Gene PAK1 (Sea Urchin)

PAK1

Species: Sea Urchin
Alias: Spk239, SPU_003438, PAK1, SPU_003534
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: PAKA

Sequence

Name Sequence Type Origin Length Description Download
PAK1.AA Protein None 566 None Fasta, JSON
PAK1.kin_dom Protein Kinase Domain None 252 None Fasta, JSON

Protein domain

Protein domains of PAK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD PAK1.AA PBD 90-148 61 1.9e-27 98.13 Pfam 1-60 (60) Show / Hide 
Range on Protein: 90-148
Range on HMM: 1-60/60
Sequence Identity: 61% (37 aa)

EISLP-TKFEHTVHVGFDNITGEFTGMPEKWAQLLSSSSISKTEQKNNPQAVLDALKFYD
.|| | | |.||.|||.|. ||.|||||. |..||.||.||| |||.|||||.|...|| 
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ
PBD PAK1.AA PBD 91-126 55 7e-14 53.36 SMART 1-38 (38) Show / Hide 
Range on Protein: 91-126
Range on HMM: 1-38/38
Sequence Identity: 55% (21 aa)

ISLPT-KFEHTVHVG-FDNITGEFTGMPEKWAQLLSSS
||.||  |.|.|||| .|. ||||||.|. |. ||...
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
Kinase PAK1.AA PAKA 293-544 73 1.1e-201 676.35 In-house 1-260 (260) Show / Hide 
Range on Protein: 293-544
Range on HMM: 1-260/260
Sequence Identity: 73% (190 aa)

YSKFEKIGQGASGVVYTAIEVATGQE--VAIKQMNLQQQPKKELIINEILVMRENKHQNIVNYLDSYLVSDELWVVMEFLAGGSLTDVVTETC------M
| ..||||||||| ||.|....|.||  |||||||...||||||||||||||.|.||.|||||.|||||.||||||||...||.||||.|..|      |
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

DEGQIASVCRECLQALQFLHQRHVIHRDIKSDNILLGMDGNVKLTDFGFCAQITPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMIEGE
|||||| |||||||.|.|.|..|.||||||||||||||||.||.||||||||.|.||.||.|||||||||||||..||||..||||||||||||||||||
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGE

PPYLNENPLRALYLIATNGTPDIHNPDRLSPVFRNFLAKCLETDVDKRADGEMLLKHPFL
||||||.||||.|||||||.|||..||..|. |..||.|||. |||.||. ..||.||||
PPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase PAK1.AA STE20 293-544 49 1.1e-164 553.42 In-house 1-288 (288) Show / Hide 
Range on Protein: 293-544
Range on HMM: 1-288/288
Sequence Identity: 49% (142 aa)

YSKFEKIGQGASGVVYTAIEVATGQE----VAIKQMNLQQQ----PKKELIINEILVMRENKHQNIVNYLDSYLVS----DELWVVMEFLAGGSLTDVVT
| ..||||||..|.||.|... ||..    ||||.||| ..    ...|.|..||..|.. ||.|||.|..|||..    ||||.|||...||||||...
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

ETC----------MDEGQIASVCRECLQALQFLHQRHVIHRDIKSDNILLGMDGNVKLTDFGFCAQITP-----EQSKRTTMVGTPYWMAPEVVTR----
...          |.| ||| .|||.||.|..||..|.||||||.|||||..||.|||.|||.|||.|.     .|.|| |.|||||||||||. .    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-KQYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIA--TNGTPDIHN--PDRLSPVFRNFLAKCLETDVDKRADGEMLLKHPFL
 |.|. |.|||||||.||||.||||||....|.||...|.  .|..|.  .  |.. || |..|..|||. |..||.  . ||||||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase PAK1.AA PAKB 294-544 56 6.6e-137 461.12 In-house 2-252 (252) Show / Hide 
Range on Protein: 294-544
Range on HMM: 2-252/252
Sequence Identity: 56% (141 aa)

SKFEKIGQGASGVVYTAIEVATGQEVAIKQMNLQQQPKKELIINEILVMRENKHQNIVNYLDSYLVSDELWVVMEFLAGGSLTDVVTETCMDEGQIASVC
 .. ||| |  |.|  | |  ||. ||.|.|.|  |   ||  ||. .||. .|.|||.  .|||| |||||||||. ||.|||.||.| |.| ||| ||
DNYVKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHTRMNEEQIATVC

RECLQALQFLHQRHVIHRDIKSDNILLGMDGNVKLTDFGFCAQITPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMIEGEPPYLNENPL
| .|||| .|| . ||||||||| |||  ||.|||.|||||||.  |  ||  .|||||||||||. |  ||..||||||||| |||..||||| || ||
RQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPPL

RALYLIATNGTPDIHNPDRLSPVFRNFLAKCLETDVDKRADGEMLLKHPFL
.|.  |  .  | . |  . ||. |.|| ..|  |. .|.  . ||.||||
QAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase PAK1.AA STE 293-544 33 3.7e-130 438.71 In-house 1-359 (359) Show / Hide 
Range on Protein: 293-544
Range on HMM: 1-359/359
Sequence Identity: 33% (122 aa)

YSKFEKIGQGASGVVYTAIEV------ATGQE---------VAIKQMNLQQQ-----------------PKKELIINEILVMRENK--HQNIVNYLDSYL
. . ||||.||.|.||.|. .       ||..         .|||||||...                  ... |..|| .|.. .  |.|||.|...|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VS-------DELWVVMEFLAGGSLTDVVTETCMD---------------EGQIASVCRECLQA-LQFLHQRHVIHRDIKSDNILLGMDGNVKLTDFGFCA
.        ||||..||...||||.|.. ....                | ||| .||..|.. |..||. |.||||||..||||     |||.|||.|.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QITPE----------------QSKRTTMVGTPYWMAPEVVTR------KQYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATN-----------
|.|..                |.||.|.|||| ||||||...      |.|. |.||||||...|||..|.||. ...|.||...|..|           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----GTPDIHN-----------------PDRLSPVFRNFLAKCLETDVDKRADGEMLLK--HPFL
    . | . .                 |...|| |..|..|||. | .||.. . |||  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase PAK1.AA YSK 293-544 42 6.9e-104 313.72 In-house 1-257 (257) Show / Hide 
Range on Protein: 293-544
Range on HMM: 1-257/257
Sequence Identity: 42% (111 aa)

YSKFEKIGQGASGVVYTAIEVATGQEVAIKQMNLQQQPKK-ELIINEILVMRENKHQNIVNYLDSYLVSDELWVVMEFLAGGSLTDVVTE---TCMDEGQ
..| |.|| |  |.|| .|.. |.. ||||  .| .     |.|  || .  . . ..| .|. ||| .  ||..||...|||. |         .|| .
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IASVCRECLQALQFLHQRHVIHRDIKSDNILLGMDGNVKLTDFGFCAQITPEQSKRTTMVGTPYWMAPEVVTR--KQYGPKVDIWSLGIMAIEMIEGEPP
|| . || |..| .||.  .||||||. |.||  .|.||| |||  .|||  | || |.|||||||||||.     .|  |.||||||| |.||  ||||
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPP

YLNENPLRALYLIATNGTPDIHNPD-RLSPVFRNFLAKCLETDVDKRADGEMLLKHPFL
|    |.|.. ||  |  |     .   |  | .| . ||. |  .|   . |||| | 
YCDYHPMRVMFLIPKNNPPKLE--GRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase PAK1.AA S_TKc 293-544 31 3.4e-99 336.77 SMART 1-231 (231) Show / Hide 
Range on Protein: 293-544
Range on HMM: 1-231/231
Sequence Identity: 31% (86 aa)

YSKFEKIGQGASGVVYTAIEVATGQEVAIKQMNLQQQPKKELIINEILVMRENKHQNIVNYLDSYLVSDELWVVMEFLAG--GSLTDVVTETC-------
| . .|||.|| |.|| .... ||..||||...       | |..|| .... .| |||...|..   |.|..|||.. |  |.| |.  .         
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

MDEGQIASVCRECLQALQFLHQRHVIHRDIKSDNILLGMDGNVKLTDFGFCAQITPEQSKRTTMVGTPYWMAPEVVTRKQYGP-KVDIWSLGIMAIEMIE
..| ........ ..||...|....||||.| .||||    ..|..|||...|.       ||..|||..|||||.   .||. |.|.||.|.. .||. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GEPPYLNENPLRALYLIATNGTPDIHNPDRLSPVFRNFLAKCLETDVDKRADGEMLLK-------HPFL
|.||.   .. . . .|              || ...|. |||. | .||     .|.       ||..
GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PAK1.AA Pkinase 293-544 29 2.1e-97 334.67 Pfam 1-293 (293) Show / Hide 
Range on Protein: 293-544
Range on HMM: 1-293/293
Sequence Identity: 29% (87 aa)

YSKFEKIGQGASGVVYTAIEVATGQEVAIKQMNLQQQPKKELIIN----EILVMRENKHQNIVNYLDSYLVSDELWVVMEFLAGG----SLTDVVT---E
| . .|||.|..|.|| .... ||..||.|..... . .......    || .|.. .| ||| ..|..  .|....|||.. ||    .| |...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TCM--DEGQIASVCRECLQALQFLHQRHVIHRDIKSDNILLGMDGNV----KLTDFGFCAQI-TPEQSKRTTMVGTPYWMAPEVVT-RKQYGPKVDIWSL
.|.  .| .. ..... |..|...|.. .||||.|..|||.  .|..    |..|||...|. .  .|  || .|||..|||||.  .. ||||||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIMAIEMIEGEPPYLNE----NPLRALYLIATNGTPDIHNPDRLS---------------------PVFRNFLAKCLETDVDKRADGEMLLKHPFL
|.. .||. |.||. ..    | .. ...|. .. |..| .   .                     . .. |. .||. |  ||   | .|.||..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PAK1.AA MST 293-544 44 4e-97 309.25 In-house 1-254 (254) Show / Hide 
Range on Protein: 293-544
Range on HMM: 1-254/254
Sequence Identity: 44% (113 aa)

YSKFEKIGQGASGVVYTAIEVATGQEVAIKQMNLQQQPKKELIINEILVMRENKHQNIVNYLDSYL--VSDELWVVMEFLAGGSLTDVV--TETCMDEGQ
... ||.|||. |.|| ||   ||..||||...       . ||.||  | . | ..|| | .||.     ..| |||. ..||. |..  |     | |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQ

IASVCRECLQALQFLHQRHVIHRDIKSDNILLGMDGNVKLTDFGFCAQITPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMIEGEPPYL
||....  || || ||... ||||||. ||||  .|. || |||  .| |  . || | .|||||||||| .   |  |.||||||| |||| ||.||| 
IACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYS

NENPLRALYLIATNGTPDIHNPDRLSPVFRNFLAKCLETDVDKRADGEMLLKHPFL
.  | ||. .| ..  |   .|.. |. | .|..|||  . ..|.  | ||.||| 
DIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase PAK1.AA KHS 293-544 42 5.4e-81 272.15 In-house 1-258 (258) Show / Hide 
Range on Protein: 293-544
Range on HMM: 1-258/258
Sequence Identity: 42% (110 aa)

YSKFEKIGQGASGVVYTAIEVATGQEVAIKQMNLQQQPKKELIINEILVMRENKHQNIVNYLDSYLVSDELWVVMEFLAGGSLTDVVTET-CMDEGQIAS
|    ..| |  | || | ...... .|.| . .. .   ..|  ||..|.. .| ||| |  |||  | ||..||.  |||| |.   |  . | ||| 
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAY

VCRECLQALQFLHQRHVIHRDIKSDNILLGMDGNVKLTDFGFCAQITPEQSKRTTMVGTPYWMAPEV--VTRK-QYGPKVDIWSLGIMAIEMIEGEPPYL
|||| ||.|..||..  .|||||  ||||  .|.||| |||  ||||   .||   .||||||||||  | ||  |.   |||..|| |||. |  ||  
VCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMF

NENPLRALYLIATNG--TPDIHNPDRLSPVFRNFLAKCLETDVDKRADGEMLLKHPFL
.  |.|||.|..  .   | ... .. |. | .|.  .|  .  ||   | ||.|||.
DLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase PAK1.AA STE11 293-544 34 2.4e-76 259.95 In-house 1-303 (303) Show / Hide 
Range on Protein: 293-544
Range on HMM: 1-303/303
Sequence Identity: 34% (105 aa)

YSKFEKIGQGASGVVYTAIEVATGQEVAIKQMNLQQQPK----------K----ELIINEILVMRENKHQNIVNYLDSYLV---SDELWVVMEFLAGGSL
. | |.||.|| |.||... | ||...|.||. .| . .          .    ..|  || .|.  .|.||| |... |     |.. . ||. .||||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

TDVVTET--C--MDEGQIASVCRECLQALQFLHQRHVIHRDIKSDNILLGMDGN-VKLTDFGFCAQITPEQSKRTT----------MVGTPY--------
 ..      .  .||  |    .  |..||.||. ..|||||| .||||  ||| .||.||| . ..  . .. ..          | ||||        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMAPEVVTRKQ---YGPKVDIWSLGIMAIEMIEGEPPYLNE--NPLRALYLIATNGTPDIHNPDRLS------PVFRNFLAKCLETDVDKRADGEMLLKH
||||||... .   || |.||||||   |||. | ||. |   |.  |.. |... .| .  |...|      .  |.|| .|.| |  ||.    ||.|
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

PFL
||.
PFI
Kinase PAK1.AA MKC 293-544 38 1.1e-75 257.72 In-house 1-260 (260) Show / Hide 
Range on Protein: 293-544
Range on HMM: 1-260/260
Sequence Identity: 38% (100 aa)

YSKFEKIGQGASGVVYTAIEVA-----TGQEVAIKQMNLQQQPKKELIINEILVMRENKHQNIVNYLDSYLVSD-ELWVVMEFLAGGSLTDVVTE-TCMD
|   ...| |. | || |  .        ..|||| |.     ..    ||| . .  .| ||| |. |....| |.| ||||. || |..         
YKFLHQVGKGGFGTVYCAKYNNPHSTYDKCRVAIKKMPHVTKKHQRNNLNEIGFLNYCNHPNIVKYHCSHMKHDDEIWMVMEFMQGGTLEEASQNSHKFC

EGQIASVCRECLQALQFLHQRHVIHRDIKSDNILLGMDGNVKLTDFGFCAQITPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMIEGEP
| .|| ||.| ||.|. ||  . .|||.|| ||    || .|| |||.|.  . | ...  |.| |.||.||    ||..  .||||.|| . ||  |.|
ESCIAYVCKEMLQGLMYLHEHNIVHRDLKSANIMMNTDGEIKLIDFGLCIDVSHE-KEEIHMCGSPFWMSPEMIQQKQHSYPCDIWSFGICLLEMANGRP

PYLNENPLRALYLIATNGTPD---IHNPDRLSPVFRNFLAKCLETDVDKRADGEMLLKHPFL
|.  .... |  . ||||  .      | . |. |. || .||. |  ||.  | ||||||.
PH-HKSRMKAMFMVATNGCKFPKEFDDPCHWSDCFHDFLWQCLQMDPHKRPTAEQLLKHPFI
Kinase PAK1.AA MSN 293-544 40 4.4e-75 247.33 In-house 1-265 (265) Show / Hide 
Range on Protein: 293-544
Range on HMM: 1-265/265
Sequence Identity: 40% (108 aa)

YSKFEKIGQGASGVVYTAIEVATGQEVAIKQMNLQQQPKKELIINEILVMRENKHQNIVNYLDSYL------VSDELWVVMEFLAGGSLTDVVTET---C
..  | .|.|. | ||  . | ||| .||| |....    |.  .  .. .   |.||. |   ..        . ||.|||| . ||.||.| .|    
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQS

MDEGQIASVCRECLQALQFLHQRHVIHRDIKSDNILLGMDGNVKLTDFGFCAQITPEQSKRTTMVGTPYWMAPEVVT-----RKQYGPKVDIWSLGIMAI
. |  || .||| |. |..|||..|||||||  |.||  . .||| |||  ||.     .| | .||||||||||.      .  |  . |.||.|| ||
LKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITAI

EMIEGEPPYLNENPLRALYLIATNGTPDIHNPDRLSPVFRNFLAKCLETDVDKRADGEMLLKHPFL
|| ||.||  .  |.|||.||  |  | .    . |  | ||. |||  .  .| . | .|||||.
EMAEGQPPLCDMHPMRALFLIPRNPPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase PAK1.AA Pkinase_Tyr 293-487 25 3.1e-25 86.09 Pfam 1-216 (270) Show / Hide 
Range on Protein: 293-487
Range on HMM: 1-216/270
Sequence Identity: 25% (55 aa)

YSKFEKIGQGASGVVYTAIEV----ATGQEVAIKQMNLQQQPK---KELIINEILVMREN-KHQNIVNYLDSYL-VSDE--LWVVMEFLAGGSLTDVVTE
 .. .|.|.|| |.|| ..       |...||.| .. .  ..   .|  ..|. .|..  .|.|||...   .  ..   ...|||. ..|.| |   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

T-----CMDEGQIASVCRECLQALQFLHQRHVIHRDIKSDNILLGMDGNVKLTDFGFCAQI--TPEQ-SKRTTMVGTPYWMAPEVVTRKQYGPKVDIWSL
        .  .. . |..  .....|.... ||||.   |.|.. .. || .||| .  |  . .   ||.       |||||.   . .  | |.|| 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GIMAIEMIE-GEPP-Y
|.   |..  || | |
GVLMWEIFTYGEQPTY
Kinase PAK1.AA TyrKc 293-544 21 1.2e-23 85.85 SMART 1-280 (280) Show / Hide 
Range on Protein: 293-544
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

YSKFEKIGQGASGVVYTAIEVATGQEVAIKQMNLQQQPKKELIINEILVMREN--KHQNIVNYLDSYLVS-------DELWVVMEFLAGGSLTDVVTETC
 .. .|.| || |.|| ..     ..||.| ..      .| ...|. .|..   .|.|||. .   . .       . |..|||. ..|.| |   .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--MDEGQIASVCRECLQALQFLHQRHVIHRDIKSDNILLGMDGNVKLTDFGFCAQITPE----QSKRTTMV----GTP-----YWMAPEVVTRKQYGPKV
      .  | |    .  ..||....||||.   |.|.| .. || .||| .  |. .     || . ..    |.       |||||.   . . .| 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DIWSLGIMAIEMIE-GEPPYLN-----ENPLRALYLIATNGTPDIHNPDR--------LSPVFRNFLAKCLETDVDKRADGEMLLKHPFL
|.|| |..  |.   |..|| .      .. ... .. . . ...  |.          ..   .   .| . | ..|   . .  | ..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQ--PPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF