Gene LZK (Sea Urchin)

LZK

Species: Sea Urchin
Alias: LZK, SPU_000105, Spk225
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: LZK

Sequence

Name Sequence Type Origin Length Description Download
LZK.AA Protein None 943 None Fasta, JSON
LZK.kin_dom Protein Kinase Domain None 242 None Fasta, JSON

Protein domain

Protein domains of LZK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LZK.AA LZK 146-385 81 3.8e-215 721.02 In-house 1-241 (241) Show / Hide 
Range on Protein: 146-385
Range on HMM: 1-241/241
Sequence Identity: 81% (196 aa)

IRNLQWLGSGAQGAVFLGWYRTEPVAVKKVRDEKETDIKHLRKLNHPNIVTIKGVCTLAPCFCILMEYCPFGQLYEVLRDGREIPPQLMIDWSKQIAQGM
|..|||||||||||||.||.|.|.||||||||.|||||||||||.||||...|||||..||.||.|||||.||||||||..|.|.||||.||||||||||
ISELQWLGSGAQGAVFRGWFRNETVAVKKVRDLKETDIKHLRKLKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVLRERRTITPQLMVDWSKQIAQGM

HYLHIHKIIHRDLKSPNVLVANNDILKISDFGTSREWNEK-STKMSFAGTVAWMAPEVIRNEPCSEKVDVWSFGVVLWELLTGEMPYKDVDSSAIIWGVG
||||.||||||||||||.|...||..||.|||||..|||. ||||||.|||||||||||||||||||||.|||||||||.||.|.|||||||.|||||||
HYLHQHKIIHRDLKSPNILISHNDVVKICDFGTSHMWNEMDSTKMSFCGTVAWMAPEVIRNEPCSEKVDIWSFGVVLWEMLTCEIPYKDVDSMAIIWGVG

SNSLQLPIPSTCPEGFKLLMMQCWSAKTRNRPSFRQILMHI
||||.||.||||||||||||.||||.|.||||||||||||.
SNSLHLPMPSTCPEGFKLLMKQCWSQKPRNRPSFRQILMHW
Kinase LZK.AA MLK 146-385 46 4.90000000001e-150 504.73 In-house 1-291 (291) Show / Hide 
Range on Protein: 146-385
Range on HMM: 1-291/291
Sequence Identity: 46% (134 aa)

IRNLQWLGSGAQGAVFLGWYRTEP-----VAVKKVR-------------DEKETDIKHLRKLNHPN----IVTIKGVCTLAPC-FCILMEYCPFGQLYEV
|....|.|||..|.|..|..| .      ||||.||             ...|....|||.|.|||    |. ..|||.  || |||.||||..|.||.|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LRDGR--------------EIPPQLMIDWSKQIAQGMHYLHIHK---IIHRDLKSPNVLVAN------NDILKISDFGTSREWNEK-STKMSFAGTVAWM
|...|               ........|..|.|.|||||| ..   ||||||||.|.|...      ...|||.||||||.|... ...||.|||.|||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM

APEVI---RNEPCSEKVDVWSFGVVLWELLTGEMPYK-DVDSSAIIWGVGSNSLQLPIPSTCPEGFKLLMMQCWSAKTRNRPSFRQILMHI
|||||   |.|..|||.||||.||||||.||.|.||| ..|..||.|.|. |.| .||||||||..| ||.|||... ..|||||||..| 
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase LZK.AA TKL 152-385 28 1.1e-105 357.37 In-house 1-364 (364) Show / Hide 
Range on Protein: 152-385
Range on HMM: 1-364/364
Sequence Identity: 28% (107 aa)

LGSGAQGAVFLGWYRT----------EPVAVKKVR----------------------------------DEKETDIKHLRKLNHPNIVTIKGVCTLAPC-
.|||. | |. | .|           ..||||| .                                  ...|  |.....|.||||| ..|.|.  || 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FCILMEYCPFGQLYEVLRDGREIPPQLMIDWSKQIAQGMHYLHIHK--------IIHRDLKSPNVLVANNDI--------------LK
            .|| ||||| | |...|       ......|...||.||.||| ..        ||||||||.|.|| .|                .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

ISDFGTSREWNEKS--------------------TKMSFAGTVAWMAPEVIRNE----------------PCSEKVDVWSFGVVLWELLTGEMPYKDVDS
|.|||.||......                    |.|.  || .||||||.|..                . |||.||.|||.||||.||.. ||.| ..
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

S---------AIIWGVGSNSLQLPIP------------STCPEGFKLLMMQCWSAKTRNRPSFRQILMHI
.         .....|....|..|||            ..||...| ||..||... ..|||| .|| ..
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LZK.AA TKL-Unique 148-385 35 4.2e-80 272.44 In-house 1-290 (290) Show / Hide 
Range on Protein: 148-385
Range on HMM: 1-290/290
Sequence Identity: 35% (103 aa)

NLQWLGSGAQGAVFLGWYRTEPVAVKKVR-------DEKETDIKHL---RKLN-HPNIVTIKGVCT----LAPCFCILMEYCPFGQLYEVLR--------
 .  .|.|..|.|. | .|..|||.|.         ..... ....    ||. |||||.. |.|.     .| .|| ||||| | ||.||         
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

--DGREIPPQLMIDWSKQIAQGMHYLHIHK--IIHRDLKSPNVLVANN-----DILKISDFGTSREWNEKSTKMSFA-----------GTVAWMAPEVIR
  .  ....|....  ..|||||.|||  .  ||||||||.|.|| ||        ||.|||.|.  | |..||..            |.  ||||||.|
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSK-FNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

N--EPCSEKVDVWSFGVVLWELLTGEM------PYKDVDSSAIIWGVGS--NSLQLPIPSTCPEGFKLLMMQCWSAKTRNRPSFRQILMHI
.  .  |||.||.|||.||||..|..       ||...|. ...  | .   ....|||. ||. .. |. |||     .|||| .|.  .
MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase LZK.AA ZAK 146-384 42 8.3e-74 251.52 In-house 1-257 (257) Show / Hide 
Range on Protein: 146-384
Range on HMM: 1-257/257
Sequence Identity: 42% (111 aa)

IRNLQWLGSGAQGAVFLG-WYRTE----PVAVKKV-RDEKETDIKHLRKLNHPNIVTIKGVCTLAPC-FCILMEYCPFGQLYEVLRDGR--EIP------
|      | |  |.|. . |         .|||||   |||  |  | |. | ||.   |.|   |  . |  ||   | ||      |  |.       
IQFFDHCGVGTFGSVYRANWISQDGSQREIAVKKVFKIEKEAEI--LSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSLYDYIHSNRSQEMDSSSGGN

-PQLMIDWSKQIAQGMHYLH---IHKIIHRDLKSPNVLVANNDILKISDFGTSREWNEKSTKMSFAGTVAWMAPEVI-RNEPCSEKVDVWSFGVVLWELL
     . |  |||.||||||     ||||||||| || .. | ..|| ||||||.     | ||. || .|||||.|   || .|  ||||.||||||.|
SMDHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVIDKNGVCKICDFGTSRDFHHHCTHMSWVGTFPWMAPEMILQSEPVTETCDVWSYGVVLWEML

TGEMPYKDVDSSAIIWGVGSNSLQLPIPSTCPEGFKLLMMQCWSAKTRNRPSFRQILMH
| | |||| .   | | .      | ||. ||  || || ||| .  . ||..|||   
TREVPYKDYEEFQIFWMIVQKNIRLTIPPSCPRPFKQLMHQCWKMDPKDRPNMRQIQSI
Kinase LZK.AA Pkinase_Tyr 146-385 32 3.6e-73 248.42 Pfam 1-270 (270) Show / Hide 
Range on Protein: 146-385
Range on HMM: 1-270/270
Sequence Identity: 32% (89 aa)

IRNLQWLGSGAQGAVFLGWYR------TEPVAVKKVRDEKETD----------IKHLRKL-NHPNIVTIKGVCT-LAPC--FCILMEYCPFGQLYEVLRD
|. .. ||.|| | |..| ..      . |||||....    .          .| ...| .|||||   ||||        .| |||.| | |.. ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----GREIPPQLMIDWSKQIAQGMHYLHIHKIIHRDLKSPNVLVANNDILKISDFGTSREW----NE-KSTKMSFAGTVAWMAPEVIRNEPCSEKVDVWS
    .. .... ..... |||.|| ||. ...|||||   |.||..| . ||.||| .|      .  .... .    . |||||.|..  ...| ||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDVWS

FGVVLWELLT-GEMP-YKDVDSSAIIWGVGSNSLQLPIPSTCPEGFKLLMMQCWSAKTRNRPSFRQILMHI
|||..||..| ||.| |.... . ..  .. .  ..|.|  ||.    ||.||| ..  .||.|..|. ..
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase LZK.AA TyrKc 146-385 32 7e-73 249.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 146-385
Range on HMM: 1-280/280
Sequence Identity: 32% (92 aa)

IRNLQWLGSGAQGAVFLGWYRTEPVAVKKVRDEKETD-----IKHLRKL--NHPNIVTIKGVCTLA-------PCFCILMEYCPFGQLYEVLRDGRE-IP
|. .. ||.|| | |..| .. ..||||......        .. ..||  .||||| . ||||         .  .|.|||.| | | . ||. |. ..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC

PQLMIDWSKQIAQGMHYLHIHKIIHRDLKSPNVLVANNDILKISDFGTSREWNEK--------STKMSF--AGT----VAWMAPEVIRNEPCSEKVDVWS
.. ..... |||.|| ||| ...|||||   |.||..| . |||||| ||.. ..          ...    |     . |||||.|.   ...| ||||
MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWS

FGVVLWELLT-GEMPYKDV----DSSAIIWGVGSNSLQLPIPST--------CPEGFKLLMMQCWSAKTRNRPSFRQILMHI
|||..||..| |..|| ..     | . .     .   .|.|          ||.    .| ||| ..  .||.|..|   .
FGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LZK.AA Pkinase 146-385 27 2e-69 241.77 Pfam 1-293 (293) Show / Hide 
Range on Protein: 146-385
Range on HMM: 1-293/293
Sequence Identity: 27% (81 aa)

IRNLQWLGSGAQGAVFLGWYRTEP--VAVKKVRDEKETD-----------IKHLRKLNHPNIVTIKGVCTLAPCFCILMEYCPFG----QLYEVLR--DG
.. .. .|||. | |...  . ..  ||||... ..| .           |. ...|||||||.......  .  .. ||||. |     |.....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

REI--PPQLMIDWSKQIAQGMHYLHIHKIIHRDLKSPNVLVANNDIL----KISDFGTSRE--WNEKSTKMSFAGTVAWMAPEVIR-NEPCSEKVDVWSF
. .  ...  ... .||..|. |.| ..|||||||. |.|. ||. .    ||.||| ..   .  .|  ..|.||  .||||||| ... . |||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVVLWELLTGEMPYKDV------DSSAIIWGVGSNSLQLPIPSTCP-------------------EGFKLLMMQCWSAKTRNRPSFRQILMH--I
|..|.|.|.|. |...       |  ..|  ...  |  ..| .|.                   | .| ..  |.  .   ||...||| |  .
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase LZK.AA Dicty4 146-387 35 4.2e-68 226.26 In-house 1-277 (277) Show / Hide 
Range on Protein: 146-387
Range on HMM: 1-277/277
Sequence Identity: 35% (98 aa)

IRNLQWLGSGAQGAVFLGWYRTEPVAVKKV--RDEK--ETDIKHLRK-------LNHPNIVTIKGVCT----LAPCFCILMEYCPFGQLYEVLRD-----
|   | .|.|. | |..|  |   |||||   . ..  |  .. .||       . ||||.. .| ||      . .|| .||.| | ||..|.|     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

GREIPPQ--LMID---WSKQIAQGMHYLHI--HKIIHRDLKSPNVLVANNDILKISDFGTSR---EWNEKST-KMSFAGTVAWMAPEVIRNEPCSEKVDV
  .|...  |..      . .|.|| .||     |||||||| | ||  |   |..||| |.   .  ....  |. .||..|||||| ...|  ||.||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

WSFGVVLWELLTGEMPYK--DVDSSAIIWGVGSNSLQLPIPSTCPEGFKLLMMQCWSAKTRNRPSFRQILMH--IDI
 ||| ||||.||.. ||     .   .. .|..  | .|||. ||  .| |.  ||.    .|||| .|.     . 
YSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase LZK.AA S_TKc 146-387 26 3.9e-67 230.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 146-387
Range on HMM: 1-231/231
Sequence Identity: 26% (70 aa)

IRNLQWLGSGAQGAVFLGWYRT--EPVAVKKVRDEKETDIKHLRKLNHPNIVTIKGVCTLAPCFCILMEYCPF--GQLYEVLRDGRE------IPPQLMI
 . |. .|.|| | |.... .   . ||.|....  .  |. |.| .|||||....|.    .... ||||.   | |...... .       .|.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

DWSKQIAQGMHYLHIHKIIHRDLKSPNVLVANNDILKISDFGTSREWNEKSTKMSFAGTVAWMAPEVIRNEPCSE-KVDVWSFGVVLWELLTGEMPYKDV
 . .||.... |.| |.|||||||  |.|. .   .||.||| .|.       ..| ||  .|||||.   . .  |.|.||.|..|.|.|.|. |.   
FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--

DSSAIIWGVGSNSLQLPIPSTCPEGFKLLMMQCWSAKTRNRPSFRQILM-------HIDI
.  ...  .|            .. .| ....|.    ..||.  ..|        |  .
QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LZK.AA TK 146-385 19 1.9e-64 214.68 In-house 1-486 (486) Show / Hide 
Range on Protein: 146-385
Range on HMM: 1-486/486
Sequence Identity: 19% (93 aa)

IRNLQWLGSGAQG---AVFLGWYRT---------------------------EPVAVKKVR----DEKET--------------------DIKHLR--KL
|. .. ||.|. |    |..|..|.                           .||||| ..    ...|                      .| ..  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

NHPNIVTIKGVCTLAPC------------FCILMEYCPFGQ----LYEVLRDGRE---------------------------------------------
.||||| . ||||   .            ..|.|||.| |     | . ||. |.                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IPPQLMIDWSKQIAQGMHYLHIH------KIIHRDLKSPNVLVANNDI-----------LKISDFG---
                               .... .. .. |||.|| ||| .      ...||||   |.||..|..            ||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----TSREWN--EKSTKMSFAGT-------------------------VAWMAPEVIR---------NEPCSEKVDVWSFGVVLWELLT-GEMPYKDVD
      .|. .  .  ...|  ||                         . |||||...         .  ...| |||||||..||..| |..||    
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SS---------AIIWGVGSN--------------SLQLPIPSTCP--------------EGFKLLMMQCWSAKTRNRPSFRQILMHI
|.         . .     .               ...| |  ||              | . .||.|||... . ||.|.|..  .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase LZK.AA TK-Unique 146-385 31 1.9e-59 203.62 In-house 1-294 (294) Show / Hide 
Range on Protein: 146-385
Range on HMM: 1-294/294
Sequence Identity: 31% (92 aa)

IRNLQWLGSGAQGAVFLGWYR--------TEPVAVKKVR-DEKETD-------IKHLRKLN-HPNIVTIKGVCTLAP-CFCILMEYCPFGQLYEVLRDGR
..... .|.|| | |. | ..        .  ||||... .. .||       |.....|  |||||.. |.||     ..|.||||| | |   ||  |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

--------------------------EIPPQLMIDWSKQIAQGMHYLHI--HKIIHRDLKSPNVLVANNDILKISDFGTSREWN-EKSTKMS---FAGTV
                          .| |.... . .|||.|| ||.   .||.|||| . |||.... ..||.||| .|. . .. . |.   .   .
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

AWMAPEVIR--NEPC-SEKVDVWSFGVVLWELLT-GEMPYKDVDSSAIIWGVGSNSLQLPIPSTC-PEGFKLLMMQCWSAKTRNRPSFRQILMHI
.|||||...   ... ..| |||||||..||..| |..|| ..... |.  .  .   .| |. | .. .  || .||. .   |||||||.  .
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECI-RDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase LZK.AA LRRK 186-387 36 1.4e-58 200.89 In-house 111-351 (351) Show / Hide 
Range on Protein: 186-387
Range on HMM: 111-351/351
Sequence Identity: 36% (88 aa)

LRKLNHPNIVTIKGVCTLAPCFCILMEYCPFGQLYEVLR----DGR-----EIPPQLMIDWSKQIAQGMHYLHIHK--IIHRDLKSPNVLVANND-----
...||||||| .||.| . |. |. ||| |.| ||..|.    ||.     .|...| .  . ||| || ||| |.  ||||||||||.|.   .     
MSHLNHPNIVSLKGFC-IHPL-CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSP

-------ILKISDFGTSR--EWNEKSTKMSFAGTVAWMAPEVIR---NEPCSEKVDVWSFGVVLWELLTGE-MPYKDVD----S--SAIIWGVGSNSLQL
       . ||.|||.||      ..  . . |.  |||||..|   .| ..||||. |||..||||||..  |. . |    .    .|    .. |  
NYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRP

PIPST-CPE-----GFKLLMMQCWSAKTRNRPSFRQILMHIDI
.||.. ||.      .. |...||... ..||.| ||.  .  
TIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase LZK.AA MLK 267-385 53 4.3e-58 190.49 In-house 163-280 (280) Show / Hide 
Range on Protein: 267-385
Range on HMM: 163-280/280
Sequence Identity: 53% (64 aa)

NNDILKISDFGTSREWNEKSTKMSFAGTVAWMAPEVIRNEPCSEKVDVWSFGVVLWELLTGEMPYKDVDSSAIIWGVGSNSLQLPIPSTCPEGFKLLMMQ
.| .||| |||  ||| .   .|| ||| ||||||||.    |.  ||||.||.|||||||| ||. .|  |. .||  | | ||||||||| .. ||  
CNKQLKITDFGLAREWHKTT-RMSAAGTYAWMAPEVIKESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQD

CWSAKTRNRPSFRQILMHI
||      ||.| .||  .
CWNQDPHKRPKFSEILQQL
Kinase LZK.AA MLK 146-265 37 9.3e-35 112.14 In-house 1-136 (280) Show / Hide 
Range on Protein: 146-265
Range on HMM: 1-136/280
Sequence Identity: 37% (52 aa)

IRNLQWLGSGAQGAVFLGWYRTEPVAVKKVRDEKETDIKHL--------------RKLNHPNIVTIKGVCTLAPCFCILMEYCPFGQLYEVLRDGREIPP
..  . .|.|  | |. . .. | ||||  | . | |.                   |.||||. ..|||   | .|..||||  | |  |.. |. |||
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCA-GKRIPP

QLMIDWSKQIAQGMHYLHIHK---IIHRDLKSPNVLV
. ...|  |||.||.|||      |||||||| |.|.
HVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILI
Kinase LZK.AA LRRK 146-175 25 0.18587 0.9 In-house 1-31 (351) Show / Hide 
Range on Protein: 146-175
Range on HMM: 1-31/351
Sequence Identity: 25% (8 aa)

IRNLQWLGSGAQG-AVFLGWYRTEPVAVKKV
..  . .|.|. |  |. . .| .||.|...
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRM