Gene MEK3 (Sea Urchin)

MEK3

Species: Sea Urchin
Alias: MEK3, Spk244, SpMKK3/6, SPU_007587
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: MEK3

Sequence

Name Sequence Type Origin Length Description Download
MEK3.AA Protein None 340 None Fasta, JSON
MEK3.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of MEK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MEK3.AA MEK3 53-315 68 4.6e-230 770.59 In-house 1-264 (264) Show / Hide 
Range on Protein: 53-315
Range on HMM: 1-264/264
Sequence Identity: 68% (181 aa)

MIVIENLGRGAYGIVDKTRHEPTESIMAVKKMRAQVNSTEDKRILMDMDVAMRSSDCVYTVEFYGALFQEGDVWICMEVMDTCLDKLYKNKLKPQKIFVP
|.||..|||||||||||.||.....|||||..|..|||.|.||.|||||..||||||.|||.||||.|.|||||||||||||||||.|....||.....|
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDTCLDKFYRHVYKPHGMHIP

ENILSRISFSIVSALKYLQTRLKVIHRDVKPSNVLANHNGKIKLCDFGISGQLVNSMAKTQDAGSRQYMAPERIDPDMSAKGYDVKSDVWSFGITMIEIA
|.||..|..||||||.|....||||||||||||||.||.|..|.|||||||.||.|||||.|||...|||||||||.|..|||||||||||.||||||.|
EDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEMA

TNAYPYERWHDMFQQLTQVVKGTSPALPKEK-FSEDIQDFINKCLKKNCTERPSYTRLLEHEFI
...|||..||..||||.|||....|.||.|| ||.|.|||||.|||||..|||||..|.||.|.
IGRYPYDNWHTPFQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase MEK3.AA STE7 53-315 48 1.8e-171 575.97 In-house 1-288 (288) Show / Hide 
Range on Protein: 53-315
Range on HMM: 1-288/288
Sequence Identity: 48% (143 aa)

MIVIENLGRGAYGIVDKTRHEPTESIMAVKKMRAQVNS-TEDKRILMDMDVAMRSSDCVYTVEFYGALFQEGD--VWICMEVMD-TCLDKLYKNKLKP--
. .|. ||.|.||.|.| ||.|.  |||||..|...|. .| |.|||..|| ....|| |.| ||||...|||  .|||||.|| .||||.||. .|   
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

--QKIFVPENILSRISFSIVSALKYLQTRLKVIHRDVKPSNVLANHNGKIKLCDFGISGQLVNSM-AKTQDAGSRQYMAPERIDPDMSAKGYDVKSDVWS
  .| ..||.|| .|.......|.|| ...|.|||||||||.| |..| .|||||||.||||.|| |.| ..| ..||||||||.  . ..|||.|||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDG--NKQHYDVRSDVWS

FGITM-IEIATNAYPYERWHD-----------------MFQQLTQVVKG-TSPALPKEKFSEDIQDFINKCLKKNCTERPSYTRLLE-HEFI
.|||| ||.||  |||..|..                 .|.|||..|.. ..| ||  |||.. |||.||||.|...|||.|..|.. |.||
LGITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP--KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase MEK3.AA MEK4 56-315 49 9.90000000001e-144 472.11 In-house 4-275 (275) Show / Hide 
Range on Protein: 56-315
Range on HMM: 4-275/275
Sequence Identity: 49% (135 aa)

IENLGRGAYGIVDKTRHEPTESIMAVKKMR-AQVN-----STEDKRILMDMDVAMRSSDCVYTVEFYGALFQEGDVWICMEVMDTCLDKLYKNKLKPQKI
.. .|.||.| | | .| ....|||||. |   |        | || ||..|| |.|..|.| | ||||.|.||| ||||| ||. .||.||   . || 
LGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYMVQKS

FVPENILSRISFSIVSALKYLQTRLKVIHRDVKPSNVLANHNGKIKLCDFGISGQLVNSMAKTQDAGSRQYMAPERIDPDMSAKGYDVKSDVWSFGITMI
 .||||. .|   .| || || . .|.|||||||||.| .  | .|||||||.||||.|.||| ||| |.|||||||||  .  |||..||||| ||||.
RIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLGITMY

EIATNAYPYERWH--DMFQQLTQVVKGTSPALPKEKF----SEDIQDFINKCLKKNCTERPSYTRLLEHEFI
|.||  .||. |    .| |...|||| .| | ....    |... .|||.|| |.  .||.| .|....|.
EVATGKFPYRKWNDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase MEK3.AA MEK7 53-315 46 3.4e-119 402.28 In-house 1-269 (269) Show / Hide 
Range on Protein: 53-315
Range on HMM: 1-269/269
Sequence Identity: 46% (125 aa)

MIVIENLGRGAYGIVDKTRHEPTESIMAVKKMRAQVNSTEDKRILMDMDVAMRSSDCVYTVEFYGALFQEGDVWICMEVMDTCLDKLYKNKLKPQKIFVP
.  |. .| |  | | | ||  .  ||||| ||   |. | ||||||.||   . || | |  .|..  . |||||||.| ||.||| |   .|.  |.|
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECMSTCCDKLLKRIKHPKLDFIP

ENILSRISFSIVSALKYLQTRLKVIHRDVKPSNVLANHNGKIKLCDFGISGQLVNSMAKTQDAGSRQYMAPERIDP-DMSAKGYDVKSDVWSFGITMIEI
| |. ... .|..||.|| .   ..||||||||.|    | |||||||||| .| |.|.|  ||   ||||||||| |     ||. .||||.|||..| 
EQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVEL

ATNAYPYERWHDMFQQLTQVVKG--TSPALPKEK---FSEDIQDFINKCLKKNCTERPSYTRLLEHEFI
||  |||.     |  .| .      .| ||...   || | ..|..|||.|. ..|| | .|..|.||
ATGQYPYPGCDMEFEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase MEK3.AA STE 53-315 29 6.9e-104 351.43 In-house 1-359 (359) Show / Hide 
Range on Protein: 53-315
Range on HMM: 1-359/359
Sequence Identity: 29% (109 aa)

MIVIENLGRGAYG-IVDKTRHE-----PTESI---------MAVKKMR----------------AQVNSTEDKRILMDMDVAMRSSD-CVYTVEFYGALF
   || .|.||.|  . . .|.     .|  .         ||.|.|.                 ..|..| ..||..... ..... . . |..||. |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

QEG-------DVWICMEVMD-TCLDKLYKNKLKPQK---------IFVPENILSRISFSIVSALKYLQTRLKVIHRDVKPSNVLANHNGKIKLCDFGISG
.||       ..||||| ||  .||...|.| ...|          ..||.....| ..|. .| |.  ....||||.||.|.|      .||||||..|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLVNSMA----------------KT-QDAGSRQYMAPERIDPDMSA--KGYDVKSDVWSFGITMIEIATNAYPYERWHDM---------------FQQLT
||..|||                |.  ..|.  .||||.|... ..  ||||.|.|.||.|.|.|| ||  .|.   |.|               |.|| 
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-

QVVKGTSPALPK------------------EKFSEDIQDFINKCLKKNCTERPSYTRLLE--HEFI
..|.|..| ||                   .|.|.. .|||||||.|.  .||... ||.  |.||
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MEK3.AA STE7-Unclassified 53-315 34 3.7e-86 292.56 In-house 1-301 (301) Show / Hide 
Range on Protein: 53-315
Range on HMM: 1-301/301
Sequence Identity: 34% (104 aa)

MIVIENLGRGAYGIVDKTRHEP------TESIMAVKKMRAQVN-STEDKRILMDMDVAMRSSDCVYTVEFYGALFQEGD---VWICMEVMDT-CLD---K
  ... ||.|..| | | .|..      .  ||| |. . . | ..  | ||.   .    . . | | .||| ..|.    . |||| ||   ||   .
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

LYKNKLK----PQKIFVPENILSRISFSIVSALKYLQTRLKVIHRDVKPSNVLANHNGKIKLCDFGISGQLVNSM--AKTQDAGSRQYMAPERIDPDMSA
.||. ..    . .. .|| .|..| ...  .|.||  ....||||.||.|.| | .| .|.||||..|||.|..  |||  .|  .||.||||  .|. 
IYKKMYERGPIRGGW-IPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKT-WVGCQMYMSPERIQGQMPH

K-GYDVKSDVWSFGITMIEIATNAYPYE------RWHDM--------FQQLTQVVKGTSPALPKEK----FSEDIQDFINKCLKKNCTERPSYTRLLE-H
. .| ||||.||.|.| .| ||  ||||         .         .. |. .|. ..| ||...    .|.. .|||.||.||. .|||... ||. |
RPSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEH

EFI
..|
PWI
Kinase MEK3.AA MEK5 53-315 40 3.6e-67 229.45 In-house 1-254 (254) Show / Hide 
Range on Protein: 53-315
Range on HMM: 1-254/254
Sequence Identity: 40% (108 aa)

MIVIENLGRGAYGIVDKTRHEPTESIMAVKKMRAQVNSTEDKRILMDMDVAMRSSDCVYTVEFYGALFQEGDVWICMEVMDTCLDKLYKNKLKPQKIFVP
.   . || |  | | |. | |.  |.||| .  ..    .|.|. ....  .  |  | . |||| | |  . || | ||     .|.         .|
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYK-CDSPYIIGFYGAFFVENRISICTEFMDGGSLDMYRC--------IP

ENILSRISFSIVSALKYLQTRLKVIHRDVKPSNVLANHNGKIKLCDFGISGQLVNSMAKTQDAGSRQYMAPERIDPDMSAKGYDVKSDVWSFGITMIEIA
| || |.. .||  | ||   ||..||||||||.| | .|.|||||||.| |||||...|   |   |||||||    |   | . ||||| || ..|.|
EHILGRMTVAIVKGLNYLWN-LKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTY-IGTNAYMAPERI----SGDQYGIHSDVWSLGIFFMEMA

TNAYPYERWHDMF------QQLTQVVKGTSPALPKEKFSEDIQDFINKCLKKNCTERPSYTRLLEHEFI
|  .||             | |  .|   .| || .||||   .|||.|..|   .||    |..| ||
TGRFPYPQIQRDQGELMPIQLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase MEK3.AA S_TKc 53-315 26 1.6e-63 218.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 53-315
Range on HMM: 1-231/231
Sequence Identity: 26% (72 aa)

MIVIENLGRGAYGIVDKTRHEPTESIMAVKKMRAQVNSTEDKRILMDMDVAMRSSDCVYTVEFYGALFQEGDVWICMEVMDT---CLDKLYKNKLKPQKI
  ... .|.||.| | | ||  |  |.|.|...        ..|.  ... ..  .. . | .|..    ......|| .|.    | .. |.. .. . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

F-VPENILSRISFSIVSALKYLQTRLKVIHRDVKPSNVLANHNGKIKLCDFGISGQLVNSMAKTQDAGSRQYMAPERIDPDMSAKGYDV-KSDVWSFGIT
|  ||    ..   |..||.|.  . ..||||.||.|.| ..   ||.||||.. ||      |   |.. ||||| .       ||.  |.|.||.|..
FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCI

MIEIATNAYPYERWHDMFQQLTQVVKGTSPALPKEKFSEDIQDFINKCLKKNCTERPSYTRLLE-------HEFI
..| ..   |..      |.. ....           |..  |||.|||.|. ..||.   .|.       |...
LYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MEK3.AA MEK1 53-257 40 1.2e-56 191.92 In-house 1-195 (297) Show / Hide 
Range on Protein: 53-257
Range on HMM: 1-195/297
Sequence Identity: 40% (84 aa)

MIVIENLGRGAYGIVDKTRHEPTESIMAVKKMRAQVNSTEDKRILMDMDVAMRSSDCVYTVEFYGALFQEGDVWICMEVMD-TCLDKLYKNKLKPQKIFV
. .|. || |  |.| | ||..|  ||| | ..  .  .  . |. .. | .      | | |||| ...|.. |||| ||   || . |.        .
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQV-LHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA-----GRI

PENILSRISFSIVSALKYLQTRLKVIHRDVKPSNVLANHNGKIKLCDFGISGQLVNSMAKTQDAGSRQYMAPERIDPDMSAKGYDVKSDVWSFGITMIEI
||.|| ..|  ..  | ||. . |..||||||||.| | .| |||||||.||||. |||     | | ||.|||    .    | |.||.||.|. ..|.
PEKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPER----LQGTHYTVQSDIWSMGLSLVEM

ATNAYP
|   ||
AIGRYP
Kinase MEK3.AA STE20 54-315 31 1.5e-48 167.57 In-house 2-288 (288) Show / Hide 
Range on Protein: 54-315
Range on HMM: 2-288/288
Sequence Identity: 31% (92 aa)

IVIENLGRGAYGIVDKTRHEPTESI----MAVKKMRAQVNS---TEDKRILMDMDVAMRSSDCVYTVEFYGALFQE----GDVWICMEVMDT-CLDKLYK
  .| .|.|.|| | | .| ||  .     |.|||     .    | . |.   .. |. ... . |..||. . .     . ||.|| ..  .|  ..|
ELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISI-MKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

NKLKPQK----IFVPENILSRISFSIVSALKYLQTRLKVIHRDVKPSNVLANHNGKIKLCDFGISGQLVN----SMA-K-TQDAGSRQYMAPERIDPDMS
...| .|        |   . |   .. .|.||  . ..||||.|  |.| ...|..||.||| ..|| .    .|. |     |.  .|||| |  . .
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYL-HSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEG

-AKGYDVKSDVWSFGITMIEIATNAYPYERWHDMFQQLTQVVKG--TSPALP---KEKFSEDIQDFINKCLKKNCTERPSYTRLLEHEFI
  |||| |.|.||.||| || |.   ||   | | . . .. |.   .| |    ..|.| . .||..||| |.  .||. . ||.|.||
PDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPM-RAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MEK3.AA Pkinase 53-315 23 3.8e-46 164.24 Pfam 1-293 (293) Show / Hide 
Range on Protein: 53-315
Range on HMM: 1-293/293
Sequence Identity: 23% (71 aa)

MIVIENLGRGAYGIVDKTRHEPTESIMAVKKMRAQVNSTEDKRIL---MDMDVAMRSSDCVYTVEFYGALFQEGDVWICMEVMDTCLDKLYKNK--LK--
  ... .|.|..| | | .|  |. | |||... . .. . ....   .   .  |  .. . |..|..   .......|| ..  |  .   .  ..  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTW

PQKIF-VPENILSRISFSIVSALKYLQTRLKVIHRDVKPSNVLANHNGKI----KLCDFGISGQ--LVNSMAKTQDAGSRQYMAPERIDPDMSAKGYDVK
 .. |  .|. . ..   |...|.|.    ..||||.||.|.| ..|| |    |.||||.. |  . |.   |  .|.. ||||| |    ....|. |
RHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPK

SDVWSFGITMIEIATNAYPYE------RWHDMFQQLTQVVKGTSPALPKEKFS-------------------EDIQDFINKCLKKNCTERPSYTRLLEHE
.|.||.|....| ..   |.       . ||. | . .. ..  .    .. |                   |. .|||..||.|....||. . .|.|.
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

FI
..
WF
Kinase MEK3.AA MSN 53-315 32 8.2e-43 139.05 In-house 1-265 (265) Show / Hide 
Range on Protein: 53-315
Range on HMM: 1-265/265
Sequence Identity: 32% (89 aa)

MIVIENLGRGAYGIVDKTRHEPTESIMAVKKMRAQVNSTEDKRILMDMDVAMRSSDCVYTVEFYGALF------QEGDVWICMEVMDT-CLDKLYKNKLK
  ..| .| |.|| | | ||. | .. |.| |  .|.  |.  | .....  . |     . .||| .      ..  .|. ||   .  .  | |.   
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVM--DVREDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMT--

PQKIFVPENILSRISFSIVSALKYLQTRLKVIHRDVKPSNVLANHNGKIKLCDFGISGQLVNSMAKTQD-AGSRQYMAPERIDPDMSAK-GYDVKSDVWS
 .   . |. .  |.  |.  | .| .. ||||||.|  |||  || ..|| |||.| ||   . .     |   .|||| |. | . .  || .||.||
-KGQSLKEDWIAYICREILRGLAHLHQH-KVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWS

FGITMIEIATNAYPYERWHDMFQQLTQVVKGTSPALPKEKFSEDIQDFINKCLKKNCTERPSYTRLLEHEFI
 ||| ||.|  . |    | | . |  . . . | |  .|.|   ..|..||| ||  .||.  ..|.| ||
VGITAIEMAEGQPPLCDMHPM-RALFLIPRNPPPKLKSKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase MEK3.AA TyrKc 53-315 21 6.7e-15 18.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 53-315
Range on HMM: 1-280/280
Sequence Identity: 21% (66 aa)

MIVIENLGRGAYGIVDKTRHEPTESIMAVKKMRAQVNSTEDKRILMDMDVAMRSS--DCVYTVEFYGALFQE-------GDVWICMEVMDT--CLDKLYK
   .. ||.||.|.| | .        |||....       . ..  . . |..   .    | .||.  |.       . ..| || |.   ..| | |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARI-MCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

NKLKPQKIFVPENILSRISFSIVSALKYLQTRLKVIHRDVKPSNVLANHNGKIKLCDFGISGQLVNS-----MAKTQDA----GSRQ-----YMAPERID
.. |     ..   |  ... | .   ||  . ..||||    |.| ..|. .| .||| |  . .        .. ..    |..       |||| | 
HRPK-----LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

PDMSAKG-YDVKSDVWSFGITMIEIATNAYPYERW-----HDMFQQLTQVVKGTSPALPKE-------KFSEDIQDFINKCLKKNCTERPSYTRLLEHEF
     .| .  ||||||||..| || |.  .          . .. . .| .|  .  |..         .... . . .| . .  .||. . .  ||.
----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HEC

I
.
F
Kinase MEK3.AA MEK1 264-315 44 3.2e-13 41.01 In-house 246-297 (297) Show / Hide 
Range on Protein: 264-315
Range on HMM: 246-297/297
Sequence Identity: 44% (23 aa)

MFQQLTQVVKGTSPALPKEKFSEDIQDFINKCLKKNCTERPSYTRLLEHEFI
.|  |  .|..  | ||.. |||..|||..|||.||  ||    .|. | ||
IFEMLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase MEK3.AA Pkinase_Tyr 235-274 34 3e-06 21.82 Pfam 191-232 (270) Show / Hide 
Range on Protein: 235-274
Range on HMM: 191-232/270
Sequence Identity: 34% (15 aa)

YDVKSDVWSFGITMIEIATNA-YP-YERWHDMFQQLTQV-VKG
. .||||||||..| || |    | |. . . .. . ..  .|
FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDG
Kinase MEK3.AA Pkinase_Tyr 185-202 44 2.005707 2.06 Pfam 141-158 (270) Show / Hide 
Range on Protein: 185-202
Range on HMM: 141-158/270
Sequence Identity: 44% (8 aa)

NVLANHNGKIKLCDFGIS
|.| ..|...| |||| .
NCLVTENNVVKICDFGLA