Gene Musk (Sea Urchin)

Musk

Species: Sea Urchin
Alias: Musk, SPU_024610, Spk279
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: Musk

Sequence

Name Sequence Type Origin Length Description Download
Musk.AA Protein None 838 None Fasta, JSON
Musk.kin_dom Protein Kinase Domain None 280 None Fasta, JSON

Protein domain

Protein domains of Musk.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG Musk.AA IG 116-203 21 3e-16 61.25 SMART 1-58 (58) Show / Hide 
Range on Protein: 116-203
Range on HMM: 1-58/58
Sequence Identity: 21% (20 aa)

LRNKTVELGDDVRLRCHVDPGSALQSEIWWKFNGIPIGDSAFFSIKSKARSSSLKINGASLEHA---GVYTCVVENQFGKTAS-PPVHLVVL
 .  || .|..|.|.| |        .|||.                      | | ....|..   |.|.|...   |.. | ....| |.
PP-VTVKEGETVTLTC-VS-------QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set Musk.AA I-set 109-192 22 2.8e-10 37.4 Pfam 1-83 (92) Show / Hide 
Range on Protein: 109-192
Range on HMM: 1-83/92
Sequence Identity: 22% (20 aa)

PMIEKSGLRNKTVELGDDVRLRCHVDPGSALQS-EIWWKFNGIPIGD-SAFFSIKSKA-RSSSLKINGASLEHAGVYTCVVENQFGK
| ...   .. .|  |...|. |.|   .     .. |. .| |.   |  .... .    ..| | ..  . .|.||||..| ||.
PKFTQKP-KDVEVQEGETARFECQV---TGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGE
IGc2 Musk.AA IGc2 122-191 23 5.8e-09 37.01 SMART 1-56 (56) Show / Hide 
Range on Protein: 122-191
Range on HMM: 1-56/56
Sequence Identity: 23% (17 aa)

ELGDDVRLRCH--VDPGSALQSEIWWKFNGIPIGDSAFFSIKSKARSSSLKINGASLEHAGVYTCVVENQFG
. |..|.|.|.   .|.   .    |.. | |.             ...|.|  ...|..|.|||...|  |
HEGQSVTLTCPATGNPDPNIH----WYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Musk.AA V-set 91-202 18 3.5e-07 26.59 Pfam 1-128 (128) Show / Hide 
Range on Protein: 91-202
Range on HMM: 1-128/128
Sequence Identity: 18% (26 aa)

EEEVKP-PEEMQQPVTGSRPMIEKSGLRNKTVELGDDVRLRCHVDPGS--ALQS-EIWWKFNGIPIGDSAFFSI-------------------KSKAR--
 ..|.. |.. . |                ||..|..|.|.||.  ..    ..  | | .   | | .  . |                   | . .  
QSQVTQHPPRGC-PW-------------WVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFS

------SSSLKINGASLEHAGVYTCVVENQFGKTASPPVHLVV
      . ||.|. ..... |.|.|.| |    .  . ..|.|
GNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set Musk.AA I-set 206-248 34 3.8e-09 33.57 Pfam 1-43 (92) Show / Hide 
Range on Protein: 206-248
Range on HMM: 1-43/92
Sequence Identity: 34% (15 aa)

PTIVKGPGNHSVGYGQLLNLSCTVEASPPPRVAWFKNTEPLPQ
|.... | .  |  |. ....|.|. .||| | |||. .||..
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRP
IGc2 Musk.AA IGc2 218-274 32 3.8e-05 24.24 SMART 1-56 (56) Show / Hide 
Range on Protein: 218-274
Range on HMM: 1-56/56
Sequence Identity: 32% (19 aa)

GYGQLLNLSCTVEASPPPRVAWFKNTEPLPQWTGKEMIVINVT--QSATYSCFYRNVIK
  || . | | ....| | . |.|  .|||  ....  . |||  .| .|.|. || . 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP--WNWTLTIKNVTPEDSGYYTCYARNPWG
IG Musk.AA IG 212-289 16 0.000318 21.28 SMART 1-58 (58) Show / Hide 
Range on Protein: 212-289
Range on HMM: 1-58/58
Sequence Identity: 16% (14 aa)

PGNHSVGYGQLLNLSCTVEASPPPRVAWFKNTEPLPQWTGKEMIVINVTQS-----ATYSCFYRNVIKNEDKFAA-KYGVVTVT
|. ..|  |. ..|.| |.     .. |.             ... ||. .     .|| |  .       .  . .   .||.
PP-VTVKEGETVTLTC-VS-----QIWWY-------------LTI-NVQPEDSQQHGTYYCQAT-----HGQYWSIQGTTLTVQ
Kinase Musk.AA Musk 550-821 61 2.3e-226 755.45 In-house 1-282 (282) Show / Hide 
Range on Protein: 550-821
Range on HMM: 1-282/282
Sequence Identity: 61% (174 aa)

VIYEKDIGEGAFGRVFMASAPKLVAGEAETSVAVKMLKATADKVVTEYFNREAQMIARFSHQNIVKLLGVCFVGRPLCLLLEYMSEGDLEDYLHSRSPHR
.||..|||||||||||.|.||.||..|.||.|||||||..|.|.....|.|||.|.|.|.|.||||||||||||||.|||.|||..|||...|||.||||
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

SNSRTSNSPG----------SGLKTYEKLNMAKQIACGMAYLNEMMFVHRDIATRNCLINSRTDVKISDFGLARYVGHKECFVGHKEEHIPIRWTAPEAL
..|||....|          ..||.|..|.||||||||||||.||||||||.||||||||...||||.||||.||..|.....||...||||||..||..
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESI

WDYQFTYASDVWSFGVLLWELFSYAEQPYLNLSHEDVFLHTRQGYRLSSLENTPQKVHQIMGECWQANPADRPFFKQLQDSL
|..||||.||||..||.|||.||||.|||....||.|....|||..||..||.||||.|.|..|||.||||||||.|.....
WYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase Musk.AA Pkinase_Tyr 550-821 39 2e-115 391.55 Pfam 1-270 (270) Show / Hide 
Range on Protein: 550-821
Range on HMM: 1-270/270
Sequence Identity: 39% (110 aa)

VIYEKDIGEGAFGRVFMASAPKLVAGEAETSVAVKMLKATADKVV--TEYFNREAQMIARF-SHQNIVKLLGVCF-VGRP--LCLLLEYMSEGDLEDYLH
..  | .||||||.|... .     .. .. ||||||| .|..     | | |||..   . .|.|||.|.|||   |.|  ... .|||  ||| |||.
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SRSPHRSNSRTSNSPGSGLKTYEKLNMAKQIACGMAYLNEMMFVHRDIATRNCLINSRTDVKISDFGLARYVGHKECF-VGHKEEHIPIRWTAPEALWDY
...          ...  |.. ..|.|. |||.||.|| .. ..|||.|.||||...   |||.||||||.. ...   . ...  .||.|.|||.. ..
KHR----------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYG

QFTYASDVWSFGVLLWELFSYAEQP-YLNLSHEDVFLHT-RQGYRLSSLENTPQKVHQIMGECWQANPADRPFFKQLQDSL
 || .|||||||||.||.|.| ||| | ..| |.|. .  ..|||.   ||.|......| .||...|.||| |....  |
KFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Musk.AA TyrKc 550-821 36 1.2e-114 388.06 SMART 1-280 (280) Show / Hide 
Range on Protein: 550-821
Range on HMM: 1-280/280
Sequence Identity: 36% (112 aa)

VIYEKDIGEGAFGRVFMASAPKLVAGEAETSVAVKMLKATADKVVTEYFNREAQMIARF--SHQNIVKLLGVCFVG-------RPLCLLLEYMSEGDLED
.  .| .||||||.|. . .         . |||||||. |     | | |||..  ..  .|.|||.|.|||  .        ||....|||. ||| |
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLHSRSPHRSNSRTSNSPGSGLKTYEKLNMAKQIACGMAYLNEMMFVHRDIATRNCLINSRTDVKISDFGLARYVGHK-------ECFVG--HKEEH--I
||... |.             |.. ..|... ||||||.|| .. ..|||.|.||||....  ||||||||.|.....       .  .   || ..  .
YLRKHRPK-------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML

PIRWTAPEALWDYQFTYASDVWSFGVLLWELFSYAEQPYLN-----LSHEDVFLHTRQGYRLSSLEN--------TPQKVHQIMGECWQANPADRPFFKQ
||||.|||.. .. || .||||||||..||.|.| .||| .     .| ..|. . .||||.   .|         |....||| .||...|.||| |..
PIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

LQDSL
. . .
IHECF
Kinase Musk.AA TK 550-821 22 3.3e-108 363.97 In-house 1-486 (486) Show / Hide 
Range on Protein: 550-821
Range on HMM: 1-486/486
Sequence Identity: 22% (110 aa)

VIYEKDIGEGAFG---RVFMASAPKLV--------------------AGEAETSVAVKMLKATADKVVTEYFN-------------REAQMIARFS----
....| .|||.||   .|... .  .                      ....| |||||||....   .| |              .||.... ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HQNIVKLLGVCFVG------------RPLCLLLEYMSEGD----LEDYLHSRSPHRSNSRTSNS-----------------------------------
 |.|||.|.|||. |            .|.....|||. ||    | |||....|.....  ...                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------------------------PGSGLKTYEKLNMAKQIACGMAYLNEM------MFVHRDIATRNCLINSRTD-----------VKISDFG---
                           . . | . ..| |. ||||||.|| ..       |||||.|.||||....             .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARYVGHKECFVGHK------------------------EEHIPIRWTAPEALW---------DYQFTYASDVWSFGVLLWELFSYA-EQPYLNL
     |||......  . ..                           .||||.|||.|          .  || .|||||||||.||.|.|. |..| ..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SH---------EDVFLHTRQG--------------YRLSSLENTP--------------QKVHQIMGECWQANPADRPFFKQLQDSL
|.         ..|. . |.|              .|.   .. |              . ....| .||...|.||| |.||.. |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Musk.AA UTK 550-821 33 1.6e-93 317.04 In-house 1-296 (296) Show / Hide 
Range on Protein: 550-821
Range on HMM: 1-296/296
Sequence Identity: 33% (101 aa)

VIYEKDIGEGAFGRVFMASAPKLVAGEAETSVAVKMLKATADKVVTE----YFNREAQ---MIARFS-HQNIVKLLGVCFVGRPLCLLLEYMSEGDLEDY
|.  ...|.|||| |..|.. .    . |  |||| ....||.  ..    .| .||.   | ..|. |.|...|.|||. . |.....|||..||| .|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LHSRSPHRSNSRTSNSPGSGLKTYEKLNMAKQIACGMAYLNEMMFVHRDIATRNCLINSR-------TDVKISDFG---LARYVG---------HKECFV
| . .|          ..  |.  ..| || .||.||.|| .. |||||.| ||||...        ...||.|||   ..|.|.           . . 
LRRHRPTPP------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYM

GHKEEHIPIRWTAPEALWDY-QFTYASDVWSFGVLLWELFSYAEQPYLNLSHEDVFLHTRQG--YRLSSLENTPQKVHQIMGECWQANPADRPFFKQLQD
 .  . .||||.||||| .  .|| .||||||||..||..... .|| ..|...|..  . |  ||. . .  |  | ..| .||...|..|| |..| .
AQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQ

SL
 .
QM
Kinase Musk.AA Trk 550-821 40 2.4e-85 289.28 In-house 1-275 (275) Show / Hide 
Range on Protein: 550-821
Range on HMM: 1-275/275
Sequence Identity: 40% (113 aa)

VIYEKDIGEGAFGRVFMASAPKLVAGEAETSVAVKMLKATADKVVTEYFNREAQMIARFSHQNIVKLLGVCFVGRPLCLLLEYMSEGDLEDYLHSRSPHR
..  ...||||||.||.|   .|.  .  . |||| ||  ..    . |.|||..     ||.|||. |||  ..|| .  |||  |||  || .. |  
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKDASE-NARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDA

SNSRTSNSP---GSGLKTYEKLNMAKQIACGMAYLNEMMFVHRDIATRNCLINSRTDVKISDFGLARYVGH-KECF-VGHKEEHIPIRWTAPEALWDYQF
.   . . |      |   . |  ||||| || |. .  |||||.||||||.  . .|||.|||. | |    . . |||.    ||||  ||.    .|
M-CYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHH-TMLPIRWMPPESIMYRKF

TYASDVWSFGVLLWELFSYAEQPYLNLSHEDVFLHTRQGYR-LSSLENTPQKVHQIMGECWQANPADRPFFKQLQDSL
|| |||||||| .|| |.|  ||.  ||   |   . ||   |   .  || | .||  |||  |  |   |.. | .
TYESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase Musk.AA Src 550-821 36 1.9e-80 273.04 In-house 1-255 (255) Show / Hide 
Range on Protein: 550-821
Range on HMM: 1-255/255
Sequence Identity: 36% (99 aa)

VIYEKDIGEGAFGRVFMASAPKLVAGEAETSVAVKMLKATADKVVTEYFNREAQMIARFSHQNIVKLLGVCFVGRPLCLLLEYMSEGDLEDYLHSRSPHR
.  .. .|.| || |.|.          .| |||| ||.      .| | .|||    ..|...|.|. ||  . |     ||||.| | |||.      
IKLCRKLGQGQFGEVWMG------YWNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-----

SNSRTSNSPGSGLKTYEKLNMAKQIACGMAYLNEMMFVHRDIATRNCLINSRTDVKISDFGLARYVG-HKECFVGHKEEHIPIRWTAPEALWDYQFTYAS
      .. |. |.  . . || |.| ||||| .| ..||| | || |..    .|. |||||| .   ..  . ...  .||.||||||.   .||  |
------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKS

DVWSFGVLLWELFSYAEQPYLNLSHEDVFLHTRQGYRLSSLENTPQKVHQ-IMGECWQANPADRPFFKQLQDSL
||||||.||.|...|   ||   . ..|. .  .|||.   .| |..... || .||.. | .|| |. ||. |
DVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase Musk.AA TK-Unique 550-821 32 1e-78 267.83 In-house 1-294 (294) Show / Hide 
Range on Protein: 550-821
Range on HMM: 1-294/294
Sequence Identity: 32% (97 aa)

VIYEKDIGEGAFGRVFMASAPKLVAGEAET-SVAVKMLKATADKV-VTEYFNREAQMIARFSHQNIVKLLGVCFVGR-PLCLLLEYMSEGDLEDYLH-SR
.  .. ||||||| |. . . .. ... .. .|||||||. |... . ..... ..| .   |.|||..||.|     | ....||.. |.|..||. .|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

SPHRSN-----------SRTSNSPGSGLKTYEKLNMAKQIACGMAYLNE--MMFVHRDIATRNCLINSRTDVKISDFGLARYVGHKECFVGH-KEEHIPI
 ..|..           ....  . . ..    .. |.||||||.|| .  ...||||...||.|....  .||.|||.||.| . .  .   ... |||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWTAPEALW--DYQF-TYASDVWSFGVLLWELFSYAEQPYLNLSHEDVFLHTRQGYRLSSLENT-PQKVHQIMGECWQANPADRPFFKQLQDSL
|| |||.|   . .. |. |||||||||.||.|.. ..|| ... .|.  . |.|||.   |.  .. ....| .||| .| .|| | |. . |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase Musk.AA InsR 550-823 37 1.8e-76 256.39 In-house 1-278 (278) Show / Hide 
Range on Protein: 550-823
Range on HMM: 1-278/278
Sequence Identity: 37% (105 aa)

VIYEKDIGEGAFGRVFMASAPKLVAGEAET--SVAVKMLKATA-DKVVTEYFNREAQMIARFSHQNIVKLLGVCFVGRPLCLLLEYMSEGDLEDYLHSRS
..  .  |.|.|| |    |  .|..|...   .|.| ... | ..  .|. | ||    .| . ..|.|||||  | |     | |  ||| .|| || 
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLN-EASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRR

PHRSNSRTSNSPGSG----LKTYEKL-NMAKQIACGMAYLNEMMFVHRDIATRNCLINSRTDVKISDFGLARYVGHKECFVGHKEEHIPIRWTAPEALWD
|        | ||        ..... .|| .|. |||||.   ||||| | |||..|    ||| |||..| .         .    |.|| ||| | |
PEEEF----NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKD

YQFTYASDVWSFGVLLWELFSYAEQPYLNLSHEDVFLHT-RQGYRLSSLENTPQKVHQIMGECWQANPADRPFFKQLQDSLAS
  || .||||||||.|||  . .||||  || | |     . |  |  .|| |......|  ||| .| .|| |... ..|  
GVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase Musk.AA CTKA 550-821 37 5.7e-74 247.92 In-house 1-290 (290) Show / Hide 
Range on Protein: 550-821
Range on HMM: 1-290/290
Sequence Identity: 37% (111 aa)

VIYEKDIGEGAFGRVFMASAPKLVAGEAE---------TSVAVKMLKATADKVVTEYFNREAQMIA--RFSHQNIVKLLGVCFVGRPLCLLLEYMSEGDL
      |||| .| || |    .  .. .         . |||||||. |     . |  || . .   |.| |.. |||||    |.    |.|. |||
HCIMFKIGEGHYGQVFRA----WLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDL

EDYLH-SRSPH---------RSNSRTSNSPGSGLKTYEKLNMAKQIACGMAYLNEMMFVHRDIATRNCLINSRTDVKISDFGLARYVGHK-ECFVGHKEE
  ||  .|.           ||  | |  | . ....|.  || ||| || || || ||||| | ||||. .   .||.|||..|        ..  .  
HCYLRACRPADGQVCPARARRSIPR-SFHPIE-VHAHEQVYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQR

HIPIRWTAPEALWDYQFTYASDVWSFGVLLWELFSYAEQPYLNLSHEDVFLHTRQG--YRLSSLENTPQKVHQIMGECWQANPADRPFFKQLQDSL
 .|.|| |||||    |. |||||.|||||||..| .| |.. .|   |      .   ||    | || .   | |||.  |. || | .|| .|
VMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase Musk.AA Eph 550-821 38 6.7e-73 244.19 In-house 1-264 (264) Show / Hide 
Range on Protein: 550-821
Range on HMM: 1-264/264
Sequence Identity: 38% (107 aa)

VIYEKDIGEGAFGRVFMASAPKLVAGEAET---SVAVKMLKATADKVVTEYFNREAQMIARFSHQNIVKLLGVCFVGRPLCLLLEYMSEGDLEDYLHSRS
.  || ||.| || |      ||  |..|.    ||.|.|||..       | .||  .  |.| ||..| ||   .||.  . |||  | | ..|  . 
IKIEKVIGAGEFGEVCCGRL-KLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHD

PHRSNSRTSNSPGSGLKTYEKLNMAKQIACGMAYLNEMMFVHRDIATRNCLINSRTDVKISDFGLARYVGHKE----CFVGHKEEHIPIRWTAPEALWDY
               ...   . | . || || || .| .|||| | || |.||.   |.||||| | .  ..     .       ||||||||||.   
G-------------QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTR-GGKIPIRWTAPEAIAYR

QFTYASDVWSFGVLLWELFSYAEQPYLNLSHEDVFLHTRQGYRLSSLENTPQKVHQIMGECWQANPADRPFFKQLQDSL
.|| ||||||.|...||  || | || ..|  ||     ||||| .  . |.  ||.| .|||  ...|| |.|..  |
KFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase Musk.AA Fer 550-822 31 2.2e-70 238.92 In-house 1-283 (283) Show / Hide 
Range on Protein: 550-822
Range on HMM: 1-283/283
Sequence Identity: 31% (92 aa)

VIYEKDIGEGAFGRVFMA--SAPKLVAGEAET---SVAVKMLKAT-ADKVVTEYFNREAQMIAR-FSHQNIVKLLGVCFVGRPLCLLLEYMSEGDLEDYL
|. .| .|||||| |. .      . .. ...    |.||..|.. |.|   . | .||...   ..| |.||. |||    |. ...|... |.|..||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

HSRSPHRSNSRTSNSPGSGLKTYEKLNMAKQIACGMAYLNEMMFVHRDIATRNCLINS-RTDVK--ISDFGLARY-VGHKECFVGH-KEEHIPIRWTAPE
   .               ... ||..|. |.||||.|| ..  .||||| ||||.    . .|  |||||..|   ....    . |.. .||||.|||
KKNKNK------------TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPE

ALWDYQFTYASDVWSFGVLLWELFSYAEQPYLN---------LSHEDVFLHTRQGYRLSSLENTPQKVHQIMG-ECWQANPADRPFFKQLQDSLA
.. .  .....|||||||..|| |. ...||..         .  ...   .. ||..   ...|  . |||   |||..| ||| .|...  | 
TWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase Musk.AA S_TKc 550-829 23 3.9e-45 157.19 SMART 1-231 (231) Show / Hide 
Range on Protein: 550-829
Range on HMM: 1-231/231
Sequence Identity: 23% (67 aa)

VIYEKDIGEGAFGRVFMASAPKLVAGEAETSVAVKMLKATADKVVTEYFNREAQMIARFSHQNIVKLLGVCFVGRPLCLLLEYMSE--GDLEDYLHSRSP
    . ||.||||.|. .   |         ||.|..|        | . || |.  .  | |||||..|.     |.. .||..   ||| ||...| .
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

HRSNSRTSNSPGSGLKTYEKLNMAKQIACGMAYLNEMMFVHRDIATRNCLINSRTDVKISDFGLARYVGHKECFVGHKEEHIPIRWTAPEALWDYQFTY-
|. .        ...   .   ...||.|...|. .. ..|||.   | |...   .||.|||||| .         .       . ||| |   .... 
HGLR--------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKC

ASDVWSFGVLLWELFSYAEQPYLNLSHEDVFLHTRQGYRLSSLENTPQKVHQIMGECWQANPADRPFFKQLQD-SLASMECEWL
..|.||.|..|.|...  . |.    .... ..             .. . ...  |.| .|..||   ..    .. .  .|.
KCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Musk.AA Pkinase 550-713 26 2.5e-26 94.17 Pfam 1-160 (293) Show / Hide 
Range on Protein: 550-713
Range on HMM: 1-160/293
Sequence Identity: 26% (48 aa)

VIYEKDIGEGAFGRVFMASAPKLVAGEAETS--VAVKMLKATADKVVTEYFNR---EAQMIARFSHQNIVKLLGVCFVGRPLCLLLEYMSEG----DLED
   .. ||.|.||.|         . .  |.  |||| .|   .|   .. .|   |.|. .|..| |||.|....  .. ... .||.  |    || |
YHIGRKIGSGSFGCV-------YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

YLHSRSPHRSNSRTSNSPGSGL--KTYEKLNMAKQIACGMAYLNEMMFVHRDIATRNCLINSRTDV----KISDFGLAR
|..             . . ..     |  ....||..|..|. .| ..|||.   |.||... ..    ||.|||||.
YIST------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAK
Kinase Musk.AA Pkinase 731-821 14 5.8e-07 25.69 Pfam 175-293 (293) Show / Hide 
Range on Protein: 731-821
Range on HMM: 175-293/293
Sequence Identity: 14% (17 aa)

IRWTAPEALW-DYQFTYASDVWSFGVLLWELFSYAEQPYLNL----SHEDVFLHTRQGYRLSSLENTP-----------------------QKVHQIMGE
... ||| .  .   ....|.||.|..|.|...  . |. .     .  |     ..  .    .. |                       .   ...  
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

CWQANPADRPFFKQLQDS--L
|.. .|..|| ..|.  .  .
CLCKDPKKRPTAEQILQHPWF