Gene TK6 (Sea Urchin)
TK6
Sequence
Protein domains of TK6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | TK6.AA | TK-Unique | 57-287 | 37 | 3.1e-102 | 345.96 | In-house | 12-271 (294) | Show / Hide |
Range on Protein: 57-287 Range on HMM: 12-271/294 Sequence Identity: 37% (99 aa) FGQVWRGEIRGVPGKEKKKIEAAVRDLS-GLEGV-QDNLLEAVTALWELPDHINLVKCLGCCV---EQAFIVYEYVLCGTLLTYLQTNAGKTRSSYRVYA ||||||||..|..... |.. .|| | .. .. ....| ..||.||.|.|.|||||. |. .|..||. ||.|..||.|.....|... .|. FGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQ-TYG NVR-------SVVRR--VKEPDLFTFAWQIAKGMAFLSS--QKIVHGNLRASNVLLSKNKICKIADYGLT----------GITQTSKTVHRWLSPEAML- |.. . .|. ... ||..||||||.||..|.| .||||..| |.||||. .|.|||.|.|.. ... ... .||..||... NLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKC -TGTC-STESDVWSYGVLLWELVTLGAQPYPGVSDCELTERITNGYIMRRPLHC-GEDLPS .|.. .|.|||||.|||.||..||||.||||...... |.|..||.| .| || ..... YHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYN |
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| Kinase | TK6.AA | TK | 57-285 | 18 | 7.9e-69 | 229.62 | In-house | 12-460 (486) | Show / Hide |
Range on Protein: 57-285
Range on HMM: 12-460/486
Sequence Identity: 18% (84 aa)
FG---QVWRGEIRGVPG-------------------KEKKKIEAAVRDLSGLEGVQDN------------------LLEAVTALWE-LPDHINLVKCLGC
|| .|..|| || .. ||..|.. || | . ... ..|. . . | .| |.|...|.
FGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGV
CVEQ--------------AFIVYEYVLCGT----LLTYLQTNAGKTRSSYRVYANVRSVVRR--------------------------------------
|... || ||. .| |..||... .|.. . ..|... ...
CTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPP
--------------------VKEPDLFTFAWQIAKGMAFLSSQ------KIVHGNLRASNVLLSKNKI-----------CKIADYGLT------------
. ..| ..||||.||..|.|. ..||..| | |.|...|.. |||||.||.
LTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIY
---GITQTS--------------------------KTVHRWLSPEAML---------TGTCSTESDVWSYGVLLWELVTLGAQPYPG-VSD---------
. .| | ||..||... .|...|.|||||.|||.||..|.|..||.| .|.
SDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDN
CELTERITNG--------------YIMRRPLHCGE-------------DL
|. |....| . | .| || . ..
QEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEE
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| Kinase | TK6.AA | Pkinase_Tyr | 57-285 | 32 | 1.5e-64 | 219.23 | Pfam | 12-245 (270) | Show / Hide |
Range on Protein: 57-285
Range on HMM: 12-245/270
Sequence Identity: 32% (80 aa)
FGQVWRGEIRGVPGKEKKKIEAAV---RDLSGLEG-VQDNLLEAVTALWELPDHINLVKCLGCCV---EQ--AFIVYEYVLCGTLLTYLQTNAGKTRSSY
||.|..|. .| ....||. || .. . | .. ... . . .|..| |.|...|.|. |. .|| ||. .| ||.||...
FGEVYKGTWKG--DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR-------
RVYANVRSVVRRVKEPDLFTFAWQIAKGMAFLSSQKIVHGNLRASNVLLSKNKICKIADYGLTGIT----QT-SKTV-----HRWLSPEAMLTGTCSTES
. .... .|| ..|||||||..|.|....| |.| |.|...|...||.| ||. . |. .|..||.. .| ..|.|
-------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKS
DVWSYGVLLWELVTLGAQP-YPGVSDCELTERI-TNGYIMRRPLHCGEDL
||||.|||.||..|.|.|| |||.|. |. |.| .|| | .| .| ...
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEI
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| Kinase | TK6.AA | Src | 105-285 | 33 | 8.1e-46 | 153.61 | In-house | 52-229 (255) | Show / Hide |
Range on Protein: 105-285 Range on HMM: 52-229/255 Sequence Identity: 33% (65 aa) DHINLVKCLGCCVEQ--AFIVYEYVLCGTLLTYLQTNAGKTRSSYRVYANVRSVVRRVKEPDLFTFAWQIAKGMAFLSSQKIVHGNLRASNVLLSKNKIC .| .||. . | . .|| || | ||.||. .. |... |.| .|.|.|.|||.|.|....| |.| ||| ..| .| RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK---------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVC KIADYGLTGITQ------TSKTVHR----WLSPEAMLTGTCSTESDVWSYGVLLWELVTLGAQPYPGVSDCELTERITNGYIMRRPLHCGEDL |.|| || ... .... .. | ||| . |. .. |||||.|.||.|.|| | |||| . | ... .|| | .| .| . | KVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDEL |
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| TyrKc | TK6.AA | TyrKc | 43-313 | 25 | 1.3e-44 | 155.48 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 43-313
Range on HMM: 1-280/280
Sequence Identity: 25% (81 aa)
IRFYSQIGPIGALPFGQVWRGEIRGVPGKEKKKIEAAVRDLSGLEGVQDNLLEAVTALWEL-PDHINLVKCLGCCV---------EQAFIVYEYVLCGTL
|.. ..| || ||.|..|. . |. || | . ... . .| ..| |.|...|.|. |. .|| ||. | |
ITLGKKLG-EGA--FGEVYKGTWK---------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL
LTYLQTNAGKTRSSYRVYANVRSVVRRVKEPDLFTFAWQIAKGMAFLSSQKIVHGNLRASNVLLSKNKICKIADYGLT-GITQT--------SKTV----
. ||. . .| .. .|| |.||||.||..|.|....| | | |.|...|...||.| ||. |. ...
KDYLRKHRPK-----------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHK
-HR------WLSPEAMLTGTCSTESDVWSYGVLLWELVTLGAQPYPG-----VSDCELTERITNGYIMRRPLH-CGEDL----PSTRVQDSIANFIYL--
. |..||.. .|...|.|||||.||..||. |.|.||||| .|. |. |.. .|| |..| . . . . .. . . .
GGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDP
----GFSYLPESETSRL
|| . ...
EDRPTFSEI----HECF
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| Kinase | TK6.AA | UTK | 57-285 | 25 | 2.9e-43 | 145.87 | In-house | 12-271 (296) | Show / Hide |
Range on Protein: 57-285
Range on HMM: 12-271/296
Sequence Identity: 25% (70 aa)
FGQVWRGEIRGVP---GKEKKKIEAAVRDLSGLEGVQ---DNLLEAV-TALWELPD-HINLVKCLGCCV--EQAFIVYEYVLCGTLLTYLQTNAGKTRSS
||.| ... . .. .. .... ..... .. | ..|| .. .. | |... .| |. |. ||.|| | |..||.... ...
FGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPP--
YRVYANVRSVVRRVKEPDLFT------FAWQIAKGMAFLSSQKIVHGNLRASNVLLSKN-------KICKIADYG---LT-GIT----------------
.|...| .||.|| ||..|.|...||..| | |.|. .. .|||||.| .. ..
--------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMA
Q-TSKTVHRWLSPEAMLTG-TCSTESDVWSYGVLLWELVTLGAQPYPGVSDCELTERITNG--YIMRRPLHCGEDL
| . || .|||. . . .| |||||.||..||..| |..|||| |. .......|| | |..| .|....
QHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPV
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| Kinase | TK6.AA | Fer | 105-285 | 31 | 4.2e-37 | 123.96 | In-house | 67-256 (283) | Show / Hide |
Range on Protein: 105-285 Range on HMM: 67-256/283 Sequence Identity: 31% (64 aa) DHINLVKCLGCCVEQA--FIVYEYVLCGTLLTYLQTNAGKTRSSYRVYANVRSVVRRVKEPDLFTFAWQIAKGMAFLSSQKIVHGNLRASNVLLSKNKI- ||.| ||. | || . || |.. .| |..||..| .| |.. ... .. |.|.||..| |....| . | |.|..|.|. DHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYLKKNKNK----------------TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVK --CKIADYGLTGIT---QTSKTVH--------RWLSPEAMLTGTCSTESDVWSYGVLLWELVTLGAQPYPG------VSDC--ELTER-ITNGYIMRRPL |||.| |. . ..... . |||.||.. ||..|...||||.||..|| | ||.|||| . .. .. |..|| |. |. KKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPN HCGEDL |. ... HMPPEI |
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| Kinase | TK6.AA | VEGFR | 164-278 | 40 | 3.3e-36 | 126.61 | In-house | 174-300 (332) | Show / Hide |
Range on Protein: 164-278 Range on HMM: 174-300/332 Sequence Identity: 40% (52 aa) DLFTFAWQIAKGMAFLSSQKIVHGNLRASNVLLSKNKICKIADYGLTGI---------TQTS--KTVHRWLSPEAMLTGTCSTESDVWSYGVLLWELVTL || .. |.|.|| ||.|.|..|. | | |.||. |.. || | || .... . .|..||. .| ||||||||.||| .| DLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSL GAQPYPGVS-DCELTERITNGYIMRRP |. |||||. | |. |. .|| ||.| GGSPYPGVQIDEEFCNRLKDGYRMRAP |
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| Kinase | TK6.AA | TKL | 52-251 | 19 | 7.9e-36 | 125.36 | In-house | 1-284 (364) | Show / Hide |
Range on Protein: 52-251 Range on HMM: 1-284/364 Sequence Identity: 19% (61 aa) IGALPFGQVWRGEIRGVPGKEKKK----IEAAVRDLSGLEGVQDNL---------------------------LEAVTALWELPDHINLVKCLG------ || ||.|..|. || .| . . . || .. . ... .| .. . .| |.|...| IGSGGFGEVYKGKWRGWGG-KC-PSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP ---CCVE------QAFIVYEYVLCGTLLTYLQTNAGKTRSSYRVYANVRSVVRRVKEPDLFTFAWQIAKGMAFLSSQK--------IVHGNLRASNVLLS .|.. | .||.||. .|.|| ||. . .. .| .||.||..| |.. |.| .| .|.|. CGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVD KNKI--------------CKIADYGLTGITQ-----------------------TSKTVH---RWLSPEAML----------------TGTCSTESDVWS .| |||.|.|| . |. |. ||..||.. .. |. .||.| ENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYS YGVLLWELVT .|..|||..| FGIVLWEILT |
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| Kinase | TK6.AA | SrcB | 118-285 | 36 | 7.7e-34 | 111.78 | In-house | 66-225 (251) | Show / Hide |
Range on Protein: 118-285
Range on HMM: 66-225/251
Sequence Identity: 36% (64 aa)
EQAFIVYEYVLCGTLLTYLQTNAGKTRSSYRVYANVRSVVRRVKEPDLFTFAWQIAKGMAFLSSQKIVHGNLRASNVLLSKNKICKIADYGLTGITQT--
| .|. ||. |.|| .|.|. | ... | | .. ||| |||.. . .| ||| |.| |. .|||||.|| | .
EPIYIITEYMAKGCLLDFLKTDEGS----------------KLSLPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNE
------SKTVHRWLSPEAMLTGTCSTESDVWSYGVLLWELVTLGAQPYPGVSDCELTERITNGYIMRRPLHCGEDL
| .| |||. |. |||||.|.|| |.|| | |||| . | . . || | || | |.|
YTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEEL
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| Kinase | TK6.AA | Ret | 235-285 | 52 | 1.2e-18 | 60.33 | In-house | 216-266 (293) | Show / Hide |
Range on Protein: 235-285 Range on HMM: 216-266/293 Sequence Identity: 52% (27 aa) TESDVWSYGVLLWELVTLGAQPYPGVSDCELTERITNGYIMRRPLHCGEDL | |||||.|||.||.||.|| ||||. | . || | || | | . TKSDVWSFGVLCWEIVTMGANPYPGIPPERLWQLLKTGYRMDRPENCSEEM |
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| Kinase | TK6.AA | Ret | 164-210 | 55 | 3.3e-18 | 58.73 | In-house | 136-182 (293) | Show / Hide |
Range on Protein: 164-210 Range on HMM: 136-182/293 Sequence Identity: 55% (26 aa) DLFTFAWQIAKGMAFLSSQKIVHGNLRASNVLLSKNKICKIADYGLT .. .||||| |||..||. |.|| | | |||. .|||| |.||| MIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLT |
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| Kinase | TK6.AA | FGFR | 222-285 | 43 | 3.6e-18 | 58.46 | In-house | 204-268 (293) | Show / Hide |
Range on Protein: 222-285 Range on HMM: 204-268/293 Sequence Identity: 43% (28 aa) WLSPEAMLTGTCSTESDVWSYGVLLWELVTLGAQPYPGVS-DCELTERITNGYIMRRPLHCGEDL | ||| ..|||||||||||| |.| ||||.. || . |. | .| .| ... WMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEI |
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| Kinase | TK6.AA | FGFR | 162-209 | 43 | 2.1e-16 | 52.38 | In-house | 135-182 (293) | Show / Hide |
Range on Protein: 162-209 Range on HMM: 135-182/293 Sequence Identity: 43% (21 aa) EPDLFTFAWQIAKGMAFLSSQKIVHGNLRASNVLLSKNKICKIADYGL ..|| .|.|.|.|| .| |.|..| | | ||| . . . ||.|.|| QKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGL |
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| Kinase | TK6.AA | Pkinase | 102-259 | 22 | 6.5e-14 | 50.28 | Pfam | 56-214 (293) | Show / Hide |
Range on Protein: 102-259 Range on HMM: 56-214/293 Sequence Identity: 22% (40 aa) ELPDHINLVKCLGCCV--EQAFIVYEYVLCG----TLLTYLQTNAGKTRSSYRVYANVRSVVRRV--KEPDLFTFAWQIAKGMAFLSSQKIVHGNLRASN .| .| | |...... .| ||. .| | .|..| . ... | .. ...||..|.... |..|.| | .| RL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST----------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPEN VLLSKNKIC----KIADYGL-----TGITQTSKTV---HRWLSPEAML-TGTCSTESDVWSYGVLLWELVTLGAQPYPG .|...| . ||.| || . . .|. ....|| . ....|.||.|..|.|... | |.|| ILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPG |
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| S_TKc | TK6.AA | S_TKc | 46-314 | 17 | 2.6e-13 | 18.25 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 46-314 Range on HMM: 1-231/231 Sequence Identity: 17% (51 aa) YSQIGPIGALPFGQVWRGEIRGVPGKEKKKIEAAVRDLSGLEGVQDNLLEAVTALWELPDHINLVKCLGCCV-EQAFIVYEYVLC--GTLLTYLQTNAG- | . .|| ||.|... .. . . |. .. .... . | . .| |.||...... . ..| ||. |.|..|.. . . YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRH KTRSSYRVYANVRSVVRRVKEPDLFTFAWQIAKGMAFLSSQKIVHGNLRASNVLLSKNKICKIADYGLTGITQTSKTVHRWLSPEAMLTGTCST-ESDVW ..| .. | . ...||....... |..|.| | .|.||.. ||.| || . | ...|| . .. ..|.| GLR-------------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVL---GYGKCKCDWW SYGVLLWELVTLGAQPYPGVSDCELTERITNGYIMRRPLHCGEDLPSTRVQDSIANFIYLGFSYLPE------SET-------SRLI | |..|.|... | |.| . .. ..| .. .|| . . || . . SCGCILYEMLC-GYPPFP--QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF |
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| Kinase | TK6.AA | FGFR | 57-83 | 42 | 0.163442 | 0.86 | In-house | 12-39 (293) | Show / Hide |
Range on Protein: 57-83 Range on HMM: 12-39/293 Sequence Identity: 42% (12 aa) FGQVWRGEIRGVPGK-EKKKIEAAVRDL |||||..| |.. . ..|.| || | FGQVWMAEAKGIDCDRPEKEITVAVKML |
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