Gene Tie (Sea Urchin)

Tie

Species: Sea Urchin
Alias: Tie, Spk301, SPU_024044
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: Tie

Sequence

Name Sequence Type Origin Length Description Download
Tie.AA Protein None 1693 None Fasta, JSON
Tie.kin_dom Protein Kinase Domain None 196 None Fasta, JSON

Protein domain

Protein domains of Tie.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG Tie.AA IG 125-206 14 0.041359 9.27 SMART 1-58 (58) Show / Hide 
Range on Protein: 125-206
Range on HMM: 1-58/58
Sequence Identity: 14% (13 aa)

HFTMTASPGDNITITMQITTRTRTPDYLIWAHDELPLPYNATRFGFKDRYSIPAVGQEDA---GIYQAYPPDDPTQGG--YMRLIVR
   .|...|...|.|  ..       .. |                     |  |  ||.   |.|.       .. .    .|.|.
PP-VTVKEGETVTLTC-VS-------QIWWY------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
EGF_2 Tie.AA EGF_2 221-248 35 2e-08 29.82 Pfam 1-29 (29) Show / Hide 
Range on Protein: 221-248
Range on HMM: 1-29/29
Sequence Identity: 35% (11 aa)

CPTCSN-GGECDDV-TGVCVCPPG-FHGDTC
|  |.. .| |..  .|.|.|..| ..||.|
C--CNGHHGTCNNQGCGKCQCDDGWWQGDHC
EGF Tie.AA EGF 216-249 32 5.4e-05 23.83 SMART 1-32 (32) Show / Hide 
Range on Protein: 216-249
Range on HMM: 1-32/32
Sequence Identity: 32% (13 aa)

GCTNECPTCSNG-----GECDDVTGVCVCP-PGFHGDTCE
 |      |..|     |.|   .  | || ||..| .||
ECA----PCHHGGCEQHGTCI--SYTC-CPGPGYTG-RCE
EGF_CA Tie.AA EGF_CA 219-249 41 0.00031 8.84 SMART 3-34 (34) Show / Hide 
Range on Protein: 219-249
Range on HMM: 3-34/34
Sequence Identity: 41% (15 aa)

NECPTCSNGG---ECDDVTG--VCVCPPGFHGDTCE
.||  |.|||    | .  |   | ||||..  .||
DEC-PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE
Laminin_EGF Tie.AA Laminin_EGF 225-249 26 0.000749 16.77 Pfam 8-41 (59) Show / Hide 
Range on Protein: 225-249
Range on HMM: 8-41/59
Sequence Identity: 26% (9 aa)

SNG-GECDD-------VTGVCV-CPPGFHGDTCE
| . ..||        .||.|. | ... |. |.
SVNDDQCDPDDEHCGKHTGQCHNCKHNVTGRHCD
EGF Tie.AA EGF 217-247 30 0.009712 12.22 Pfam 1-36 (36) Show / Hide 
Range on Protein: 217-247
Range on HMM: 1-36/36
Sequence Identity: 30% (11 aa)

CTNECPTCSNGGECDDV--TGVCVCPPG---FHGDT
|. .   |...|.| |.  .  | ||||   ..|..
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF Tie.AA EGF 264-295 26 0.05433 11.74 SMART 1-32 (32) Show / Hide 
Range on Protein: 264-295
Range on HMM: 1-32/32
Sequence Identity: 26% (10 aa)

MCTGNSCEH-----MQFCLPDPYGCSCA-TGFAGLACD
 |    |.|      . |.   | | |.  |. |  | 
ECA--PCHHGGCEQHGTCI--SYTC-CPGPGYTG-RCE
EGF_2 Tie.AA EGF_2 311-336 32 0.081805 9.16 Pfam 1-29 (29) Show / Hide 
Range on Protein: 311-336
Range on HMM: 1-29/29
Sequence Identity: 32% (10 aa)

CHCEN-GGLCDPYAG---CLCVGN-WTGPTC
| | . .| |. . |   | |  . |.|..|
C-CNGHHGTCNNQ-GCGKCQCDDGWWQGDHC
EGF Tie.AA EGF 265-293 30 0.149888 8.25 Pfam 1-36 (36) Show / Hide 
Range on Protein: 265-293
Range on HMM: 1-36/36
Sequence Identity: 30% (11 aa)

CTGN--SCEHMQFCLPDP--YGCSCATG---FAGLA
|. |   | |  .|.. |  | | |. |   ..|  
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF Tie.AA EGF 306-337 28 0.431841 1.46 SMART 1-32 (32) Show / Hide 
Range on Protein: 306-337
Range on HMM: 1-32/32
Sequence Identity: 28% (11 aa)

GCLQTCHCENG-----GLCDPYAGCLCV-GNWTGPTCE
 |.    |..|     | |     | |    .|| .||
ECA---PCHHGGCEQHGTCI-SYTC-CPGPGYTG-RCE
EGF_2 Tie.AA EGF_2 298-307 45 2.526681 4.5 Pfam 19-29 (29) Show / Hide 
Range on Protein: 298-307
Range on HMM: 19-29/29
Sequence Identity: 45% (5 aa)

CPDG-HYGAGC
|.|| ..|. |
CDDGWWQGDHC
Laminin_EGF Tie.AA Laminin_EGF 283-307 30 5.874961 2.95 Pfam 28-59 (59) Show / Hide 
Range on Protein: 283-307
Range on HMM: 28-59/59
Sequence Identity: 30% (10 aa)

CS-CATGFAGLACDEACPDGHYG------A-GC
|. |  ...|  ||. | .|..|      . ||
CHNCKHNVTGRHCDR-CKPGYWGDPWCDPPQGC
EGF_2 Tie.AA EGF_2 351-380 27 0.016317 11.35 Pfam 1-29 (29) Show / Hide 
Range on Protein: 351-380
Range on HMM: 1-29/29
Sequence Identity: 27% (10 aa)

CADSGECQN-GGTCD-PCLG---CLCTED-LAGPTC
|     |.. .|||. .  |   | |.     |..|
C-----CNGHHGTCNNQ--GCGKCQCDDGWWQGDHC
EGF Tie.AA EGF 350-381 28 0.168749 6.12 SMART 1-32 (32) Show / Hide 
Range on Protein: 350-381
Range on HMM: 1-32/32
Sequence Identity: 28% (11 aa)

LCADSGECQNG-----GTCDPCLGCLCT-EDLAGPTCQ
 ||    |..|     |||     | |  .   | .|.
ECA---PCHHGGCEQHGTCI-SYTC-CPGPGYTG-RCE
EGF Tie.AA EGF 351-379 22 5.705279 2.97 Pfam 1-36 (36) Show / Hide 
Range on Protein: 351-379
Range on HMM: 1-36/36
Sequence Identity: 22% (8 aa)

CADS-GECQNGGTCDPCL---GCLCTED---LAGPT
|..  . |...||| .      | |..     .|..
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
IG Tie.AA IG 490-576 15 4.4e-08 34.09 SMART 1-58 (58) Show / Hide 
Range on Protein: 490-576
Range on HMM: 1-58/58
Sequence Identity: 15% (14 aa)

WLAEVVNLDQRAKFHCRVEGLSYQDVNVTLVTPSSHVIESGELVGPTSSPTFLFSIPGVTKGDE---GTYHCIADGITGSDQQ--ECSLEVF
    .|.. ......| |.       ....                       . | .|.. |.   ||| | |    |....  .  |.|.
PP-VTVKEGETVTLTC-VS-------QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set Tie.AA I-set 545-575 35 3e-06 23.84 Pfam 62-92 (92) Show / Hide 
Range on Protein: 545-575
Range on HMM: 62-92/92
Sequence Identity: 35% (11 aa)

IPGVTKGDEGTYHCIADGITGSDQQECSLEV
| .|...|||.| |.|    |... ...|.|
ISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 Tie.AA IGc2 496-565 17 0.00025 16.38 SMART 1-56 (56) Show / Hide 
Range on Protein: 496-565
Range on HMM: 1-56/56
Sequence Identity: 17% (12 aa)

