Gene MKK7 (Sea Urchin)
MKK7
Sequence
Protein domains of MKK7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | MKK7.AA | MEK7 | 209-402 | 74 | 3.7e-165 | 554.98 | In-house | 1-198 (269) | Show / Hide |
Range on Protein: 209-402 Range on HMM: 1-198/269 Sequence Identity: 74% (148 aa) LESIGELGFGSCGHVIRMRHKESGTILAVKQMRRSGNKEENKRILMDLDVVLKSHNCPFIVQCLGAIVTPSEVWICMEQMATCLDKLIKKLREP----VP |..||..|.||||||..||||.||.|.|||||||.|||||||||||||||....|.||.||||.|...|.|.||||||.|.||.|||.|....| .| LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECMSTCCDKLLKRIKHPKLDFIP EQIIGKMVVAIVNALNYLKEKHGVMHRDVKPSNMLLDEKGVVKLCDFGISGRLVDSKARTRSAGCAAYMAPERIDPPDPNNPDYDVRADVWSLGISLV |||||||||||.|||.|||||||.|||||||||.|||..|..||||||||||.|||||.||||||.||||||||||||||||.||.|||||||||.|| EQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLV |
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| Kinase | MKK7.AA | STE7 | 209-402 | 53 | 1.3e-126 | 426.97 | In-house | 1-205 (288) | Show / Hide |
Range on Protein: 209-402
Range on HMM: 1-205/288
Sequence Identity: 53% (112 aa)
LESIGELGFGSCGHVIRMRHKESGTILAVKQMRRSGNK-EENKRILMDLDVVLKSHNCPFIVQCLGAIVTPSE--VWICMEQMA-TCLDKLIKKLRE---
|| ||||| |..|.| ||||.||.|.|||..|.. |. ||.|.|||.|||. |...||.|||. ||..| . .||||| |. .||||..|.. .
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR
-----PVPEQIIGKMVVAIVNALNYLKEKHGVMHRDVKPSNMLLDEKGVVKLCDFGISGRLVDSK-ARTRSAGCAAYMAPERIDPPDPNNPDYDVRADVW
..||||.||..||....|.||.|||...||||||||.|....| ||||||||.|.||||. |.|...||..||||||||. |...||||.|||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDG---NKQHYDVRSDVW
SLGISL-V
||||.. .
SLGITMGI
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| Kinase | MKK7.AA | MEK4 | 209-402 | 52 | 2.7e-93 | 304.88 | In-house | 1-203 (275) | Show / Hide |
Range on Protein: 209-402 Range on HMM: 1-203/275 Sequence Identity: 52% (108 aa) LESIGELGFGSCGHVIRMRHKESGTILAVKQMRRSGN------KEENKRILMDLDVVLKSHNCPFIVQCLGAIVTPSEVWICMEQMATCLDKLIK----K |. .||.| |. | | |.||||| |.|||. | . . | || ||..||| || ||| ||. ||. ||||| | . .||. | . LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYMV LREPVPEQIIGKMVVAIVNALNYLKEKHGVMHRDVKPSNMLLDEKGVVKLCDFGISGRLVDSKARTRSAGCAAYMAPERIDPPDPNNPDYDVRADVWSLG . .||.|.|. |..|.|||||||.| . |||||||| ||| .| ||||||||.| |||| |.|. ||| ||||||||| | . ||.| |||||| QKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDP-EQNMDGYDIRSDVWSLG ISLV | .. ITMY |
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| Kinase | MKK7.AA | MEK3 | 209-402 | 52 | 8.8e-90 | 304.58 | In-house | 1-197 (264) | Show / Hide |
Range on Protein: 209-402 Range on HMM: 1-197/264 Sequence Identity: 52% (104 aa) LESIGELGFGSCGHVIRMRHKESGTILAVKQMRRSGNKEENKRILMDLDVVLKSHNCPFIVQCLGAIVTPSEVWICMEQMATCLDKLIKKLRE----PVP .. | ||| | | | |||. ||||.||| .| . | | ||.|||.|. | ||. |. ||. |||||| | |||||. .. . .| MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDTCLDKFYRHVYKPHGMHIP EQIIGKMVVAIVNALNYLKEKHGVMHRDVKPSNMLLDEKGVVKLCDFGISGRLVDSKARTRSAGCAAYMAPERIDPPDPNNPDYDVRADVWSLGISLV | |.||. . || ||.|..|. | |||||||| |. .| ||.||||||| |||| | | ||| |||||||| |. | |||..||||||| .. EDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERID-PEMNQKGYDVKSDVWSLGITMI |
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| Kinase | MKK7.AA | STE | 209-402 | 29 | 2.3e-69 | 236.74 | In-house | 1-259 (359) | Show / Hide |
Range on Protein: 209-402
Range on HMM: 1-259/359
Sequence Identity: 29% (77 aa)
LESIGELGFGSCG-HVIRMRHKES--------------GTILAVKQMR----------------RSGNKEENKRILMDLDVVLKSHN-CPFIVQCLGAIV
.| |...| |..| . |.|| . |.| |.|||. .. |.|| ..||..... |... .|.||...|. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
TP-------SEVWICMEQMA-TCLDKLIK---KLREP----------VPEQIIGKMVVAIVNALNYLKEKHGVMHRDVKPSNMLLDEKGVVKLCDFGISG
.|.||||| |. .||..|| . .| .||..|......|. .| |....|...|||.||.| || |||||||..|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG
RLVDSKA-----------------RTRSAGCAAYMAPERIDPPDPN-NPDYDVRADVWSLGISLV
.|.|| | |. .|. .||||.|.. . . ...||...|.||||. ..
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTII
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| Kinase | MKK7.AA | MEK1 | 209-409 | 42 | 2.3e-56 | 190.97 | In-house | 1-194 (297) | Show / Hide |
Range on Protein: 209-409 Range on HMM: 1-194/297 Sequence Identity: 42% (86 aa) LESIGELGFGSCGHVIRMRHKESGTILAVKQMRRSGNKEENKRILMDLDVVLKSHNCPFIVQCLGAIVTPSEVWICMEQM-ATCLDKLIKKLREPVPEQI .| ||||| | | |...||...| |.| | .. . |. .| || | |.|| || . |. ||||.| || ..|| . .||.| FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQ-VLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA-GRIPEKI IGKMVVAIVNALNYLKEKHGVMHRDVKPSNMLLDEKGVVKLCDFGISGRLVDSKARTRSAGCAAYMAPERIDPPDPNNPDYDVRADVWSLGISLVTISFA .||. ||.. | ||..|| .|||||||||.| .| .||||||.||.|.|| | | .||.|||. | |..|.||.|.||| . LGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERL-----QGTHYTVQSDIWSMGLSLVEMAIG SY | RY |
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| Kinase | MKK7.AA | STE7-Unclassified | 209-401 | 37 | 8.5e-55 | 188.37 | In-house | 1-215 (301) | Show / Hide |
Range on Protein: 209-401 Range on HMM: 1-215/301 Sequence Identity: 37% (81 aa) LESIGELGFGSCGHVIRMRHKE------SGTILAVKQMRRSGN-KEENKRILMDLDVVLKSHNCPFIVQCLGAIVTPSE---VWICMEQMAT-CLD---K || ...|| |. | | .|| .|.| | |. . | | | ||. | .. | .|.||.. || .. . |||| |. || . LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID LIKKLRE-------PVPEQIIGKMVVAIVNALNYLKEKHGVMHRDVKPSNMLLDEKGVVKLCDFGISGRLVDSK--ARTRSAGCAAYMAPERIDPPDPNN . ||. | ..||...||.. .. ..| ||.||| . |||.||.| |...|| ||.||||..|.|... | | .|| ||.|||| |. IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTW-VGCQMYMSPERIQGQMPHR PDYDVRADVWSLGISL |.| |. |.||||... PSYSVKSDIWSLGLTI |
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| Kinase | MKK7.AA | MEK5 | 209-402 | 41 | 1.4e-42 | 147.74 | In-house | 1-182 (254) | Show / Hide |
Range on Protein: 209-402 Range on HMM: 1-182/254 Sequence Identity: 41% (80 aa) LESIGELGFGSCGHVIRMRHKESGTILAVKQMRRSGNKEENKRILMDLDVVLKSHNCPFIVQCLGAIVTPSEVWICMEQMATCLDKLIKKLREPVPEQII . || | | | . | || ||||| . | |.|. .|... | |.|. || . . || | | . .. .||.|. IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSPYIIGFYGAFFVENRISICTEFMDGGSLDMYRC----IPEHIL GKMVVAIVNALNYLKEKHGVMHRDVKPSNMLLDEKGVVKLCDFGISGRLVDSKARTRSAGCAAYMAPERIDPPDPNNPDYDVRADVWSLGISLV |.| |||| |||| . .||||||||||| .| .||||||.| ||.| .|| | |||||||| .| . .|||||||... GRMTVAIVKGLNYLWNLK-IMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTY-IGTNAYMAPERI-----SGDQYGIHSDVWSLGIFFM |
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| Kinase | MKK7.AA | Pkinase | 209-401 | 25 | 6.5e-42 | 149.28 | Pfam | 1-202 (293) | Show / Hide |
Range on Protein: 209-401 Range on HMM: 1-202/293 Sequence Identity: 25% (54 aa) LESIGELGFGSCGHVIRMRHKESGTILAVKQMRRSGNKEENKRIL---MDLDVVLKSHNCPFIVQCLGAIVTPSEVWICMEQMAT-----CLDKLIK-KL .. .. .| || | | . .|| .| | |||.......|.. .... . . . .. |.|.||..... ........|| . | .|. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR REPV--PEQIIGKMVVAIVNALNYLKEKHGVMHRDVKPSNMLLDEKGVV----KLCDFGISGR--LVDSKARTRSAGCAAYMAPERIDPPDPNNPDYDVR . .. .|. . ... |. .|.|. . .|..|||.||.| |.|..|.. |.||||.. . . | .| ||||| | ...|. . HGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPK ADVWSLGISL .|.||.|. | VDMWSCGCIL |
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| Kinase | MKK7.AA | CAMK | 214-399 | 14 | 1.7e-34 | 108.07 | In-house | 1-322 (425) | Show / Hide |
