Gene Eph (Sea Urchin)

Eph

Species: Sea Urchin
Alias: SPU_027145, Eph, Spk261
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
Eph.AA Protein None 999 None Fasta, JSON
Eph.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of Eph.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd Eph.AA Ephrin_lbd 22-198 39 1.8e-66 207.45 Pfam 1-190 (190) Show / Hide 
Range on Protein: 22-198
Range on HMM: 1-190/190
Sequence Identity: 39% (75 aa)

EVKLYDSNAFSG-LYWTVYPPQDP--DSQTYVGWTESGAS-----YERIFQTC-HVSDPR-DNWLRMPYIERQGANRIHVEVKFTMYSCTGIVDAQ-LCK
|| | |. .  . | || ||.  .  |    ..|.| .         | .| | .|..|  .|||| ..|||.||.||.|| |||| .|  .  .   ||
EVVLMDTKTATSDLGWTTYPYN-GRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTCK

ETFDVYFYQSDT-DEATETSPDWTAPPYQKVARIAAEGR-FSDPDTL-DEEVVNVRIENFGPVTANGFYIAFRDQGACMALLQVRIFYQVC
|||..|.|.||. |.|. ..| |  ..| |. .|||. . |.. |   .  ..|. . ..||..  |||.||.||||||||. ||..|..|
ETFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd Eph.AA EPH_lbd 22-198 41 5.4e-60 206.53 SMART 1-184 (184) Show / Hide 
Range on Protein: 22-198
Range on HMM: 1-184/184
Sequence Identity: 41% (80 aa)

EVKLYDS-NAFSGLYWTVYPPQDPDSQTYVG--WTESGASYER-----IFQTCHVSD---PR-DNWLRMPYIERQGANRIHVEVKFTMYSCTGIVDAQL-
|| | |.  . . | || |||         |  | | ..  |.     ..|.|.| .   |  .||||  .|.|.||.||.||.||||  |  .  .   
EVVLMDTKTETGELGWTTYPP--------HGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGV

-CKETFDVYFYQSDTDEATETSPDWTAPPYQKVARIAAEGRFSDPDTLDEE-VVNVRIENFGPVTANGFYIAFRDQGACMALLQVRIFYQVC
 ||||| .|.|.||.| ||...| | ..||.|. .|||. .|.  |. |.   .|. .  |||.. .|||.||.||||||||. ||.||. |
SCKETFNLYYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
GCC2_GCC3 Eph.AA GCC2_GCC3 262-306 24 4.4e-09 32.49 Pfam 1-49 (49) Show / Hide 
Range on Protein: 262-306
Range on HMM: 1-49/49
Sequence Identity: 24% (12 aa)

GYEASADRTRCEECQIGTFKSDIGTTECSPCPAK-S---HADTVAVTRC
|.  ..   .|| | .||... .| ..| |||.  .   .   .... |
GTYYNKGQNPCEPCPRGTYQNEEGQDSCIPCPPGKTTTDYPGSTSESDC
FN3 Eph.AA FN3 328-413 18 1.6e-07 32.23 SMART 1-69 (69) Show / Hide 
Range on Protein: 328-413
Range on HMM: 1-69/69
Sequence Identity: 18% (18 aa)

PSAPTS---LTAVVDEKSS-----VVTLTWRNPENLGGRTDIDFRIDCKRCPADVQFSSIQRIGQGYEVNVSRLSSH----TTYEFKVHSYNE-VSSQG
|..|.    |...   ..|      |||.|  |           .. ..                   . |. |. .    |.|||.|  .|.    .|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-----------IVGYR-------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 Eph.AA FN3 430-518 22 3.6e-13 51.01 SMART 1-69 (69) Show / Hide 
Range on Protein: 430-518
Range on HMM: 1-69/69
Sequence Identity: 22% (23 aa)

PSAVRD---LKVVEDDVNDE----SIKLRWRQPLFPNGEITNYQVIYRTSAETQENVKYHYQAVLDGEVQETTVHGLVPG----TEYVFEVAANTA--SG
|.....   |.|.. . .      |. |.|  |      |..|.                            ||.||.||    |||.| |.| ..   |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR---------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAG

VG
 |
EG
Kinase Eph.AA Eph 641-896 70 2.8e-201 674.97 In-house 1-264 (264) Show / Hide 
Range on Protein: 641-896
Range on HMM: 1-264/264
Sequence Identity: 70% (186 aa)

IRILEVIGGGEFGDVCSGLMLMP-DKTTI---KVAVKTLKTGATDKDRSDFLSEASIMGQFDHPNVIKLLGVVTKTRPAMIVTEFMENGSLDKYLRENDG
|.| .|||.||||.||.| . .|  |. .    ||.||||.|.|.|.| ||||||||||||||||.|.| |||||.||.|||||.|||||||..||..||
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

RFTVTQLLGMMRGVGFGMRFLSEMNFVHRDLAARNILVNEHLVCKVADFGLSR--RKEL--DGAYETRGGKIPIRWTAPEAIGYKKFTSASDVWSLGVVM
.|||.||.||.||...||..||.||.|||||||||||||..|||||.||||||  ...   ...|.|||||||||||||||| |.|||||||||| |.||
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM

WEIMSYGERPYWNWPNQDVIKAVEKGYRLPPPMECPEAIHQLMLDCWQRDRNHRPTFTTIVSTL
||.|||||||||...|||||||.|.||||||||.||||.|||||||||.||||||.|..|||.|
WEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase Eph.AA Pkinase_Tyr 641-896 45 6.8e-144 487.95 Pfam 1-270 (270) Show / Hide 
Range on Protein: 641-896
Range on HMM: 1-270/270
Sequence Identity: 45% (124 aa)

IRILEVIGGGEFGDVCSGLML-MPDKTTIKVAVKTLKTGATDKD--RSDFLSEASIMGQF-DHPNVIKLLGVVT-KTRP--AMIVTEFMENGSLDKYLRE
|......| |.||.|. | .   ||.|.|.||||.|| ||....  | ||..||.|| |. .|||...|.||.| . .|   .||.|.|..|.|..|||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---DGRFTVTQLLGMMRGVGFGMRFLSEMNFVHRDLAARNILVNEHLVCKVADFGLSRRKELDGAY--ETRGGKIPIRWTAPEAIGYKKFTSASDVWSL
.   ....|. .||.| . .  || .|...|..||||||||.||.| .|.|..||||.|  . |. |   . |||.||.|.|||.| |.|||..||||| 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVVMWEIMSYGERP-YWNWPNQDVIKAV-EKGYRLPPPMECPEAIHQLMLDCWQRDRNHRPTFTTIVSTL
||.||||..||| | |....|..|.... |.|||.|.|. ||. |..||..||. | ..||||. |.. |
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Eph.AA TyrKc 641-896 40 3.5e-134 453.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 641-896
Range on HMM: 1-280/280
Sequence Identity: 40% (118 aa)

IRILEVIGGGEFGDVCSGLMLMPDKTTIKVAVKTLKTGATDKDRSDFLSEASIMGQF--DHPNVIKLLGVVTKT-------RPAMIVTEFMENGSLDKYL
|. ....| |.|| |. | .       |.||||.|| .|    | ||..||.|| ..  .|||...|.||.|.         | |||.|.|..|.|..||
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RENDGRFTVTQLLGMMRGVGFGMRFLSEMNFVHRDLAARNILVNEHLVCKVADFGLSRRKELD-------GAYETR---GGK--IPIRWTAPEAIGYKKF
|.. ..... .|| ..  .  ||..|...|..||||||||.||.| ...|..||||||  . |         | ..   |||  .||||.|||.| |.||
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TSASDVWSLGVVMWEIMSYGERPYWN-----WPNQDVIKAVEKGYRLPPPME--------CPEAIHQLMLDCWQRDRNHRPTFTTIVSTL
|..||||| ||.||||..||. ||..      .||.||. |..|||.|.| .        ||....|.|..||..| . ||||..|.. .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Eph.AA TK 641-896 24 6.5e-125 420.96 In-house 1-486 (486) Show / Hide 
Range on Protein: 641-896
Range on HMM: 1-486/486
Sequence Identity: 24% (118 aa)

IRILEVIGGGEFG---DVCSGLMLMPD----------------------KTTIKVAVKTLK--TGATDKDRSD-----------FLSEASIMGQFD----
|......| |.||   .|. |.. ...                      .....||||.||  ........ |           ||.||..| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNVIKLLGVVTKT------------RPAMIVTEFMENGS----LDKYLRENDGR--------------------------------------------
 |||...|.||.|.             .| |||.|.|..|.    |..|||.....                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FTVTQLLGMMRGVGFGMRFLSEM------NFVHRDLAARNILVNEHLV-----------CKVADFG---
                               .|. ||| |.. .  ||..|...      |||||||||||.||.|..|           ||.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRRKELDGAYETRG-------------------------GKIPIRWTAPEAIG---------YKKFTSASDVWSLGVVMWEIMSYG-ERPYWNW
     |.|. . |. | ...                         ||.||||.|||..          |.|||..|||||.||.||||..|| | .|...
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PN---------QDVIKAVEKG--------------YRLPPPMECP--------------EAIHQLMLDCWQRDRNHRPTFTTIVSTL
.|         |.|.. ...|              .|.|.|. ||              |....||..||..| ..||||..... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Eph.AA UTK 641-896 37 1.1e-110 373.98 In-house 1-296 (296) Show / Hide 
Range on Protein: 641-896
Range on HMM: 1-296/296
Sequence Identity: 37% (112 aa)

IRILEVIGGGEFGDVCSGLMLMPD--KTTIKVAVKTLKTGATDKDRSD----FLSEAS---IMGQFD-HPNVIKLLGVVTKTRPAMIVTEFMENGSLDKY
..... .| |.||.|. .    ..   .. .||||.....|.. . ..    |. ||    .|.||. ||||..|.||.|.  | |||||.||||.|..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR-------ENDGRFTVTQLLGMMRGVGFGMRFLSEMNFVHRDLAARNILVNEH-------LVCKVADFG---LSRRKE---------LDGAYETRG-GK
||       ...  .| .|.|.|.. .  || .|....||||||||||.||..|       .|||.||||   .|||            .  |  .. ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPIRWTAPEAIGYK-KFTSASDVWSLGVVMWEIMSYGERPYWNWPNQDVIKAVEKG--YRLPPPMECPEAIHQLMLDCWQRDRNHRPTFTTIVSTL
.||||.||||. .  .||..|||||.|||.|||...| .|| .. |..|...|..|  ||.|.| .||... .||..||. |   ||.| ..|...
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase Eph.AA Src 641-896 44 2.1e-107 363.11 In-house 1-255 (255) Show / Hide 
Range on Protein: 641-896
Range on HMM: 1-255/255
Sequence Identity: 44% (117 aa)

IRILEVIGGGEFGDVCSGLMLMPDKTTIKVAVKTLKTGATDKDRSDFLSEASIMGQFDHPNVIKLLGVVTKTRPAMIVTEFMENGSLDKYLR-ENDGR-F
|. .. .| | ||.|  |.     . ..|||||||| |    .  .|| || || ...|.....|. |...  |  ||||.|..||| .||. . .||  
IKLCRKLGQGQFGEVWMGYW----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

TVTQLLGMMRGVGFGMRFLSEMNFVHRDLAARNILVNEHLVCKVADFGLSRRKELD-GAY-ETRGGKIPIRWTAPEAIGYKKFTSASDVWSLGVVMWEIM
 ..||. |   |  || .|..||..||||||||.||.|..||||||||| |  . |   |    | |.||.||||||| | .||  ||||| |. ..||.
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIV

SYGERPYWNWPNQDVIKAVEKGYRLPPPMECPEAIHQ-LMLDCWQRDRNHRPTFTTIVSTL
.||  ||  . |..|...||.|||.| |..||. ... .|| ||..|   |||| .. . |
TYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase Eph.AA SFK-Src 641-900 44 1.2e-101 302.01 In-house 1-259 (259) Show / Hide 
Range on Protein: 641-900
Range on HMM: 1-259/259
Sequence Identity: 44% (119 aa)

IRILEVIGGGEFGDVCSGLMLMPDKTTIKVAVKTLKTGATDKDRSDFLSEASIMGQFDHPNVIKLLGVVTKTRPAMIVTEFMENGSLDKYLRENDGR-FT
||  .  | | ||||  |      .||  ||||||| ||.  .   ||.|| .| .  ||| |.|  | |   |  |.|| | .|||  ||.|  ||  .
IRLEKKLGSGQFGDVWKGRW---NNTT-EVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR

VTQLLGMMRGVGFGMRFLSEMNFVHRDLAARNILVNEHLVCKVADFGLSRRKELDGA-YETR-GGKIPIRWTAPEAIGYKKFTSASDVWSLGVVMWEIMS
. ||  |   |  || .| . |||||||||||.|| .  ||||.|||.||  . |   |. . | | ||.||||||  . .|   ||||| |. | ||  
MPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVT

YGERPYWNWPNQDVIKAVEK--GYRLPPPMECPEAIHQLMLDCWQRDRNHRPTFTTIVSTLDRLI
||  ||    |. |.. |..  |||.| |  ||.. ...|.||||     |||| .    ..   
YGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase Eph.AA TK-Unique 641-896 35 9.20000000001e-101 341.06 In-house 1-294 (294) Show / Hide 
Range on Protein: 641-896
Range on HMM: 1-294/294
Sequence Identity: 35% (104 aa)

IRILEVIGGGEFGDVCSGLML---MPDKTTIKVAVKTLKTGATDKDRSDFLSEASIMGQFD-HPNVIKLLGVVTKTR-PAMIVTEFMENGSLDKYLREND
.....||| |.|| |. | .    ...  ...||||.|| .||| |..|||.|...| . . |||....||. ||.  | ||. |....|.|..|||.. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

GR-------------------------FTVTQLLGMMRGVGFGMRFLSE--MNFVHRDLAARNILVNEHLVCKVADFGLSRRKELDGAYETRG--GKIPI
.                           .  .|.  . ..  || .|..  ...|||||.|||.|..|..|||..|||..|. . .|.|.. .  |.|||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWTAPEAIG--YKKF-TSASDVWSLGVVMWEIMSYGERPYWNWPNQDVIKAVEKGYRLPPPMEC-PEAIHQLMLDCWQRDRNHRPTFTTIVSTL
|| |||..   .. . |. |||||.||.||||...|..|| . |. |.......|||.| | .| ......||  |||... .||.|..|.. |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase Eph.AA Fer 641-897 34 2.8e-97 329.51 In-house 1-283 (283) Show / Hide 
Range on Protein: 641-897
Range on HMM: 1-283/283
Sequence Identity: 34% (99 aa)

IRILEVIGGGEFGDVCSG---LMLMPDKTTI----KVAVKTLKTGATDKD-RSDFLSEASIMGQ-FDHPNVIKLLGVVTKTRPAMIVTEFMENGSLDKYL
. . ...| | ||.|..|   |... .|.      .|.||..|. ...|. . .|. || || . .|||||.|. || .   | ||| ||. .||||.||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RENDGR-FTVTQLLGMMRGVGFGMRFLSEMNFVHRDLAARNILVNE-HLVCK--VADFGLSRRKELDGAYETRG---GKIPIRWTAPEAIGYKKFTSASD
..|...  .. ... |  ..  ||..| ..| .|||.||||.|. .  ...|  ..|||.|| .. .|   . .    |.||||.|||.. .. .....|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSLGVVMWEIMSYGERPYWN----WPNQDV----IKA-VEKGYRLPPPMECPEAIHQLML-DCWQRDRNHRPTFTTIVSTLD
||| ||..|||.. |. || .      .  |    .|. ..|||..|.| ..|..| |.|. .|||.| . |||...|. .| 
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase Eph.AA RTKC 641-896 42 2.2e-91 301.88 In-house 1-261 (261) Show / Hide 
Range on Protein: 641-896
Range on HMM: 1-261/261
Sequence Identity: 42% (112 aa)

IRILEVIGGGEFGDVCSGLMLMPD-KTTIKVAVKTLKTGATDKDRSDFLSEASIMGQFDHPNVIKLLGVVTKTRPAMIVTEFMENGSLDKYLRENDGRFT
. .|.  | | || |  .|.  |     . ||.| |.  | |.||.  | || .| ||.||||..| ||||. .|  .| ||.|.|||  || .|    |
LTLLDELGRGAFGIVYKALLEEPGGMPGYLVACKSLHHTAMDNDRQELLEEAAVMAQFEHPNVVHLIGVVTVGKPILVVLEFCERGSLKSYLMNNP-DCT

