Gene CSK2 (Sea Urchin)

CSK2

Species: Sea Urchin
Alias: CSK2, SPU_004037, Spk295
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: Csk

Sequence

Name Sequence Type Origin Length Description Download
CSK2.AA Protein None 222 None Fasta, JSON
CSK2.kin_dom Protein Kinase Domain None 196 None Fasta, JSON

Protein domain

Protein domains of CSK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CSK2.AA Csk 15-212 69 7.6e-157 527.37 In-house 1-201 (251) Show / Hide 
Range on Protein: 15-212
Range on HMM: 1-201/251
Sequence Identity: 69% (140 aa)

LKLGEEIGHGFFGAVKVGEYQNKKVAVKVISGD-NEAAQSIVAEASIMTQLRHPNLVALIGVIPDQPNSISIVLEFMAKGNLLDYVRSRGRTVITRKLQL
|.|||.||||.||.|..|||||.|||||.|..| |..||...||||.||||||||||.|||||..|.|...||.|.|.||||.||.|||||.||||. .|
LHLGECIGHGEFGDVMQGEYQNRKVAVKCIKCDGNGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVITRRQLL

KFSIDIGAGMCYLEQKLFVHRDLAARNILISEDDVAKVSDFGLAQDNSTQLG--TGGKIPVKWTAPEAYKKKLFTTKSDVWSFGILLWELFSFGRVPYPR
||..|...|||||||| ||||||||||||.|||.||||||||||.....|..  |.||.|.|||||||...| |.||||||||||||||..|||||||||
KFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKEECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFGRVPYPR

V
.
I
Kinase CSK2.AA Pkinase_Tyr 15-212 42 9.6e-91 307.95 Pfam 1-219 (270) Show / Hide 
Range on Protein: 15-212
Range on HMM: 1-219/270
Sequence Identity: 42% (94 aa)

LKLGEEIGHGFFGAVKVGEYQ------NKKVAVKVI--SGDNEA--AQSIVAEASIMTQL-RHPNLVALIGVIP--DQPNSISIVLEFMAKGNLLDYVRS
...|...|.| || |. |..       . .||||..  . . |.   ..  .||.||.|| .|||.| |.||.   ..||.| ||.|.|..|.|||| |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R--GRTVITRKLQLKFSIDIGAGMCYLEQKLFVHRDLAARNILISEDDVAKVSDFGLAQDN----ST-QLGTGGKIPVKWTAPEAYKKKLFTTKSDVWSF
.  ..  .| |  |.....| .|| |||.| ..||||||||.|..|. |.|..||||| |        . ..|||.|.||.|||. . . ||||||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILLWELFSFGRVP-YPRV
|.|.||.|..|. | || .
GVLMWEIFTYGEQPTYPGM
Kinase CSK2.AA TK 15-221 21 2.5e-83 279.1 In-house 1-416 (486) Show / Hide 
Range on Protein: 15-221
Range on HMM: 1-416/486
Sequence Identity: 21% (91 aa)

LKLGEEIGHGFFG---AVKVGEYQNK---------------------------KVAVKVISGDNEAAQS-IVA--------------EASIMTQLR----
..||...|.| ||    |  ||....                           .||||..  .....|    .              ||..| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLVALIGVIPDQPNS-----------ISIVLEFMAKGN----LLDYVRSRGRT--------------------------------------------
 |||.| |.||. .. ..           . ||.|.|..|.    |.|| |.. ..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------VITRKLQLKFSIDIGAGMCYLEQK------LFVHRDLAARNILISEDDV-----------AKVSDFG---
                               .| . .| .. .| .|| ||..|       ||||||||||.|..|..|           .|..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAQDN--------STQLGT--------------------GGKIPVKWTAPEAYKKKL---------FTTKSDVWSFGILLWELFSFGRVPYPRVV
     || |         ... ||                    |||.|..|.|||. ...          |||||||||||.|.||.|..|..||.  .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SY---------SEMLLR
|           |.. .
SNQDVWKDGDNQEVMEY
Kinase CSK2.AA Src 15-210 44 7.2e-80 271.04 In-house 1-202 (255) Show / Hide 
Range on Protein: 15-210
Range on HMM: 1-202/255
Sequence Identity: 44% (92 aa)

LKLGEEIGHGFFGAVKVGEYQN-KKVAVKVISGDNEAAQSIVAEASIMTQLRHPNLVALIGVIPDQ-PNSISIVLEFMAKGNLLDYVR--SRGRTVITRK
.|| ...| | || |  | ...  |||||... .. . .   .|| ||..|||..||.|  |  .  |  | || |.|..|.|||| .  ..||..  ..
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEP--IYIVTEYMSHGSLLDYLKKDGEGRHLHLPQ

LQLKFSIDIGAGMCYLEQKLFVHRDLAARNILISEDDVAKVSDFGLA---Q--DNSTQLGTGGKIPVKWTAPEAYKKKLFTTKSDVWSFGILLWELFSFG
| . ..  . .||.|||.. ..||||||||.|..|. |.|| |||||   .  |.     .| |.|.|||||||     ||.|||||||||||.|....|
L-IDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYG

RVPYP
|||||
RVPYP
Kinase CSK2.AA TyrKc 15-222 31 3.4e-70 240.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-222
Range on HMM: 1-280/280
Sequence Identity: 31% (90 aa)

LKLGEEIGHGFFGAVKVGEYQNKKVAVKVISGDNEAAQSIVAEASIMTQL--RHPNLVALIGVIPDQP------NSISIVLEFMAKGNLLDYVRSRGRTV
..||...|.|.|| |  |..   .||||..  |    . .  ||.||..|  .|||.|.|.||. .|         . ||.|.|..|.|.|| |..... 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

ITRKLQLKFSIDIGAGMCYLEQKLFVHRDLAARNILISEDDVAKVSDFGLAQDNSTQ--------LGT-----GGK--IPVKWTAPEAYKKKLFTTKSDV
.. |  |.|...| .|| ||..| ..||||||||.|..|. ..|.|||||. |              .     |||  .|..|.|||. ... |||||||
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WSFGILLWELFSFGRVPYPRV----------------------VSY-------------------------------SEMLLRF
||||...||.|..|  ||| .                        .                               ||   .|
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase CSK2.AA UTK 15-210 33 2.2e-65 222.66 In-house 1-242 (296) Show / Hide 
Range on Protein: 15-210
Range on HMM: 1-242/296
Sequence Identity: 33% (81 aa)

LKLGEEIGHGFFGAVKVGEYQN-------KKVAVKVIS--GDNEAAQS----IVAEAS---IMTQLR-HPNLVALIGVIPDQPNSISIVLEFMAKGNLLD
..||...|.| || | ......        .||||| .  .| . ..     .  ||    .| |.. |||.. |.|| . |   . ||.|.|..|.|..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGV-CTQEEPWMIVTEYMENGDLRS

YVR----SRG-RTVITRKLQ-LKFSIDIGAGMCYLEQKLFVHRDLAARNILISED-------DVAKVSDFG---LAQDNST-------------QLGTGG
|.|    . . .... .. | |... || .|| ||... ||||||||||.|. ..        |.|..|||   .. . .|             .    .
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQD

KIPVKWTAPEAYKKK-LFTTKSDVWSFGILLWELFSFGRVPYP
..|..|.||||. .   |||||||||||...||....||.|||
RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYP
Kinase CSK2.AA SFK-Abl 17-210 44 4.5e-62 201.3 In-house 3-199 (251) Show / Hide 
Range on Protein: 17-210
Range on HMM: 3-199/251
Sequence Identity: 44% (88 aa)

LGEEIGHGFFGAVKVGEYQNKKVAVKVISGDNEAAQSIVAEASIMTQLRHPNLVALIGVIPDQPNSISIVLEFMAKGNLLDYVRS-RGRTVITRKLQLKF
||.  | | .| | .|.. |..||.| |  .   .     || || ...||||| ||||       . || |||  |||||| .| ..|  |     .  
LGHRLGEGQYGEVYKGIWNNHRVAIKTIKDESMETKDFMKEAHIMKRMQHPNLVRLIGVCTRE-GPMYIVQEFMNYGNLLDYLQSPQSRIQIDHVSMMHC

SIDIGAGMCYLEQKLFVHRDLAARNILISEDDVAKVSDFGLAQDNS---TQLGTGGKIPVKWTAPEAYKKKLFTTKSDVWSFGILLWELFSFGRVPYP
   |  ||  || . |.|||||||| |. .    || |||.|   .       .| |.|.||||||.     || ||||||||| |||   .| ||||
AQQIADGMSFLEEQHFIHRDLAARNCLVGDNLQIKVADFGMARFVDSDFYEARIGTKMPIKWTAPESLCYDIFTIKSDVWSFGITLWEIATYGDVPYP
Kinase CSK2.AA Src-Unclassified 15-210 38 6.2e-62 211.15 In-house 1-229 (284) Show / Hide 
Range on Protein: 15-210
Range on HMM: 1-229/284
Sequence Identity: 38% (88 aa)

LKLGEEIGHGFFGAVKVGEYQN-KKVAVKVISGD------NEAAQ-----SIVAEASIMTQLRHPNLVALIGVIPDQPNSISIVLEFMAKGNLLDYVRSR
..|  ..| | ||.|  | . .   ||||    .      .||          .|| ||...||.|||.| .|  .|   . |. |.| .| ||.. |  
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVC-SQEEPYYIITEYMINGSLLQWLREG

G-RTVITRKL-------QLKFSIDIGA----GMCYLEQKLFVHRDLAARNILISEDD-----VAKVSDFGLA-----QDNSTQLGTGGKIPVKWTAPEAY
| ..   . .            .|| |    || ||| |  |||||||||.|| .       |.|| |||||     ||      || . |.||.|||. 
GGQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECF

KKKLFTTKSDVWSFGILLWELFSFGRVPYP
    |..||||||.||||||..  |..|||
IYGNFSIKSDVWSYGILLWEIMTKGQTPYP
Kinase CSK2.AA Tec 15-211 40 2.1e-61 210.28 In-house 1-201 (254) Show / Hide 
Range on Protein: 15-211
Range on HMM: 1-201/254
Sequence Identity: 40% (84 aa)

LKLGEEIGHGFFGAVKVGEYQNK-KVAVKVISGDNEAAQS---IVAEASIMTQLRHPNLVALIGVIPDQPNSISIVLEFMAKGNLLDYVRSRGRTVITRK
|.. .|.| | || |. |..... .||.| |   .| . |    . || .|. | ||.|| | ||   |   | || |.|..| ||.| |... . ..  
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMI---KEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQ-RPIYIVTEYMEHGCLLNYLREHKHHFQKNM

-LQLKFSIDIGAGMCYLEQKLFVHRDLAARNILISEDDVAKVSDFGLAQ---DNSTQLGTGGKIPVKWTAPEAYKKKLFTTKSDVWSFGILLWELFSFGR
 . |.  .|.  || |||.. |.|||||||| |.... | ||||||..    |      .| | |||| .||  .   .  |||||.||.| || || |.
AILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGK

VPYPR
.||..
MPYEN
Kinase CSK2.AA Abl 15-212 42 8.7e-61 201.32 In-house 1-202 (252) Show / Hide 
Range on Protein: 15-212
Range on HMM: 1-202/252
Sequence Identity: 42% (86 aa)

LKLGEEIGHGFFGAVKVGEYQ--NKKVAVKVISGDNEAAQSIVAEASIMTQLRHPNLVALIGVIPDQPNSISIVLEFMAKGNLLDYVRSRGRTVITRKLQ
. . . .| | .| | .| ..  .. |||| .  |. . .  ..|| || ...||||| |.||    |    |. |||..||||||.|. .|. ..    
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREP-PFYIITEFMCYGNLLDYLRECDREELPAVVL

LKFSIDIGAGMCYLEQKLFVHRDLAARNILISEDDVAKVSDFGLA---QDNSTQLGTGGKIPVKWTAPEAYKKKLFTTKSDVWSFGILLWELFSFGRVPY
|     |  || |||.. |.|||||||| |..|... || |||||   .|.      | | |.||||||.   . | .||||| ||.||||.  .|  ||
LYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPY

PRV
| .
PGI
Kinase CSK2.AA TK-Unique 15-214 34 5.5e-60 205.49 In-house 1-245 (294) Show / Hide 
Range on Protein: 15-214
Range on HMM: 1-245/294
Sequence Identity: 34% (85 aa)

LKLGEEIGHGFFGAVKVGEYQN--------KKVAVKVIS-GDNEA-AQSIVAEASIMTQLR-HPNLVALIGVIP-DQPNSISIVLEFMAKGNLLDYVRSR
|..|..|| | || |  ||. .        |.||||    . ..   |    |...| .|  |||.| ..|.   .. ..  |..|....|||..| |..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC

GRT------------------------VITRKLQLKFSIDIGAGMCYLEQ--KLFVHRDLAARNILISEDDVAKVSDFGLAQDNST-----QLGTGGKIP
...                         |. |. . | ..|  || ||..  | .|||||.|||.|..|| |.|..|||.| | .|       .. |.||
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

VKWTAPEAYK--KKLF-TTKSDVWSFGILLWELFSFGRVPYPRVVS
..| |||. |  .. . ||||||||||.|.||.|..|  |||.. .
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPW
Kinase CSK2.AA Syk 15-209 40 2.6e-58 199.33 In-house 1-210 (257) Show / Hide 
Range on Protein: 15-209
Range on HMM: 1-210/257
Sequence Identity: 40% (87 aa)

LKLGEEIGHGFFGAVKVGEYQNK---------KVAVKVIS--GDNEA-AQSIVAEASIMTQLRHPNLVALIGVIPDQPNSISIVLEFMAKGNLLDYVRSR
| ...|||.| || |. | |. |         |||.|. .  . . |  | ...||..| || ||  | .||.   .  .   |.|    | ...|    
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGIC--HAEMMMMVMEMAELGPMHKYLQQH

GRTVITRKLQLKFSI-DIGAGMCYLEQKLFVHRDLAARNILISEDDVAKVSDFGL-----AQDNSTQLGTGGKIPVKWTAPEAYKKKLFTTKSDVWSFGI
 |  || .  |.     .  |||||| | ||||||||||.|      ||.||||.     | ..  |  |.|| |||| |||   .  |  ||||||||.
-RHEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGV

LLWELFSFGRVPY
..|| || |  ||
TMWEMFSYGQKPY
Kinase CSK2.AA Pkinase 15-210 29 4.3e-32 114.54 Pfam 1-213 (293) Show / Hide 
Range on Protein: 15-210
Range on HMM: 1-213/293
Sequence Identity: 29% (63 aa)

LKLGEEIGHGFFGAVKVGEYQNKK--VAVKVISGDNEAA---QSIVA--EASIMTQLRHPNLVALIGVIPDQPNSISIVLEFMAKG----NLLDYVRSRG
...|. || | || |. .  ..    ||||.|. ..|     |. .   |..||  |.||| | |...  | ...| .|.|.. .|     | ||.. . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

RTVI--TRKLQLKFSIDIGAGMCYLEQKLFVHRDLAARNILISEDDVA----KVSDFGLAQ---DNSTQLGTGGKIPVKWTAPEAYK-KKLFTTKSDVWS
....  . .   ..   |  |. |. .. ..||||   ||||.....     |..|||||      . .  |.      . |||  .  .  ..|.|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

FGILLWELFSFGRVPYP
.|..|.|... || |.|
CGCILYEMLC-GRPPFP
Kinase CSK2.AA S_TKc 15-222 24 4.1e-29 103.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 15-222
Range on HMM: 1-231/231
Sequence Identity: 24% (61 aa)

LKLGEEIGHGFFGAVKVGEYQN--KKVAVKVISGDNEAAQSIVAEASIMTQLRHPNLVALIGVIPDQPNSISIVLEFMAK--GNLLDYVRSRGR----TV
 .....||.| || |. .   .  ..||.|.|.      ..|  | .|. . .|||.| |..|. |  ... .|.|..    |.|.|| ..|||     .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

ITRKLQLKFSIDIGAGMCYLEQKLFVHRDLAARNILISEDDVAKVSDFGLAQDNSTQLGTGGKIPVKWTAPEAYKKKLFTT-KSDVWSFGILLWELFSFG
..     ..   |  .. |. .. ..||||   |||..|  . |..|||||        |       . |||      ... |.|.||.|..|.|... |
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-G

RVPYPRVVSY---------------------------SEMLLR----------F
. |.|  .                                .|.          |
YPPFP-QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF