Gene LIMK (Sea Urchin)

LIMK

Species: Sea Urchin
Alias: LIMK, SPU_022207, Spk306
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: LISK
Subfamily: LIMK

Sequence

Name Sequence Type Origin Length Description Download
LIMK.AA Protein None 368 None Fasta, JSON
LIMK.kin_dom Protein Kinase Domain None 278 None Fasta, JSON

Protein domain

Protein domains of LIMK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LIMK.AA LIMK 66-336 64 1.9e-235 788.45 In-house 1-287 (287) Show / Hide 
Range on Protein: 66-336
Range on HMM: 1-287/287
Sequence Identity: 64% (184 aa)

LIKGEVLGQGFFGKAVKVTHRYTGEVMVIKELVRYSDSAQRDFLKEVKVLRSLDHYHVLKFIGVLYRDKRLNLVTEFVGGGTLENIISDLDKPFPWLQRI
||.|||||.||||.|.|||||.||||||.|||.|.....||.|||||||.|.|||.||||||||||.|||||.|||...||.|.|||.|.|.||||.||.
LIHGEVLGKGFFGQAIKVTHRQTGEVMVMKELHRCDEETQRTFLKEVKVMRCLDHPHVLKFIGVLYKDKRLNMVTEYIKGGCLKNIIHDMDQPFPWQQRV

NAARDIASGMSYLHSMGIIHRDLNSNNCLVRDDGSVVVADFGLARVFIDENDSRCP-------------NSFGPGRDKHQP--AGRKKRYTMVGTAFWMA
..|||||.||||||||.||||||||.|||||.|.|||||||||||..|||....|.             |...|.|..|.|  ..||||||.||...|||
RFARDIACGMSYLHSMCIIHRDLNSHNCLVREDRSVVVADFGLARLMIDERKQSCNMTPGGYGSGANMDNPMEPKRTLHKPKSRDRKKRYTVVGNPYWMA

PEMLKGKDYNERVDVFSFGIVMCELIGRVSACPDDLPRSGDFGLDEVPFMAQCC-DTCPKTFHQIMLMCVRMDSDERPSFDELDQRL
|||..||.|.|.||||||||||||.||||.||||..||..||||....|...|| |.||..|..||.||..||.|.||.||.|.|.|
PEMMNGKSYDEKVDVFSFGIVMCEIIGRVYACPDCMPRTMDFGLNQQEFWEKCCPDQCPPPFFPIMFMCCDMDPDMRPCFDKLHQWL
Kinase LIMK.AA LISK 71-336 44 9.69999999999e-174 569.08 In-house 1-296 (296) Show / Hide 
Range on Protein: 71-336
Range on HMM: 1-296/296
Sequence Identity: 44% (132 aa)

VLGQGFFGKAVKVTHRYTGEVMVIKELVR-----YSDSAQRDFLKEVKVLRSLDHYHVLKFIGVLYR-DKRLNLVTEFVGGGTLENIISDLDK---PFPW
..|.|||||..|.|||.||.||.||.. |     . ...|. .|.||.....|.|.....|.||.|. |..|..|||...||.|.....| ||   |.||
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

LQRINAARDIASGMSYLHSMGIIHRDLNSNNCLVR----DDGSVVVADFGLARVFIDENDSRCP------------NSFGPGRDKHQP--AGRKKRYTMV
 ||.. |.|||.||||||||.||||||.|.|||||    .. ...|.|||.||....||.|.|.            |.....|.....  . ||.|.|..
PQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRMTIC

GTAFWMAPEMLKGKDYNERVDVFSFGIVMCELIGRVSACPDDLPRSG--DFGLDEVPFMAQCCDT-CPKTFHQIMLMCVRMDSDERPSFDELDQRL
||..|||||||.|..|.|..||||||||.||.|.|| |.||..||..  |||||   |....|.. ||. |......|...| ..||||.|..|.|
GTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTPQHDFGLDYEEFWQKICPDDCPPPFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase LIMK.AA TESK 70-338 40 3.6e-100 317.08 In-house 1-292 (292) Show / Hide 
Range on Protein: 70-338
Range on HMM: 1-292/292
Sequence Identity: 40% (119 aa)

EVLGQGFFGKAVKVTHRYTGEVMVIKELV-RYSDSAQRDFLKEVKVLRSLDHYHVLKFIGVLYRDKRLNLVTEFVGGGTLENIISDLDKPFPWLQRINAA
| .| |||    ||.|| .| |||.|    .   . .   |.||. .  | |  .|.| ||  .. .|  .||.. ||.||.. .| . . .| |.|. |
EKIGSGFFSEVYKVRHRASGQVMVLKMNKQKIWRANRHNMLREVQLMNKLQHPNILRFMGVCVHQGQLHALTEYINGGCLEQLLADSELHLSWTQKIHLA

RDIASGMSYLHSMGIIHRDLNSNNCLVR---DDG-SVVVADFGLARVF-----IDENDSRCPNSF----------GPGRDKHQPA--GRKK-RYTMVGTA
 ||| ||||||| |. |||| | |||||   ... . ||.|||||||.        |  | |.|           ||  .|   .  ...| .   ||..
YDIARGMSYLHSKGVFHRDLTSKNCLVRQRDNNQYEAVVGDFGLARVLGCMPDPPPNSPRTPESPEPDIIDAPNGGPMLEKIPVYCMDSRKEKMAVVGSP

FWMAPEMLKGKDYNERVDVFSFGIVMCELIGRVSACPDDLPRSGDFGLDEVPFMAQCCDTCPKTFHQIMLMCVRMDSDERPSFDELDQRLSS
.||||| |.|  |.|..||||||||.||.| |. | ||..|| ..||||   |   | . ||. | |.   |  ||  .||.| |. ..|  
YWMAPEVLRGEWYDEKADVFSFGIVLCEIIARIQADPDYMPRTEKFGLDYQAFKEMCPMDCPEPFLQLAFHCCNMDPKDRPVFHEITKHLEW
Kinase LIMK.AA TKL 72-336 24 9.4e-81 274.59 In-house 1-364 (364) Show / Hide 
Range on Protein: 72-336
Range on HMM: 1-364/364
Sequence Identity: 24% (92 aa)

LGQGFFGKAVKVTHRY--------TGEVMVIKELVRYSDS---------------------------AQRDFLKEVKVLRSLDHYHVLKFIG--------
.|.|.||.  | ..|         ||.....| . . .|.                           ..  . .|......|.| ....|.|        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-VLYR----DKRLNLVTEFVGGGT-LENIISDLDKPFPWLQRINAARDIASGMSYLHSMG--------IIHRDLNSNNCLVRDDGS--------------
 | ..    .. | .|.|.. ||. |....        | ||.. |.|||.||.|||||.        ||||||.|.|.|| ...               
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

VVVADFGLARVFIDENDSRC---------PNSFGPGRDKHQPAGRKKRYTMVGTAFWMAPEMLKGK----------------DYNERVDVFSFGIVMCEL
. ..||||.|..  .... .         .         ||  .||...| .||  |||||.|.|.                .|.|..||.|||||..|.
CKICDFGLSRFMSQSGNMNDTMTTMMESAE---------HQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI

IG--RVSACPDDLPRS------GDFGLDEV----PFMA---------QCCDTCPKTFHQIMLMCVRMDSDERPSFDELDQRL
.   |. ....  |.        .| .. .    | .          ..|..||. . ..| .|  .| ..||||.|. .||
LTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LIMK.AA LISK-DD1 111-336 31 1.8e-61 210.54 In-house 44-290 (290) Show / Hide 
Range on Protein: 111-336
Range on HMM: 44-290/290
Sequence Identity: 31% (84 aa)

EVKVLRS---LDHYHVLKFIGVLYR-------------DKRLNLVTEFVGGGTLENIISDL------------DKPFPWLQRINAARDIASGMSYLHSMG
|.|.|..   . |  . .|||. ..             . .| .||||..|| | ... .             ..|.||  |.. |.|||..|.|||| .
EIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWYLKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSKN

IIHRDLNSNNCLVRDD-GSVV---VADFGLARVFIDENDSRCPNSFGPGRDKHQPAGRKKRYTMVGTAFWMAPEMLKGKDYNERVDVFSFGIVMCELIGR
|||||| |.| || .   |     | |||.||.|     ..                .....|..||  |||||.. | .|....||||||.|  ||| |
IIHRDLKSKNILVDENGDSQWRIKVCDFGFARMFEQKKNQQ----------------NNRHMTICGTDNWMAPEVILGMSYDWSCDVFSFGMVLLELITR

VSACPDDLPRS--GDFGLDEVPFMA-QCCDT--CPKTFHQIMLMCVRMDSDERPSFDELDQRL
.   .. ..||   .|..|.  |      .   ||. |    . |   | ..||||.|  |.|
KKPDKRMWQRSPMNCFDIDQEEFRQQKIPKDNDCPREFMDLCMWCCKYDPNNRPSFKEIVQTL
Kinase LIMK.AA S_TKc 66-340 22 1.3e-55 191.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 66-340
Range on HMM: 1-231/231
Sequence Identity: 22% (64 aa)

LIKGEVLGQGFFGKAVKVTHRYTGEVMVIKELVRYSDSAQRDFLKEVKVLRSLDHYHVLKFIGVLYRDKRLNLVTEFVGG--GTLENIISDLDKP-----
  .....|.| |||  |..|. ||... ||..        .....|...|.. .| .. |...| .  ..| .|.|...|  |.|  .| .  ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FPWLQRINAARDIASGMSYLHSMGIIHRDLNSNNCLVRDDGSVVVADFGLARVFIDENDSRCPNSFGPGRDKHQPAGRKKRYTMVGTAFWMAPEMLKGKD
||  .    .. |.... |.||.|||||||   | |. .   . ..||||||..                           .|..|| ..||||.|    
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------------------TTFCGTPWYMAPEVL---G

YNE-RVDVFSFGIVMCELIGRVSACPDDLPRSGDFGLDEVPFMAQCCDTCPKTFHQIMLMCVRMDSDERPSFDELDQ-----RLSSFS
|.  ..|. |.|... |.. .    |           ..   . ...   .. . ...  | ..| ..||.  |. |     ..  . 
YGKCKCDWWSCGCILYEMLCGYPPFP-----------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LIMK.AA Pkinase 66-276 25 2.5e-51 181.61 Pfam 1-206 (293) Show / Hide 
Range on Protein: 66-276
Range on HMM: 1-206/293
Sequence Identity: 25% (58 aa)

LIKGEVLGQGFFGKAVKVTHRYTGEVMVIKELVRYSDSAQRD--FLK--EVKVLRSLDHYHVLKFIGVLYRDKRLNLVTEFVGGG----TLENIIS-DLD
. .|...|.| ||.  | .|. ||.. ..|.. . ... . |   ..  |......|.| ........ ...... .|.|...||     |  .|| . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KPF--PWLQRINAARDIASGMSYLHSMGIIHRDLNSNNCLVRDDGSV----VVADFGLARVFIDENDSRCPNSFGPGRDKHQPAGRKKRYTMVGTAFWMA
..|  .. . .. .. |..|. |.|||||||||| . |.|. ..| .     ..|||||..|                           .| .|| ..||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------------------Y-NNS-MTTFCGTPWYMA

PEMLK-GKDYNERVDVFSFGIVMCELI
|| .. |..|  .||..|.|... |..
PEVIRGGQYYGPKVDMWSCGCILYEML
Kinase LIMK.AA STE 67-276 24 1.3e-47 164.47 In-house 1-262 (359) Show / Hide 
Range on Protein: 67-276
Range on HMM: 1-262/359
Sequence Identity: 24% (69 aa)

IKG-EVLGQGFFGKAVKVTHRY---------------TGEVMVIK--ELVRYS---------------DSAQRDFLKEVKVLRSLD--HYHVLKFIGVLY
 .| |..|.| ||. .|  ..                |||.| ||  .| . .               .. . ..|||.|... ..  | .. |..|  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

RD-------KRLNLVTEFVGGGTLENIIS-------DLD------KPFPWLQRINAARDIASG-MSYLHSMGIIHRDLNSNNCLVRDDGSVVVADFGLAR
..         |... |...||.|. ||        .|.      ..||  | .  .|.|  | ..||||..|||||. . | |.     |  .|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VFIDENDSRCPNSFGPGRDKHQPAG--------RKKRYTMVGTAFWMAPEMLKG------KDYNERVDVFSFGIVMCELI
 ..|....    |          ..         .||.|.|||  |||||....      |.|....|. |.|....|..
QLTDSMANI-Q-S----------NNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA
Kinase LIMK.AA TKL-Unique 68-276 27 1.4e-45 157.73 In-house 1-222 (290) Show / Hide 
Range on Protein: 68-276
Range on HMM: 1-222/290
Sequence Identity: 27% (64 aa)

KGEVLGQGFFGKAVKVTHRYTGEVMVIKELVRYSDSA-Q--RDFLKEVKVLRSLD-HYHVLKFIGVLY----RDKRLNLVTEFVGGGTLENIIS------
 ....|.| .|.  |...| . .| .... .  .||  .  ..| .||...  |. |  .....|.        .....|.|.. ||.| . ..      
FWNKIGEGGYGQVYKGKWRGY-PVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---DLDKPFPWLQRINAARDIASGMSYLHSMG--IIHRDLNSNNCLVRDD-----GSVVVADFGLARVFIDENDSRCPNSFGPGRDKHQPAGRKKRYTMV
      ......||.. |.|||.|| |||. .  |||||| | | ||  .      .. ..||||...   .|..   .. | .             | .
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR-----------NQTRC

GTAFWMAPEMLKG--KDYNERVDVFSFGIVMCELI
|...|||||.|..  ..|.| .||.|||||. |..
GSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIA
Kinase LIMK.AA TK 66-336 14 1.5e-45 150.19 In-house 1-486 (486) Show / Hide 
Range on Protein: 66-336
Range on HMM: 1-486/486
Sequence Identity: 14% (73 aa)

LIKGEVLGQGFFG---KAVKV-------------------------THRYTGEVMVIKELVRYSDSAQRD-----------------FLKEVKVLRS--L
.. |..||.| ||   .  |                           .. . .   .| |   ....|..                 .. | |....  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHYHVLKFIGVLYRD------------KRLNLVTEFVGGGT----LENIISDLDKP--------------------------------------------
.| ......||  ..            . . .|.|.. .|     | .   . ...                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FPWLQRINAARDIASGMSYLHSM------GIIHRDLNSNNCLVRDDGS-----------VVVADFGLAR
                               ..  |..  ...||.||.||||.      ...||||   |||| ...            . .|||||.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------VFIDENDSRCPNS----------FGPGRDKHQPAGRKKRYTMV--GTAF---WMAPEMLKGKD---------YNERVDVFSFGIVMCELIGRV
         |...|  .  |          |         .  .  |..   |. .   ||||| |...          . .  ||.|||..| |.  . 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFE------D-DP-WQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYG

SACPDD-LPRSG----DFGLDEVPFMAQ-------------------CC-DTCP--------------KTFHQIMLMCVRMDSDERPSFDELDQRL
 . .   .. ..    . ...||  . .                    . . ||              . ....|..| . | ..||.|..| ..|
QEPYYGGMSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase LIMK.AA Pkinase_Tyr 66-210 30 3.1e-38 130.1 Pfam 1-159 (270) Show / Hide 
Range on Protein: 66-210
Range on HMM: 1-159/270
Sequence Identity: 30% (48 aa)

LIKGEVLGQGFFGKAVKVTHR----YTGEVMVIKELVRYSDSAQ---RDFLKEVKVLRSL-DHYHVLKFIGVLY-RDKR--LNLVTEFVGGGTLENIISD
...|..||.| ||. .| | .     |.    .| |  .... |   .||..|.|....| .| ......|| . ...   . .|.|.. .| | .   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

L---DKPFPWLQRINAARDIASGMSYLHSMGIIHRDLNSNNCLVRDDGSVVVADFGLAR
    ..|..  . .. ...||.||.||.|...|||||   |||| ... | ..||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase LIMK.AA TyrKc 66-336 24 4.6e-37 130.38 SMART 1-280 (280) Show / Hide 
Range on Protein: 66-336
Range on HMM: 1-280/280
Sequence Identity: 24% (71 aa)

LIKGEVLGQGFFGKAVKVTHRYTGEVMVIKELVRYSDSAQRDFLKEVKVLRSL--DHYHVLKFIGVLYRD-------KRLNLVTEFVGGGTLENIISDLD
. .|..|| |.||. .| | .   .   .| |  ..   ..||..| .....|  .| ......||   .       . | .|.|.. .| | . . .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

KPFPWLQRINAARDIASGMSYLHSMGIIHRDLNSNNCLVRDDGSVVVADFGLARVFIDENDSRCPNSFGPGRDKHQPAGRKKRYTMVGTAFWMAPEMLKG
. ... . .. . .||.||.||||...|||||   |||| ... | ..||||.| .|.. |..        ...   .  .|   ..    ||||| .. 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSR-DIYDDDQQG------ESKDYYRKKEHKGGKTMLPIRWMAPECINY

KDYNERVDVFSFGIVMCELIGRVSACPDD-----LPRSGDFGLDEVPFMAQCCDT--------CPKTFHQIMLMCVRMDSDERPSFDELDQRL
. ...  ||.|||..| |.  .    . .     .. .  . . .  ..  . .         ||.  .|||..| . | ..||.| |. ...
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LIMK.AA UTK 66-275 26 1.3e-36 122.77 In-house 1-233 (296) Show / Hide 
Range on Protein: 66-275
Range on HMM: 1-233/296
Sequence Identity: 26% (63 aa)

LIKGEVLGQG-----FFGKAVKVTHRYTGEVMVIKELVRYSD--SAQR---DFLKEVK---VLRSLD-HYHVLKFIGVLYRDKRLNLVTEFVGGGTLENI
.. |. ||||     ......... . .  .. .|.... .|   ...   ||..| .   ..  .. |..||...||  ... . .|||.  .| | . 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

ISDLDKPFP----WLQ---RINAARDIASGMSYLHSMGIIHRDLNSNNCLVRDDG-------SVVVADFG---LARVFIDENDSRCPNSFGPGRDKHQPA
  .  . .|    ||    |.  |.|||.||.||||.|..||||   |||| ...       ....||||   ..|   .. .|         |.. .. 
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSN--------RYWESYY

GRKKRYTMVGTAFWMAPEMLKGK-DYNERVDVFSFGIVMCEL
 ..   ... .  ||||| |    .. .  ||.|||.|. |.
YMAQHQDRW-PIRWMAPEALTHHTRFTTKSDVWSFGVVCWEI
Kinase LIMK.AA MLK 66-210 29 4.9e-28 94.4 In-house 1-181 (291) Show / Hide 
Range on Protein: 66-210
Range on HMM: 1-181/291
Sequence Identity: 29% (53 aa)

LIKGEVLGQGFFGKAVKVTHRYTG----EVMVIKELVRY-----SDSAQRDFLKEVKVLRSLDHYH----VLKFIGVLYRD-KRLNLVTEFVGGGTLENI
.   |..| | |||  | . | .     .| | .   |      ... |.|| .|.. || |.|      . .| ||  .. . . .|.|.. || | |.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

ISD-LDKPF------------PWLQRINAARDIASGMSYLHSMG---IIHRDLNSNNCLVRD------DGSVVVADFGLAR
. .  .|..            .  . .| | ..|.||.|||||    ||||||.| | |. .      .| ....|||..|
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR
Kinase LIMK.AA MLK 242-278 40 2.1e-11 35.94 In-house 193-232 (291) Show / Hide 
Range on Protein: 242-278
Range on HMM: 193-232/291
Sequence Identity: 40% (16 aa)

MVGTAFWMAPEML---KGKDYNERVDVFSFGIVMCELIGR
. ||. |||||..   ..  |.| .||.|.|.|. |.. |
NAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase LIMK.AA MLK 306-336 38 8.6e-07 19.74 In-house 261-291 (291) Show / Hide 
Range on Protein: 306-336
Range on HMM: 261-291/291
Sequence Identity: 38% (12 aa)

TCPKTFHQIMLMCVRMDSDERPSFDELDQRL
|||. . . | .|  .|. .||||..  | |
TCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase LIMK.AA UTK 305-336 34 1e-06 18.71 In-house 265-296 (296) Show / Hide 
Range on Protein: 305-336
Range on HMM: 265-296/296
Sequence Identity: 34% (11 aa)

DTCPKTFHQIMLMCVRMDSDERPSFDELDQRL
. || .  ..|. | ..| .|||.|..|.|..
WDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase LIMK.AA TKL-Unique 307-336 43 5e-06 17.61 In-house 261-290 (290) Show / Hide 
Range on Protein: 307-336
Range on HMM: 261-290/290
Sequence Identity: 43% (13 aa)

CPKTFHQIMLMCVRMDSDERPSFDELDQRL
||| .  .. .| . |...||||||   ||
CPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase LIMK.AA Pkinase_Tyr 305-336 31 9e-06 20.13 Pfam 239-270 (270) Show / Hide 
Range on Protein: 305-336
Range on HMM: 239-270/270
Sequence Identity: 31% (10 aa)

DTCPKTFHQIMLMCVRMDSDERPSFDELDQRL
. ||.  ...|..| . | ..||.| |. ..|
ENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase LIMK.AA Pkinase_Tyr 247-272 42 0.000139 16.15 Pfam 179-204 (270) Show / Hide 
Range on Protein: 247-272
Range on HMM: 179-204/270
Sequence Identity: 42% (11 aa)

FWMAPEMLKGKDYNERVDVFSFGIVM
.||||| .. . ...  || |||..|
KWMAPECINYGKFTTKSDVWSFGVLM
Kinase LIMK.AA STE 305-332 21 0.313286 0.25 In-house 324-351 (359) Show / Hide 
Range on Protein: 305-332
Range on HMM: 324-351/359
Sequence Identity: 21% (6 aa)

DTCPKTFHQIMLMCVRMDSDERPSFDEL
. . . |.. .  | ..| ..||. ..|
HKWSPEFKDFINKCLQKDPNKRPTASQL