Gene MEKK4 (Sea Urchin)

MEKK4

Species: Sea Urchin
Alias: SPU_015281, MEKK4, Spk347
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: MEKK4

Sequence

Name Sequence Type Origin Length Description Download
MEKK4.AA Protein None 1466 None Fasta, JSON
MEKK4.kin_dom Protein Kinase Domain None 219 None Fasta, JSON

Protein domain

Protein domains of MEKK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MEKK4.AA MEKK4 1234-1461 49 1.4e-146 493.25 In-house 1-271 (271) Show / Hide 
Range on Protein: 1234-1461
Range on HMM: 1-271/271
Sequence Identity: 49% (138 aa)

WQRGFKIGEGQFGTTVYSCINMNTGETLAVKEMRFQRNDHQVIRDIADEIKNLEGIRHPNLVRYYGVEIHRVRYPHSVIGVLNHHSETRTTLKFVCHLE-
||||..||||||| .||.|.||.|.|..|.||||||||||..|..||||||..|||.|||||||||||.||      ..  .   |.  .||..||||  
WQRGDHIGEGQFG-KVYTCMNMDTHEVMAMKEMRFQRNDHKAIKNIADEIKIFEGIKHPNLVRYYGVEVHR----EEMYIFMEYCSQ--GTLERVCHLGG

----HEISLIIKN----MNDLNQH------------------------------------FMPYKIYSKMLSAYHNSYMAPEVINQTGKD-----KPGYG
    |.|....|.    .|.|.||                                    .||....|.|..|    ||||||...|.||       |.|
NMQEHMIRQYTKQLLRAVNYLHQHGIVHRDIKPANIFLDKCTVLKLGDFGCSVKLQNHSQTMPGEFQSTMGTA---AYMAPEVYTYTEKDETTGSYSGHG

RQADIWSLGCVVIEMVTGKRPWH---DYDHEFTIMYKVGEGAVPHIPDAMNPEGKEFLSNCLKHDCTKRWTANKLLDHPFL
|.||||||||||.||.|||||||   .|||.|.||||||.|..|||||.|.||||.|...||.||...|||||.||||.|.
RAADIWSLGCVVVEMMTGKRPWHGQTQYDHNFQIMYKVGMGHYPHIPDKMSPEGKDFFDHCLEHDPKDRWTANELLDHTFC
Kinase MEKK4.AA STE11 1349-1461 50 1.1e-58 201.3 In-house 186-303 (303) Show / Hide 
Range on Protein: 1349-1461
Range on HMM: 186-303/303
Sequence Identity: 50% (62 aa)

FMPYKIY-SKMLSAYHNSYMAPEVINQTGKDKPGYGRQADIWSLGCVVIEMVTGKRPWHDYDH-EFTIMYKVGEGAVPHIP--DAMN------PEGKEFL
.|.. .| |.|...    .||||||.|.|.|  ||||.||||||||.||||.|||.|||.||| ....|.|.|.|. ||.|  . |       .|...||
SMTGTPYNSMMGTPM---WMAPEVIKQEGRD--GYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFL

SNCLKHDCTKRWTANKLLDHPFL
..|..||. ||.||| ||.|||.
RHCFEHDPKKRPTANQLLQHPFI
Kinase MEKK4.AA STE 1366-1461 36 1.5e-40 140.96 In-house 228-359 (359) Show / Hide 
Range on Protein: 1366-1461
Range on HMM: 228-359/359
Sequence Identity: 36% (48 aa)

YMAPEVINQTGKD-KPGYGRQADIWSLGCVVIEMVTGKRPWHD-YDH----EFTIMYKVGE---------GAVPHIPD-------------------AMN
.||||||.| |.. ..||....|||||||..|||.||| |||| ...    .....|....         |  | .||                    . 
WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWS

PEGKEFLSNCLKHDCTKRWTANKLLD--HPFL
|| |.|...||. |  ||.||..||   |||.
PEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MEKK4.AA STE11-Unclassified 1366-1461 40 6.6e-39 135.53 In-house 201-308 (308) Show / Hide 
Range on Protein: 1366-1461
Range on HMM: 201-308/308
Sequence Identity: 40% (46 aa)

YMAPEVIN---QTGKDKPGYGRQADIWSLGCVVIEMVTGKRPWHDYDH--EFTIMYKVG-EGAVPHIPDAMN-----------PEGKEFLSNCLKHDCTK
.||||||.   ||     |..| .|||||||.|||| |||.|| ...   .  ...|.. ..  | ||  .            .|.|.||. |.. |  |
WMAPEVIKNSTQT-----GHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKK

RWTANKLLDHPFL
|.||| || |||.
RPTANQLLQHPFI
Kinase MEKK4.AA STE11 1234-1303 41 1.4e-34 121.17 In-house 1-81 (303) Show / Hide 
Range on Protein: 1234-1303
Range on HMM: 1-81/303
Sequence Identity: 41% (34 aa)

WQRGFKIGEGQFGTTVYSCINMNTGETLAVKEMRFQRND------------HQVIRDIADEIKNLEGIRHPNLVRYYGVEIH
||.| .||.|.|| |||.|.|..||| .|||....|.|.            |.....|..||| .....|.|.|||||...|
WQKGEIIGKGAFG-TVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLH
Kinase MEKK4.AA ASK 1366-1461 46 5.8e-30 96.7 In-house 161-254 (254) Show / Hide 
Range on Protein: 1366-1461
Range on HMM: 161-254/254
Sequence Identity: 46% (45 aa)

YMAPEVINQTGKDKPGYGRQADIWSLGCVVIEMVTGKRPWHDYDHEFTIMYKVGEGAV-PHIPDAMNPEGKEFLSNCLKHDCTKRWTANKLLDHPFL
||||||| |  .   |||. |||||.|| ..|| ||| |.|. ..    |.|||   . |.||...  | |.|.  | . | .|| .|..||  |||
YMAPEVIDQGQR---GYGKPADIWSFGCTMVEMATGKPPFHELGEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase MEKK4.AA Pkinase 1366-1461 28 1.1e-26 95.38 Pfam 177-293 (293) Show / Hide 
Range on Protein: 1366-1461
Range on HMM: 177-293/293
Sequence Identity: 28% (35 aa)

YMAPEVINQTGKDKPGYGRQADIWSLGCVVIEMVTGKRPWHDY------DHEFTIMYKVGEGAVPHIPDA-------------------MNPEGKEFLSN
|||||||.    . ..||. .|.||.||...||..|. |. .       |. . |  . |     ..|                     ...|.|.|...
YMAPEVIR----GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

CLKHDCTKRWTANKLLDHPFL
||. |..||.||  .| ||..
CLCKDPKKRPTAEQILQHPWF
Kinase MEKK4.AA MEKK15 1366-1461 42 2.8e-25 88.57 In-house 173-264 (264) Show / Hide 
Range on Protein: 1366-1461
Range on HMM: 173-264/264
Sequence Identity: 42% (42 aa)

YMAPEVINQTGKDKPGYGRQADIWSLGCVVIEMVTGKRPWHDYDHEFTIMYKVGEG--AVPHIPDAMNPEGKEFLSNCLKHDCTKRWTANKLLDHPFL
.||||||. |     ||||..||||.|| | || |.| || | |     |. .| .   .| .|.    . ..|   ||  |   | || .|| |||.
WMAPEVIMET-----GYGRKSDIWSIGCTVFEMATRKPPWADMD-RMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase MEKK4.AA S_TKc 1234-1461 21 4.3e-23 83.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 1234-1461
Range on HMM: 1-231/231
Sequence Identity: 21% (60 aa)

WQRGFKIGEGQFGTTVYSCINMNTGETLAVKEMRFQRNDHQVIRDIADEIKNLEGIRHPNLVRYYGVEIHRVRYPHSVIGVLNH---------HSETR--
.. . |||.| || .|| |.. .||.  |.|...         ..|  ||. |.  .|||.|..|.|  .   . . |   ...         ..  |  
YEILRKIGKGAFG-KVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----TTLKFVCHLEHEISLIIKNMNDLN-------------------------QHFMPYKIYSKMLSAYHNSYMAPEVINQTGKDKPGYGR-QADIWSLG
     .   .... ..| . .. . ...                          ..     ..   . .   ||||||.        |||.  .|.||.|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL-----TTFCGTPW---YMAPEVL--------GYGKCKCDWWSCG

CVVIEMVTGKRPWHDYDHEFTIMYKVGEGAVPHIPDAMNPEGKEFLSNCLKHDCTKRWTANKLLD-------HPFL
|...||..|. |..   ...... |.|            ||.|.|...||. | .||.|| ..|        ||..
CILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MEKK4.AA CAMK 1365-1461 23 1.4e-22 68.97 In-house 284-425 (425) Show / Hide 
Range on Protein: 1365-1461
Range on HMM: 284-425/425
Sequence Identity: 23% (33 aa)

SYMA-PEVINQTGKD---------KPGYGRQADIWSLGCVVIEMVTGKRPWHDYD------------HEFTIMYKVGEGAVPHIPDAMNP----------
.||| |||.|. |..         ||.||...|.||.|..   |..|. |. . .            ..  .. |. .|    .|. . |          
EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWW

-------------EGKEFLSNCLKHDCTKRWTANKLLDHPFL
             | | .....|. | .||.|.   |.||..
DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MEKK4.AA STE20 1366-1461 35 4.2e-22 77.78 In-house 188-288 (288) Show / Hide 
Range on Protein: 1366-1461
Range on HMM: 188-288/288
Sequence Identity: 35% (36 aa)

YMAPEVINQTGKDKPGYGRQADIWSLGCVVIEMVTGKRPWHDYDHEFTIMYKV--GEGAVPHI---PDAMNPEGKEFLSNCLKHDCTKRWTANKLLDHPF
.||||||.. .  . ||.  .||||||   |||..|. | .|.     ....   ...  .     |.   || ..|...||  |  ||.|| .|| |||
WMAPEVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPF

L
.
I
Kinase MEKK4.AA MEKK2 1366-1461 37 2.5e-21 74.09 In-house 172-262 (262) Show / Hide 
Range on Protein: 1366-1461
Range on HMM: 172-262/262
Sequence Identity: 37% (36 aa)

YMAPEVINQTGKDKPGYGRQADIWSLGCVVIEMVTGKRPWHDYDHEFTIMYKVGEGAVPHIPDAMNPEGKEFLSNCLKHDCTKRWTANKLLDHPFL
.|.|||||       ||||.||.||.|| |.||.| | || .|.    |     .   |..|. .  ....||  | ..    |  |. || | | 
WMSPEVINGE-----GYGRKADVWSIGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase MEKK4.AA STE11-Unclassified 1234-1304 42 8.1e-20 66.95 In-house 1-77 (308) Show / Hide 
Range on Protein: 1234-1304
Range on HMM: 1-77/308
Sequence Identity: 42% (33 aa)

WQRGFKIGEGQFGTTVYSCINMNTGETLAVKEMRFQRND------HQV-IRDIADEIKNLEGIRHPNLVRYYGVEIHR
|| |  ||.| || .||.|.| |||| .|||... . ..      ... |  |..|.| |.  .|.| |.|||.|||.
WQKGEFIGKGSFG-QVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHK
Kinase MEKK4.AA STE 1234-1303 25 8.8e-18 59.46 In-house 1-101 (359) Show / Hide 
Range on Protein: 1234-1303
Range on HMM: 1-101/359
Sequence Identity: 25% (26 aa)

WQRGFKIGEGQFGTTVYSCINM-----NTGET---------LAVKEMRFQRND---------------HQVIRDIADEIKNLEGIR--HPNLVRYYGVEI
|..  |||.| |||... . .       |||.          |.|.|......               |. . .|  ||| .   .  ||| |.||| ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

H
.
K
Kinase MEKK4.AA STE7-Unclassified 1365-1461 28 1.4e-17 58.63 In-house 185-301 (301) Show / Hide 
Range on Protein: 1365-1461
Range on HMM: 185-301/301
Sequence Identity: 28% (33 aa)

SYMAPEVINQTGKDKPGYGRQADIWSLGCVVIEMVTGKRPWH------DYDHE--------FTIMYKVGEGAVPHIPD-----AMNPEGKEFLSNCLKHD
.||.|| |.    ..|.|. . |||||| . .|..||| |         |.          ...  .. .  || .||        .| . | |.|.| .
MYMSPERIQGQMPHRPSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKH

CTKRWTANKLLD-HPFL
 . | ..  ||  ||..
PRERPDIHQLLNEHPWI
Kinase MEKK4.AA STE20 1234-1299 34 1.7e-10 34.9 In-house 1-71 (288) Show / Hide 
Range on Protein: 1234-1299
Range on HMM: 1-71/288
Sequence Identity: 34% (25 aa)

WQRGFKIGEGQFGTTVYSCINMNTGET----LAVKEMRFQRNDH--QVIRDIADEIKNLEGIRHPNLVRYYG
..   |||.| .| .|| ...  |||      |.| |     |   . ..||  ||  .   .||| |.|||
YELLEKIGQGSYG-KVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYG
Kinase MEKK4.AA Pkinase 1234-1300 31 1.8e-10 38.14 Pfam 1-68 (293) Show / Hide 
Range on Protein: 1234-1300
Range on HMM: 1-68/293
Sequence Identity: 31% (22 aa)

WQRGFKIGEGQFGTTVYSCINMNTGETLAVKEMRFQRNDHQVIRDIAD--EIKNLEGIRHPNLVRYYGV
...| |||.| ||.  | |.. .||.. |||... ....... .  .   ||. .  ..||| ||.|..
YHIGRKIGSGSFGCV-YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDW
Kinase MEKK4.AA MEKK2 1234-1299 36 2.1e-10 33.91 In-house 1-68 (262) Show / Hide 
Range on Protein: 1234-1299
Range on HMM: 1-68/262
Sequence Identity: 36% (25 aa)

WQRGFKIGEGQFGTTVYSCINMNTGETLAVKEMRFQRNDHQVIRDIA---DEIKNLEGIRHPNLVRYYG
|.||  .| | ||  || |  . ||  |||| ..|. .. .  ...     ||. |  ..|. .| |||
WRRGKLLGQGAFG-RVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYG
Kinase MEKK4.AA STE7-Unclassified 1235-1303 29 5.6e-10 31.45 In-house 2-76 (301) Show / Hide 
Range on Protein: 1235-1303
Range on HMM: 2-76/301
Sequence Identity: 29% (22 aa)

QRGFKIGEGQFGTTVYSCINM-----NTGETLAVKEMRFQRNDHQVIRDIADEIKNLEGIR-HPNLVRYYGVEIH
.|. ..|.| .|| |. ..        .| . | |. . . ||   .. |  |.| |..   ||..|.||| ..|
ERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYH
Kinase MEKK4.AA CAMK 1239-1300 18 8.5e-09 23.72 In-house 1-106 (425) Show / Hide 
Range on Protein: 1239-1300
Range on HMM: 1-106/425
Sequence Identity: 18% (20 aa)

KIGEGQFGTTVYSCINMNTG------------ETLAVKE-------------------MRFQRNDH------QVIRD-IADEIKNLEG-------IRHPN
..|.|.|| .|. ||. ||.            .  |.|                    .......|      .. |. .  ||. .         ..|||
TLGRGSFG-KVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

LVRYYGV
... | |
IIKLYEV
Kinase MEKK4.AA TyrKc 1234-1461 18 1.2e-07 -99.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 1234-1461
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

WQRGFKIGEGQFGTTVYSCINMNTGETLAVKEMRFQRNDHQVIRDIADEIKNLEGI--RHPNLVRYYGVEIHRVR-----YPHSVI----------GVLN
 . | |.|||.||. .    .    .. ||| ..        ..|. .|.. .  .  .|||.|| ||| ..  |      |. ..            | 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

HHSETRTTLKFVCHLEHEIS---------------------LIIKNM----------NDLNQH-FM----PYKI-----YSKMLSAYHNSYMAPEVINQT
 | ..  ..|  ..  . |.                     |. .|            |.  .  .     |.       .|..  .    ||||.| ..
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR--WMAPECI-NY

GKDKPGYGRQADIWSLGCVVIEMVT-GKRPWHDY----DHEFTIMYKVGEGAVPHIPDA--------MNPEGKEFLSNCLKHDCTKRWTANKLLDHPFL
||    .  . |.|| | .  |. | |. |. .        . .. .| .|  . .|.         . .|  .  . | ..|  .| | . .  | ..
GK----FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MEKK4.AA MEKK15 1234-1300 36 9.1e-07 20.6 In-house 1-69 (264) Show / Hide 
Range on Protein: 1234-1300
Range on HMM: 1-69/264
Sequence Identity: 36% (26 aa)

WQRGFKIGEGQFGTTVYSCINMNTGETLAVKEMRFQRND----HQVIRDIADEIKNLEGIRHPNLVRYYGV
|..|  .| | .| ||| |   |||  .||| .  .  |    .|  | . .|.. |  ..| |.| | ||
WKKGNILGKGAYG-TVY-CGLTNTGQLIAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGV
Kinase MEKK4.AA ASK 1240-1299 31 4e-06 16.29 In-house 2-58 (254) Show / Hide 
Range on Protein: 1240-1299
Range on HMM: 2-58/254
Sequence Identity: 31% (19 aa)

IGEGQFGTTVYSCINMNTGETLAVKEMRFQRNDHQVIRDIADEIKNLEGIRHPNLVRYYG
.| | .| .||   .|.|   .|.||.  .  |..  . . .||.  . .|| |.|.| |
LGKGTYG-IVYAGRDMHTQVRIAIKEI--PERDSRYVQPLHEEIALHKQLRHRNIVQYLG
Kinase MEKK4.AA Pkinase_Tyr 1239-1300 36 1.1e-05 19.91 Pfam 6-72 (270) Show / Hide 
Range on Protein: 1239-1300
Range on HMM: 6-72/270
Sequence Identity: 36% (25 aa)

KIGEGQFGTTVYSCINM----NTGETLAVKEMRFQRNDHQV--IRDIADEIKNLEGI-RHPNLVRYYGV
|.|||.|| .|| ..      ||. . ||| .. .  .|.   ..|   |.| .  . .|||.||.|||
KLGEGAFG-EVYKGTWKGDPDNTKIPVAVKMLK-EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGV
Kinase MEKK4.AA Pkinase_Tyr 1367-1405 34 0.001197 12.98 Pfam 181-216 (270) Show / Hide 
Range on Protein: 1367-1405
Range on HMM: 181-216/270
Sequence Identity: 34% (14 aa)

MAPEVINQTGKDKPGYGRQADIWSLGCVVIEMVT-GKRP-W
||||.||        .  . |.|| | .  |..| |. | .
MAPECINYGK-----FTTKSDVWSFGVLMWEIFTYGEQPTY