Gene Raf (Sea Urchin)

Raf

Species: Sea Urchin
Alias: Raf, Spk315, SPU_027524
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: RAF
Subfamily: RAF

Sequence

Name Sequence Type Origin Length Description Download
Raf.AA Protein None 803 None Fasta, JSON
Raf.kin_dom Protein Kinase Domain None 258 None Fasta, JSON

Protein domain

Protein domains of Raf.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RBD Raf.AA RBD 116-186 35 1.5e-21 77.51 Pfam 1-77 (77) Show / Hide 
Range on Protein: 116-186
Range on HMM: 1-77/77
Sequence Identity: 35% (27 aa)

QSVRAFLPNQQRTSVLAKSGTTLKYCLSKAMKMRELTPEMCIVYRVN-----PRMALSWDTDMMYLAG-EEISVELK
  ....|||.||..| ...| |.. .|.|. |.. |.|..| ||||       . .| |.||  .|.| .|. ||..
KFCCVHLPNNQRCVVEVRPGMTVRDMLMKICKRHGLNPMCCHVYRVGDPHEGEKKPLDWHTDISWLPGPQELWVENL
RBD Raf.AA RBD 116-186 34 2.9e-19 71.22 SMART 1-76 (76) Show / Hide 
Range on Protein: 116-186
Range on HMM: 1-76/76
Sequence Identity: 34% (26 aa)

QSVRAFLPNQQRTSVLAKSGTTLKYCLSKAMKMRELTPEMCIVYRVN-----PRMALSWDTDMMYLAGEEISVELK
  .. .||..|||.| ...| |.. .|.|. |.| |.||.|.|.|..      . .| |...  ||.|.|. ||..
KFCCVHLPDNQRTVVKVRPGMTVHDMLMKICKKRGLNPECCHVFRRHHPHEGEKKPLDWHQPISYLPGQELWVENR
C1_1 Raf.AA C1_1 198-246 32 3e-17 66.95 Pfam 1-55 (55) Show / Hide 
Range on Protein: 198-246
Range on HMM: 1-55/55
Sequence Identity: 32% (18 aa)

HNFVRK-TFFAIAFCDSCQKLL-----FHGFRCQTCSYKFHQRCANKVPTICIST
|..|.. .|  ..||. |....     . |..||.| |..|.||..|||. |.  
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 Raf.AA C1 198-243 27 1.9e-12 48.57 SMART 1-61 (61) Show / Hide 
Range on Protein: 198-243
Range on HMM: 1-61/61
Sequence Identity: 27% (17 aa)

HNFVRKTFFAIAFCDSCQKLLFH---------GFRCQTCSYKFHQRCANKVPT-------IC
|......|   ..|. |.|....         |.||. | ||.|..|. |||         |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 Raf.AA C1_3 209-236 23 2e-06 17.69 Pfam 1-30 (30) Show / Hide 
Range on Protein: 209-236
Range on HMM: 1-30/30
Sequence Identity: 23% (7 aa)

AFCDSCQKLLF--HGFRCQTCSYKFHQRCA
 .|. |.. .    ...| .| . .|..||
FTCNCCGLPIYRDPFYHCMQCDFMLHEDCA
Kinase Raf.AA RAF 493-752 65 2.9e-196 642.28 In-house 1-282 (282) Show / Hide 
Range on Protein: 493-752
Range on HMM: 1-282/282
Sequence Identity: 65% (185 aa)

IRLGSRIGAGSFGTVFSGQWHGSVAVKRLNVKDPTPSQLQA---FKNEVAVLRKTRHANILLFMGCTSKPQ---LAIVTQWCEGSSLYKHLHVLDT--KL
.....|||.||||||..|.|||.||||.|||.||||.|.||   |||||||..||||.|||||||..||||   .||||||||.||||.|.|| .|  |.
VMVMTRIGSGSFGTVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKF

VMHQLIDISRQTAQGMDYLHAKNIIHRDLKSNNIFLHDDLTVKIGDFGLATVKSRWS--GSQQFEQPSGSILWMAPEVIR-----------MRDTNPYSF
 ||.|||||||..||||||||||||||||||||||||.|.|||||||||.|||.|||  |.||||||...||||||||||           |.|.|||||
DMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSF

QSDVYAFGVVLFELVTQSLPY-QNIKHKDQIIWMVGRGYLQPDLSKVRNDTPKALKRLITDCYALNRDERPLFPVVLAALES
|||||.||.|..||.|...|| ..|...||||.|.|||||.|||||||.|.|||..||..||....|.|||||. .|.... 
QSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase Raf.AA RAF 493-750 56 2.4e-180 605.42 In-house 1-275 (275) Show / Hide 
Range on Protein: 493-750
Range on HMM: 1-275/275
Sequence Identity: 56% (156 aa)

IRLGSRIGAGSFGTVFSGQWHGSVAVKRLNVKDPTP-SQLQAFKNEVAVLRKTRHANILLFMGCTSKP---QLAIVTQWCEGSSLYKHLHVLDT-KLVMH
...|.||| |.||||. |.||| |||| ||.|.||| .|||||||||....|||| ||.||||...||   ..|||||||.||.||.|.|| .| |. |.
VQIGERIGQGRFGTVYRGHWHGDVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKTEKFDMN

QLIDISRQTAQGMDYLHAKNIIHRDLKSNNIFLHDDLTVKIGDFGLATVK-SRWS--GSQQFEQPSGSILWMAPEVIRMR---------DTNPYSFQSDV
..|.|..|..||||||||||||||||||.|||||....|.|.||||.||| .||.  ..||..||.|.|.|||||||||          |.||.||||||
WTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDV

YAFGVVLFELVTQSLPYQNIKHKDQIIWMVGRGYLQPDLSKVRNDTPKALKRLITDCYALNRDERPLFPVVLAAL
||||.|..||.....|||.|....||||||.||||..|.||.|...||..|.|...|.. ...|||.|. ... .
YAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase Raf.AA TKL 499-750 26 4.8e-94 318.73 In-house 1-364 (364) Show / Hide 
Range on Protein: 499-750
Range on HMM: 1-364/364
Sequence Identity: 26% (100 aa)

IGAGSFGTVFSGQWHG-----------SVAVKRLNVK------------------------DPTPSQLQAFKNEVA-VLRKTRHANILLFMG-CTSKPQ-
|| |.||.|. |.|.|            ||||.....                        ||..|... |..|.. .....|| ||..||| |.. |. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LAIVTQWCEGSSLYKHLHVLDTKLVMHQLIDISRQTAQGMDYLHA--------KNIIHRDLKSNNIFLHDDLT--------------V
            |.||...|.| ||. .||       .||........|.||.|||.        ..||||||||.||......|              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDFGLATVKS------------------RWSGSQQFEQPSGSILWMAPEVIRMR--DTN-----------PYSFQSDVYAFGVVLFELVTQSLPYQNI
||.||||....|                  . .....   . |.. ||||||.|.   .|.           .|| ..|||.||.||.|..|  .||...
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

KHKDQI--------IWMVGRGYLQPDLS---------KVRNDTPKALKRLITDCYALNRDERPLFPVVLAAL
.. ..|        ..||.   |.| .             .|.|. .|.|..|| . . ..|| |  .|  |
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Raf.AA Pkinase 493-750 22 1.5e-71 248.8 Pfam 1-293 (293) Show / Hide 
Range on Protein: 493-750
Range on HMM: 1-293/293
Sequence Identity: 22% (66 aa)

IRLGSRIGAGSFGTVFSGQWHGS---VAVKRLNVKDPTPSQLQAFKN--EVAVLRKTRHANILLFMGCT-SKPQLAIVTQWCEGS----SLYKHLH-VLD
...|..||.||||.|. ....|.   ||||......  ....|.  .  |...... .| ||. . ..  .|. . .|. .|||     .|. ...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TKL--VMHQLIDISRQTAQGMDYLHAKNIIHRDLKSNNIFLHDDLTV----KIGDFGLATVKSRWSGSQQFEQPSGSILWMAPEVIRMRDTNPYSFQSDV
...   ....... .|...|..|.|...|||||||. ||..... ..    ||.||||| ... .  .. .  . |.. .|||||||  . ..|.  .|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPKVDM

YAFGVVLFELVTQSLPYQNI----KHKDQIIWMVGRGYLQPDLS-KVRNDTP-----------------KALKRLITDCYALNRDERPLFPVVLAA--L
...|..|.|...  .|...     .  ||.  .. ... ... .    .. .                 ...| .|..| ...  .|| .. .|    .
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Raf.AA KSR 493-750 36 9.3e-69 233.52 In-house 1-272 (272) Show / Hide 
Range on Protein: 493-750
Range on HMM: 1-272/272
Sequence Identity: 36% (101 aa)

IRLGSRIGAGSFGTVFSGQWHGSVAVKRLNVK-DPTPSQ-LQAFKNEVAVLRKTRHANILLFMG-CTSKPQLAIVTQWCEG-SSLYKHLHVLDTKLVMHQ
. .| .|| | ||.|. | ||| ||.| .. .     .. | .|| ||. ...||| || |||| | . |.||||.  | |  .|| |.||  .|| |  
LKYGECIGQGRFGKVHRGHWHGEVAIKLYYMDHIHDEHHDLEDFKDEVMMYKNTRHENIVLFMGACMNPPHLAIVMSLCKGSQTLYHHIHVRREKLDMNR

LIDISRQTAQGMDYLHAKNIIHRDLKSNNIFLHDDLTVKIGDFGLATVK---SRWSGSQQFEQPSGSILWMAPEVIRMRDT---------NPYSFQSDVY
 ..| .| .||| ||||| ||| |||| |||.     | | ||||  ..       .. .   | |    .||| ||   .         .|.| .||||
TMQIAQQICQGMGYLHAKGIIHKDLKSKNIFYENKGKVVITDFGLFSITRLLHCCQREDHLCIPHGWLCYLAPELIRAMRPNYDEYQCMCLPFSHHSDVY

AFGVVLFELVTQSLPYQNIKHKDQIIWMVGRG-YLQPDLSKVRNDTPKALKRLITDCYALNRDERPLFPVVLAAL
||| ...|. .  .|...     .||| ...|  . ..|. |     . .| ..  | . . .||| |   .  |
AFGTIWYEMICGEWPFKY-QCAESIIWQMCQGEGMRQVLRNVQ--CGREMKEILMMCWSYEPQERPTFQDIMKML
Kinase Raf.AA TKL-Unique 495-750 33 6.1e-68 232.03 In-house 1-290 (290) Show / Hide 
Range on Protein: 495-750
Range on HMM: 1-290/290
Sequence Identity: 33% (100 aa)

LGSRIGAGSFGTVFSGQWHGS-VAVKRLNV-KDPTPSQLQAFKNEVAVLRKTR-HANILLFMG-CT----SKPQLAIVTQWCEGSSLYKHLH--------
 .. ||.|..|.|. | |.|. ||.|....  |. .. .| |.||| .. | . |.||...|| |.    . |.. ||.  |.|.|||..||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-VLDTKLVMHQLIDISRQTAQGMDYLHAKN--IIHRDLKSNNIFLHDD-----LTVKIGDFGLATVKSRWSGSQQF-------EQPSGSILWMAPEVIRM
    .|| | | ... .. ||||.||| ..  |||||||| |. .  .     . .|| ||||....|. . .          . . ||..||||||.||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

RDTNPYSFQSDVYAFGVVLFELVTQSL------PYQNIKHKDQIIWMVGR--GYLQPDLSKVRNDTPKALKRLITDCYALNRDERPLFPVVLAAL
   . || .||||.||.|| |..|  .      |||.. . .|.. ||      ..| ..   |. || .. ||..| . . ..|| |  ..  |
NF-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQ-EQWCEMVHYMEENYRPPIP---NHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase Raf.AA TK 493-750 17 1.1e-59 198.48 In-house 1-486 (486) Show / Hide 
Range on Protein: 493-750
Range on HMM: 1-486/486
Sequence Identity: 17% (84 aa)

IRLGSRIGAGSFG---TVFSGQWHG----------------------------SVAVKRLNVK-DPTPSQLQA--------------FKNEVAVLR--KT
|.||  .|.| ||   .|. |.|.|                             |||| |  . . .. . ..              . .| ....  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHANILLFMG-CTSK------------PQLAIVTQWCEGSS----LYKHLHVLDTK--------------------------------------------
.| ||. . | || .            . . ||. .... .    | ..|.  . |                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LVMHQLIDISRQTAQGMDYLHAK------NIIHRDLKSNNIFLHDDLT-----------VKIGDFGLAT
                               | ||||. ...| |.|| |||.|      |..||||   |. ......           .||.||||. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

VKS----RWSGSQQFEQPSGS----------------------------ILWMAPEVIRMRD------TNPYSFQSDVYAFGVVLFELVTQS-LPYQNIK
..|    |  .| .    ..|                            | |||||... |       .. .. .|||..|||...|..|    ||    
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

HK---------DQIIWMVGRG--------------YLQPDLSKVR----------NDTPKALKRLITDCYALNRDERPLFPVVLAAL
.          .... .. ||              . .|                .  |... .|...| ... ..|| |  .. .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Raf.AA Dicty4 493-752 34 2.9e-57 189.58 In-house 1-277 (277) Show / Hide 
Range on Protein: 493-752
Range on HMM: 1-277/277
Sequence Identity: 34% (98 aa)

IRLGSRIGAGSFGTVFSGQWHGS-VAVKRLNVKDPT--PSQLQAFKNEVAVLRKTRHANILLFMG-CT----SKPQLAIVTQWCEGSSLYKHLHV-----
|  ..||| ||||.|. | | |. |||| || .  .   . |..|..||. . | || ||.|||| ||     .. . |||  .   .||. ||      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-LDTKLVMHQLID---ISRQTAQGMDYLHAKN--IIHRDLKSNNIFLHDDLTVKIGDFGLATVKSRWSGSQQ-FEQPSGSILWMAPEVIRMRDTNPYSFQ
   .||     .    . . .|.|| .||. |  |||||||| |.   ....||..||||.... . .  ..    . |. .|||||| .    .||   
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMH---QPYNEK

SDVYAFGVVLFELVTQSLPYQ-NIKHKDQIIWMVGRGYLQPDLSKVRNDTPKALKRLITDCYALNRDERPLFPVVLAA--LES
.||| || ||.|..|   |||  ..  .|..  |..  | | ..   ...|. .|.||..|   .   || |. .. .  ||.
ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIP---DWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase Raf.AA MLK 493-750 30 1.6e-56 194.07 In-house 1-291 (291) Show / Hide 
Range on Protein: 493-750
Range on HMM: 1-291/291
Sequence Identity: 30% (92 aa)

IRLGSRIGAGSFGTVFSGQWHGSV------AVKRLN-VKDPTPSQ----LQAFKNEVAVLRKTRHAN----ILLFMGCTSKP-Q-LAIVTQWCEGSSLYK
|..   ||.|||| |..|.|..        |||| .  ..   |.     ..|. |.  ||. .| |    |  |.|. ..| . ..||...|||.||| 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

HLHVLDTKLV-------------MHQLIDISRQTAQGMDYLHAKN---IIHRDLKSNNIFLHD------DLTVKIGDFGLATVKSRWSGSQQFEQPSGSI
 ||  ..|               ........ | |.||.|||..    |||||||| || ...      ..|.|| |||... ...   .  . .. |. 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNA-GTY

LWMAPEVIRMRDTNPYSFQSDVYAFGVVLFELVTQSLPYQNIKHKDQIIWMVGRGYLQPDLSKVRNDTPKALKRLITDCYALNRDERPLFPVVLAAL
 |||||||     ..||  .||. .|||| |..|  .||...    .|.|.|.   | | . .     |. .|.|...|   .  .|| |  ..  |
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST---CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase Raf.AA S_TKc 493-753 21 2.8e-54 187.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 493-753
Range on HMM: 1-231/231
Sequence Identity: 21% (59 aa)

IRLGSRIGAGSFGTVFSGQWHG---SVAVKRLNVKDPTPSQLQAFKNEVAVLRKTRHANILLFMGCTSKPQLAIVTQWCEG--SSLYKHLHVLDTK----
 ...  || |.||.|. .....    ||.|...         . ...|...|.| .| ||  . ..     | .|.  |.|   .|.....   ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LVMHQLIDISRQTAQGMDYLHAKNIIHRDLKSNNIFLHDDLTVKIGDFGLATVKSRWSGSQQFEQPSGSILWMAPEVIRMRDTNPYSF-QSDVYAFGVV
 .   .   . .|......|.| ..|||||||  ||.| .  ..||.|||||..              |.  .|||||.      .|..  .|....|..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCI

LFELVTQSLPYQNIKHKDQIIWMVGRGYLQPDLSKVRNDTPKALKRLITDCYALNRDERPLFPVVLA------ALESL
|.|...   |..   . .... ..|               .. .| .|  |   . ..||    .|.      . . .
LYEMLCGYPPFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Raf.AA Pkinase_Tyr 493-634 32 2.5e-47 160.94 Pfam 1-158 (270) Show / Hide 
Range on Protein: 493-634
Range on HMM: 1-158/270
Sequence Identity: 32% (52 aa)

IRLGSRIGAGSFGTVFSGQWH-------GSVAVKRLNVKDPTPSQ---LQAFKNEVAVLRKT-RHANILLFMGCTS---KP-QLAIVTQWCEGSSLYKHL
|..|  .|.|.||.|. | |.         |||| |  |. . ..   ...| .|......  .| ||. ..|. .   .| |. ||.  ... .|...|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

HVL---DTKLVMHQLIDISRQTAQGMDYLHAKNIIHRDLKSNNIFLHDDLTVKIGDFGLA
.     . .| |..|.....| |.||.||..||.|||||   |. ......|||.|||||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase Raf.AA TK-Unique 493-750 26 1.5e-46 158.52 In-house 1-294 (294) Show / Hide 
Range on Protein: 493-750
Range on HMM: 1-294/294
Sequence Identity: 26% (78 aa)

IRLGSRIGAGSFGTVFSGQWHG--------SVAVKRLNVKDPTPSQLQAFKNEVAVLR-KTRHANILLFMGCTSKP--QLAIVTQWCEGSSLYKHLH---
...|..|| |.||.|. |.  |        ....  .. .. |. . |.|..| .... ...| ||. ..||. |.  .  |.  .|....| ..|.   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

----------------------VLDTKLVMHQLIDISRQTAQGMDYLHA--KNIIHRDLKSNNIFLHDDLTVKIGDFGLAT-VKSRWSGSQQFEQPSGSI
                      .... . ...|. .  | |.|| ||.   |.|.|||| . |..| .|...||.|||.|. |  .   | . .|   .|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

LWMAPEVIRMRDTNPY-SFQSDVYAFGVVLFELVTQ-SLPYQNIKHKDQIIWMVGRGYLQPDLSKV-RNDTPKALKRLITDCYALNRDERPLFPVVLAAL
 |||||...   ...| . .|||..|||...|..|  . || ... || |. .. .|| .|. ... ......    |.  |  ....||| |  ..  |
RWMAPESLKCY-HGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMPQPEHCCSHEMYN----LMKSCWQWEPEERPSFRQIKHRL
Kinase Raf.AA STE 493-692 22 6.3e-46 158.89 In-house 1-268 (359) Show / Hide 
Range on Protein: 493-692
Range on HMM: 1-268/359
Sequence Identity: 22% (63 aa)

IRLGSRIGAGSFGTVFSGQWH-GS-----------------VAVKRLNVKDPTP---------------SQLQAFKNEVAVLRKTR--HANILLFMGCTS
 .. ..|| |.||||. .  |  .                 .|.|..|... ..               ...| ...|. ...| .  | ||  . ||  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KP--------QLAIVTQWCEGSSLYKHLH-VLDTKLVM------------HQLIDISRQTAQG-MDYLHAKNIIHRDLKSNNIFLHDDLTVKIGDFGLAT
|         .| |.  ...| || . .. .  ..  .            .|.. | ||. .| ..||| ..|||||.|. ||.|     ||. |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

--VKSRW------------SGSQQFEQPSGSILWMAPEVIRMRDTN---PYSFQSDVYAFGVVLFELVTQSLPY
  ..|              ...|.     |.  |||||||. ....   .|....|.. .| .. |..|   |.
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW
Kinase Raf.AA TyrKc 493-750 28 4.9e-43 150.2 SMART 1-280 (280) Show / Hide 
Range on Protein: 493-750
Range on HMM: 1-280/280
Sequence Identity: 28% (83 aa)

IRLGSRIGAGSFGTVFSGQWHGSVAVKRLNVKDPTPSQLQAFKNEVAVLRKT--RHANILLFMGCTSK--------PQLAIVTQWCEGSSLYKHLHVLDT
|.||  .| | ||.|. |.|   |||| |.        ...| .|  ...|   .| ||. . |. ..        ..| ||.  ... .| ..|.    
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

KLVMHQLIDISRQTAQGMDYLHAKNIIHRDLKSNNIFLHDDLTVKIGDFGLATVKSRW-----SGSQQFE----QPS--GSILWMAPEVIRMRDTNPYSF
|| | .|.... | |.||.||| ||.|||||   |. .....||||.||||.           |..        .      | |||||.|   ... ...
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFTT

QSDVYAFGVVLFELVTQ-SLPYQNI----KHKDQIIWMVGRGYLQPDLSKVRND-------TPKALKRLITDCYALNRDERPLFPVVLAAL
.|||..|||...|. |    || ..    .  ...|  | .||    . .  ||        |... .....| . . ..|| |  .   .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR---MPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Raf.AA Pkinase_Tyr 655-750 25 5e-14 48.13 Pfam 180-270 (270) Show / Hide 
Range on Protein: 655-750
Range on HMM: 180-270/270
Sequence Identity: 25% (25 aa)

WMAPEVIRMRDTNPYSFQSDVYAFGVVLFELVTQS-LP-YQNIKHKDQIIWMV-GRGYLQPDLSKVRNDTPKALKRLITDCYALNRDERPLFPVVLAAL
|||||.|. .    .. .|||..|||...|..|    | |...    ... ..  .||    . .   ..|. . .|...| . . ..|| |  ..  |
WMAPECINYGK---FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYR---MPC-PENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL