Gene KHS (Sea Urchin)

KHS

Species: Sea Urchin
Alias: SpMEKK5, KHS, SPU_024316, Spk238
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: KHS

Sequence

Name Sequence Type Origin Length Description Download
KHS.AA Protein None 861 None Fasta, JSON
KHS.kin_dom Protein Kinase Domain None 258 None Fasta, JSON

Protein domain

Protein domains of KHS.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase KHS.AA KHS 18-275 82 2.6e-198 665.13 In-house 1-258 (258) Show / Hide 
Range on Protein: 18-275
Range on HMM: 1-258/258
Sequence Identity: 82% (213 aa)

FELLQRIGSGTYGDVYKARMTAAGTLSAIKVIKIEPGDDFTIIQQEILMMKDCRHANIVGYFGSYLRREKLWIAMEYCGGGSLQDIYHMTGHLAELQIAY
.|||||.||||||||||||......|.|.||||.||||||..|||||.|||||||.|||.||||||||.||||.||||||||||||||.||.|.||||||
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAY

VCQQTLTGLAYMHTLGKMHRDIKGANILLTDDGDVKLADFGVSAQITQTIAKRKSFIGTPYWMAPEVAAVERKGGYDFQCDIWAVGITAIELAELQPPMF
||..||.||.|.|. ||||||||||||||||.|||||||||||||||.||||||||||||||||||||||||||||. .|||||||||||||||||||||
VCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMF

DLHPMRALFLMSKSNFVPPKLKDKNKWSPIFHAFIKTALIKNPKKRPTASKLLQHPYF
|||||||||||.|||| |||||||.|||..||.|.|.||.|||||||||.||||||..
DLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase KHS.AA STE20 18-275 51 5.69999999999e-160 537.74 In-house 1-288 (288) Show / Hide 
Range on Protein: 18-275
Range on HMM: 1-288/288
Sequence Identity: 51% (148 aa)

FELLQRIGSGTYGDVYKARMTAAGTL----SAIKVIKIEPG----DDFTIIQQEILMMKDCRHANIVGYFGSYLRR----EKLWIAMEYCGGGSLQDIYH
.|||..||.|.||.||||. .  | .     |||....|.     |..  ||.||..||.|.| ||| |.||||.     ..|||.|||||||||.||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---MTGH------LAELQIAYVCQQTLTGLAYMHTLGKMHRDIKGANILLTDDGDVKLADFGVSAQITQ----TIA-KRKSFIGTPYWMAPEVAAVER--
   ..|       . | ||||.|...| ||.| |  ...|||||..|||||.||.||||||||.||.|.    |.. ||..|.|||||||||| . ..  
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

KGGYDFQCDIWAVGITAIELAELQPPMFDLHPMRALFLMSKSNFVPPKLKD--KNKWSPIFHAFIKTALIKNPKKRPTASKLLQHPYF
..|||. ||||..||||||.|| .||.||.|||||.|.. |..  ||.|||  ..|||| || |... | |.|.||||||.||.||..
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase KHS.AA STE 18-275 35 2.6e-128 432.59 In-house 1-359 (359) Show / Hide 
Range on Protein: 18-275
Range on HMM: 1-359/359
Sequence Identity: 35% (128 aa)

FELLQRIGSGTYGDVYKARMT------AAGTL---------SAIKVIKIEPG-----------------DDFTIIQQEILMMKDCR--HANIVGYFGSYL
.|....||.|..| ||||.          | .          |||....|.                  ...  |..|| .||.|.  | ||| |.|.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

R-------REKLWIAMEYCGGGSLQDIYH---MT-----------GHLAELQIAYVCQQTLTG-LAYMHTLGKMHRDIKGANILLTDDGDVKLADFGVSA
.       ...|||.|||..|||| ||..   ..           ... | ||||.|.|.| | |.| | ....|||||.|||||     |||.||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QITQTIA----------------KRKSFIGTPYWMAPEVAAVER---KGGYDFQCDIWAVGITAIELAELQPPMFDLHPMRALFLMSKSN----------
|.|...|                ||..|.||| ||||||   ..   ..|||..|||| .|.|.||.|. .||..|.|||||.|.. ...          
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---FVPPKLKD-----------------KNKWSPIFHAFIKTALIKNPKKRPTASKLLQ--HPYF
   . ||.|.|                 . |||| |. ||.  |.|.|.||||||.||.  || .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase KHS.AA MST 18-275 48 8.9e-119 379.19 In-house 1-254 (254) Show / Hide 
Range on Protein: 18-275
Range on HMM: 1-254/254
Sequence Identity: 48% (126 aa)

FELLQRIGSGTYGDVYKARMTAAGTLSAIKVIKIEPGDDFTIIQQEILMMKDCRHANIVGYFGSYL--RREKLWIAMEYCGGGSLQDIYHMTGH-LAELQ
|... ..| | || ||||     | . |||.....   |.  |  || .|..|   .||.|.|||.    . .|| |||||.||. ||   |.  | | |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVN--EDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQ

IAYVCQQTLTGLAYMHTLGKMHRDIKGANILLTDDGDVKLADFGVSAQITQTIAKRKSFIGTPYWMAPEVAAVERKGGYDFQCDIWAVGITAIELAELQP
|| ....|| ||.| |   |.||||| .||||  .|  ||||||||.| | | ||| ..|||||||||||     . .||   |||. ||||||.||  |
IACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVI---QEIKYDCKADIWSLGITAIEMAEGMP

PMFDLHPMRALFLMSKSNFVPPKLKDKNKWSPIFHAFIKTALIKNPKKRPTASKLLQHPYF
| .|.|||||.|.  ..   ||..||  .||. |  |..  |.||| .|.||  ||||| .
PYSDIHPMRAMFMIPQK--PPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase KHS.AA YSK 18-275 46 2.9e-113 342.44 In-house 1-257 (257) Show / Hide 
Range on Protein: 18-275
Range on HMM: 1-257/257
Sequence Identity: 46% (123 aa)

FELLQRIGSGTYGDVYKARMTAAGTLSAIKVIKIEPG-DDFTIIQQEILMMKDCRHANIVGYFGSYLRREKLWIAMEYCGGGSLQDIYHMT--GHLAELQ
|  . .|| | .|.|||.     .   |||.|  |   |.   |||||    .|   .|  |.||||.  |||| ||||||||. |       | . | .
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IAYVCQQTLTGLAYMHTLGKMHRDIKGANILLTDDGDVKLADFGVSAQITQTIAKRKSFIGTPYWMAPEVAAVERK-GGYDFQCDIWAVGITAIELAELQ
|| .    | || |.|   | ||||| ||.||. .|||||.||||..|||.|  ||  |.||||||||||  .     .|||  ||| .||||.|.|  .
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEV--ICQEVSYYDFKADIWSLGITAYEMAKGE

PPMFDLHPMRALFLMSKSNFVPPKLKDKNKWSPIFHAFIKTALIKNPKKRPTASKLLQHPYF
||  |.||||..||  |.|  ||||... ..|  |  |.   | |.|..||.|. || |   
PPYCDYHPMRVMFLIPKNN--PPKLEGR-SYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase KHS.AA PAKA 18-275 41 3e-100 339.33 In-house 1-260 (260) Show / Hide 
Range on Protein: 18-275
Range on HMM: 1-260/260
Sequence Identity: 41% (111 aa)

FELLQRIGSGTYGDVYKARMTAAGTL--SAIKVIKIEPGDDFTIIQQEILMMKDCRHANIVGYFGSYLRREKLWIAMEYCGGGSLQDIYHMTG-----HL
.. .. || |  | ||.|  .. ..    |||.....  .    |  |||.||.|.| ||| |  |||  ..||..||| .||.| |.   .       .
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

AELQIAYVCQQTLTGLAYMHTLGKMHRDIKGANILLTDDGDVKLADFGVSAQITQTIAKRKSFIGTPYWMAPEVAAVERKGGYDFQCDIWAVGITAIELA
 | ||||||...| || ..|  .  |||||  ||||  ||.||..|||  ||.||   ||..  ||||||||||  . ||  ||   |||  || |||..
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEV--IRRK-QYDEKVDIWSLGIMAIEMI

ELQPPMFDLHPMRALFLMSKS-NFVPPKLKDKNKWSPIFHAFIKTALIKNPKKRPTASKLLQHPYF
| .||  .  | ||..| ..      |..||..|||. |. | .. | .....|..|..||.||..
EGEPPYLNEPPLRAMYLIATNGK---PDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase KHS.AA MSN 18-275 49 1.1e-96 319.83 In-house 1-265 (265) Show / Hide 
Range on Protein: 18-275
Range on HMM: 1-265/265
Sequence Identity: 49% (132 aa)

FELLQRIGSGTYGDVYKARMTAAGTLSAIKVIKIEPGDDFTIIQQEILMMKD-CRHANIVGYFGSYLR------REKLWIAMEYCGGGSLQDIYHMT--G
||| . .| |||| ||| | . .| | ||||....  |.   |.||| |.|    | ||. |.| ...      ...||. ||.|| ||. |. .||   
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVR-EDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQ

HLAELQIAYVCQQTLTGLAYMHTLGKMHRDIKGANILLTDDGDVKLADFGVSAQITQTIAKRKSFIGTPYWMAPEVAAVER--KGGYDFQCDIWAVGITA
 | |  |||.|   | |||..|.   .|||||| |.|||.. .||| |||||||. .|. .| .|||||||||||| | .   .  ||.. |.|.|||||
SLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITA

IELAELQPPMFDLHPMRALFLMSKSNFVPPKLKDKNKWSPIFHAFIKTALIKNPKKRPTASKLLQHPYF
||.|| |||. |.||||||||. .    |||||   |||  || |. . |||| ..||.. ..|.||. 
IEMAEGQPPLCDMHPMRALFLIPRN--PPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase KHS.AA PAKL 18-275 43 6e-93 315.11 In-house 1-256 (256) Show / Hide 
Range on Protein: 18-275
Range on HMM: 1-256/256
Sequence Identity: 43% (114 aa)

FELLQRIGSGTYGDVYKARMTAAGTLSAIKVIKIEPGDDFTIIQQEILMMKDCRHANIVGYFGSYLRR-EKLWIAMEYCGGGSLQDIYHMTGH-LAELQI
||.    | | || ||||     ..  ||||| | .  .   |. || . | |.  ||| ||||      ..|| |.||  ||  |.   ..  | | ||
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQI

AYVCQQTLTGLAYMHTLGKMHRDIKGANILLTDDGDVKLADFGVSAQITQTIA-KRKSFIGTPYWMAPEVAAVERKGGYDFQCDIWAVGITAIELAELQP
. . |||| || | |  .  ||||| |||||. |..||.|||||| |.  .     .. ||||||||||.     |  |.  ||||  ||||||.|.  |
SVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEII---NKQNYNNKCDIWSLGITAIEMADGFP

PMFDLHPMRALFLMSKSNFVPPKLKDKNKWSPIFHAFIKTALIKNPKKRPTASKLLQHPYF
|  |. ||||.      |  ||....  .||| |  |. . . | | ||. .. || ||  
PHYDMPPMRAMYMI--PNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase KHS.AA S_TKc 18-275 32 2.5e-91 310.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-275
Range on HMM: 1-231/231
Sequence Identity: 32% (88 aa)

FELLQRIGSGTYGDVYKARMTAAGTLSAIKVIKIEPGDDFTIIQQEILMMKDCRHANIVGYFGSYLRREKLWIAMEYCGG--GSLQDIYHMTGH------
.|.|. ||.|..| |||.| .  | . |||.||         |..|| ..|  .| ||| .....   ..|.. ||||.|  |.| |. .  |.      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LAELQIAYVCQQTLTGLAYMHTLGKMHRDIKGANILLTDDGDVKLADFGVSAQITQTIAKRKSFIGTPYWMAPEVAAVERKGGYDF-QCDIWAVGITAIE
. | .......|.. .|.|.| .| .|||.| .||||..   .|..|||...|.       ..|.|||..|||||       ||..  ||.|..|.. .|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYE

LAELQPPMFDLHPMRALFLMSKSNFVPPKLKDKNKWSPIFHAFIKTALIKNPKKRPTASKLLQ-------HPYF
..  .||    .... . ..                || .  ||.  | |.|.||||| ..||       ||.|
MLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase KHS.AA SLK 18-275 41 1.1e-89 302.68 In-house 1-259 (259) Show / Hide 
Range on Protein: 18-275
Range on HMM: 1-259/259
Sequence Identity: 41% (109 aa)

FELLQRIGSGTYGDVYKARMTAAGTLSAIKVIKIEPGDDFTIIQQEILMMKDCRHANIVGYFGSYLRREKLWIAMEYCGGGSLQDIYHMTGH-LAELQIA
.|..  .| | .| ||||.    . . | |.|.|. ...      || .. .| | |||. ...|   .|||. .|.|.|| .  |    .| | | ||.
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ

YVCQQTLTGLAYMHTLGKMHRDIKGANILLTDDGDVKLADFGVSAQITQTIAKRKSFIGTPYWMAPEVAAVE--RKGGYDFQCDIWAVGITAIELAELQP
|||.... .| ..|    .|||.|  |||.| ||||.||||||||. ..|. || .|||||||||||| . |  .   ||.. |||..||| ||.|.. |
YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP

PMFDLHPMRALFLMSKSNFVPPKLKDKNKWSPIFHAFIKTALIKNPKKRPTASKLLQHPYF
|  .. ||| |. . ||.  ||.|.   .||  |. |.| .| |.|..|.|...|.||...
PHHEMNPMRVLLKIQKSE--PPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase KHS.AA NinaC 18-275 39 2.3e-77 263.35 In-house 1-267 (267) Show / Hide 
Range on Protein: 18-275
Range on HMM: 1-267/267
Sequence Identity: 39% (107 aa)

FELLQRIGSGTYGDVYKARMTAAGTLSAIKVIKIEPGDDFTIIQQEILMMKDCRHANIVGYFGSYLRREK-----LWIAMEYCGGGSLQDI----YHMTG
.|    || |||| |.|.     | . |.|.       |  |      . . | | |.| ..| | . .|     ||. |||| |||  |.      .  
WEIYETIGKGTYGKVFKVKNKDNGQIAAVKIQHYIHDHDEEIEAEYNILRDYCDHPNVVRFYGMYYKKDKCNGDQLWFVMEYCNGGSVTDMVKGLLKCGR

HLAELQIAYVCQQTLTGLAYMHTLGKMHRDIKGANILLTDDGDVKLADFGVSAQITQTIAKRKSFIGTPYWMAPEVAAVE--RKGGYDFQCDIWAVGITA
 . |  |||.   .. ||  .|    .|||.|| ||||| .| ||| |||||||.. |  .|   .|||.|||||| | .  .   ||  ||.|. ||||
RMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLGITA

IELAELQPPMFDLHPMRALFLMSKSNFVPPKLKDKNKWSPIFHAFIKTALIKNPKKRPTASKLLQHPYF
|||.   ||..|.|||||.|        ||.|   ..|.  |  ||   |.|.  |||. . .|.||. 
IELGDGDPPFADMHPMRAMFKIPRN--PPPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI
Kinase KHS.AA Pkinase 18-275 29 2.7e-70 244.66 Pfam 1-293 (293) Show / Hide 
Range on Protein: 18-275
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

FELLQRIGSGTYGDVYKARMTAAGTLSAIKVIKIEPGDDFTIIQQ-----EILMMKDCRHANIVGYFGSYLRREKLWIAMEYCGGG----SLQDIYH--M
......||||..| |||..    | . |.|.|| . ...    |.     || .|| ..| ||| ..... .. .... ||||.||    .| |. .  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

TGHL--AELQIAYVCQQTLTGLAYMHTLGKMHRDIKGANILLTDDGDV----KLADFGVSAQI-TQTIAKRKSFIGTPYWMAPEVAAVERKGGYDFQCDI
 | .   | ..  .. |.| ||.|.|  | .|||.| .|||. ..|..    |..|||...|. .      ..| |||..|||||  .    .|.  .|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV--IRGGQYYGPKVDM

WAVGITAIELAELQPPMFDL----HPMRALFLMSKSNFVPPKLKDKNK-------------------WSPIFHAFIKTALIKNPKKRPTASKLLQHPYF
|..|.. .|..  .||  .     . .. .... .    |..    ..                   ||. .  |||  | |.|||||||  .||||.|
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase KHS.AA Pkinase_Tyr 18-205 24 4.3e-21 72.07 Pfam 1-203 (270) Show / Hide 
Range on Protein: 18-205
Range on HMM: 1-203/270
Sequence Identity: 24% (50 aa)

FELLQRIGSGTYGDVYKARMT----AAGTLSAIKVIKIEPGDD---FTIIQQEILMMKDC-RHANIVGYFGSYL-RREK--LWIAMEYCGGGSLQDIYHM
 .... .|.| .|.|||....      ..  |.|..|    ..        .|. .||   .| ||| . |  . ..|   ..| |||. .|.| |  . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----TGHLAELQIAYVCQQTLTGLAYMHTLGKMHRDIKGANILLTDDGDVKLADFGVSAQI-----TQTIAKRKSFIGTPYWMAPEVAAVERKGGYDFQC
     ..|   ..   |.|   |..| .  .  |||.   |.|.|... || .||| .  |       . .. ..      |||||. .  .   .  . 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGK-LPIKWMAPECINYGK---FTTKS

DIWAVGIT
|.|. |..
DVWSFGVL
Kinase KHS.AA TyrKc 18-275 23 9e-17 48.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 18-275
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

FELLQRIGSGTYGDVYKARMTAAGTLSAIKVIKIEPGDDFTIIQQEILMMKDC--RHANIVGYFGSYLRR-------EKLWIAMEYCGGGSLQDIYHMTG
 .|.. .|.| .| |||....   .  |.|..| .       . .|. .|.    .| |||  .|  .         | |.| |||. .|.|.|  . ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

H-LAELQIAYVCQQTLTGLAYMHTLGKMHRDIKGANILLTDDGDVKLADFGVSAQITQT-------IAKRKSF-IGTP-----YWMAPEVAAVERKGGYD
. |   .  . | |   | .| |  .  |||.   |.|..... || .||| |  |.           .||.   |.       |||||.    ..| . 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFT

FQCDIWAVGITAIELAEL-QPPMFD-----LHPMRALFLMSKSNFVPPKLKDKNK-----WSPIFHAFIKTALIKNPKKRPTASKLLQHPYF
.. |.|. |..  |.  . |.|  .     . . ... .  . .  |.   |         ..  .  .|.    .|..||| | .  | .|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
CNH KHS.AA CNH 525-841 26 4.9e-88 299.69 SMART 1-375 (375) Show / Hide 
Range on Protein: 525-841
Range on HMM: 1-375/375
Sequence Identity: 26% (101 aa)

CSASWVHPETRDQ----YIIFGCDEGIYMFNLTQI----HEGAMDQMFPRK---TTWLYIINNIMMSLSGKNPSIYQHNLVALVDKNPHRFHMPSRFGEK
| ..|.|| |.||    ....| ..|||..|. .     ||| . . ..|.   ..|.| .||..|..|||.| .| |.||.|. |.  .   | .   .
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPHI---Q

LQRIPDKLVPRKFALSHKVPDTKG-CTKCCV-VRNPYNSHKYLCGALPAGVVLL-QWYEPMNKFLQVKV--------------FDCPLPPEIKVFEMLIK
  .....|||||.... |.||||| | .||| .....  ...||.|..  |... |||.||.||. .|.              |. |.. ...||.... 
DHMCNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHH

PDAEFPIVCVGVAR------GLDRSHLTFD-----------VVNLNSTSSWFVEHPPTEKLL--DVVCVSQIER------DTVLVCFDSEVKVVNLNGRP
.. |.| .|.|.        | ..   . .           .||.|..|.|| . ... . .  ....|.|...      |..|.|.| ... ||. |  
DSFERPWICIGCDKPVGGMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYG-S

RNSKKLLTELHFDFAVDKLVVLQDSVLAFHRHGMQGRSFRSNEV-TQEICDK----SKLFTLLG----HEKLTVLKSHP
  ....  .||..|.. ..........||. .|.|.|.. ..|. ||.|.|.    .. | ||.     ..  .. |.|
EWRRWRNPILHWEFMPEYFAYHYPYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCECRDRKIFYCSQP
CNH KHS.AA CNH 530-831 26 7.5e-84 289.68 Pfam 1-336 (336) Show / Hide 
Range on Protein: 530-831
Range on HMM: 1-336/336
Sequence Identity: 26% (93 aa)

VHPETRDQYIIFG-CDEGIYMFNL----TQIHEGAMDQMFPRKTTWLYIIN--NIMMSL--SGKNPSIYQHNLVALVDKNPHRFHMPSRFGEKLQRIPDK
|.| |..|....| .|||.|. |.      .|.. . |.|.|. |..|.|.  ||....  ..||...|.|.| .| .|....... .   .   || ..
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSRRVTQIYVIEEFNILIMISGCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRI-ER

LVPRKFALSHKVPDTKGCTKCCVVRNPYNSHKYLCGALPA-----GVVLLQWYEPMNKF-------------LQVKV-FDCPLPPEI-KVFEMLIKPDAE
..|||||...|.||||.|...|..||.|. ...||.|..      ......||.||.||               ..  |. |||  .  .|.|.. |  |
IMPRKFAMWQKLPDTKHCHFFCWIRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLP-PMTECFSMHWLP-QE

FPIVCVGVARGLDRSHLTFDVVNLN--STSSWFVEHPPTEK----------LLDVVCVSQIERD-TVLVCFDSEVKVVNLNGRPRNSKKLLTELHFDFAV
 | .|||.          |..|||.  ....|.. .|   .           ....|. .|..| ..|.|.| ... ||..|.|| .| .  |...... 
KPKLCVGC-------QKGFHIVNLDGTGQPWWLH-DPADHSVQQDFMARRENCKPICMHRINDDEEFLLCYDECCVYVNKQGWPRSRK-HDWEIMWEGMP

DKLVVLQDSVLAFHRHGMQGRSFRSN-EV---TQEICDKSKLFTLLGH
.  . .....|||| .....|..... |.   .|.|....  | ..| 
QSFACCYPYLLAFHPNFIEIRHVETGSEWDACVQCIPGQNIRFLHSGS