Range on Protein: 214-399
Range on HMM: 1-322/425
Sequence Identity: 14% (47 aa)
ELGFGSCGHVIRMRHKESG------------TILAVKQMRRSGNK--------------------------EENKRILMDLDVVLKS-------HNCPFI
.|| || | | . .||... . |.| . .. | ..... .. ..|. . | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
VQCLGAIVT-------------------PSEVWICM---EQMATC------LDKLIKKLR-------------EPVPEQIIGKMVVAIVNALNYLKEKHG
.... .. . ...... | | . .|..... . ..|. ... |. |..|. ...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN-
VMHRDVKPSNMLLDEK-----------------GVVKLCDFGISGRLVDSK------------------------ARTRSAGCAAYMA-PERIDP-P---
..||| || | |||.. . .|..||| . .. ... . . |. .||| || . .
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
-----DPNNPDYDVRADVWSLGI
| ..| |. .|.||.|.
MQNATDEEKPYYGPKCDMWSCGV
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| Kinase | MKK7.AA | S_TKc | 209-410 | 22 | 6.2e-33 | 116.66 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 209-410 Range on HMM: 1-231/231 Sequence Identity: 22% (59 aa) LESIGELGFGSCGHVIRMRHKESGTILAVKQMRRSGNKEENKRILMDLDVVLKSHNCPFIVQCLGAIVTPSEVWICMEQMAT---CLDKLIKKLREP--- | . ..| |. | | . |||..| | |.|... ..|. ... | ..|.||........ ......|| . . | ..||| . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --VPEQIIGKMVVAIVNALNYLKEKHGVMHRDVKPSNMLLDEKGVVKLCDFGISGRLVDSKARTRSAGCAAYMAPERIDPPDPNNPDYDV-RADVWSLGI || . ... |..||.|. .. |..|||.||.| |||| ..|.||||.. .| | | ||||| . |. ..|.||.|. FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGC SLVTISF-------------------------------------------------ASYI | .. ILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF |
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| Kinase | MKK7.AA | TKL | 215-399 | 18 | 1.2e-29 | 103.88 | In-house | 1-277 (364) | Show / Hide |
Range on Protein: 215-399
Range on HMM: 1-277/364
Sequence Identity: 18% (52 aa)
LGFGSCGHVIRMRHKE--------SGTILAVKQMRRSG----------------------NKEENKRILMDLDVVLKSHN---CPFIVQCLGAIVTPSE-
.| |. | | . ... .|. |||.... | .|.... . ....... .| |||..|. |.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------VWICMEQM-ATC-LDKLIKKLREPVPEQIIGKMVVAIVNALNYLKE-------KHGVMHRDVKPSNMLLDEKGV--------------
.| || . . |. |. . . ... | ..||| | .. ||| |..| |.||..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC
VKLCDFGISGRL--------------------VDSKARTRSAGCAAYMAPERIDPPDPNNP-----------DYDVRADVWSLGI
.|.||||.| .. . .|.. . | ..|||| .. .... .|. ..||.| ||
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGI
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| Kinase | MKK7.AA | TyrKc | 209-416 | 18 | 1.3e-08 | -83.16 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 209-416
Range on HMM: 1-280/280
Sequence Identity: 18% (52 aa)
LESIGELGFGSCGHVIRMRHKESGTILAVKQMRRSGNKEENKRILMDLDVVLKS-HNCPFIVQCLGAIVTP-------SEVWICMEQMAT-CLDKLIKKL
.. . .|| | | | . . | . ||| .. . . .. . . | . | ||...|..... ..| || |. .|.. ..|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH
REPVPEQIIGKMVVAIVNALNYLKEKHGVMHRDVKPSNMLLDEKGVVKLCDFGISGRLVDS------KARTRSA---GCA-----AYMAPERI-------
|. .. . .. . | . .|| .| .. ||| | |..|...|| .||| | . | | |.. |. |||| |
RPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT
------------------DPPDPN-----NPDYDVRADVWSL----GISL--------VTISFASYI---------------TIREAY
..| |. ....|...| . . . . .|.|
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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