Gene TK8 (Sea Urchin)

TK8

Species: Sea Urchin
Alias: Spk266, TK8, SPU_004747
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: TK-Unique

Sequence

Name Sequence Type Origin Length Description Download
TK8.AA Protein None 464 None Fasta, JSON
TK8.kin_dom Protein Kinase Domain None 279 None Fasta, JSON

Protein domain

Protein domains of TK8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TK8.AA TK-Unique 156-431 50 6.00000000001e-159 534.35 In-house 1-294 (294) Show / Hide 
Range on Protein: 156-431
Range on HMM: 1-294/294
Sequence Identity: 50% (150 aa)

LVIGAVVGTGSFGKVVRGDAEGIIKPACKT-VVAIKMLKEHATGLDHQDLLKELSVMKLLKPHPNIVTLFGCCTKDGYESPLIIMEYLPNGNLLSHLRSS
|..| |.|.|.|| | ||...||.|. .|. .||.||||..||..|.||.|||...|| |..|||||...|||||.. |...|||||.|.|||...||..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC

RQ---RV-------EDFEMHRTSMRTT-LSPTDLIRYAYEIANGMAYLSS--MMCIHRDLAARNILLSRDGVCKLSDFGLARDVMNGGVYQRK-TQGRVP
|.   ..       .||.... ..||. .|| ||...|..||.||.||.|  ....||||.|||.||..|.|||..|||.||||...|||... .|||.|
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

IRWMALESLL--DNVY-TIQSDVWSFGVLMWEIVTIGSYPYPGVPSKKLIKDLQKGYRMPRPEHC-SEEIYSILLECWRDENKQRPTFDQLRHRL
|||||.|||.  ...| |..|||||||||||||.| |..||||.|.|........|||||.|||| |.|.|... .||..|...||.|.|..|||
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase TK8.AA Pkinase_Tyr 156-431 42 1.2e-128 436.38 Pfam 1-270 (270) Show / Hide 
Range on Protein: 156-431
Range on HMM: 1-270/270
Sequence Identity: 42% (119 aa)

LVIGAVVGTGSFGKVVRGDAEGIIKPACKTVVAIKMLKEHATGLD--HQDLLKELSVMKLLKPHPNIVTLFGCCT-KDGYESPLIIMEYLPNGNLLSHLR
...| . | |.||.|..| . |  .   |. ||.|||||.|.  .  ..|...|...|| |  ||||| | |.|| ...  ...|.||| |.|.||..||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SSRQRVEDFEMHRTSMRTTLSPTDLIRYAYEIANGMAYLSSMMCIHRDLAARNILLSRDGVCKLSDFGLARDVMNGGVY-QRKTQGRVPIRWMALESLLD
. |           . .  |.. ||. ....||.||.||.|. ||||||||||.|.....|.| .|||||||..| . | . .. |..||.|||.|.. .
KHR-----------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINY

NVYTIQSDVWSFGVLMWEIVTIGSYP-YPGVPSKKLIKDL-QKGYRMPRPEHCSEEIYSILLECWRDENKQRPTFDQLRHRL
...|..|||||||||||||.| |  | |||..   ... . ..|||||.||.|..|||.....||. . ..|||| .....|
GKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TK8.AA TyrKc 156-431 37 8.49999999999e-128 431.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 156-431
Range on HMM: 1-280/280
Sequence Identity: 37% (116 aa)

LVIGAVVGTGSFGKVVRGDAEGIIKPACKTVVAIKMLKEHATGLDHQDLLKELSVMKLL-KPHPNIVTLFGCCTKDGY-----ESPLIIMEYLPNGNLLS
.. | . | | ||.|..| .         . ||.|||||.|    ..|...|...|. | . ||||| |.|.||..|      | ..|.||| |.|.|..
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

HLRSSRQRVEDFEMHRTSMRTTLSPTDLIRYAYEIANGMAYLSSMMCIHRDLAARNILLSRDGVCKLSDFGLARDVMNG------GVYQRKT---QGR--
.||..| .              |.. ||. ... ||.||.||.|. ||||||||||.|.......| |||||.||. ..      . | ||.   .|.  
YLRKHRPK--------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTM

VPIRWMALESLLDNVYTIQSDVWSFGVLMWEIVTIGSYPYPG-----VPSKKLIKDLQKGYRMPRPEH--------CSEEIYSILLECWRDENKQRPTFD
.||||||.|.. ....|..||||||||.|||| | |  ||||     .. . .|.....|||||.|..        |..|.|.| ..||. . ..|||| 
LPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFS

QLRHRL
......
EIHECF
Kinase TK8.AA TK 156-431 25 1.4e-120 406.14 In-house 1-486 (486) Show / Hide 
Range on Protein: 156-431
Range on HMM: 1-486/486
Sequence Identity: 25% (125 aa)

LVIGAVVGTGSFG---KVVRGDAEGII--------------------KPACKTVVAIKMLKEHATGLDHQDLL-------------KELSVMKLLK----
...| . | | ||   .| .| ..|..                    |   || ||.|||||...  . . ..             .|...||...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHPNIVTLFGCCTKDGY----------ESPLIIMEYLPNGN----LLSHLRSSRQ-------------------------------RVEDFEMHRTSMR-
 ||||| |.|.||...           | ..|.||| |.|.    |...||..|                                ..|. ... .... 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

----------TTLSPTDLIR-------------------YAYEIANGMAYLSSMMC------IHRDLAARNILLSRDGV-----------CKLSDFG---
          ..|. .||..                   ... ||.||.||.|. |      .||||||||.|.....|           ||..|||   
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARDVMNGGVYQRKT------------------------QGRVPIRWMALESLLDNV---------YTIQSDVWSFGVLMWEIVTIGSYPYPG-V
     ||||. ... | ||.                        .|..|||||| |.|.|.|         .|..|||||||||||||.| |  ||.| .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PS---------KKLIKDLQKG--------------YRMPRPEHCS--------------EEIYSILLECWRDENKQRPTFDQLRHRL
..         . ... |..|              .|||.|.||.              ||.| ....||. . ..||||.||...|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TK8.AA FGFR 156-431 44 3.9e-114 385.47 In-house 1-293 (293) Show / Hide 
Range on Protein: 156-431
Range on HMM: 1-293/293
Sequence Identity: 44% (131 aa)

LVIGAVVGTGSFGKVVRGDAEGIIKP--ACKTVVAIKMLKEHATGLDHQDLLKELSVMKLLKPHPNIVTLFGCCTKDGYESPL-IIMEYLPNGNLLSHLR
|..|.. | | ||.|... |.|| .   . .. ||.||||. .|  |  ||  |. .||.   |.||. | |||| .|   || .| || . |||   ||
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEG---PLYVIVEYCHHGNLRDFLR

SSRQRV--EDFEMH-------RTSMRT-------TLSPTDLIRYAYEIANGMAYLSSMMCIHRDLAARNILLSRDGVCKLSDFGLARDVMNGGVYQRKTQ
. |      ...         |..  .        |.  ||.. || .| || || |  ||||||||||.| . | | | .|||||||. .   |  .| 
ARRPPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTN

GRVPIRWMALESLLDNVYTIQSDVWSFGVLMWEIVTIGSYPYPGVP-SKKLIKDLQKGYRMPRPEHCSEEIYSILLECWRDENKQRPTFDQLRHRL
|| || |||.|.| |.||| ||||||.|||.||| | |  |||..|    | | |. |.|| .|..||.||| .. .||. . .||||| ||   |
GRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase TK8.AA Tie 165-431 46 2.4e-96 293.77 In-house 2-267 (267) Show / Hide 
Range on Protein: 165-431
Range on HMM: 2-267/267
Sequence Identity: 46% (127 aa)

GSFGKVVRGDAEGIIKPACKTVVAIKMLKEHATGLDHQDLLKELSVMKLLKPHPNIVTLFGCCTKDGYESPLIIMEYLPNGNLLSHLRSSRQRVED--FE
| ||.|..     | |   |  |||||.|| |   ||.|   || ||  .  ||||. | | | . ||    . .|| | ||||  ||.||    |  | 
GNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYL--YVAIEYAPYGNLLDFLRKSRVIETDPAFA

MHRTS-----MRTTLSPTDLIRYAYEIANGMAYLSSMMCIHRDLAARNILLSRDGVCKLSDFGLARDVMNGGVYQRKTQGRVPIRWMALESLLDNVYTIQ
. .|.     . .|||   ....| ..|.|| |||   ||||||||||||     |||..||||.|      || .|| ||.|.||||.|||   ||| .
REHTTRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRGDE---VYVKKTMGRLPVRWMAIESLNYSVYTTK

SDVWSFGVLMWEIVTIGSYPYPGVPSKKLIKDLQKGYRMPRPEHCSEEIYSILLECWRDENKQRPTFDQLRHRL
|||||.|||.||||..|  || |.   .| . | .|||| .|  | .|.| .. .||||   .||.| |.  .|
SDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase TK8.AA UTK 156-431 32 2.3e-91 309.86 In-house 1-296 (296) Show / Hide 
Range on Protein: 156-431
Range on HMM: 1-296/296
Sequence Identity: 32% (100 aa)

LVIGAVVGTGSFGKVVRGDAEGIIKPACKTVVAIKMLKEHATGLDHQD----LLKELS---VMKLLKPHPNIVTLFGCCTKDGYESPLIIMEYLPNGNLL
. .|.  | | || | ..... .  .. . .||.| ...||.. . ..    ...|     .|| .. |||.. | | ||...   ..|..|| .||.|.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP--WMIVTEYMENGDLR

SHLRSSRQRVEDFEMHRTSMRTTLSPTDLIRYAYEIANGMAYLSSMMCIHRDLAARNILLSRDG-------VCKLSDFG---LARDVM---------NGG
| ||..|. ..         .. |. .... .|. ||.||.||.|. ..||||||||.|. ...       |||..|||   ..|.|          .  
SYLRRHRPTPP-------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESY

VYQRKTQGRVPIRWMALESLLDN-VYTIQSDVWSFGVLMWEIVTIGSYPYPGVPSKKLIKDLQKG--YRMPRPEHCSEEIYSILLECWRDENKQRPTFDQ
 |..  |.|.|||||| |.| ..  .|..||||||||..|||.| |. ||||    .... . .|  ||||.|..|....| ....||. .   ||.|..
YYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFED

LRHRL
|. ..
LVQQM
Kinase TK8.AA Src 156-431 37 1.3e-89 304.02 In-house 1-255 (255) Show / Hide 
Range on Protein: 156-431
Range on HMM: 1-255/255
Sequence Identity: 37% (106 aa)

LVIGAVVGTGSFGKVVRGDAEGIIKPACKTVVAIKMLKEHATGLDHQDLLKELSVMKLLKPHPNIVTLFGCCTKDGYESP-LIIMEYLPNGNLLSHLRSS
.      |.| || |  |   | .|      ||.| ||.    .. ...|.|  .|| |. |...| |.  |...    | .|. ||  .|.||  |.  
IKLCRKLGQGQFGEVWMGYWNGNTK------VAVKTLKPGT--MSPEAFLQEAQIMKKLR-HEKLVQLYAVCSQEE---PIYIVTEYMSHGSLLDYLKK-

RQRVEDFEMHRTSMRTTLSPTDLIRYAYEIANGMAYLSSMMCIHRDLAARNILLSRDGVCKLSDFGLARDVMNGG--VYQRKTQGRVPIRWMALESLLDN
           ..   .|. ..||  |  .|.|||||.||  |||||||||.| . . |||  |||||| ..  .  .|  ..  ..||.|.| | .. .
-----------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYG

VYTIQSDVWSFGVLMWEIVTIGSYPYPGVPSKKLIKDLQKGYRMPRPEHCSEEIYS-ILLECWRDENKQRPTFDQLRHRL
..|| |||||||.|..|||| | .||||   .  .. ...|||||.|..| .|.|  |.|.||. . .|||||. |.. |
RFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase TK8.AA Ret 276-433 52 1.5e-83 283.89 In-house 136-293 (293) Show / Hide 
Range on Protein: 276-433
Range on HMM: 136-293/293
Sequence Identity: 52% (83 aa)

DLIRYAYEIANGMAYLSSMMCIHRDLAARNILLSRDGVCKLSDFGLARDVMNGGVYQRKTQGRVPIRWMALESLLDNVYTIQSDVWSFGVLMWEIVTIGS
..| .|  |  ||.|||.|  .||||||||.|.    .|| ||||| |||   . | .. ..|.|. ||| ||| |.||| .|||||||||.|||||.| 
MIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGA

YPYPGVPSKKLIKDLQKGYRMPRPEHCSEEIYSILLECWRDENKQRPTFDQLRHRLET
 ||||.|  .|   |  |||| ||| ||||.|.|.. ||..|   || |  .   .| 
NPYPGIPPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase TK8.AA VEGFR 276-431 51 2.1e-80 273.4 In-house 174-332 (332) Show / Hide 
Range on Protein: 276-431
Range on HMM: 174-332/332
Sequence Identity: 51% (82 aa)

DLIRYAYEIANGMAYLSSMMCIHRDLAARNILLSRDGVCKLSDFGLARD-VMNGGVYQRKTQ-GRVPIRWMALESLLDNVYTIQSDVWSFGVLMWEIVTI
||| |.. .|.|| .|.|  |||||||||||||. . | | .||||||.    .  | ||.. || ||.|||.||. |.|||..|||||.||..||| . 
DLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSL

GSYPYPGVP-SKKLIKDLQKGYRMPRPEHCSEEIYSILLECWRDENKQRPTFDQLRHRL
|  |||||    .... |  |||| .|. |  ||| | |.||. | ..||.|. | ..|
GGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase TK8.AA InsR 156-433 36 5.8e-80 268.25 In-house 1-278 (278) Show / Hide 
Range on Protein: 156-433
Range on HMM: 1-278/278
Sequence Identity: 36% (103 aa)

LVIGAVVGTGSFGKVVRGDAEGIIKPACKT--VVAIKMLKEHATGLDHQDLLKELSVMKLLKPHPNIVTLFGCCTKDGYESPLIIMEYLPNGNLLSHLRS
.|...  | ||||.|  | |.||..    .   .||| ..| |.  .  . |.| ||||  . | ..| |.| |..   .  ...||    |.| |.|||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCH-HVVRLLGVCSR--GQPMYVVMEMMTYGDLKSYLRS

SRQRVEDFEMHRTSMRTTLSPTDLIRYAYEIANGMAYLSSMMCIHRDLAARNILLSRDGVCKLSDFGLARDVMNGGVYQRKTQGRVPIRWMALESLLDNV
 |  .|. .. ..      .. ...  | ||. ||||| .   .|||||.|| . ..|. .|  |||..||.     | . . |  |.|||| ||| | |
RRPEEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGV

YTIQSDVWSFGVLMWEIVTIGSYPYPGVPSKKLIKDL-QKGYRMPRPEHCSEEIYSILLECWRDENKQRPTFDQLRHRLET
.| .||||||||..||.|| |. || |       |     |  . .|| |.|  . .   ||.   | |||| .. | |  
FTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase TK8.AA PDGFR 272-431 51 1.6e-72 232.08 In-house 198-358 (358) Show / Hide 
Range on Protein: 272-431
Range on HMM: 198-358/358
Sequence Identity: 51% (83 aa)

LSPTDLIRYAYEIANGMAYLSSMMCIHRDLAARNILLSRDGVCKLSDFGLARDVMNGGVYQRKTQGRVPIRWMALESLLDNVYTIQSDVWSFGVLMWEIV
|. .||. ..| .|.||..| |  |.||||||||.||    | |  |||||||.||   |  |   | |. ||| ||. |.|||.||||||.|.| ||| 
LTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIF

TIGSYPYPGVP-SKKLIKDLQKGYRMPRPEHCSEEIYSILLECWRDENKQRPTFDQLRHRL
. |. ||||.|  .|  |  ..|||| .|.| .||||.|  .||  . ..|||| ||   |
SLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase TK8.AA Pkinase 156-431 24 7.6e-50 176.71 Pfam 1-293 (293) Show / Hide 
Range on Protein: 156-431
Range on HMM: 1-293/293
Sequence Identity: 24% (78 aa)

LVIGAVVGTGSFGKVVRGDAEGIIKPACKTVVAIKMLKEHATGL-DHQDLLK--ELSVMKLLKPHPNIVTLFGCCTKDGYESPLIIMEYLPNG----NLL
..|| ..| ||||.| ..   |  |     .||.| .| . .    .| ...  |...|| |  |||||.|.....     .. ..|||...|     | 
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLF

SHLRSSRQRVEDFEMHRTSMRTTL--SPTDLIRYAYEIANGMAYLSSMMCIHRDLAARNILLSRDGVC----KLSDFGLARDVMNGGVYQRKTQGRVPIR
....              ......  |. ....|.|.|. |..|. || .|||||   |||....|..    |..|||||. .     ..  |   . ..
DYIST-------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPW

WMALESLL-DNVYTIQSDVWSFGVLMWEIVTIGSYPYPGV-------PSKKLIKDLQKGYRMPRPEHCS-------------------EEIYSILLECWR
.|| | .. .. |.  .|.||.|....| .. |  |.||        . ... ..... .. ..|. ||                   ||  ...  |..
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

DENKQRPTFDQLRHR--L
   |.|||..|. .   .
KDPKKRPTAEQILQHPWF
Kinase TK8.AA S_TKc 156-435 23 6.1e-47 163.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 156-435
Range on HMM: 1-231/231
Sequence Identity: 23% (68 aa)

LVIGAVVGTGSFGKVVRGDAEGIIKPACKTVVAIKMLKEHATGLDHQDLLKELSVMKLLKPHPNIVTLFGCCTKDGYESPLIIMEYLPN--GNLLSHLRS
  |. ..| |.|||| ..   .      . .||||..|        .....|....|    |||||.|....     ..  ..|||...  |.|......
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKK

SRQRVEDFEMHRTSMRTTLSPTDLIRYAYEIANGMAYLSSMMCIHRDLAARNILLSRDGVCKLSDFGLARDVMNGGVYQRKTQGRVPIRWMALESLLDNV
 . .           |  ... .  .|.|.|.....|. |.  |||||   ||||..  . |..|||||| .         |   .   .|| | |    
RGRHG---------LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---G

YTI-QSDVWSFGVLMWEIVTIGSYPYPGVPSKKLIKDLQKGYRMPRPEHCSEEIYSILLECWRDENKQRPTFDQLRH-----RLETIL
|.   .|.||.|....| .. |  |.|    ....| .            |.|  ...  |.. . ..|||  .. .     ..   .
YGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TK8.AA VEGFR 156-256 43 4.8e-25 89.53 In-house 1-102 (332) Show / Hide 
Range on Protein: 156-256
Range on HMM: 1-102/332
Sequence Identity: 43% (44 aa)

LVIGAVVGTGSFGKVVRGDAEGIIKPACKTVVAIKMLKEHATGLDHQDLLKELSVMKLLKPHPNIVTLFGCCTKDGYESPL-IIMEYLPNGNLLSHLRSS
| .| . | | ||.|. ..| || | .  |.|| ||||| || . |  |. || ... .  | | | . |||||.    || .|.|| . |||.. ||. 
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

RQ
|.
RM
Kinase TK8.AA Ret 156-255 36 1.1e-23 77.8 In-house 1-100 (293) Show / Hide 
Range on Protein: 156-255
Range on HMM: 1-100/293
Sequence Identity: 36% (37 aa)

LVIGAVVGTGSFGKVVRGDAEGIIKPACKTVVAIKMLKEH-ATGLDHQDLLKELSVMKLLKPHPNIVTLFGCCTKDGYESPLIIMEYLPNGNLLSHLRSS
|. . . | | ||.||.. |  |   .  | ||.||||.  |.     ||| |. . |..  ||... |.| |. |.   ...| ||   | | . || |
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQVN-HPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLS

R
|
R
Kinase TK8.AA PDGFR 156-255 42 6.9e-23 69.98 In-house 1-98 (358) Show / Hide 
Range on Protein: 156-255
Range on HMM: 1-98/358
Sequence Identity: 42% (43 aa)

LVIGAVVGTGSFGKVVRGDAEGIIKPACKTVVAIKMLKEHATGLDHQDLLKELSVMKLLKPHPNIVTLFGCCTKDGYESP-LIIMEYLPNGNLLSHLRSS
|. | . | | ||||| . | |..|      ||.||||. |     . |  || .|  | .| ||| | | ||. |   | .|| ||   | ||  |.. 
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGG---PIYIITEYCCYGDLLNYLHRK

R
|
R