Gene TK7 (Sea Urchin)

TK7

Species: Sea Urchin
Alias: TK7, SPU_009990, Spk281
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: TK-Unique

Sequence

Name Sequence Type Origin Length Description Download
TK7.AA Protein None 498 None Fasta, JSON
TK7.kin_dom Protein Kinase Domain None 326 None Fasta, JSON

Protein domain

Protein domains of TK7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TK7.AA TK-Unique 274-469 36 1.9e-92 313.47 In-house 78-294 (294) Show / Hide 
Range on Protein: 274-469
Range on HMM: 78-294/294
Sequence Identity: 36% (79 aa)

DPSYILTEYVTNGTLFTYLRTNGGIARTS-VYANID----TLEADHQIT-VMEQNLF--AFDVANGMEYLAN--KKVIHGNLCAHNILLTGEKRCKVADF
.| .|. ||. .|.| .||||... .|.. .|.|..    . ... . . .... |.  |...|.||||||   ||..|..|||.|.|||. |.||..||
EPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDF

GLTT-------LSNLVTKDGIYEMWLSPERLS--DGLC-SAEDDVWAYGVLVWEIMTYGRRPYSELGKENLQEMLISGYRLIVPQGC-DQTTANLMKSCW
|...       .|.  ..  |. .|..||.|.  .| . . . |||..||| |||.|.| .||... .....|..  |||. .|..|  ... |||||||
GMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCW

QEKEGERPTFEKIKNQL
|... |||.|..||..|
QWEPEERPSFRQIKHRL
Kinase TK7.AA TK 275-469 19 4.9e-63 209.86 In-house 129-486 (486) Show / Hide 
Range on Protein: 275-469
Range on HMM: 129-486/486
Sequence Identity: 19% (70 aa)

PSYILTEYVTNGT----LFTYLRTNGGIART---------------------------SVYANIDTLEA-------------------------------
| .|..||. .|     | .|||.. . ...                           |.. | .  .                                
PWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLT

-DHQITVMEQNLFAFDVANGMEYLANK------KVIHGNLCAHNILLTGEKR-----------CKVADFGLTT-----LSNLVTKDGIYEM---------
 .||.|. ..  .....|.|||||. |      ...|..|.|.|.|.. ...           ||.|||||.      |.  . .|. |           
CKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRP

------------------------WLSPERLSDGL---------CSAEDDVWAYGVLVWEIMTYG-RRPYSELGK---------ENLQEMLISG------
                        |..|| | |.          .. . |||..|||.|||.|||   .| ..           . . |.| .|      
MWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRS

--------YRLIVPQGCD--------------QTTANLMKSCWQEKEGERPTFEKIKNQL
        .|.  |..|               .  . ||..||...  .||||. ...||
GLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TK7.AA Pkinase_Tyr 277-469 33 4.4e-56 190.55 Pfam 83-270 (270) Show / Hide 
Range on Protein: 277-469
Range on HMM: 83-270/270
Sequence Identity: 33% (69 aa)

YILTEYVTNGTLFTYLRTNGGIARTSVYANIDTLEADHQITVMEQNLFAFDVANGMEYLANKKVIHGNLCAHNILLTGEKRCKVADFGLTTLSNLVTKDG
|| .||. .| | .|||..               | ....|. .   .....|.|||||..|. ||  |.| |.|.| .. .|..||||. .    ..|.
YIVMEYMPHGDLLDYLRKHR--------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI---YNDD

IY-EM---------WLSPERLSDGLCSAEDDVWAYGVLVWEIMTYGRRP-YSELGKENLQEML-ISGYRLIVPQGCDQTTANLMKSCWQEKEGERPTFEK
 |  .         |..|| ...| .. . |||..||| |||.|||. | | ..  | . |..  .|||.  |..| .   .|||.||...  .||||. 
YYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSE

IKNQL
| .||
IHEQL
TyrKc TK7.AA TyrKc 144-469 22 1.7e-51 178.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 144-469
Range on HMM: 1-280/280
Sequence Identity: 22% (82 aa)

SVSLRSIGDGQFGHVWKGETRGLTVNDGHVIPVAARELPASLTDDDILDNLVPLWSL-KTHENVVQVFGCCLKT-------EPSYILTEYVPNGTLFTYL
 . .. .| |.|| |.||. .         |.||   | ..    |... .  . .| . |.|.|. .|.|..        || .|..||.|.| |  ||
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RTNGGIARTSVYANIDTLEADHQITVMEQNLFAFDVANDPSYILTEYVTNGTLFTYLRTNGGIARTSVYANIDTLEADHQITVMEQNLFAFDVANGMEYL
| ...                                                                           ... .   |....|.|||||
RKHRPK--------------------------------------------------------------------------LCMKDLLSFCWQIACGMEYL

ANKKVIHGNLCAHNILLTGEKRCKVADFGLTTLSNLV----TKDGIY-------EM------WLSPERLSDGLCSAEDDVWAYGVLVWEIMTYGRRPYSE
. |..||  | | |.|.. ....|..||||.            .  |       .       |..|| . .| .. . |||..||. |||.|||  ||..
HSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPG

-----LGKENLQEMLISGYRLIVPQG--------CDQTTANLMKSCWQEKEGERPTFEKIKNQL
     .  . . | . .|||.  |.         | .   ..||.||.|.  .||||. |. ..
MIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase TK7.AA Tie 277-469 36 5.3e-45 134.5 In-house 68-267 (267) Show / Hide 
Range on Protein: 277-469
Range on HMM: 68-267/267
Sequence Identity: 36% (73 aa)

YILTEYVTNGTLFTYLRTNGGIARTSVYANIDTL--EADHQITVMEQNL--FAFDVANGMEYLANKKVIHGNLCAHNILLTGEKRCKVADFGLTTLSNLV
|. .||   | |  .||    |   . .|  .|   . .   |.  | .  || |||.||.||..|..||  | | |||      ||.|||||       
YVAIEYAPYGNLLDFLRKSRVIETDPAFAREHTTRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRGDEVY

TKDGIYEM---WLSPERLSDGLCSAEDDVWAYGVLVWEIMTYGRRPYSELGKENLQEMLISGYRLIVPQGCDQTTANLMKSCWQEKEGERPTFEKIKNQL
 |  .  .   |.  | |       . |||.||||.|||.. |  ||  .   .| | |  |||.  |. ||    .||. ||...  |||.| .|  ||
VKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase TK7.AA UTK 275-469 28 5.9e-42 141.31 In-house 84-296 (296) Show / Hide 
Range on Protein: 275-469
Range on HMM: 84-296/296
Sequence Identity: 28% (64 aa)

PSYILTEYVTNGTLFTYLRTNGGIARTSVYANIDTLEADHQITVMEQNLFAFDVANGMEYLANKKVIHGNLCAHNILLTGE-------KRCKVADFG---
| .|.|||  || | .|||...  ..          ...|. |  ..  .| |.|.||.||......|..|.| |.|..           ||.||||   
PWMIVTEYMENGDLRSYLRRHRPTPP----------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGG

LTTLSN------------LVTKDGIYE---MWLSPERLSDG-LCSAEDDVWAYGVLVWEIMTYGRRPYSELGKENLQEMLISG--YRLIVPQGCDQTTAN
.. . |            ......  .    | .|| | ..   .   |||..||..|||.|.||.|| ... ... . .  |  ||.  |..|  .  .
MSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYR

LMKSCWQEKEGERPTFEKIKNQL
||..||.    |||.|| .  |.
LMHRCWHYDPQERPDFEDLVQQM
Kinase TK7.AA TK-Unique 144-273 30 5.2e-41 139.19 In-house 1-142 (294) Show / Hide 
Range on Protein: 144-273
Range on HMM: 1-142/294
Sequence Identity: 30% (43 aa)

SVSLRSIGDGQFGHVWKGETRGLT--VNDGHVIPVAARELPASLTD-DDILDNLVPLWSLKTHENVVQVFGCCLKT-EPSYILTEYVPNGTLFTYLRTNG
.. ...||.|.||.||.|| .|..   .. ... | ... .|..|| .| |...  ...|. |.|.|| .||| |. || .|. ||.|.|.| .||||..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

GIARTS-VYANID----TLEADHQIT-VMEQNLF--AFDVAN
. .|.. .|.|..    . ... . . .... |.  |...|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIAC
Kinase TK7.AA Src 274-469 31 8.6e-41 136.29 In-house 67-255 (255) Show / Hide 
Range on Protein: 274-469
Range on HMM: 67-255/255
Sequence Identity: 31% (65 aa)

DPSYILTEYVTNGTLFTYLRTNGGIARTSVYANIDTLEADHQITVMEQNLFAFDVANGMEYLANKKVIHGNLCAHNILLTGEKRCKVADFGLTTLSNLVT
.| || ||| ..| | .||.                 .  ... . ..  .|  ||.||.||  ...||  | | |.|   .  ||||||||      ..
EPIYIVTEYMSHGSLLDYLKK---------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR----LI

K--DGIYEM---------WLSPERLSDGLCSAEDDVWAYGVLVWEIMTYGRRPYSELGKENLQEMLISGYRLIVPQGCDQTTAN-LMKSCWQEKEGERPT
|  | .|..         |  || .. |  .   ||| .|.| .||.|||| ||    ..   ...  |||.  |..| .   . .|. ||...  .|||
KEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPT

FEKIKNQL
|| . . |
FEYLQWFL
Kinase TK7.AA Abl 275-469 34 1.4e-37 122.61 In-house 69-252 (252) Show / Hide 
Range on Protein: 275-469
Range on HMM: 69-252/252
Sequence Identity: 34% (70 aa)

PSYILTEYVTNGTLFTYLRTNGGIARTSVYANIDTLEADHQITVMEQNLFAFDVANGMEYLANKKVIHGNLCAHNILLTGEKRCKVADFGLTTLSNLVTK
| ||.||....| |  ||| ..   |... |          ....     |  .| ||.|| ... ||  | | | |.  ..  |||||||. .     |
PFYIITEFMCYGNLLDYLRECD---REELPA----------VVLL---YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARM----MK

DGIYEM---------WLSPERLSDGLCSAEDDVWAYGVLVWEIMTYGRRPYSELGKENLQEMLISGYRLIVPQGCDQTTANLMKSCWQEKEGERPTFEKI
| .|           |  || |     |.  ||||.|||.||| |||  ||  .  ..  . |  |||.  |.|| .   .||. ||| .. .||.|..|
DDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEI

KNQL
 ...
HHAM
Kinase TK7.AA Frk 265-473 31 9.6e-36 121.16 In-house 58-260 (260) Show / Hide 
Range on Protein: 265-473
Range on HMM: 58-260/260
Sequence Identity: 31% (70 aa)

NLFAFDVANDPSYILTEYVTNGTLFTYLRTNGGIARTSVYANIDTLEADHQITVMEQNLFAFDVANGMEYLANKKVIHGNLCAHNILLTGEKRCKVADFG
.|.|    ..| ||.|| . .|.| .||..   |...            .|. . ..   |  || || || ..  ||  | | |.|.  .. ||.||||
QLYAVCTVEEPIYIITELMRHGSLQEYLQA---INDKG-----------RQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFG

LTTLSNLVTKDG-IYEM---------WLSPERLSDGLCSAEDDVWAYGVLVWEIMTYGRRPYSELGKENLQEMLISGYRLIVPQGCDQTTANLMKSCWQE
|  .  |.  .  |||          |  ||       .   |||..|.|. ||.|||| ||. .   .  .|.  |||.  | .|.|.  ..|  ||..
LARV--LMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHS

KEGERPTFEKIKNQLGDKV
.  .||||| .. .| |  
DPMKRPTFETLQWKLEDYF
Kinase TK7.AA TKL 277-469 20 2e-30 106.74 In-house 114-364 (364) Show / Hide 
Range on Protein: 277-469
Range on HMM: 114-364/364
Sequence Identity: 20% (56 aa)

YILTEYVTNGTLFTYLRTNGGIARTSVYANIDTLEADHQITVMEQ-NLFAFDVANGMEYLAN--------KKVIHGNLCAHNILLTGEKR----------
.| .||. .|.|. ||                          ..|   .| |.| ||.|| .        ...|| .|  .|||.    .          
CIVMEYCPGGSLLHYLH-------------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPN

----CKVADFGLTTLSN-----------------------LVTKDGIYEMWLSPERLSDG----------------LCSAEDDVWAYGVLVWEIMTYGRR
    ||..|||| .  .                          . .    |..|| | .                   |   ||...|.. |||.| ..|
ADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILT-RCR

PYSELGKENLQ---------EMLIS-GYRLIVP------------QGCDQTTANLMKSCWQEKEGERPTFEKIKNQL
||.... .  .         .| .. |.|. .|              |..  ..||. ||...  .||.|..|. .|
PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase TK7.AA FGFR 381-469 42 1.1e-26 87.96 In-house 204-293 (293) Show / Hide 
Range on Protein: 381-469
Range on HMM: 204-293/293
Sequence Identity: 42% (38 aa)

WLSPERLSDGLCSAEDDVWAYGVLVWEIMTYGRRPYSELG-KENLQEMLISGYRLIVPQGCDQTTANLMKSCWQEKEGERPTFEKIKNQL
|  || | |     . ||| |||| |||||||  ||      | | . |..|.|.  |. | |    .| .|| .| ..|||| ..  .|
WMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase TK7.AA Fer 381-470 31 1.3e-25 84.31 In-house 184-283 (283) Show / Hide 
Range on Protein: 381-470
Range on HMM: 184-283/283
Sequence Identity: 31% (31 aa)

WLSPERLSDGLCSAEDDVWAYGVLVWEIMTYGRRPYSE---------LGKENLQEMLISGYRLIVPQGCDQTTANLMK-SCWQEKEGERPTFEKIKNQLG
||.|| ...|..| . |||..||. |||.| |  || .         . |.. .    .||..  |...  . ...|. .|||..  .|||. .|...| 
WLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase TK7.AA TK 144-273 16 1.8e-21 68.08 In-house 1-245 (486) Show / Hide 
Range on Protein: 144-273
Range on HMM: 1-245/486
Sequence Identity: 16% (40 aa)

SVSLRSIGDGQFG---HVWKGETRGLTVNDGHV-------------------IPVAARELP--ASLTDDDILD-----------------NLVPLWS-LK
 . .. .| ||||    |.||| ||.  ..|..                   .|||   |   .. .... .|                  .  . . | 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

THENVVQVFGCCLKT------------EPSYILTEYVPNGT----LFTYLRTNGGIART---------------------------SVYANIDTLEA---
 |.|.|. .|.|..             || .|..||.|.|     | .|||.. . ...                           |.. | .  .    
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

-----------------------------DHQITVMEQNLFAFDVAN
                             .||.|. ..  .....|.
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIAC
Kinase TK7.AA Pkinase 277-469 17 2.3e-13 48.33 Pfam 76-293 (293) Show / Hide 
Range on Protein: 277-469
Range on HMM: 76-293/293
Sequence Identity: 17% (42 aa)

YILTEYVTNG----TLFTYLRTNGGIARTSVYANIDTLEADHQI--TVMEQNLFAFDVANGMEYLANKKVIHGNLCAHNILLTGEKRC----KVADFGLT
|. .||. .|     ||.|..|                ...  .  .  |   ..  .. |.||. ....||  |   |||.  .  .    |..|||| 
YMVMEYCEGGLYVMDLFDYIST----------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA

----TLSNLVTKDGIY-EMWLSPERLS-DGLCSAEDDVWAYGVLVWEIMTYGRRPYSEL-------GKENLQEMLISGYRLIVPQGCD------------
    . .|  ...      ...|| .  .   . . |.|..|....| .. || |...         .. ... .   ..   |. |.            
KQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFH

-------QTTANLMKSCWQEKEGERPTFEKIKNQ--L
       ..   ..|.|.. .  .|||.| |..   .
WTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase TK7.AA FGFR 324-365 52 3.1e-13 41.4 In-house 141-182 (293) Show / Hide 
Range on Protein: 324-365
Range on HMM: 141-182/293
Sequence Identity: 52% (22 aa)

FAFDVANGMEYLANKKVIHGNLCAHNILLTGEKRCKVADFGL
.|. || |||||| .|.||  | | |.| | .   |..||||
CAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGL
Kinase TK7.AA S_TKc 144-467 16 4.4e-13 14.93 SMART 1-220 (231) Show / Hide 
Range on Protein: 144-467
Range on HMM: 1-220/231
Sequence Identity: 16% (54 aa)

SVSLRSIGDGQFGHVWKGETRGLTVNDGHVIPVAARELPASLTDDDILDNLVPLWSLKTHENVVQVFGCCLKTEPSYILTEYVPNGTLFTYLRTNGGIAR
   || || | || |.|.  ..          ||  ...                                                             
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK-------------------------------------------------------------

TSVYANIDTLEADHQITVMEQNLFAFDVANDPSYILTEYVTN--GTLFTYLRTNGGIARTSVYANIDTLEADHQITVMEQNLFAFDVANGMEYLANKKVI
 ...  |. |.   .     . . .|.   |  |. .||. .  |.||.|.. .|.  .            .....  .   ..  .....||. ....|
EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL------------RFPFPE-HARFYMYQICCALEYCHSHGII

HGNLCAHNILLTGEKRCKVADFGLTTLSNLVTKDGIYEMWLSPERLSDGLCSA-EDDVWAYGVLVWEIMTYGRRPYSELGKENLQEMLISGYRLIVPQGC
|  |   ||||.   . |..|||| ..    |  |  . ...|| |     .  . |.|. |....| .. |. |..          .   ...|.    
HRDLKPENILLDE--HIKICDFGLARQL--TTFCGTPW-YMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---------QMQMMFKKIG----

DQTTANLMKSCWQEKEGERPTFEKIKN
..   .... |.|    .|||  .. .
SPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase TK7.AA TKL 150-235 21 1.9e-12 41.17 In-house 1-129 (364) Show / Hide 
Range on Protein: 150-235
Range on HMM: 1-129/364
Sequence Identity: 21% (28 aa)

IGDGQFGHVWKGETRGLTVNDGHVIP------VAARELPA---SLTDD-------------------------DILDNLVPLWSLKTHENVVQVFGCCLK
|| | || |.||. || ..  .   |      ||   ..    .....                         . . . . . |   |.|.||  |.|. 
IGSGGFGEVYKGKWRGWGG-KC---PSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCC

TEP-------------SYILTEYVPNGTLFTYL
 ..              .| .||.|.|.|. ||
PPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYL
Kinase TK7.AA Fer 275-365 28 2.8e-11 34.77 In-house 83-160 (283) Show / Hide 
Range on Protein: 275-365
Range on HMM: 83-160/283
Sequence Identity: 28% (27 aa)

PSYILTEYVTNGTLFTYLRTNGGIARTSVYANIDTLEADHQITVMEQNLFAFDVANGMEYLANKKVIHGNLCAHNILLTGEKR---CKVADFGL
| .|. |....| | .||..|...                 ... |   .....|.|||||  |..||  . | |.|.. .|    ||..|||.
PIMIVMEFCNGGSLDSYLKKNKNK----------------TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGM
Kinase TK7.AA UTK 144-239 25 1.9e-09 28.5 In-house 1-105 (296) Show / Hide 
Range on Protein: 144-239
Range on HMM: 1-105/296
Sequence Identity: 25% (27 aa)

SVSLRSIGDGQFGHVWKGETRGLT---VNDGHVIPVAARELPASLTDD---DILDNLV---PLWSLKTHENVVQVFGCCLKTEPSYILTEYVPNGTLFTY
   .| .| |.|| | |.. .  .     ..  ..|. .. .|  . .   |..        .  .. |.||... | |.. || .|.||| .|| | .|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRTNG
||...
LRRHR
Kinase TK7.AA Abl 203-239 43 3.1e-09 26.46 In-house 54-90 (252) Show / Hide 
Range on Protein: 203-239
Range on HMM: 54-90/252
Sequence Identity: 43% (16 aa)

HENVVQVFGCCLKTEPSYILTEYVPNGTLFTYLRTNG
|.|.||. | | .  | ||.||....| |  ||| ..
HPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECD
Kinase TK7.AA Pkinase_Tyr 203-273 27 3.6e-09 31.67 Pfam 63-122 (270) Show / Hide 
Range on Protein: 203-273
Range on HMM: 63-122/270
Sequence Identity: 27% (20 aa)

HENVVQVFGCCL-KTEP--SYILTEYVPNGTLFTYLRTNGGIARTSVYANIDTLEADHQITVMEQNLFAFDVAN
|.|.|.  |.|. . ||   || .||.|.| | .|||..               | ....|. .   .....|.
HPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR--------------EDKQPLTMKDLLQMCWQIAK
Kinase TK7.AA Fer 150-240 24 3.9e-09 27.39 In-house 7-105 (283) Show / Hide 
Range on Protein: 150-240
Range on HMM: 7-105/283
Sequence Identity: 24% (24 aa)

IGDGQFGHVWKGE---TRGLTVNDG-HVIPVAAREL-PASLTDDDILDNLVPLWSLKT---HENVVQVFGCCLKTEPSYILTEYVPNGTLFTYLRTNGG
.| | || |.||.   .... ..     ..|.   .  ...|.. | . .     ...   | |||. .| |   .| .|. |....| | .||..|..
LGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYLKKNKN
Kinase TK7.AA Frk 147-240 31 5e-09 27.06 In-house 4-92 (260) Show / Hide 
Range on Protein: 147-240
Range on HMM: 4-92/260
Sequence Identity: 31% (31 aa)

LRSIGDGQFGHVWKGETRGLTVNDGHVIPVAARELPASLTD-DDILDNLVPLWSLKTHENVVQVFGCCLKTEPSYILTEYVPNGTLFTYLR--TNGG
.| .| |||| || |            .||| ..| .   | .| | .   . .|. |  ..|..  |   || ||.|| . .|.| .||.  .. |
IRRLGSGQFGEVWEGLWN-------NTTPVAVKTLKPGTMDPNDFLREAQIMKKLR-HPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKG
Kinase TK7.AA FGFR 145-238 30 3.5e-08 23.93 In-house 2-99 (293) Show / Hide 
Range on Protein: 145-238
Range on HMM: 2-99/293
Sequence Identity: 30% (30 aa)

VSLRSIGDGQFGHVWKGETRGLTVN-DGHVIPVAARELPASLTDDDILDNLVPLWSLK---THENVVQVFGCCLKTEPSYILTEYVPNGTLFTYLRTN
.    .| | || ||..|  |.  .   . | ||   | .. ||.|. |    .  .|    |.|..   |||    | |.. || . | |  .|| .
TLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRAR
Kinase TK7.AA Src 203-240 43 1e-07 22.24 In-house 53-91 (255) Show / Hide 
Range on Protein: 203-240
Range on HMM: 53-91/255
Sequence Identity: 43% (17 aa)

HENVVQVFGCCLKTEPSYILTEYVPNGTLFTYLR-TNGG
||..|| .  | . || || |||  .| | .||. .  |
HEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEG
Kinase TK7.AA Tie 152-236 28 2.2e-07 17.79 In-house 1-84 (267) Show / Hide 
Range on Protein: 152-236
Range on HMM: 1-84/267
Sequence Identity: 28% (25 aa)

DGQFGHVWKGETRGLTVNDGHVIPVAARELPASLTDDDILD---NLVPLWSLKTHENVVQVFGCCLKTEPSYILTEYVPNGTLFTYLR
.| || | |   .     || .. || . .     .||  |    |  .  . .| |.. . | | .    |. .|| | | |  .||
EGNFGQVMKAMIK----KDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLR
Kinase TK7.AA Pkinase 144-241 20 1e-05 21.26 Pfam 1-103 (293) Show / Hide 
Range on Protein: 144-241
Range on HMM: 1-103/293
Sequence Identity: 20% (23 aa)

SVSLRSIGDGQFGHVWKGETRGLTVNDGHVIPVAARELPASLTDDDILD------NLVPLWSLKTHENVVQVFGCCLKTEPSYILTEYVPNG----TLFT
 . .| || | || |.|.  .|          ||  ... . .... .        .  . .|  |.|.|. ....      |. .||...|     ||.
YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

YLR--TNGGI
|..   .|..
YISTWRHGCF
Kinase TK7.AA Pkinase_Tyr 147-177 41 0.001213 12.96 Pfam 4-32 (270) Show / Hide 
Range on Protein: 147-177
Range on HMM: 4-32/270
Sequence Identity: 41% (13 aa)

LRSIGDGQFGHVWKGETRGLTVNDGHVIPVA
.. .| |.||.|.||. .|    |.. ||||
GKKLGEGAFGEVYKGTWKG--DPDNTKIPVA
Kinase TK7.AA Src 147-161 60 0.001335 8.05 In-house 4-18 (255) Show / Hide 
Range on Protein: 147-161
Range on HMM: 4-18/255
Sequence Identity: 60% (9 aa)

LRSIGDGQFGHVWKG
.| .|.|||| ||.|
CRKLGQGQFGEVWMG