sequence Identity: 44% (103 aa)

EEKKRSETLLYEVLPRSVAEQLKQGK-SVDPESYENVTIFFSDIVGFTSLSSQSTPLEVVALLNDLYTCFDSIIANFD-----VYKVETIGDAYMVVSGL
.||.. ..||...|||.||.|||||. .|.|..|..||| |.||||||.|.|..||..|| .|||.||.||.||....     .|||||||||||||||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PIRNG-------------------FAHAREIAQMSLALLGAVTSFKIRHR----PDEQLKLRAGIHSGPCVAGVIGVKMPRYCLFGDTVNTTSRMESTGE
| ||.                    .||..||...|  . ....|...|.    |...|..| |||.||.|.||.|..|||||.||||||..|||||||.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

ALKIHTSLTCKTIL-------DKFQIFVLEL
. .|| | . . .|        ..  |..| 
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc Npr3.AA Guanylate_cyc 795-981 41 1.7e-92 318.38 Pfam 1-214 (214) Show / Hide 
Range on Protein: 795-981
Range on HMM: 1-214/214
Sequence Identity: 41% (88 aa)

VDPESYENVTIFFSDIVGFTSLSSQST----PLEVVALLNDLYTCFDSIIANF--DVYKVETIGDAYMVVSGLPIR-----NGFAHAREIAQMSLALLGA
| ...|..|||.|.||||||...|...    |...| .|||.|||||......  ..|||.||||.||.||||| .     .. .||. .|.|.|... .
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

VTSFKIRHRPDEQ-----LKLRAGIHSGPCVAGVIG--VKMPRYCLFGDTVNTTSRMESTGEAL--KIHTSLTCKTILDKFQIFVLEL----RGLVEMKG
.... . | . |.     ...| |||.||.||||||   .|||||..|||||..|||||||...  ||| | . ...| .   |. |.    || ...||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGQQ---TTFWLLS
||..   .|..|  
KGKMGEMETYFLHG
HNOBA Npr3.AA HNOBA 768-789 54 1.2e-08 32.86 Pfam 213-234 (234) Show / Hide 
Range on Protein: 768-789
Range on HMM: 213-234/234
Sequence Identity: 54% (12 aa)

EEKKRSETLLYEVLPRSVAEQL
||||....|||...|.|||..|
EEKKKTDDLLYSMFPKSVANRL