NLDQRAKFHCRVEGLSYQDVNVTLVTPSSHVIESGELVGPTSSPTFLFSIPGVTKGDEGTYHCIADGITG
. .| . . |...|    ..  .     .  ..               .|  ||..|.|.|.|.| .  |
HEGQSVTLTCPATGNPDPNIHWYK----GQPLP----------WNWTLTIKNVTPEDSGYYTCYARNPWG
FN3 Tie.AA FN3 579-664 14 0.001543 19.0 SMART 1-69 (69) Show / Hide 
Range on Protein: 579-664
Range on HMM: 1-69/69
Sequence Identity: 14% (14 aa)

PVPVNS---PIIVDTNSR------AVEINLNIDEYTGDGPIQGVELQYKRVGGDAWTPMTVSINEASAAVVPNLVHN----QDYEVRVVLWRRGSGGRG
| |.     . ..|..|.       |..  .             ...|.                   ..|..|. .    . ||.||.   ....|.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-----------IVGYR-------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 Tie.AA FN3 679-762 16 0.000197 21.97 SMART 1-69 (69) Show / Hide 
Range on Protein: 679-762
Range on HMM: 1-69/69
Sequence Identity: 16% (16 aa)

PTAEFW---LRLTTPIEE----WSSIELNWSQIRDTGDELSGFRIEYQKSGGSVRTVEIPDSGTRTHKLTGLLAN----THYTVILIPFNC--GGDS
| .      ||.|   .     | |..| |.            ...|.                  ...||| ..    | |.. .. .|   .| .
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP----------IVGYR------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 Tie.AA FN3 776-861 22 3.8e-11 44.28 SMART 1-69 (69) Show / Hide 
Range on Protein: 776-861
Range on HMM: 1-69/69
Sequence Identity: 22% (22 aa)

PGPVGN---FQLTVTSSD------TITASWRIPEETRGDIVHYSIKVFEKVDGVVSDTAHWDDTTQNTVSQIFNLKPY----TSYVVEVYARTV-LVGEI
|||..|   ...| ..|.      ..| ||  |      ||.|.                           . .|||.    | |.. |.|..   .|| 
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR-------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 Tie.AA FN3 874-959 21 2.8e-12 48.03 SMART 1-69 (69) Show / Hide 
Range on Protein: 874-959
Range on HMM: 1-69/69
Sequence Identity: 21% (21 aa)

SGPPST---PSVIGQTMD-----TRMSFAWRPPPVDQRNGVIIVYEWNVMYVTTDGVYQSDVENVTETLATLTNLIPN----RRYTFKVRAFTL--EGPG
 |||.    ..|   | .     . ..  | ||        |. |.                       .|.|.| |.     .|.|.|||..    |.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--------IVGYR-----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 Tie.AA FN3 1145-1230 20 5.9e-10 40.32 SMART 1-69 (69) Show / Hide 
Range on Protein: 1145-1230
Range on HMM: 1-69/69
Sequence Identity: 20% (20 aa)

PGPVGN---LQLIVKSSD------RITANWRIPEETRGVIQSYFIRVFEKVDGVVSDTALLDRRSDNTVFQIFDLKPY----TSYVVEVYATTK-HPSEG
|||..|   |..   .|.       .|  |  |      | .|                          . . .|||.    | |.. |.| .. .  ||
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR-------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 Tie.AA FN3 1245-1330 21 3.3e-12 47.78 SMART 1-69 (69) Show / Hide 
Range on Protein: 1245-1330
Range on HMM: 1-69/69
Sequence Identity: 21% (21 aa)

SGPPST---PSVIGQTMD-----TRMSFAWHPPPVDQRNGVIIVYEWNVMYVTTDGVYQSDVENVTETLATLTNLIPN----RRYTFKVRAFTL--EGPG
 |||.    ..|   | .     . ..  | ||        |. |.                       .|.|.| |.     .|.|.|||..    |.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--------IVGYR-----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase Tie.AA Tie 1498-1693 74 3.7e-165 507.19 In-house 1-196 (267) Show / Hide 
Range on Protein: 1498-1693
Range on HMM: 1-196/267
Sequence Identity: 74% (146 aa)

EGNFGQVMKATVKKDGGVIEVAVKTLKDGTSEADRKDFMGELEIMCKVGTHPNIVNLVGACEHQGILYVATEYARYGNLLNFLRSSRTIEADSPFPSSPT
||||||||||..||||...|||.|..|...||.|..|||||||.|||||.||||.||||||||.|.||||.|||.|||||.|||.||.||.|..|....|
EGNFGQVMKAMIKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAFAREHT

SRFKVNVSTSLTAEQILGFAADVALGMQHLAQKGCVHRDLAARNILVCDNYVCKVTDFGLSRSDEVYVKTTAGRLPVRWMAIESLNYSVYTTKSDV
.||||||...|...|||.||||||.|||.|.||.|.||||||||||||.|||||..||||||.||||||.|.||||||||||||||||||||||||
TRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRGDEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDV
Pkinase_Tyr Tie.AA Pkinase_Tyr 1489-1693 40 2e-90 306.87 Pfam 1-197 (270) Show / Hide 
Range on Protein: 1489-1693
Range on HMM: 1-197/270
Sequence Identity: 40% (88 aa)

LTLENFVIAEGNFGQVMKATVK--KDGGVIEVAVKTLKDGTSEAD--RKDFMGELEIMCKVGTHPNIVNLVGACE-HQGI--LYVATEYARYGNLLNFLR
.|.   .. ||.||.|.|.| |  .|.. |.||||.||.|... .  |.||| |..||.. | |||||.|.|.|  ...   .|. .||. .|.||..||
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SSRTIEADSPFPSSPTSRFKVNVSTSLTAEQILGFAADVALGMQHLAQKGCVHRDLAARNILVCDNYVCKVTDFGLSR---SDEVY-VKTTAGRLPVRWM
. |                  .   .|| ...|......| ||..|..|.|.||||||||.|| .| |.|..||||.|   .|. | .|.. |.||..||
KHR------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM

AIESLNYSVYTTKSDV
| |..||...||||||
APECINYGKFTTKSDV
Kinase Tie.AA TK 1490-1693 22 1.8e-77 259.12 In-house 1-377 (486) Show / Hide 
Range on Protein: 1490-1693
Range on HMM: 1-377/486
Sequence Identity: 22% (87 aa)

TLENFVIAEGNFG---QVMKATVK-----------------------KDGGVIEVAVKTLKDG--TSEADRKD--------------FMGELEIMCK-VG
     .. ||.||   .|.|....                       |.||...||||.||.|  .|.....|              .. |...||  .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

THPNIVNLVGACEHQ------------GILYVATEYARYGN----LLNFLRSSRTIEADSPFPSSPTSRFKVNVSTS-----------------------
 |||||.|.|.| ..            . ... .||. .|.    |...||..|  . ...  ... .. ... .                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSK-LHHCMKGDITYSHESNSPCPEEQD

--------------------------------LTAEQILGFAADVALGMQHLAQK------GCVHRDLAARNILVCDNYV-----------CKVTDFGLS
                                || .| | .....| ||..|..|      ..|||||||||.||..|.|           ||..|||||
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

R-----------SDEVYVKTT------------------------AGRLPVRWMAIESLN---------YSVYTTKSDV
|           ||. |....                         |.||.|||| |.||         | ..||||||
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDV
Kinase Tie.AA TK-Unique 1489-1693 35 1.2e-65 224.43 In-house 1-222 (294) Show / Hide 
Range on Protein: 1489-1693
Range on HMM: 1-222/294
Sequence Identity: 35% (83 aa)

LTLENFVIAEGNFGQVMKATVKK----DGGVIEVAVKTLKDGTSEADRKDFMGELEIMCKVGTHPNIVNLVGACEHQG-ILYVATEYARYGNLLNFLRSS
|.... || ||.|||| ...|..    ..  . ||||.|||. .. |..||. |...| ..| |||||...|.|   .   . . ||...|||...||..
LEVGD-VIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

RTI----------EADSPFPSSPTSRFK-----VNVSTS-LTAEQILGFAADVALGMQHLAQ--KGCVHRDLAARNILVCDNYVCKVTDFGLSR---SDE
|                         |.       ..|. .. .. . || ..| ||..||.  |..|||||.|||.|. ...|||..|||..|    ..
RPAMRQHQTYGNLK------------FDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNG

VYVKT-TAGRLPVRWMAIESLN--YSVY-TTKSDV
||... . ||.|.|||| |||   . .| ||||||
VYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDV
Kinase Tie.AA FGFR 1489-1693 43 1.5e-65 222.37 In-house 1-221 (293) Show / Hide 
Range on Protein: 1489-1693
Range on HMM: 1-221/293
Sequence Identity: 43% (97 aa)

LTLENFVIAEGNFGQVMKATVK---KD--GGVIEVAVKTLKDGTSEADRKDFMGELEIMCKVGTHPNIVNLVGACEHQGILYVATEYARYGNLLNFLRSS
|||   .. || |||| .|..|   .|     | |||| ||.. .. |  |   |.|.|  .| |.||.|| |.|  .| |||  ||.  |||  |||. 
LTLGK-MLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRAR

RTIE----ADSP-----FPSSPTSRFKVNVSTSLTAEQILGFAADVALGMQHLAQKGCVHRDLAARNILVCDNYVCKVTDFGLSR---SDEVYVKTTAGR
|  .     ||.      |..|.    ...   ||  .   .|  || ||. || . |.||||||||.|| |.|| |. ||||.|   . . | ||| ||
RPPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGR

LPVRWMAIESLNYSVYTTKSDV
||. ||| |.|   |||..|||
LPIKWMAPEALFDRVYTHQSDV
Kinase Tie.AA UTK 1498-1693 33 2.5e-58 198.17 In-house 9-223 (296) Show / Hide 
Range on Protein: 1498-1693
Range on HMM: 9-223/296
Sequence Identity: 33% (76 aa)

EGNFGQVMKATVKKDG---GVIEVAVKTLK-DGTSEADRK---DFMGELE---IMCKVGTHPNIVNLVGACEHQGILYVATEYARYGNLLNFLRSSRTIE
.|.||.| ||.....    ..  ||||... ..... ..    ||| |     .| ..  |||...||| |  .. ....|||.. |.|...||..|   
QGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTP

ADSPFPSSPTSRFKVNVSTSLTAEQILGFAADVALGMQHLAQKGCVHRDLAARNILVCDN-------YVCKVTDFG---LSRSDE------------VYV
                  ..|| .| |..|.|.| |||.|...|.|||||||||.||...       .|||. |||   .||                | 
P--------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYM

KTTAGRLPVRWMAIESLNYS-VYTTKSDV
.. ..|.|.|||| |.|..   .||||||
AQHQDRWPIRWMAPEALTHHTRFTTKSDV
Kinase Tie.AA VEGFR 1495-1693 35 5.4e-58 198.98 In-house 6-260 (332) Show / Hide 
Range on Protein: 1495-1693
Range on HMM: 6-260/332
Sequence Identity: 35% (90 aa)

VIAEGNFGQVMKAT---VKKDGGVIEVAVKTLKDGTSEADRKDFMGELEIMCKVGTHPNIVNLVGACEH---QGILYVATEYARYGNLLNFLRSSRTI--
.. .| ||||..|.   ..|  . . |||| || |      .  | ||...  .|.| | ||. |.|     .| | |  || ..|||.|.||. |    
MLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTKRMYFV

----------------------------EADSPFPSSPTSRFKVNVSTS---------------LTAEQILGFAADVALGMQHLAQKGCVHRDLAARNIL
                             . . | || .| |.   | .               || |  . ..  || ||  || . |.||||||||||
PYPDKSPHMRQRKECMGPQDHQDHKRRRDSGNSFQSSFGSFFRMKKSYDDVEPDEVFEDMWKDPLTMEDLICYSFQVARGMEFLASRKCIHRDLAARNIL

VCDNYVCKVTDFGLSRS----DEVYVKTTA-GRLPVRWMAIESLNYSVYTTKSDV
.| |.| |  ||||.|.    |  ||. .  |||| .|||.||.   ||||.|||
LCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDV
Kinase Tie.AA RTKB 1498-1693 36 3e-51 171.04 In-house 9-193 (264) Show / Hide 
Range on Protein: 1498-1693
Range on HMM: 9-193/264
Sequence Identity: 36% (72 aa)

EGNFGQVMKATVKKDGGV--IEVAVKTLKDGTSEADRKDFMGELEIMCKVGTHPNIVNLVGACEHQGILYVATEYARYGNLLNFLRSSRTIEADSPFPSS
.| ||.| .| |.  .      .|.|.|| | |. .| ||  |. .|  .|.|||.. ..| | .   . .  |.. .|||  .|| .|. . .      
NGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRASQHN------

PTSRFKVNVSTSLTAEQILGFAADVALGMQHLAQKGCVHRDLAARNILVCDNYVCKVTDFGLSR-SDEVYVKTTAGRLPVRWMAIESLNYSVYTTKS-DV
         . || ..| . |. ..| || .| |.. .||||.|||.||  .  ||. |||..| .|.  ..||. |||..|||.||. .. ||||| ||
---------PQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCTRLPIKWMAPESWAHRIYTTKSGDV
Kinase Tie.AA Src 1498-1693 36 3.7e-48 161.67 In-house 9-183 (255) Show / Hide 
Range on Protein: 1498-1693
Range on HMM: 9-183/255
Sequence Identity: 36% (73 aa)

EGNFGQVMKATVKKDGGVIEVAVKTLKDGTSEADRKDFMGELEIMCKVGTHPNIVNLVGACEHQGILYVATEYARYGNLLNFLRSSRTIEADSPFPSSPT
.|.|| | ... .   | ..||||||| ||   . ..|  | .|| |.  |...|.|   |      |  ||| . |.|| .|.                
QGQFGEVWMGYWN---GNTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK---------------

SRFKVNVSTSLTAEQILGFAADVALGMQHLAQKGCVHRDLAARNILVCDNYVCKVTDFGLSR--S--DEVYVKTTAGRLPVRWMAIESLNYSVYTTKSDV
         .|  .| . .|| || ||. | ..  .||||||||.|| .| |||| |||| |     |..|.  .  ..|..|.| | .|| ..|.||||
----DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDV
Kinase Tie.AA Ret 1489-1693 37 1.3e-47 160.7 In-house 1-220 (293) Show / Hide 
Range on Protein: 1489-1693
Range on HMM: 1-220/293
Sequence Identity: 37% (84 aa)

LTLENFVIAEGNFGQVMKAT---VKKDGGVIEVAVKTLKDG-TSEADRKDFMGELEIMCKVGTHPNIVNLVGACEHQG--ILYVATEYARYGNLLNFLRS
| |.  .  || ||||.||.   ..   |   |||| || .  . .  .|   |...  .|  ||... | |||  ..   . .  ||..|| |  ||| 
LQLDD-TLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRL

SRTI--EADSPFPSSPTSRFKVNV-STSLT-----AEQILGFAADVALGMQHLAQKGCVHRDLAARNILVCDNYVCKVTDFGLSR---SDEVYVKTTAGR
|| |     .   .   |          ..        |. ||  .  ||. |.    |||||||||.|| .  .||. ||||.|    |  |||   .|
SRKIGPYYEYSIGNRNCSIVDHPDGKDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDR

LPVRWMAIESLNYSVYTTKSDV
.|| |||||||   ||||||||
IPVKWMAIESLYDHVYTTKSDV
Kinase Tie.AA TyrKc 1489-1693 27 3.5e-47 163.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 1489-1693
Range on HMM: 1-280/280
Sequence Identity: 27% (86 aa)

LTLENFVIAEGNFGQVMKATVKKDGGVIEVAVKTLKDGTSEADRKDFMGELEIMCKVG-THPNIVNLVGACEHQ-------GILYVATEYARYGNLLNFL
.||.  .. ||.||.|.|.| |     |.||||.||...    |.||| |..||||.|  |||||.|.|.| .|       . |.. .||. .|.|...|
ITLGK-KLGEGAFGEVYKGTWK-----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RSSRTIEADSPFPSSPTSRFKVNVSTSLTAEQILGFAADVALGMQHLAQKGCVHRDLAARNILVCDNYVCKVTDFGLSRSDEVY--------VKTT----
|..|                       |. .. | |. ..| ||..|..|.|.||||||||.|| .|...|..||||||  . .        ....    
RKHRPK---------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHK

AGR--LPVRWMAIESLNYSVYTTKSD--------------------------------------------------------------------------
 |.  ||.||||.|..||...|||||                                                                          
GGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPED

----------V
           
RPTFSEIHECF
Kinase Tie.AA PDGFR 1605-1693 54 5.7e-33 102.92 In-house 195-286 (358) Show / Hide 
Range on Protein: 1605-1693
Range on HMM: 195-286/358
Sequence Identity: 54% (50 aa)

STSLTAEQILGFAADVALGMQHLAQKGCVHRDLAARNILVCDNYVCKVTDFGLSR---SDEVYVKTTAGRLPVRWMAIESLNYSVYTTKSDV
|  || .  |.|.  || ||  || | ||||||||||.|.|   | |. |||| |   .|  ||     |||| ||| ||.  .||||.|||
SNVLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDV
Kinase Tie.AA PDGFR 1499-1584 47 3.1e-27 84.2 In-house 10-98 (358) Show / Hide 
Range on Protein: 1499-1584
Range on HMM: 10-98/358
Sequence Identity: 47% (42 aa)

GNFGQVMKAT---VKKDGGVIEVAVKTLKDGTSEADRKDFMGELEIMCKVGTHPNIVNLVGACEHQGILYVATEYARYGNLLNFLRSSR
| ||.|. ||     | . |. |||| ||       .   | || ||   | | ||||| ||| | |  |. ||| .|| |||.|.. |
GAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKR
Kinase Tie.AA Pkinase 1495-1693 23 2.7e-24 86.97 Pfam 6-195 (293) Show / Hide 
Range on Protein: 1495-1693
Range on HMM: 6-195/293
Sequence Identity: 23% (50 aa)

VIAEGNFGQVMKATVKKDGGVIEVAVKTLKDGTSEADRKDFMG-----ELEIMCKVGTHPNIVNLVGACEHQGILYVATEYARYG----NLLNFLRSSRT
.| .|.||.| |.. |..|   .||||..|   .... .  .      |..|| ..  ||||| | ...|  . .|. .||.. |     |  ...    
KIGSGSFGCVYKCHHKGTGK--IVAVKIIK--KRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

IEADSPFPSSPTSRFKVNVSTSL--TAEQILGFAADVALGMQHLAQKGCVHRDLAARNILVCDNYVC----KVTDFGLSRS--DEVYVKTTAGRLPVRWM
                   ....  . ...  ..  .. |.... ..|..||||   |||. .|...    |..||||..      .. .|      ..|
-----------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYM

AIESLN-YSVYTTKSDV
| | .. .. |..|.|.
APEVIRGGQYYGPKVDM
Kinase Tie.AA S_TKc 1489-1687 18 4.6e-11 -14.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 1489-1687
Range on HMM: 1-231/231
Sequence Identity: 18% (48 aa)

LTLENFVIAEGNFGQVMKATVKKDGGVIEVAVKTLKDGTSEADRKDFMGELEIMCKVGTHPNIVNLVGACEHQGILYVATEYARY--GNLLNFLRSSRTI
 .. . .| .| ||.|.|.. ||     .||.| .|        .... |..|. |   |||||.| ..... . ||. .||.    |.|. .... .. 
YEILR-KIGKGAFGKVYKCRHKK--TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

EADSPFPSSPTSRFKVNVSTSLTAEQILGFAADVALGMQHLAQKGCVHRDLAARNILVCDNYVCKVTDFGLSRSD------------EVYVKTTA-----
  ..|                ..  ..  ... ........ ..| .||||   |||...  . |..||||.|              ||  . .      
GLRFP----------------FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVL-GYGKCKCDW

------------------------------------GRLPV-----RWMAIESLN-------YSVY
                                     .. .     |. | | |.           
WSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF