Gene FAK (Sea Urchin)

FAK

Species: Sea Urchin
Alias: FAK, Spk262, SPU_019686
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: FAK

Sequence

Name Sequence Type Origin Length Description Download
FAK.AA Protein None 1093 None Fasta, JSON
FAK.kin_dom Protein Kinase Domain None 205 None Fasta, JSON

Protein domain

Protein domains of FAK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B41 FAK.AA B41 5-228 20 2.1e-28 101.58 SMART 1-232 (232) Show / Hide 
Range on Protein: 5-228
Range on HMM: 1-232/232
Sequence Identity: 20% (48 aa)

AGEKMMLKVYQPNGSFNSVKCMETTDIKSVIHAVVSKLARGERAFESSFAVRLQHTLSEDCHWLHRDLTVGQVKKKYEAYHPAIEWKYELRVRYLPKNF-
 .. . ..|| ..|.  ....  .|... .. .|. ..    .     |. .. .. .   |||. . |.. ...|.   |.  .|.. .||.. |... 
SPKPRFCRVYFMDGTTLEFEVDSSTTGQDLCDHVCRHCGI-SPREHWYFGLWYEDPHED-RHWLDHWKTIMKQDVKW---HKSEPWTLHFRVKFYPPDWH

--HVLLEKDKVSFFYFYDQVRCDYMNEVAELVEQDMSLQLGCLEMRRFFKDMPQIALDKKANFDYLEKEIGLKRFIPKNVIDNTK---------PKNLRK
  . .|. |.... ||| |.| |.... . .  .. .|||..| ... ..|... ....|.......|....|||.|| .||  |         .| .||
GFPNQLQEDPTRYNYFYLQCRHDILQGRHPCPHEEECLQLAALQVQIEYGDYDPEETNNKKMTKHVQKYKSYKRFLPKQWIDSIKQSFMHYQMHHKEWRK

LILQYFKQFANLNEEQCVFKFFEVLTTIH-RFDHEKF
 |....|.......|.. .|..... . . ..  | |
RIMEWHKNHCGMTPEEAKLKYLQICQRWPPMYGVEHF
FERM_M FAK.AA FERM_M 104-217 12 6.3e-07 25.2 Pfam 1-160 (171) Show / Hide 
Range on Protein: 104-217
Range on HMM: 1-160/171
Sequence Identity: 12% (20 aa)

HVLL-EKDKVSFFYFYDQVRCDYMNEVAELVEQDMSLQLGCLEMRRFFK-DMPQIALDKKANFDYLEKE-------------IGLKRFIP----------
...   .| | . .||.|.. |....    .  .. |.|...  .  |  |... .  |. ... ...|               . |..|          
DPNRDIQDEVTRHQFYLQAKWDILEGRY-PCSEEEALMLAAYQCQIEFGSDYNPPQKHKSDYMEKEWWEQQEGMEVWLRCDNEQQERYWPAHCRLASKGR

---------------------KNVIDNTKPKNLRKLILQYFKQFANL-NEEQCVFKFFEVL
                     . ..   | |.... ||. .|. ...  .|..  .. ...
TMADSSYSEVSIRINPHCYVSPWYCKKMKQKQWEQRILEQHKNHRGMCSPEEAMLQYIQIC
Kinase FAK.AA FAK 414-588 77 2.5e-149 502.37 In-house 110-285 (285) Show / Hide 
Range on Protein: 414-588
Range on HMM: 110-285/285
Sequence Identity: 77% (136 aa)

MRMFLQAHKDELTLASLILYAYQLSMALSYLESKKFVHRDIAARNLLVVAKDNVKLGDFGLSRLLHDHSYYKAS-KGKLPIKWMAPESINFRRFTSASDV
.| .||..|..|..|.||||.|||.||..||||||||||||||||.||...|.||||||||||..||||||||| |||||||||.||||||||||.||||
LRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWMHDHSYYKASPKGKLPIKWMSPESINFRRFTTASDV

WMFGVCMWEILMYGVKPFQGVKNNEVIGRIENGERLPMPAACPPTLYSVMTLCWSYEPSKRPNFKDLKTRLKKLRL
|||||||||||||||||||.||||.||||||||||||||..|||||||.||.||.|.|||||.||.||..||....
WMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase FAK.AA Pkinase_Tyr 417-583 47 1.1e-92 314.54 Pfam 97-270 (270) Show / Hide 
Range on Protein: 417-583
Range on HMM: 97-270/270
Sequence Identity: 47% (82 aa)

FLQAH---KDELTLASLILYAYQLSMALSYLESKKFVHRDIAARNLLVVAKDNVKLGDFGLSRLLHDHSYY--KASKGKLPIKWMAPESINFRRFTSASD
.|..|   |. ||.  |. ...| .....|||||...|||.|||| ||  .  || .||||.|.... .||  |...|||||||||||.||...||..||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSD

VWMFGVCMWEILMYGVKP-FQGVKNNEVIGRI-ENGERLPMPAACPPTLYSVMTLCWSYEPSKRPNFKDLKTRL
||.|||.||||. || .| ..|..|.||. .| |.|.|.|.|  ||. .|..|..|| |.|..|| |...  .|
VWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FAK.AA FAK 592-695 80 9.1e-89 297.57 In-house 181-285 (285) Show / Hide 
Range on Protein: 592-695
Range on HMM: 181-285/285
Sequence Identity: 80% (85 aa)

KAS-KGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMYGVKPFQGVKNNEVIGRIENGERLPMPAACPPTLYSVMTLCWSYEPSKRPNFKDLKTRL
||| |||||||||.||||||||||.|||||||||||||||||||||||.||||.||||||||||||||..|||||||.||.||.|.|||||.||.||..|
KASPKGKLPIKWMSPESINFRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQL

NLLSD
  .  
KDIYQ
Kinase FAK.AA TK 415-583 23 3.2e-80 268.51 In-house 147-486 (486) Show / Hide 
Range on Protein: 415-583
Range on HMM: 147-486/486
Sequence Identity: 23% (79 aa)

RMFLQAHKDE---------------------------------------------------------------------------LTLASLILYAYQLSM
| .|......                                                                           ||.. |. ...|.. 
RDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIAC

ALSYLESK------KFVHRDIAARNLLVVAKDN-----------VKLGDFG--------LSRLL-HDHSYYKAS------------------------KG
...||.||      .|||||.|||| ||  ...           .|..|||        |.| . .|. ||..|                        .|
GMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGG

KLPIKWMAPESIN---------FRRFTSASDVWMFGVCMWEILMYGVKPFQGVKNN----------EVIGRIEN------------GERLPMP--AACP-
||||.|||||..|         ...||..||||.|||.||||..|| .|. |  .|          ||. ....            |.|..||  . || 
KLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPD

-------------PTLYSVMTLCWSYEPSKRPNFKDLKTRL
             . .| .|. ||.|.|..||.|..|. .|
WMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
TyrKc FAK.AA TyrKc 391-583 30 4.5e-74 253.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 391-583
Range on HMM: 1-280/280
Sequence Identity: 30% (87 aa)

VTLVETIGQGQFGDVHKGIYIDQ---------------------MRMF------------------------------------------LQAHKDELTL
.|| ...| |.|| |.||... .                     |...                                          |..|...|..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM

ASLILYAYQLSMALSYLESKKFVHRDIAARNLLVVAKDNVKLGDFGLSRLLHDH-------SYYKAS---KGK--LPIKWMAPESINFRRFTSASDVWMF
. |. ...| .   .||.||...|||.|||| || ..  || .|||||| ..|.       .||...    ||  |||.|||||.||...||..||||.|
KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSF

GVCMWEILMYGVKPFQG-----VKNNEVIGRIENGERLPMPAA--------CPPTLYSVMTLCWSYEPSKRPNFKDLKTRL
|||||||. || .|  |     ..| ||| ....|.|.| |.         ||. .|..|. || ..|..||.|.... ..
GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase FAK.AA Ack 418-583 39 4.7e-74 249.2 In-house 93-266 (266) Show / Hide 
Range on Protein: 418-583
Range on HMM: 93-266/266
Sequence Identity: 39% (68 aa)

LQAHKD--ELTLASLILYAYQLSMALSYLESKKFVHRDIAARNLLVVAKD-NVKLGDFGLSR-LLHDHSYYKASKGK---LPIKWMAPESINFRRFTSAS
| .|.    .... |  .. |. |...|||.| ..||| ||||.|. ..|  || .||||.| |.    ||. .  .   .|. |.|||....|.|..||
LRKHCRTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHAS

DVWMFGVCMWEILMYGVKPFQGVKNNEVIGRIE-NGERLPMPAACPPTLYSVMTLCWSYEPSKRPNFKDLKTRL
|||||||..||   || .|. |.   ... .|. .||||| | .||. .|..|  ||  .| .|| | ...  |
DVWMFGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase FAK.AA Syk 414-577 46 6.2e-70 238.65 In-house 91-257 (257) Show / Hide 
Range on Protein: 414-577
Range on HMM: 91-257/257
Sequence Identity: 46% (78 aa)

MRMFLQAHKDELTL-ASLILYAYQLSMALSYLESKKFVHRDIAARNLLVVAKDNVKLGDFGLSRLL-HDHSYYKA-SKGKLPIKWMAPESINFRRFTSAS
|  .|| |..| |  . | | . | .|   |||.|.||||| |||| | |..   |  |||.|. |  | .||.| . || |.|| |||.|... | ..|
MHKYLQQHRHEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKS

DVWMFGVCMWEILMYGVKPFQGVKNNEVIGRIENGERLPMPAACPPTLYSVMTLCWSYEPSKRPNFK
||| ||| ||| . || ||  . |. ||.  ||||.|.. |. ||. .|..| .||.|..  || | 
DVWSFGVTMWEMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase FAK.AA UTK 414-583 36 8.6e-68 230.98 In-house 97-296 (296) Show / Hide 
Range on Protein: 414-583
Range on HMM: 97-296/296
Sequence Identity: 36% (73 aa)

MRMFLQAHKDE-------LTLASLILYAYQLSMALSYLESKKFVHRDIAARNLLVVAK-------DNVKLGDFG---LSRLLH---------DHSYYKAS
.| .|. |...       ||| ... .|.. . ...||.|..|||||.|||| || .          .|..|||   .||...         .  ||.|.
LRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQ

-KGKLPIKWMAPESINFR-RFTSASDVWMFGVCMWEILMYGVKPFQGVKNNEVIGRIENG--ERLPMPAACPPTLYSVMTLCWSYEPSKRPNFKDLKTRL
  ...||.|||||... . |||..|||| ||| .|||...| .|. |  | .|. ...||   |.| |..|| ..| .|. || |.|..||.|.||  ..
HQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase FAK.AA EGFR 417-584 43 3e-65 215.52 In-house 90-258 (258) Show / Hide 
Range on Protein: 417-584
Range on HMM: 90-258/258
Sequence Identity: 43% (74 aa)

FLQAHKDELTLASLILYAYQLSMALSYLESKKFVHRDIAARNLLVVAKDNVKLGDFGLSRLL-HDHSYYKASKGKLPIKWMAPESINFRRFTSASDVWMF
... |||..    |.....|    ..||| .. |||| |||| ||     ||  ||||..|| ||   |.|. ||.|||||| |.| .|..|..|||| .
YVRQHKDNIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSY

GVCMWEILMYGVKPFQGVKNNEVIGRIENGERLPMPAACPPTLYSVMTLCWSYEPSKRPNFKDLKTRLK
|| .||.. .| ||..|.. .|.   .|.||||| |  |   .| ||  ||   .  || || | ...|
GVTCWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase FAK.AA Src 417-583 43 9.4e-62 208.57 In-house 84-255 (255) Show / Hide 
Range on Protein: 417-583
Range on HMM: 84-255/255
Sequence Identity: 43% (75 aa)

FLQ--AHKDELTLASLILYAYQLSMALSYLESKKFVHRDIAARNLLVVAKDNVKLGDFGLSRLLH--DHSYYKASKGKLPIKWMAPESINFRRFTSASDV
.|.      .| |  ||  | | .   .||||....||| |||| ||  .  .| .|||| ||.   |  |   .  |.||||.||| ||..|||  |||
YLKKDGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDV

WMFGVCMWEILMYGVKPFQGVKNNEVIGRIENGERLPMPAACPPTLYS-VMTLCWSYEPSKRPNFKDLKTRL
| ||. ..||  ||  |  | .| ||. ..|.| |.|.|. ||. ||  .|. ||  .| .|| |. |   |
WSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FAK.AA TK-Unique 422-583 38 2e-60 207.03 In-house 125-294 (294) Show / Hide 
Range on Protein: 422-583
Range on HMM: 125-294/294
Sequence Identity: 38% (65 aa)

KDELTLASLILYAYQLSMALSYLES--KKFVHRDIAARNLLVVAKDNVKLGDFGLSR-LLHDHSYYKA-SKGKLPIKWMAPESIN--FRRF-TSASDVWM
...... .|. .|.|. ....||.|  ||.||||..||| |.  . ..|..|||..| . ... | .  |.|..||.||||||.    . . |. ||||.
TEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWS

FGVCMWEILMYGVKPFQGVKNNEVIGRIENGERLPMPAAC-PPTLYSVMTLCWSYEPSKRPNFKDLKTRL
||| ||||. .|  |. |... ... .|..| |.| |. | ....|..|  ||..||..||.| ..| ||
FGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FAK.AA Eph 417-583 42 2.7e-59 197.76 In-house 94-264 (264) Show / Hide 
Range on Protein: 417-583
Range on HMM: 94-264/264
Sequence Identity: 42% (72 aa)

FLQAHKDELTLASLILYAYQLSMALSYLESKKFVHRDIAARNLLVVAKDNVKLGDFGLSRLLHDHS----YYKASKGKLPIKWMAPESINFRRFTSASDV
||  | ...| . |.   . .  .  || .  .|||| |||| || ..   |  ||||||.| | .     |  . || ||.| ||| | .|.|||||||
FLRQHDGQFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDV

WMFGVCMWEILMYGVKPFQGVKNNEVIGRIENGERLPMPAACPPTLYSVMTLCWSYEPSKRPNFKDLKTRL
| .|. |||.. || .|.    | .||  || | ||| |  ||. |.  |  || .....|| |...   |
WSYGIVMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase FAK.AA Fer 417-584 34 7.5e-58 195.6 In-house 99-283 (283) Show / Hide 
Range on Protein: 417-584
Range on HMM: 99-283/283
Sequence Identity: 34% (63 aa)

FLQAHKDE-LTLASLILYAYQLSMALSYLESKKFVHRDIAARNLLVVA-KDNVK--LGDFGLSRL--LHDHSYYKA-SKGKLPIKWMAPESINFRRFTSA
.|.  |.. .... .| ..|| .  . ||.||. .|||||||| |. . |...|  . |||.||    . ..|...    |.||.|.|||..... ....
YLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPK

SDVWMFGVCMWEILMYGVKPFQG----VKNNEV----IGR-IENGERLPMPAACPPTLYSVMT-LCWSYEPSKRPNFKDLKTRLK
.||| ||| .||| . | .|. |    .|...|    . . |..| ..|||  .||.....|.  || ..|..||..|... .||
TDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase FAK.AA Pkinase_Tyr 591-690 50 2.3e-57 194.91 Pfam 169-270 (270) Show / Hide 
Range on Protein: 591-690
Range on HMM: 169-270/270
Sequence Identity: 50% (52 aa)

KKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMYGVKP-FQGVKNNEVIGRI-ENGERLPMPAACPPTLYSVMTLCWSYEPSKRPNFKDLKT
.|...|||||||||||.||...||..||||.|||.||||. || .| ..|..|.||. .| |.|.|.|.|  ||. .|..|..|| |.|..|| |...  
RKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHE

RL
.|
QL
Kinase FAK.AA TK 591-690 33 1.3e-49 164.01 In-house 340-486 (486) Show / Hide 
Range on Protein: 591-690
Range on HMM: 340-486/486
Sequence Identity: 33% (49 aa)

KKASKGKLPIKWMAPESIN---------FRRFTSASDVWMFGVCMWEILMYGVKPFQGVKNN----------EVIGRIEN------------GERLPMP-
...|.|||||.|||||..|         ...||..||||.|||.||||..|| .|. |  .|          ||. ....            |.|..|| 
RQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQ

-AACP--------------PTLYSVMTLCWSYEPSKRPNFKDLKTRL
 . ||              . .| .|. ||.|.|..||.|..|. .|
PPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FAK.AA Ack 597-690 43 1.6e-46 154.95 In-house 172-266 (266) Show / Hide 
Range on Protein: 597-690
Range on HMM: 172-266/266
Sequence Identity: 43% (41 aa)

KLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMYGVKPFQGVKNNEVIGRIE-NGERLPMPAACPPTLYSVMTLCWSYEPSKRPNFKDLKTRL
|.|. |.|||....|.|..|||||||||..||   || .|. |.   ... .|. .||||| | .||. .|..|  ||  .| .|| | ...  |
KVPFAWCAPECLRHRQFSHASDVWMFGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase FAK.AA Syk 596-684 48 1.7e-44 151.09 In-house 169-257 (257) Show / Hide 
Range on Protein: 596-684
Range on HMM: 169-257/257
Sequence Identity: 48% (43 aa)

GKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMYGVKPFQGVKNNEVIGRIENGERLPMPAACPPTLYSVMTLCWSYEPSKRPNFK
|| |.|| |||.|... | ..|||| ||| ||| . || ||  . |. ||.  ||||.|.. |. ||. .|..| .||.|..  || | 
GKWPVKWYAPECIYYYKFSHKSDVWSFGVTMWEMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase FAK.AA UTK 591-690 41 8.1e-43 144.3 In-house 194-296 (296) Show / Hide 
Range on Protein: 591-690
Range on HMM: 194-296/296
Sequence Identity: 41% (43 aa)

KKASKGKLPIKWMAPESINFR-RFTSASDVWMFGVCMWEILMYGVKPFQGVKNNEVIGRIENG--ERLPMPAACPPTLYSVMTLCWSYEPSKRPNFKDLK
.... ...||.|||||... . |||..|||| ||| .|||...| .|. |  | .|. ...||   |.| |..|| ..| .|. || |.|..||.|.|| 
MAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLV

TRL
 ..
QQM
Kinase FAK.AA Eph 596-690 47 1.2e-42 141.05 In-house 170-264 (264) Show / Hide 
Range on Protein: 596-690
Range on HMM: 170-264/264
Sequence Identity: 47% (45 aa)

GKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMYGVKPFQGVKNNEVIGRIENGERLPMPAACPPTLYSVMTLCWSYEPSKRPNFKDLKTRL
|| ||.| ||| | .|.|||||||| .|. |||.. || .|.    | .||  || | ||| |  ||. |.  |  || .....|| |...   |
GKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase FAK.AA EGFR 592-691 44 5.7e-40 130.29 In-house 159-258 (258) Show / Hide 
Range on Protein: 592-691
Range on HMM: 159-258/258
Sequence Identity: 44% (44 aa)

KASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMYGVKPFQGVKNNEVIGRIENGERLPMPAACPPTLYSVMTLCWSYEPSKRPNFKDLKTRLN
.|. ||.|||||| |.| .|..|..|||| .|| .||.. .| ||..|.. .|.   .|.||||| |  |   .| ||  ||   .  || || | ....
HAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase FAK.AA Src 597-690 48 1.3e-39 132.26 In-house 161-255 (255) Show / Hide 
Range on Protein: 597-690
Range on HMM: 161-255/255
Sequence Identity: 48% (46 aa)

KLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMYGVKPFQGVKNNEVIGRIENGERLPMPAACPPTLYS-VMTLCWSYEPSKRPNFKDLKTRL
|.||||.||| ||..|||  |||| ||. ..||  ||  |  | .| ||. ..|.| |.|.|. ||. ||  .|. ||  .| .|| |. |   |
KFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FAK.AA TK-Unique 587-690 39 8.5e-39 131.45 In-house 187-294 (294) Show / Hide 
Range on Protein: 587-690
Range on HMM: 187-294/294
Sequence Identity: 39% (43 aa)

RLQNKKASKGKLPIKWMAPESIN--FRRF-TSASDVWMFGVCMWEILMYGVKPFQGVKNNEVIGRIENGERLPMPAAC-PPTLYSVMTLCWSYEPSKRPN
. .... |.|..||.||||||.    . . |. ||||.||| ||||. .|  |. |... ... .|..| |.| |. | ....|..|  ||..||..||.
GVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPS

FKDLKTRL
| ..| ||
FRQIKHRL
Kinase FAK.AA Fer 590-691 31 8.1e-37 122.98 In-house 167-283 (283) Show / Hide 
Range on Protein: 590-691
Range on HMM: 167-283/283
Sequence Identity: 31% (37 aa)

NKKASK-----GKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMYGVKPFQG----VKNNEV----IGR-IENGERLPMPAACPPTLYSVMT-LCWS
.....|      |.||.|.|||..... .....||| ||| .||| . | .|. |    .|...|    . . |..| ..|||  .||.....|.  || 
YGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQ

YEPSKRPNFKDLKTRLN
..|..||..|... .|.
KDPEDRPTMKEICQKLK
Kinase FAK.AA Pkinase 425-583 20 2.9e-19 69.19 Pfam 103-293 (293) Show / Hide 
Range on Protein: 425-583
Range on HMM: 103-293/293
Sequence Identity: 20% (40 aa)

L--TLASLILYAYQLSMALSYLESKKFVHRDIAARNLLVVAKDNV----KLGDFGLSRL--LHDHSYYKASKGKLPIKWMAPESIN-FRRFTSASDVWMF
.  .   .. |.||.  .| |. |....|||.   |.|.. ....    |..||||...  .   | ..   | ..  .|||| |.  .  ....|.| .
FYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW--YMAPEVIRGGQYYGPKVDMWSC

GVCMWEILMYGVKPFQGV----KNNEVIGRIENGERLPMPAACP-----------------------PTLYSVMTLCWSYEPSKRPNFKDLKTR--L
|. ..| |  |  ||.|     . .. . .|..  . | .  .|                       ... .... |. . |.|||......    .
GCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
S_TKc FAK.AA S_TKc 391-584 17 3.5e-15 45.74 SMART 1-231 (231) Show / Hide 
Range on Protein: 391-584
Range on HMM: 1-231/231
Sequence Identity: 17% (45 aa)

VTLVETIGQGQFGDVHKGIYID----------------------------------------------------QMRMFLQAHKDE-----LTLASLILY
 .....||.| || |.|.. ..                                                     .. ... .. .     ..      |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

AYQLSMALSYLESKKFVHRDIAARNLLVVAKDNVKLGDFGLSRLLHDHSYYKASKGKLPIKWMAPESINFRRFTS-ASDVWMFGVCMWEILMYGVKPFQG
.||.  || |. |....|||.   |.|.    ..|..||||.|.|        .       .|||| .    ..  ..|.| .|....| |  |  ||. 
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP-

VKNNEVIGRIENGERLPMPAACPPTLYSVMTLCWSYEPSKRPNFKDLKT--------RLK
   .... .|            .| . . .  |. ..|.|||   .. .           
-QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FAK.AA Pkinase 602-690 18 8.8e-09 32.13 Pfam 177-293 (293) Show / Hide 
Range on Protein: 602-690
Range on HMM: 177-293/293
Sequence Identity: 18% (22 aa)

WMAPESIN-FRRFTSASDVWMFGVCMWEILMYGVKPFQGV----KNNEVIGRIENGERLPMPAACP-----------------------PTLYSVMTLCW
.|||| |.  .  ....|.| .|. ..| |  |  ||.|     . .. . .|..  . | .  .|                       ... .... |.
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

SYEPSKRPNFKDLKTR--L
 . |.|||......    .
CKDPKKRPTAEQILQHPWF
Kinase FAK.AA FAK 391-411 57 1.2e-07 21.57 In-house 1-21 (285) Show / Hide 
Range on Protein: 391-411
Range on HMM: 1-21/285
Sequence Identity: 57% (12 aa)

VTLVETIGQGQFGDVHKGIYI
.||   || ||||||..|.|.
ITLNRCIGEGQFGDVYQGVYT
Kinase FAK.AA TK 391-414 37 2.6e-07 19.76 In-house 1-27 (486) Show / Hide 
Range on Protein: 391-414
Range on HMM: 1-27/486
Sequence Identity: 37% (10 aa)

VTLVETIGQGQFG---DVHKGIYIDQM
.||....|.||||   .|.||......
ITLGKKLGEGQFGSFGEVYKGEWRGRN
Pkinase_Tyr FAK.AA Pkinase_Tyr 391-410 40 2e-06 22.13 Pfam 1-20 (270) Show / Hide 
Range on Protein: 391-410
Range on HMM: 1-20/270
Sequence Identity: 40% (8 aa)

VTLVETIGQGQFGDVHKGIY
.|. ...|.|.||.|.||..
ITFGKKLGEGAFGEVYKGTW
Kinase FAK.AA UTK 391-410 50 3e-06 17.39 In-house 1-20 (296) Show / Hide 
Range on Protein: 391-410
Range on HMM: 1-20/296
Sequence Identity: 50% (10 aa)

VTLVETIGQGQFGDVHKGIY
| | ...|||.||.|||. .
VQLGRQLGQGAFGEVHKARF
Kinase FAK.AA Src 391-410 45 4e-06 16.93 In-house 1-20 (255) Show / Hide 
Range on Protein: 391-410
Range on HMM: 1-20/255
Sequence Identity: 45% (9 aa)

VTLVETIGQGQFGDVHKGIY
..|.. .||||||.| .|..
IKLCRKLGQGQFGEVWMGYW
Kinase FAK.AA EGFR 391-411 47 0.000112 11.26 In-house 1-21 (258) Show / Hide 
Range on Protein: 391-411
Range on HMM: 1-21/258
Sequence Identity: 47% (10 aa)

VTLVETIGQGQFGDVHKGIYI
. .|   | | || |.|||.|
LKKVKVLGSGAFGTVYKGIWI
Kinase FAK.AA TK-Unique 391-410 35 0.000118 12.11 In-house 1-20 (294) Show / Hide 
Range on Protein: 391-410
Range on HMM: 1-20/294
Sequence Identity: 35% (7 aa)

VTLVETIGQGQFGDVHKGIY
... ..||.|.|| |..| .
LEVGDVIGEGAFGQVWRGEV
Kinase FAK.AA Eph 391-408 38 0.000229 10.42 In-house 1-18 (264) Show / Hide 
Range on Protein: 391-408
Range on HMM: 1-18/264
Sequence Identity: 38% (7 aa)

VTLVETIGQGQFGDVHKG
... . || |.||.| .|
IKIEKVIGAGEFGEVCCG
Kinase FAK.AA Fer 391-408 55 0.000348 10.28 In-house 1-18 (283) Show / Hide 
Range on Protein: 391-408
Range on HMM: 1-18/283
Sequence Identity: 55% (10 aa)

VTLVETIGQGQFGDVHKG
||| . .| | ||.|.||
VTLGKKLGEGAFGEVYKG
Kinase FAK.AA Ack 391-408 50 0.000366 9.95 In-house 1-18 (266) Show / Hide 
Range on Protein: 391-408
Range on HMM: 1-18/266
Sequence Identity: 50% (9 aa)

VTLVETIGQGQFGDVHKG
.|| | .|.| || |..|
ITLCEKLGDGCFGVVWRG
Kinase FAK.AA Syk 391-410 50 0.004272 6.48 In-house 1-20 (257) Show / Hide 
Range on Protein: 391-410
Range on HMM: 1-20/257
Sequence Identity: 50% (10 aa)

VTLVETIGQGQFGDVHKGIY
. . . ||.| || |||| |
LVQDNEIGCGNFGSVHKGWY
Kinase FAK.AA Pkinase 391-412 31 0.053035 8.16 Pfam 1-22 (293) Show / Hide 
Range on Protein: 391-412
Range on HMM: 1-22/293
Sequence Identity: 31% (7 aa)

VTLVETIGQGQFGDVHKGIYID
 .....||.| || | |.. ..
YHIGRKIGSGSFGCVYKCHHKG
Focal_AT FAK.AA Focal_AT 947-1085 58 1.5e-96 331.86 Pfam 1-139 (139) Show / Hide 
Range on Protein: 947-1085
Range on HMM: 1-139/139
Sequence Identity: 58% (81 aa)

TLDMDRTDDYVFENTTQVVRAVMEMVNLVHAVKSDQYVNLVRDIGLALKSLLGSVDTLYSDLPGETHRGIQMAHKVLSSDMGELINAMKLAQKYATTTLD
|..|||.||||..|..|||..||||.|.||...|..|||.|...||.|..||.|||..|..||...||.|.||||||..||.|||..|.|||.||.||||
TANMDRSDDYVYCNVMQVVKSVMEMKNKVHKLPSEEYVNMVKNVGLELRKLLQSVDEIYPSLPAQCHREIEMAHKVLNKDMHELISKMRLAQQYAMTTLD

QDYKRGMIQAGHVLAVDAKNLLDAVDTARLQAQDIFMGG
|..|..|..|.||||.||||||||||.||...|...|..
QECKKQMLTAAHVLAMDAKNLLDAVDQARVRMQHAHMPH