VTQLLGMMRGVGFGMRFLSEMNFVHRDLAARNILVNEHLVCKVADFGLSRRK-ELDGAYE----TRGGKIPIRWTAPEAIGYKKFTSASDVWSLGVVMWE
  | .   . .  ||.   . .|.|||.||||.|.   | |||||||| |     |.. |     |.| .|.|||||||   .||. .||||..|. | |
EHQKVRFCYQCASGMEHIHSFGFIHRDVAARNVLLSSDLTCKVADFGLARESPCNDDSHEAYYRSRSGNLPVRWTAPEALDDRKFSEKSDVWAFGILMYE

IMSYGERPYWNWPNQDVIKAVEKGYRLPPPMECPEAIHQLMLDCWQRDRNHRPTFTTIVSTL
|   .| ||  | || |   |  |||||.| .|....  .|.|||. ..  |||| ..|  |
IYTKAEMPYDGWSNQRVWVEVCAGYRLPCPEDCHKEVYDMMMDCWMHTPHDRPTFSEVVHWL
Kinase Eph.AA Frk 641-900 45 2.7e-89 302.97 In-house 1-260 (260) Show / Hide 
Range on Protein: 641-900
Range on HMM: 1-260/260
Sequence Identity: 45% (121 aa)

IRILEVIGGGEFGDVCSGLMLMPDKTTIKVAVKTLKTGATDKDRSDFLSEASIMGQFDHPNVIKLLGVVTKTRPAMIVTEFMENGSLDKYLR--ENDGR-
|...  .| | ||.|  ||       |. |||||||.|. | .  ||| || || .  || .|.|  | |   | .|.|| |..||| .||.  .. || 
IQLIRRLGSGQFGEVWEGLW----NNTTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ

FTVTQLLGMMRGVGFGMRFLSEMNFVHRDLAARNILVNEHLVCKVADFGLSR--RKELDGAYETRGG-KIPIRWTAPEAIGYKKFTSASDVWSLGVVMWE
  ..||. |   |  || .| ..|..||||||||.||.||..||.||||| |   |.    ||.| | ..||.||||||. |.|||  ||||| |... |
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTE

IMSYGERPYWNWPNQDVIKAVEKGYRLPPPMECPEAIHQLMLDCWQRDRNHRPTFTTIVSTLDRLI
|. ||  ||    |..|.. |..|||.| | .||. . ..||.||. | ..|||| |.   |.  .
IITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase Eph.AA Csk 641-896 43 4.6e-88 298.87 In-house 1-251 (251) Show / Hide 
Range on Protein: 641-896
Range on HMM: 1-251/251
Sequence Identity: 43% (114 aa)

IRILEVIGGGEFGDVCSGLMLMPDKTTIKVAVKTLKTG---ATDKDRSDFLSEASIMGQFDHPNVIKLLGVVTKTR-PAMIVTEFMENGSLDKYLRENDG
. ..| || ||||||  |  .       ||||| .|     . ..    || |||.| |  ||| ..|.||. .      ||.|.| .|.|  |||   |
LHLGECIGHGEFGDVMQGEYQ-----NRKVAVKCIKCDGNGMAQA----FLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSR-G

RFTVTQLLGMMR--GVGFGMRFLSEMNFVHRDLAARNILVNEHLVCKVADFGLSRRKELDGAYETRGGKIPIRWTAPEAIGYKKFTSASDVWSLGVVMWE
|  .|.   ..    |. || .| . .||||||||||||| | .| || ||||. ..|  .  .. .||.|| ||||||   |||.. ||||| |. .||
RHVITRRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLA-KEECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWE

IMSYGERPYWNWPNQDVIKAVEKGYRLPPPMECPEAIHQLMLDCWQRDRNHRPTFTTIVSTL
| |.|  ||   | .|| |.||||||  .|  ||......| .||. .  .||||  ... |
IYSFGRVPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase Eph.AA S_TKc 641-900 23 4.3e-47 163.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 641-900
Range on HMM: 1-231/231
Sequence Identity: 23% (63 aa)

IRILEVIGGGEFGDVCSGLMLMPDKTTIKVAVKTLKTGATDKDRSDFLSEASIMGQFDHPNVIKLLGVVTKTRPAMIVTEFMEN--GSLDKYLRENDGR-
 .||..|| | || |. .       |  .||.| .|         ....| .|. . .|||..||..|        .|.|....  |.| .|.... .. 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTVTQLLGMMRGVGFGMRFLSEMNFVHRDLAARNILVNEHLVCKVADFGLSRRKELDGAYETRGGKIPIRWTAPEAIGYKKFTS-ASDVWSLGVVM
    |.  .   .|. .  .. .. .....||||   |||..|  . |..||||.|.         .       . ||| .   ...  ..|.||.|...
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

WEIMSYGERPYWNWPNQDVIKAVEKGYRLPPPMECPEAIHQLMLDCWQRDRNHRPTFTTIVS-----TLDRLI
.| .. |. |..    | ..| .            |||.. ..  |.|.| ..|||   .        ..  .
YEMLC-GYPPFP--QMQMMFKKIG----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Eph.AA Pkinase 641-896 22 4.3e-45 160.53 Pfam 1-293 (293) Show / Hide 
Range on Protein: 641-896
Range on HMM: 1-293/293
Sequence Identity: 22% (67 aa)

IRILEVIGGGEFGDVCSGLMLMPDKTTIKVAVKTLKTGATDK--DRSDFL-SEASIMGQFDHPNVIKLLGVV-TKTRPAMIVTEFMENG----SLDKYLR
..|...|| | || |      .  .| ..||||..|   ...  |..... ||..||  ..|||...|.... .|...  .|.|..|.|    .|  |..
YHIGRKIGSGSFGCV---YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYIS

-ENDGRF--TVTQLLGMMRGVGFGMRFLSEMNFVHRDLAARNILVNEHLVC----KVADFGLSRRKELDGAYETRGGKIPIRWTAPEAIG-YKKFTSASD
 ...|.|  .  ..  .|. .  |. .. .|...||||   |||.... ..    |..||||.. ...     . .    ... ||| |  ... ....|
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VWSLGVVMWEIMSYGERPYWNW----PNQDVIKAVEKGYRLPPPMECP-----------------------EAIHQLMLDCWQRDRNHRPTFTTIVST--
.||.|....| .. |. |...     .  | .. ...  . |.. ..|                       |.  ... .|...| . |||.. |.    
MWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

L
.
F
SAM_1 Eph.AA SAM_1 924-988 39 1.6e-26 96.86 Pfam 1-66 (66) Show / Hide 
Range on Protein: 924-988
Range on HMM: 1-66/66
Sequence Identity: 39% (26 aa)

DLSRFNSVSDWLDSLKMGRYKDSFTAAGYVRLEDIARLSQSDLPR-LGVTLAGHQKKIMKGIHSIR
|  .|..|..||.|..|..|.|.|..|||. ..........|| . .||||.||.||||. |.  .
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
Sam7 Eph.AA sam7 926-988 28 1.6e-21 74.29 In-house 1-70 (70) Show / Hide 
Range on Protein: 926-988
Range on HMM: 1-70/70
Sequence Identity: 28% (20 aa)

SRFNSVSDWLDSLKM---GRYKDSFTAAGY----VRLEDIARLSQSDLPRLGVTLAGHQKKIMKGIHSIR
  |..|..||....|   ..|.|.|...|.    . ......... || ..|.|. ||.|||.. |. .|
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
SAM Eph.AA SAM 923-990 36 4.2e-21 77.35 SMART 1-67 (67) Show / Hide 
Range on Protein: 923-990
Range on HMM: 1-67/67
Sequence Identity: 36% (25 aa)

NDLSRFNSVSDWLDSLKMGRYKDSFTAAGYVRLEDIARLSQSDLPRLGVTLAGHQKKIMKGIHSIRAQ
 |   ...|.|||.|..|..||| |...|.   . ....|..|| ..|.|..||.|||.|.|.....|
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
SAM_2 Eph.AA SAM_2 923-988 33 8.6e-21 74.19 Pfam 1-71 (71) Show / Hide 
Range on Protein: 923-988
Range on HMM: 1-71/71
Sequence Identity: 33% (24 aa)

NDLSRFNSVSDWLDSLKM-GRYKDSFTAAGYVRLEDI-ARLSQSDL--P-RLGVTLAGHQKKIMKGIHSIR
 . . |..|..||.|..| ..|||.|...|.  .|.. |.....||    |.|.|..||.|||...| ...
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK