Gene TK11 (Sea Urchin)

TK11

Species: Sea Urchin
Alias: SPU_009079, TK11, Spk265
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: TK-Unique

Sequence

Name Sequence Type Origin Length Description Download
TK11.AA Protein None 497 None Fasta, JSON
TK11.kin_dom Protein Kinase Domain None 188 None Fasta, JSON

Protein domain

Protein domains of TK11.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
EGF TK11.AA EGF 93-128 38 1.1e-08 36.12 SMART 1-32 (32) Show / Hide 
Range on Protein: 93-128
Range on HMM: 1-32/32
Sequence Identity: 38% (16 aa)

ACRYQPCLDN-----GDCILDDSARGYRCDCR-PGYSGRRCE
 |   ||  .     | ||      .|.| |. |||.| |||
ECA--PCHHGGCEQHGTCI------SYTC-CPGPGYTG-RCE
EGF TK11.AA EGF 94-126 36 3.6e-08 30.36 Pfam 1-36 (36) Show / Hide 
Range on Protein: 94-126
Range on HMM: 1-36/36
Sequence Identity: 36% (14 aa)

CRYQ--PCLDNGDCILDDSARGYRCDCRPG---YSGRR
|  .  ||. .| |.  .   ||.|.| ||   |.|.|
CNPNNNPCHHHGTCVDTP--GGYTCQCPPGYLGYTGKR
EGF_CA TK11.AA EGF_CA 90-128 40 4.1e-05 15.97 SMART 1-34 (34) Show / Hide 
Range on Protein: 90-128
Range on HMM: 1-34/34
Sequence Identity: 40% (17 aa)

DERACRYQPCLDNG---DCILDDSARGYRCDCRPGYSGRRCE
|   |   ||  .|    ||  .   .||| |.|||. |.||
DIDEC---PCQNGGPTGTCI--N-PGSYRC-CPPGYT-RHCE
EGF_2 TK11.AA EGF_2 94-127 27 0.000237 17.1 Pfam 1-29 (29) Show / Hide 
Range on Protein: 94-127
Range on HMM: 1-29/29
Sequence Identity: 27% (10 aa)

CRYQPCLD-NGDCILDDSARG-YRCDCRPG-YSGRRC
|    |   .| |. .    |  .|.| .| ..|  |
C----CNGHHGTCNNQ----GCGKCQCDDGWWQGDHC
EGF TK11.AA EGF 134-155 29 10.828957 2.04 Pfam 1-23 (36) Show / Hide 
Range on Protein: 134-155
Range on HMM: 1-23/36
Sequence Identity: 29% (7 aa)

CSLN--PCYENEICETIVDADFTC
|. |  ||  . .|      ..||
CNPNNNPCHHHGTCVDTP-GGYTC
Kinase TK11.AA TK-Unique 357-456 44 1.9e-49 168.67 In-house 133-235 (294) Show / Hide 
Range on Protein: 357-456
Range on HMM: 133-235/294
Sequence Identity: 44% (47 aa)

LLNFACDIAQGMRHIAALRY--VYMNLCAKNVLITFNNKAKLCDFSMATEVQKPLNIPIPFIEPRNRGMKRWMAYEALL--EGQY-TMKSDVWSYGIVLW
|..||..||.|| ..| .|.  |...|||.|||.| ....|.||| ||..|..  | ..  .. ..| ..||||.|.|.  .|.| |.||||||.|...|
LYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT--NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMW

EIVTL
||.||
EIFTL
Kinase TK11.AA TK 268-456 14 6.3e-42 137.84 In-house 1-390 (486) Show / Hide 
Range on Protein: 268-456
Range on HMM: 1-390/486
Sequence Identity: 14% (58 aa)

LEMGKLLYSGEFS---YVCEGDLKQ----------------------GSDVPIKVAIKLHRDENDQESITEMR-------------NEFQVLANLGK---
...|| | .|.|     |..| ...                      .......||.|  ........  ..              .| .... .     
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNILMLLGQCNRVF---------------------EQSD------------QPPFEP-----------------------------------------
 ||||. |.| | ..                      .  |             |.| .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LPQDELLNFACDIAQGMRHIAAL------RYVYMNLCAKNVLITFNNK-----------AKLCDFS---
                               |.  .|| ....||.||......      ..| ..|.| |.|.. ||.           .|..||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----MATEVQKPLNIPIPFIEPRNRGMKR----------------------WMAYEALLEGQ---------YTMKSDVWSYGIVLWEIVTL
     .| ....  .      . ..|.| .                      ||| |.|....         .| ||||||.|...|||.|.
QGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTY
Kinase TK11.AA TK-Unique 268-354 27 6.1e-28 93.5 In-house 1-89 (294) Show / Hide 
Range on Protein: 268-354
Range on HMM: 1-89/294
Sequence Identity: 27% (25 aa)

LEMGKLLYSGEFSYVCEGDLKQGS---DVPIKVAIKLHRDENDQESITEMRNEFQVLANLGKHPNILMLLGQCNRVFEQSDQPPFEPLPQ
||.|.....|.|..|. |......   | ...||.|...|......  .. .|.|.. .||.||||...||.| . . .. .  .|..|.
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPC
Kinase TK11.AA UTK 350-455 30 3.1e-23 76.32 In-house 113-235 (296) Show / Hide 
Range on Protein: 350-455
Range on HMM: 113-235/296
Sequence Identity: 30% (38 aa)

EPLPQDELLNFACDIAQGMRHIAALRYVYMNLCAKNVLITFN-------NKAKLCDFS---MATEVQ-----KPLNIPIPFIEPRNRGM--KRWMAYEAL
. |  ...| .| ||| || ...  ..|  .|.|.|.|.. .       ...|..||    |. .|.            .   ......   |||| |||
HWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSN-RYWESYYYMAQHQDRWPIRWMAPEAL

LEG-QYTMKSDVWSYGIVLWEIVT
 .. ..| ||||||.|.|.|||.|
THHTRFTTKSDVWSFGVVCWEIWT
Kinase TK11.AA Tie 352-456 37 1.2e-21 62.03 In-house 111-209 (267) Show / Hide 
Range on Protein: 352-456
Range on HMM: 111-209/267
Sequence Identity: 37% (39 aa)

LPQDELLNFACDIAQGMRHIAALRYVYMNLCAKNVLITFNNKAKLCDFSMATEVQKPLNIPIPFIEPRNRGMKRWMAYEALLEGQYTMKSDVWSYGIVLW
|  . .|.|| |.|.|| ...   ..   | |.|.|.  |  .|. || ..          .   .   |   |||| |.|    || ||||||||..||
LSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRGDE------VYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLW

EIVTL
|||.|
EIVSL
Kinase TK11.AA TyrKc 268-495 22 2.3e-17 57.94 SMART 1-280 (280) Show / Hide 
Range on Protein: 268-495
Range on HMM: 1-280/280
Sequence Identity: 22% (69 aa)

LEMGKLLYSGEFSYVCEGDLKQGSDVPIKVAIKLHRDENDQESITEMRNEFQVLANLG-KHPNILMLLGQCNR-------------VFE-----------
...|| | .|.|  |..| .|      |.||.|  ...     . ....| ... .|| .||||. |.| |               |.|           
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QSDQPPFEPLPQDELLNFACDIAQGMRHIAALRYVYMNLCAKNVLITFNNKAKLCDFSMATEV------------QKP-----LN--IPIPFIEPRNRGM
.. .|    |. ..||.|. .||.||....  ...   | | |.|.. |. .| .|| .. ..             ..      .  .||          
RKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI----------

KRWMAYEALLEGQYTMKSDVWSYGIVLWEIVTLEWGEVMKQYYRG------SQPDMVGFVGSRNFPPQSSL--------APE------------------
 |||| |.. .| .| ||||||.|...||| |.      .| | |      |  ... .| ... .||           .|.                  
-RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYG-----QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

-----IDTM
     .. .
TFSEIHECF
Kinase TK11.AA EGFR 356-455 36 6.7e-17 52.48 In-house 102-198 (258) Show / Hide 
Range on Protein: 356-455
Range on HMM: 102-198/258
Sequence Identity: 36% (37 aa)

ELLNFACDIAQGMRHIAALRYVYMNLCAKNVLITFNNKAKLCDFSMATEVQKPLNIPIPFIEPRN-RGMKRWMAYEALLEGQYTMKSDVWSYGIVLWEIV
.|||..  ||.||      | |  .| | |||.   |. |  || .|    | |..    ..    .   .||| | .... || .|||||||. .||..
HLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLA----KLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELM

T
|
T
Kinase TK11.AA TKL 357-458 23 6.6e-15 50.13 In-house 134-287 (364) Show / Hide 
Range on Protein: 357-458
Range on HMM: 134-287/364
Sequence Identity: 23% (36 aa)

LLNFACDIAQGMRHIAALR--------YVYMNLCAKNVLITFNNK--------------AKLCDFSMATEVQKPLNIPIPF--------------IEPRN
....| |||.|| .  . .         .. .|  ||.|.  |..              .|.|||  ......  |                      . 
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ

RGMKRWMAYEALL----------------EGQYTMKSDVWSYGIVLWEIVTLEW
.| .|||| |.|                 ...|. |.||.|.|||||||.| ..
CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR
Kinase TK11.AA FGFR 426-456 64 7.9e-15 46.92 In-house 204-234 (293) Show / Hide 
Range on Protein: 426-456
Range on HMM: 204-234/293
Sequence Identity: 64% (20 aa)

WMAYEALLEGQYTMKSDVWSYGIVLWEIVTL
||| ||| .  || .|||||||. |||| |.
WMAPEALFDRVYTHQSDVWSYGVLLWEIMTY
Kinase TK11.AA Pkinase_Tyr 425-456 53 9.5e-15 50.58 Pfam 179-210 (270) Show / Hide 
Range on Protein: 425-456
Range on HMM: 179-210/270
Sequence Identity: 53% (17 aa)

RWMAYEALLEGQYTMKSDVWSYGIVLWEIVTL
.||| |.. .| .| ||||||.|...|||.|.
KWMAPECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase TK11.AA Pkinase_Tyr 268-337 31 2.2e-14 49.36 Pfam 1-73 (270) Show / Hide 
Range on Protein: 268-337
Range on HMM: 1-73/270
Sequence Identity: 31% (23 aa)

LEMGKLLYSGEFSYVCEGDLK-QGSDVPIKVAIKLHRDENDQES--ITEMRNEFQVLANLGKHPNILMLLGQC
...|| | .|.|  |..| .| ....  |.||.|  ..  ..|   . .. .| ... .||.||||. |.| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVC
Kinase TK11.AA Src 425-455 61 2.6e-14 45.0 In-house 165-195 (255) Show / Hide 
Range on Protein: 425-455
Range on HMM: 165-195/255
Sequence Identity: 61% (19 aa)

RWMAYEALLEGQYTMKSDVWSYGIVLWEIVT
.|.| ||...|..| ||||||.|| |.||||
KWTAPEAINYGRFTIKSDVWSFGILLTEIVT
Kinase TK11.AA Sev 425-456 59 3.1e-12 36.91 In-house 188-219 (277) Show / Hide 
Range on Protein: 425-456
Range on HMM: 188-219/277
Sequence Identity: 59% (19 aa)

RWMAYEALLEGQYTMKSDVWSYGIVLWEIVTL
|||| | |. | .|  ||||..||  ||| ||
RWMAPESLMDGYFTTQSDVWAFGILCWEIMTL
Kinase TK11.AA DDR 425-456 50 8.4e-12 37.49 In-house 208-239 (306) Show / Hide 
Range on Protein: 425-456
Range on HMM: 208-239/306
Sequence Identity: 50% (16 aa)

RWMAYEALLEGQYTMKSDVWSYGIVLWEIVTL
|||| |..| |  | |||||. |. .||. ..
RWMAWESILLGKFTTKSDVWAFGVTMWEMFMF
Kinase TK11.AA S_TKc 268-496 16 8.2e-10 -33.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 268-496
Range on HMM: 1-231/231
Sequence Identity: 16% (45 aa)

LEMGKLLYSGEFSYVCEGDLKQGSDVPIKVAIKLHRDENDQESITEMRNEFQVLANLGKHPNILMLLGQCN----------------RVFEQSDQPPFEP
 |..... .| |. |. .  |       .||||  .          .|.| |.| .  .||||  |.. .                  .|.  .. . ..
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LPQDELLNFACDIAQGMRHIAALRYVYMNLCAKNVLITFNNKAKLCDFSMATEVQKPLNIPIPFIEPRNRGMKRWMAYEALLEGQYTM-KSDVWSY
    .|  .   ... |.... ..  .. ..  |   |.|..     |.||| .|...                |   .|| | |   .|.  |.|.|| 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GIVLWEIVT----LEWGEVMKQYYRGSQPDMVGFVGS---RN----FPPQSSLA----PEIDTMI
|..|.| ..     .  .... . .   |..  |.     ..          |.      ..  .
GCILYEMLCGYPPFP--QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TK11.AA Pkinase_Tyr 350-407 34 2.4e-09 32.3 Pfam 106-163 (270) Show / Hide 
Range on Protein: 350-407
Range on HMM: 106-163/270
Sequence Identity: 34% (20 aa)

EPLPQDELLNFACDIAQGMRHIAALRYVYMNLCAKNVLITFNNKAKLCDFSMATEVQK
.||.  .||... .||.|| . .. ...   |.|.|.|.| ||..| ||| .|  ...
QPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYN
Kinase TK11.AA Tie 277-338 29 2.1e-08 20.99 In-house 2-62 (267) Show / Hide 
Range on Protein: 277-338
Range on HMM: 2-62/267
Sequence Identity: 29% (18 aa)

GEFSYVCEGDLKQGSDVPIKVAIKLHRDENDQESITEMRNEFQVLANLGKHPNILMLLGQCN
| |  |    .|.   . ..||||  ..   ..   .   |  |.  .|.||||. |.| |.
GNFGQVMKAMIKKDGLK-MEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACE
Kinase TK11.AA Sev 268-337 35 2.4e-08 23.76 In-house 1-72 (277) Show / Hide 
Range on Protein: 268-337
Range on HMM: 1-72/277
Sequence Identity: 35% (26 aa)

LEMGKLLYSGEFSYVCEGDLKQGS---DVPIKVAIKLHRDE-NDQESITEMRNEFQVLANLGKHPNILMLLGQC
|.. ..| || |  | || .|      . ...||||  |    ||| . |.  | ..  .  |||||. ..| |
LKLRRFLGSGAFGEVYEGQAKDIDGVGEEEQRVAIKTLRKGSTDQEKQ-EFLKEAHLMSKF-KHPNIVCQMGVC
Kinase TK11.AA Src 356-399 36 3.4e-07 20.46 In-house 98-141 (255) Show / Hide 
Range on Protein: 356-399
Range on HMM: 98-141/255
Sequence Identity: 36% (16 aa)

ELLNFACDIAQGMRHIAALRYVYMNLCAKNVLITFNNKAKLCDF
.|. .|. .|.||  . . .|.   | |.|||.  || .| .||
QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADF
Kinase TK11.AA EGFR 268-337 38 3.5e-07 19.71 In-house 1-70 (258) Show / Hide 
Range on Protein: 268-337
Range on HMM: 1-70/258
Sequence Identity: 38% (27 aa)

LEMGKLLYSGEFSYVCEG-DLKQGSDVPIKVAIKLHRDENDQESITEMRNEFQVLANLGKHPNILMLLGQC
|  .| | || |  |  |    .|  | | ||||  |.. ....  || .|  |.| . .||... ||| |
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASV-DHPHLVRLLGVC
Kinase TK11.AA DDR 268-337 20 3e-06 17.76 In-house 1-83 (306) Show / Hide 
Range on Protein: 268-337
Range on HMM: 1-83/306
Sequence Identity: 20% (17 aa)

LEMGKLLYSGEFSYVCEGDLKQGSD-----VPIK--------VAIKLHRDENDQESITEMRNEFQVLANLGKHPNILMLLGQC
|  .... .|.|  | .  .  . |      ..         || |  | .  .    . . |  ... ...||||  |.| |
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVC
Kinase TK11.AA UTK 268-337 24 1.2e-05 15.35 In-house 1-79 (296) Show / Hide 
Range on Protein: 268-337
Range on HMM: 1-79/296
Sequence Identity: 24% (20 aa)

LEMGKLLYSGEFSYVCEGDLKQGS------DVPIKVAIKLHRDENDQESIT---EMRNEFQ---VLANLGKHPNILMLLGQC
.. |..| .|.|  |......| |      || .||.    .....| . .   . ..| .   .....  |||.| |.| |
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ---HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVC
Kinase TK11.AA TKL 274-335 21 1.2e-05 16.32 In-house 1-92 (364) Show / Hide 
Range on Protein: 274-335
Range on HMM: 1-92/364
Sequence Identity: 21% (20 aa)

LYSGEFSYVCEGDLKQ---------GSDVPIKVAIKLHRDE-------------------NDQESITEMRNEFQVLANLGK--HPNILMLLG
. || |. |. | ...         | || .|.  . . ||                   ||.|.  ..  | ...  . .  ||||. ..|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMG
Kinase TK11.AA FGFR 352-407 33 2.1e-05 14.34 In-house 133-188 (293) Show / Hide 
Range on Protein: 352-407
Range on HMM: 133-188/293
Sequence Identity: 33% (19 aa)

LPQDELLNFACDIAQGMRHIAALRYVYMNLCAKNVLITFNNKAKLCDFSMATEVQK
| | .|  .|  .|.||   |  . .   | | |||.| ..  | |||  |  ...
LTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHC
Kinase TK11.AA Pkinase 425-455 34 0.000133 17.36 Pfam 176-207 (293) Show / Hide 
Range on Protein: 425-455
Range on HMM: 176-207/293
Sequence Identity: 34% (11 aa)

RWMAYEALL-EGQYTMKSDVWSYGIVLWEIVT
..|| | ..    |. |.|.||.|..|.| ..
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC
Kinase TK11.AA DDR 357-402 27 0.000361 10.5 In-house 136-183 (306) Show / Hide 
Range on Protein: 357-402
Range on HMM: 136-183/306
Sequence Identity: 27% (13 aa)

LLNFACDIAQGMRHIAALRYVYMNLCAKNVLITFNNKAKLCDFS--MA
..  . .|| ||.. . .. |   | ..|.|.  .  .| |||   |.
CVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMS
Kinase TK11.AA FGFR 268-337 29 0.000563 9.38 In-house 1-74 (293) Show / Hide 
Range on Protein: 268-337
Range on HMM: 1-74/293
Sequence Identity: 29% (22 aa)

LEMGKLLYSGEFSYVCEGDLK----QGSDVPIKVAIKLHRDENDQESITEMRNEFQVLANLGKHPNILMLLGQC
| .|| |  | |  |  .  |    .  .  |.||.|   ..   . .     |  ..   |||.||. ||| |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCC
Kinase TK11.AA Pkinase 268-335 26 0.055508 8.09 Pfam 1-67 (293) Show / Hide 
Range on Protein: 268-335
Range on HMM: 1-67/293
Sequence Identity: 26% (18 aa)

LEMGKLLYSGEFSYVCEGDLKQGSD-VPIKVAIKLHRDENDQESITEMRNEFQVLANLGKHPNILMLLG
.. |. . || |. |...  |  .. | .|.  | |.... ... .   .| |....| .||||. |..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRL-NHPNIVRLYD