Gene Irak1 (Sea Urchin)

Irak1

Species: Sea Urchin
Alias: SPU_000073, Irak1, Spk303
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: IRAK

Sequence

Name Sequence Type Origin Length Description Download
Irak1.AA Protein None 608 None Fasta, JSON
Irak1.kin_dom Protein Kinase Domain None 269 None Fasta, JSON

Protein domain

Protein domains of Irak1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Irak1.AA IRAK 153-425 40 6.8e-165 554.09 In-house 2-317 (317) Show / Hide 
Range on Protein: 153-425
Range on HMM: 2-317/317
Sequence Identity: 40% (128 aa)

DGGCLIDEGGFGVVFRGRFSGEE-PCAVKKLKEHVMSEEISIEEQFNS---ELKSLCRLRHPNLVILYGYCYEPPQLCLVYELITGGALRDRLACRDTTC
... .| |||||.|.||...... ..|||||||............|..   |||..||.||||.|.|||||.|....||||.....|.|.|||.|.|..|
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC

TPKPLSWPKRLDIAWGSACGIQFLHDKG----FIHRDIKSANILLDANLTPKICDFGLVRD---KSGKLKGEISCFHTSITIGSTAYMAPEANY---GEY
.||||||..|..|.||.||||||||...    .||.||||||||||...|||||||||.|.   .|.|.|....|..||...|.|.||.||...   |..
PPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQL

SKKTDVYSFGLVLLEILTGL-PVYDDDTH---IMTKVDNIMDSCN-------------------------DVVLLIDKHAEMWNEKSAQVMYDLASRCTE
.|||||||||.||||.|||. .||||...   .......||....                         .....||.............|...|..|..
TKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCGH

QKVRRRPDIEEMVEEE
....||.|........
HRANRRCDMAWVMQQL
Kinase Irak1.AA TKL 158-425 25 3.1e-81 276.19 In-house 1-364 (364) Show / Hide 
Range on Protein: 158-425
Range on HMM: 1-364/364
Sequence Identity: 25% (97 aa)

IDEGGFGVVFRGRFSGEE---------PCAVKKLKEHVMSEEISIE-----------------------EQFNSELKSLCRLRHPNLVILYGYCYEPPQ-
| .||||.|..|.. |.          . ||||.|.| ..|. ...                       .... |.... ||||||.| ..||| .||. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCLVYELITGGALRDRLACRDTTCTPKPLSWPKRLDIAWGSACGIQFLHD--------KGFIHRDIKSANILLDANLT----------
            ||.|.|.. || |...|             |..|...| . |.|...||         .. ||||.||.|||.| |.|          
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPN

----PKICDFGLVRDKS---GKLKGEISCF----------HTSITIGSTAYMAPEA-----NYG------------EYSKKTDVYSFGLVLLEILTGLPV
    .||||||| |..|   .. ... ..           .|.  .|....||||.     ||             |||.|.||||||.|| ||||. ..
ADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP

YDDDTHIMTK---------VDNIMDSCNDVVL------LIDKHAEMWNEKSAQVMYDLASRCTEQKVRRRPDIEEMVEEE
|.|. ... .         . .. ...   .       .  | . ....   . | .|. .| ... . ||  .| ... 
YYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH--K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Irak1.AA S_TKc 152-429 25 8.4e-48 166.05 SMART 1-231 (231) Show / Hide 
Range on Protein: 152-429
Range on HMM: 1-231/231
Sequence Identity: 25% (72 aa)

KDGGCLIDEGGFGVVFRGRFSG-EEPCAVKKLKEHVMSEEISIEEQFNSELKSLCRLRHPNLVILYGYCYEPPQLCLVYELITG--GALRDRLACRDTTC
 . . .| .|.||.|...|  .  . .|.|..|           |.. .|.. | . .|||.| ||.....   |..| |.. |  | |.|..  | .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TPKPLSWPKRLDIAWGSACGIQFLHDKGFIHRDIKSANILLDANLTPKICDFGLVRDKSGKLKGEISCFHTSITIGSTAYMAPEANYGEYSK-KTDVYSF
...|..      ...  .|.....|..|.||||.| .|||||   . ||||||| |               .  .|.  |||||     |.| | |..|.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL--GYGKCKCDWWSC

GLVLLEILTGLPVYDDDTHIMTKVDNIMDSCNDVVLLIDKHAEMWNEKSAQVMYDLASRCTEQKVRRRPDIEEMVEEE-----EQYI
| .| | |.| | ..   ....  ..|.                      . . |. ..| .   ..|| . |  ..|      ...
GCILYEMLCGYPPFP---QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Irak1.AA TyrKc 155-425 29 2.6e-45 157.76 SMART 4-280 (280) Show / Hide 
Range on Protein: 155-425
Range on HMM: 4-280/280
Sequence Identity: 29% (89 aa)

GCLIDEGGFGVVFRGRFSGEEPCAVKKLKEHVMSEEISIEEQFNSELKSLCRL--RHPNLVILYGYCYEP-------PQLCLVYELITGGALRDRL-ACR
|  . || ||.|..|. .  ...|||.|||.        .| | .|.. .|.|  .|||.| |||.| ..       ..|..| |.  .|.|.|.| ..|
GKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

DTTCTPKPLSWPKRLDIAWGSACGIQFLHDKGFIHRDIKSANILLDANLTPKICDFGLVRDKSGK-LKGEISCFHTSITI----GST-----AYMAPEAN
..      |.... |...|  ||| ..||.|..||||.   |.|...|.| ||.|||| ||   .  .|     .  ..     |.        ||||. 
PK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLPIRWMAPECI

-YGEYSKKTDVYSFGLVLLEILT-GLPVYDDDTHIMTKVDNIMDSCNDVVLLIDKHAEMWNEKS---------AQVMYDLASRCTEQKVRRRPDIEEMVE
 ||... |.||.||| .. ||.| | . | ...         | |  .|. ....   |   ..          . ||.. ..| . .   ||  .| .|
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-------MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

EE
. 
CF
Kinase Irak1.AA Pkinase_Tyr 160-356 36 4.6e-45 153.25 Pfam 9-209 (270) Show / Hide 
Range on Protein: 160-356
Range on HMM: 9-209/270
Sequence Identity: 36% (76 aa)

EGGFGVVFRGRFS-----GEEPCAVKKLKEHVMSEEISIEEQFNSELKSLCRL-RHPNLVILYGYCY--EPP-QLCLVYELITGGALRDRLACRDTTCTP
|| ||.|..|.       .. |.|||.|||. |.|.  . | | .|.| .. | .|||.| ||| |.  . | |...| |.  .| |.| |  .     .
EGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR--EDK

KPLSWPKRLDIAWGSACGIQFLHDKGFIHRDIKSANILLDANLTPKICDFGLVRDKSGKLKGEISCFH-TSITIGSTAYMAPE-ANYGEYSKKTDVYSFG
.||. .  |...|  |.| ..|..|..||||.   |.|.. |.. ||||||| ||     . .   .. .. .      ||||  |||... |.||.|||
QPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI---YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFG

LVLLEILT
 .. ||.|
VLMWEIFT
Kinase Irak1.AA MLK 152-357 29 1.3e-44 152.69 In-house 1-232 (291) Show / Hide 
Range on Protein: 152-357
Range on HMM: 1-232/291
Sequence Identity: 29% (73 aa)

KDGGCLIDEGGFGVVFRGRFSGEE----PCAVKKLK---EHVMSEEISIEEQFNSELKSLCRLRHPN----LVILYGYCYEPPQ-LCLVYELITGGALRD
 .    | .|.||.|..||. ...      |||. .   .  .|.. .. ..|. | . | .|.|||     ...|| | .||. .|.| | . || | .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

RLACRDTTCTPK--------PLSWPKRLDIAWGSACGIQFLHDKGF---IHRDIKSANILLDA------NLTPKICDFGLVRDKSGKLKGEISCFHTS--
 |. ...   .           .    ...|   | |...|| .     ||||.|| |||.|.      ..| ||||||..||           .|..  
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRD-----------WHQMCT

---ITIGSTAYMAPEA----NYGEYSKKTDVYSFGLVLLEILTG
    ..|. |.||||.      . ||.| ||.|.|.|| |.||.
NMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase Irak1.AA TKL-Unique 155-357 33 6e-43 149.0 In-house 2-224 (290) Show / Hide 
Range on Protein: 155-357
Range on HMM: 2-224/290
Sequence Identity: 33% (76 aa)

GCLIDEGGFGVVFRGRFSGEEPCAVKKLKEHVMSEEISIEEQFNSELKSLCRLR-HPNLVILYGYCY----EPPQLCLVYELITGGALRDRLA----CRD
. .| |||.|.|..| . |..  |.|....   . . .... |..|.. . .|. |||.| ..|||      ||..|.| | . || |.| |.       
WNKIGEGGYGQVYKGKWRGYP-VAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

TTCTPKPLSWPKRLDIAWGSACGIQFLHDKG--FIHRDIKSANILLDAN-----LTPKICDFGLVRDKSGKLKGEISCFH---TSITIGSTAYMAPEANY
     ..|.. .|...|   | |  .|| ..   ||||.|| |.|.| |     .  |||||||.. .|  .|. ..       .  .||. .||||   
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

G---EYSKKTDVYSFGLVLLEILTG
.    ||.| |||||| || ||.|.
MNFCQYSEKSDVYSFGIVLWEIATR
Kinase Irak1.AA TK 163-425 18 3.4e-41 135.34 In-house 12-486 (486) Show / Hide 
Range on Protein: 163-425
Range on HMM: 12-486/486
Sequence Identity: 18% (92 aa)

FG---VVFRGRFSGE--------------------------EPCAVKKLKE-HVMSEEISIEE------------QFNSELKSLC--RLRHPNLVILYGY
||   .|..|.  |.                          .|.||| ||| . ||.|  ..|            .. .|.| .|   ..|||.| |||.
FGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGV

CYEP------------PQLCLVYELITGGA----LRDRLA-CRDTTCT----------------------------------------------------
| ..            . ...| |.  .|     ||| |  ||... .                                                    
CTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPP

-----------------PKPLSWPKRLDIAWGSACGIQFLHDK------GFIHRDIKSANILLDANLT-----------PKICDFGLVRDKSGKLKGEIS
                 . .|. . .| ..|  ||| ..||.|      .|.|||.   |.|.. |..            ||.|||| |..||       
LTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSG-------

CFHTSITIGS-TAY------------------------------------MAPEANY----------GEYSKKTDVYSFGLVLLEILT-G-LPVYDDDTH
    .  |.| . |                                    ||||.            | .. |.||.||| .. ||.| |  | | . ..
--VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSN

-----------IMTKVD----------------NIMD---SCNDVVLLIDKHAEMWNEKSAQVMYDLASRCTEQKVRRRPDIEEMVEEE
           .| ..                 . |     | | . .  ..    ...  ...|||  .| . . ..||. ....|. 
QDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWM-R-YRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Irak1.AA Pkinase 160-364 29 5.8e-39 138.86 Pfam 9-215 (293) Show / Hide 
Range on Protein: 160-364
Range on HMM: 9-215/293
Sequence Identity: 29% (64 aa)

EGGFGVVFRGRFSGE-EPCAVKKLKEHVMSEEISIEEQFNSELKSLCRLRHPNLVILYGYCYEPPQLCLVYELITGG----ALRDRLACRDTTCTPKPL-
.|.||.|....  |. .  |||..| .  ...  ..    ||.. . ||.||| | ||....... ...| |.  ||     | |..         ... 
SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST----WRHGCFY

-SWPKRLDIAWGSACGIQFLHDKGFIHRDIKSANILLDANLTP----KICDFGLVRDKSGKLKGEISCFHTSITIGSTAYMAPEA-N-YGEYSKKTDVYS
 |.    ....  ..|....|..|.||||.|..|||.| | ..    ||||||| . ..       | ..|    |.  |||||  . . .|..| |..|
FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTF--CGTPWYMAPEVIRGGQYYGPKVDMWS

FGLVLLEILTGLPVYDDD
.|..| | |.| | ....
CGCILYEMLCGRPPFPGH
Kinase Irak1.AA Dicty4 160-357 33 2.4e-34 112.09 In-house 9-213 (277) Show / Hide 
Range on Protein: 160-357
Range on HMM: 9-213/277
Sequence Identity: 33% (73 aa)

EGGFGVVFRGRFSGEEPCAVKKL---KEHVMSEEISIEEQFNSELKSLCRLRHPNLVILYGYCY----EPPQLCLVYELITGGALRDRLACRD---TTCT
.|.|| |..|.  | |  |||||   .. . ....   . |  | . .| .||||.. ..|.|     .|. .| | |.   | |   |  .|       
KGSFGEVYKGTWRGKE-VAVKKLNNHNQNFDENML---NEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLL--HDKPSEQQQ

PKPLSWPKRLD---IAWGSACGIQFLHDKG--FIHRDIKSANILLDANLTPKICDFGLVR----DKSGKLKGEISCFHTSITIGSTAYMAPEANYGE-YS
 ..|.|| ..    .|   | |.. ||     .||||.||.|.| |.|.. |.||||| .    ... |       . .. ..|....||||   .. | 
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHK-------DNQMTACGTPCWMAPEVMMHQPYN

KKTDVYSFGLVLLEILTG
 | ||||||.|| ||||.
EKADVYSFGIVLWEILTR
Kinase Irak1.AA LRRK 148-363 26 3.2e-34 118.47 In-house 1-285 (351) Show / Hide 
Range on Protein: 148-363
Range on HMM: 1-285/351
Sequence Identity: 26% (79 aa)

QKKVKDGGCLIDEGGFG-VVFRGRFSGE---------------------------EPCAVKKLKEH------------------------------VMSE
.|. .     | .|||| .|.|... |.                           .. |.||.. .                              ....
LKIEEQ----IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHED

EISIEEQFNSELKSLCRLRHPNLVILYGYCYEPPQLCLVYELITGGALRDRLA--CRDT-TCTPKPLSWPKRLDIAWGSACGIQFLHDKG--FIHRDIKS
 . .   |  |.  ...|.|||.| |.|.| .|  ||.| |... |.| ..|    .|     .  .||  .| ||   | |...||..   .|||| ||
CCRAFREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKS

ANILL---D---------ANLTPKICDFGLVRDKSGKLKGEISCFHTSITIGST---AYMAPE-ANYG---EYSKKTDVYSFGLVLLEILTGL-PVYDD
 ||||   .         |. . ||.|||. |          .|||.... |..    .||||  .|.   ||. |.|.||||..| |.||.. . .|.
PNILLWSSPQNHSPNYPNAHVCAKIADFGISR-M-------FQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDE
Kinase Irak1.AA Dicty4-Unclassified 157-357 33 7.3e-34 113.33 In-house 6-204 (263) Show / Hide 
Range on Protein: 157-357
Range on HMM: 6-204/263
Sequence Identity: 33% (70 aa)

LIDEGGFGVVFRGRFSGEEPCAVKKLKEHVMSEEISIEEQFNSELKSLCRLRHPNLVILYGYCYEP----PQLCLVYELITGGALRDRLACRDTTCTPKP
 | .| |  | .|   | .  ||||. |   .    . . |  |   |  . ||||| .||||  |      .| | |..  | |      .      .|
FIGKGHFSKVHKGNWKGKD-VAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSE-QQQP

LSWPK--RLDIAWGSACGIQFLHDKGFIHRDIKSANILLDANLTPKICDFGLVRDKSGKLKGEISCFHTSITIG-STAYMAPEANYGE-YSKKTDVYSFG
..      . .|   | |.|.|| . ||||||||.|||.| .   || |||. |        .|.   .  ||.   .  .||   .| |  | ||||..
IKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISR--------VIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYA

LVLLEILTG
..| | .||
MMLYELATG
Kinase Irak1.AA Ciliate-E2 157-361 19 2.2e-32 108.48 In-house 6-296 (365) Show / Hide 
Range on Protein: 157-361
Range on HMM: 6-296/365
Sequence Identity: 19% (59 aa)

LIDEGGFGVVFRGRFSGEEP-------------------CAVKKLKEHVMS----EEISIEEQFN----------SELKSLCRLRHPNLVILYGYCY--E
.| .|.||.|....   .                     ...|.    .|.    |.|. |.. .           |.. | .| |||.. .| . .   
KIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKD

PPQLCLVYELITGGALRDRLACRDTTCTPK-----PLSWPKRLDIAWGSAC---------------GIQFLHDKG-FIHRDIKSANILLDANLTPKICDF
   . || |.. || |.|..  ... .. .     .... ....| .  .                ....|| |.  ||||||  |||.     .||.||
DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDF

GLVRDKS------------GKLKGEISCFHTSIT--------------IGSTAYMAP----EANYGE------YSKKTDVYSFGLVLLEILTGLPVY
|| .. .            ....   .  .....              .|.  ||||      .|.       |..| |..|.| .| | |.| | .
GLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF
Kinase Irak1.AA STE 268-359 30 7.4e-24 81.2 In-house 163-266 (359) Show / Hide 
Range on Protein: 268-359
Range on HMM: 163-266/359
Sequence Identity: 30% (35 aa)

G-IQFLHDKGFIHRDIKSANILLDANLTPKICDFGLVRDKSGKLKGEIS--------------CFHTSITIGSTAYMAPEANYGE-------YSKKTDVY
|  ..||... ||||||.|||||      |.||||.    .|.|  ...                ..   .|.  .||||   ..       |. | |..
GLLYYLHSHHIIHRDIKPANILL-----VKLCDFGV----CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIW

SFGLVLLEILTGLP
|.|....| .|| |
SLGCTIIEMATGKP
Kinase Irak1.AA STE 152-239 20 6.1e-10 31.41 In-house 1-126 (359) Show / Hide 
Range on Protein: 152-239
Range on HMM: 1-126/359
Sequence Identity: 20% (26 aa)

KDGGCLIDEGGFGVVFRGR--------FSGEE--------PCAVKKLKEHVMS-----------EEI--SIEEQFNSELKSLCRLR--HPNLVILYGYCY
 .|   | .|.||.|....         .||.         .|.|...    .           | .  ....|.  |.| . ...  ||| |  ||...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EP-------PQLCLVYELITGGALRD
          .|... |.. || |.|
KEGHNHKNDDELWICMEYMDGGSLDD
Kinase Irak1.AA IRAK 458-599 33 5.9e-72 245.37 In-house 141-317 (317) Show / Hide 
Range on Protein: 458-599
Range on HMM: 141-317/317
Sequence Identity: 33% (60 aa)

PANILLDANLTPKICDFGLVRD---KSGKLKGEISCFHTSITIGSTAYMAPEANY---GEYSKKTDVYSFGLVLLEILTGL-PVYDDDSH---IMTKVDN
.||||||...|||||||||.|.   .|.|.|....|..||...|.|.||.||...   |...|||||||||.||||.|||. .||||...   .......
SANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEE

IMDSCN-------------------------DVVLLIDKHAEMWNEKSAQVMYDLASRCTEQKGRRRPDIEEVRRIC
||....                         .....||.............|...|..|.... .||.|...|    
IMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase Irak1.AA TKL 458-599 23 5.4e-30 105.19 In-house 168-364 (364) Show / Hide 
Range on Protein: 458-599
Range on HMM: 168-364/364
Sequence Identity: 23% (48 aa)

PANILLDANLT--------------PKICDFGLVRDKS---GKLKGEISCF----------HTSITIGSTAYMAPEA-----NYG------------EYS
..|||.| |.|              .||||||| |..|   .. ... ..           .|.  .|....||||.     ||             |||
SKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYS

KKTDVYSFGLVLLEILTGLPVYDDDSHIMTK---------VDNIMDSCNDVVL------LIDKHAEMWNEKSAQVMYDLASRCTEQKGRRRPDIEEVRRI
.|.||||||.|| ||||. ..|.|. ... .         . .. ...   .       .  | . ....   . | .|. .| ... . ||  .|.  .
EKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH--K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKR

C
 
L
Kinase Irak1.AA MLK 458-531 35 2.3e-17 56.88 In-house 155-232 (291) Show / Hide 
Range on Protein: 458-531
Range on HMM: 155-232/291
Sequence Identity: 35% (32 aa)

PANILLDA------NLTPKICDFGLVRDKSGKLKGEISCFHTS-----ITIGSTAYMAPEA----NYGEYSKKTDVYSFGLVLLEILTG
. |||.|.      ..| ||||||..||           .|..      ..|. |.||||.      . ||.| ||.|.|.|| |.||.
SHNILIDEICHDMHHGTLKICDFGTSRD-----------WHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase Irak1.AA TKL-Unique 457-531 38 7.1e-15 49.04 In-house 139-224 (290) Show / Hide 
Range on Protein: 457-531
Range on HMM: 139-224/290
Sequence Identity: 38% (33 aa)

RPANILLDAN-----LTPKICDFGLVRDKSGKLKGEISCFH---TSITIGSTAYMAPEANYG---EYSKKTDVYSFGLVLLEILTG
.. |.|.| |     .  |||||||.. .|  .|. ..       .  .||. .||||   .    ||.| |||||| || ||.|.
KSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase Irak1.AA Pkinase 458-541 32 3.3e-14 51.34 Pfam 136-221 (293) Show / Hide 
Range on Protein: 458-541
Range on HMM: 136-221/293
Sequence Identity: 32% (31 aa)

PANILLDANLTP----KICDFGLVRDKSGKLKGEISCFHTSITIGSTAYMAPEA-N-YGEYSKKTDVYSFGLVLLEILTGLPVYDDD----SHI
|.|||.| | ..    ||||||| . ..       | ..|    |.  |||||  . . .|..| |..|.|..| | |.| | ....    . .
PENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTF--CGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-H
Kinase Irak1.AA Dicty4 458-531 37 5.9e-14 43.1 In-house 142-213 (277) Show / Hide 
Range on Protein: 458-531
Range on HMM: 142-213/277
Sequence Identity: 37% (30 aa)

PANILLDANLTPKICDFGLVR----DKSGKLKGEISCFHTSITIGSTAYMAPEANYGE-YSKKTDVYSFGLVLLEILTG
..|.| |.|.. |.||||| .    ... |       . .. ..|....||||   .. |  | ||||||.|| ||||.
SHNLLVDKNWRVKVCDFGLSQYMKKHEDHK-------DNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTR
Kinase Irak1.AA STE 458-533 27 1.9e-13 43.93 In-house 180-266 (359) Show / Hide 
Range on Protein: 458-533
Range on HMM: 180-266/359
Sequence Identity: 27% (27 aa)

PANILLDANLTPKICDFGLVRDKSGKLKGEIS--------------CFHTSITIGSTAYMAPEANYGE-------YSKKTDVYSFGLVLLEILTGLP
||||||      |.||||.    .|.|  ...                ..   .|.  .||||   ..       |. | |..|.|....| .|| |
PANILL-----VKLCDFGV----CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKP
Kinase Irak1.AA TK 460-599 18 2.7e-12 36.77 In-house 270-486 (486) Show / Hide 
Range on Protein: 460-599
Range on HMM: 270-486/486
Sequence Identity: 18% (43 aa)

NILLDANLT-----------PKICDFGLVRDKSGKLKGEISCFHTSITIGS-TAY------------------------------------MAPEANY--
|.|.. |..            ||.|||| |..||           .  |.| . |                                    ||||.    
NCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSG---------VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDR

--------GEYSKKTDVYSFGLVLLEILT-G-LPVYDDDSH-----------IMTKVD----------------NIMD---SCNDVVLLIDKHAEMWNEK
        | .. |.||.||| .. ||.| |  | | . |.           .| ..                 . |     | | . .  ..    ...
VFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWM-R-YRM-H-PPHC

SAQVMYDLASRCTEQKGRRRPDIEEVRRIC
  ...|||  .| . . ..||. .....  
PPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Irak1.AA Ciliate-E2 458-535 22 4.8e-12 37.61 In-house 189-296 (365) Show / Hide 
Range on Protein: 458-535
Range on HMM: 189-296/365
Sequence Identity: 22% (26 aa)

PANILLDANLTPKICDFGLVRDKS------------GKLKGEISCFHTSIT--------------IGSTAYMAP----EANYGE------YSKKTDVYSF
| |||.     .||.|||| .. .            ....   .  .....              .|.  ||||      .|.       |..| |..|.
PENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL

GLVLLEILTGLPVY
| .| | |.| | .
GVILYEMLFGKPPF
Kinase Irak1.AA Dicty4-Unclassified 459-531 34 7.3e-12 36.87 In-house 138-204 (263) Show / Hide 
Range on Protein: 459-531
Range on HMM: 138-204/263
Sequence Identity: 34% (26 aa)

ANILLDANLTPKICDFGLVRDKSGKLKGEISCFHTSITIG-STAYMAPEANYGE-YSKKTDVYSFGLVLLEILTG
.|||.| .   || |||. |        .|.   .  ||.   .  .||   .| |  | ||||....| | .||
SNILMDKHFNIKIADFGISR--------VIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATG
Kinase Irak1.AA Pkinase_Tyr 460-530 38 1.8e-09 32.67 Pfam 141-209 (270) Show / Hide 
Range on Protein: 460-530
Range on HMM: 141-209/270
Sequence Identity: 38% (28 aa)

NILLDANLTPKICDFGLVRDKSGKLKGEISCFH-TSITIGSTAYMAPE-ANYGEYSKKTDVYSFGLVLLEILT
|.|.. |.. ||||||| ||     . .   .. .. .      ||||  |||... |.||.||| .. ||.|
NCLVTENNVVKICDFGLARDI---YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFT
Kinase Irak1.AA LRRK 502-537 43 5.1e-09 28.02 In-house 245-285 (351) Show / Hide 
Range on Protein: 502-537
Range on HMM: 245-285/351
Sequence Identity: 43% (18 aa)

YMAPE-ANYG---EYSKKTDVYSFGLVLLEILTGL-PVYDD
.||||  .|.   ||. |.|.||||..| |.||.. . .|.
WMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDE