Gene ALK2 (Sea Urchin)

ALK2

Species: Sea Urchin
Alias: SPU_016008, ALK2, Spk329
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: STKR
Subfamily: STKR1

Sequence

Name Sequence Type Origin Length Description Download
ALK2.AA Protein None 447 None Fasta, JSON
ALK2.kin_dom Protein Kinase Domain None 288 None Fasta, JSON

Protein domain

Protein domains of ALK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Activin_recp ALK2.AA Activin_recp 22-97 20 1.2e-12 43.37 Pfam 1-121 (121) Show / Hide 
Range on Protein: 22-97
Range on HMM: 1-121/121
Sequence Identity: 20% (25 aa)

LQCN-CDDYS------CE--GT------NRCEA----------LRKCFSSITEVDG----IIMKRM---GCVNTEEQFN----MFCKM----HPYP---D
|.|  |. |.      |.   .      . ||.             |. |....|.    ....||   ||.  .|. .    . ||     |. |    
LKCYFCNGYWEYDYQICHENENNFEIPVHTCETHPDKMCFYCYDGQCYVSWEYNDDEEDTEQHQRMHMYGCWSLNENCPQCHPFMCKSYKHTHSPPHRHG

ISVLC-CN-RSFCNNDLQPTF
 .. | |. ...||..|.|..
HNHECWCCETDYCNRNLTPPP
Kinase ALK2.AA Type1 139-426 66 3.9e-265 727.47 In-house 1-290 (290) Show / Hide 
Range on Protein: 139-426
Range on HMM: 1-290/290
Sequence Identity: 66% (194 aa)

INLLQQVGKGRYGEVWMGTWQGDTVAVKIFSSIDEKSWFRETEIYNTVMLRHENILAFFASDMTSRQSCTQLWLIMEYHERGSLYDYLNRHVLDARQMCR
|......|||||||||.|.|.|..||||||.|.||.|||||||||.|||.||||||.|.|.||....|.||||||..|||.||||||||||.||..||.|
IQMIECIGKGRYGEVWRGKWRGENVAVKIFFSRDERSWFRETEIYQTVMMRHENILGFIAADMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLDTQQMLR

LALTACSGLVHLHTEITCNN--SKPAIAHRDIKTKNILVKRNLTCCIADLGLAVLHTQREDNIDMGTNTRVGTKRYMAPELLEETMDVRCFESFKRVDVY
||.....||.|||.||....  .||||||||||.|||.||.|..|||||||||| |.|..|.||.|.|.|||||||||||.|.|||...||||.|..|.|
LAYSCACGLAHLHMEIFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIGQNPRVGTKRYMAPEVLDETMNMNCFESYKMADIY

AFGLVMWEIARRCEVGGMVADYKPPFFEYVPSDPSFDDMRKVACIEKLRPNIPNRWTNNTVLTSMAKLMKECWCPTASARHTSLRVKKTL
.||||||||||||||||.|.||..|....||.||||.||||| |..||||||||||........|||||||||.....||||.||.||||
SFGLVMWEIARRCEVGGIVEDYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRWQSHPCMRHMAKLMKECWYQNPHARHTALRIKKTL
Kinase ALK2.AA STKR 139-426 57 6.4e-214 697.37 In-house 1-312 (312) Show / Hide 
Range on Protein: 139-426
Range on HMM: 1-312/312
Sequence Identity: 57% (178 aa)

INLLQQVGKGRYGEVWMGTWQG----DTVAVKIFSSIDEKSWFRETEIYNTVMLRHENILAFFASDMTSR-QSCTQLWLIMEYHERGSLYDYLNRHVLDA
|.|....|||||||||.| |.|    .|||||||.| ||.|||||||||.|.|.|||||| |.|.||... .|.||.|||.||||.|||.|||.||..| 
IQLIECIGKGRYGEVWKGKWRGNGEKETVAVKIFPSRDEQSWFRETEIYQTPMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTIDW

RQMCRLALTACSGLVHLHTEIT--CNN--SKPAIAHRDIKTKNILVKRNLTCCIADLGLAVLHTQREDNIDMG-------TNTRVGTKRYMAPELLEETM
..|||.|.....||.|||.||.  ...   ||||||||||.||||||...||||||.|||. |.. .. ||..       .||.||||||||||.|...|
HEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDGAM

DVRCFES-FKRVDVYAFGLVMWEIARRCEVGG------MVADYKPPFFEYVPSDPSFDDMRKVACIEKLRPNIPNRWT-NNTVLTSMAKLMKECWCPTAS
...|||| |||.|.||.|||||||||||..||      .|..|..|| ..||..|||.||.||.|....||||||||  |.....||.|.|.|||.. ..
NFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWDHDPE

ARHTSLRVKKTL
||.|.|.||||.
ARLTALCVKKTM
Kinase ALK2.AA Type2 139-426 38 5.8e-117 387.78 In-house 1-315 (315) Show / Hide 
Range on Protein: 139-426
Range on HMM: 1-315/315
Sequence Identity: 38% (122 aa)

INLLQQVGKGRYGEVWMGTWQGD-----TVAVKIFSSIDEKSWFRETEIYNT-VMLRHENILAFFASDM---TSRQSCTQLWLIMEYHERGSLYDYLNRH
|.|....||||.|.|| . |...     |||||||.  |  ||  | .|| . ....||||| |....           ..||..|.|..|||.||| .|
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVKIFPEQDKQSWQNEKDIYSLPYHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQH

VLDARQMCRLALTACSGLVHLHTEIT--CN--NSKPAIAHRDIKTKNILVKRNLTCCIADLGLA-VLHTQRED-NID----MGTN--TRVGTKRYMAPEL
..|   .||.|...  || |||.||.  |     ||.|||||||.||.||| ..||||||.||| ..  ...    .     .|   . |||.||||||.
TIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPEV

LEETMDVR-CFESFKRVDVYAFGLVMWEIARRCEVGG---MVADYKPPFFEYVPSD-PSFDDMRKVACIEKLRPNIPNRWTNNTVLT-SMAKLMKECWCP
|| ... . | ..||..|.||.|||.||.. || . .    | .|..|| | | .  |||.||. ..  .. ||..|. | ..  .. .   .. .||  
LEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRCTDHYPDDEVPEYQMPFEEEVGQHDPSFEDMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDCWDH

TASARHTSLRVKKTL
 | || |.. |.  .
DAEARLTAQCVQERM
Kinase ALK2.AA TKL 145-426 30 1e-109 370.77 In-house 1-364 (364) Show / Hide 
Range on Protein: 145-426
Range on HMM: 1-364/364
Sequence Identity: 30% (115 aa)

VGKGRYGEVWMGTWQG----------DTVAVKIFSS-------------------------IDEKSWFRETEIYNTVM---LRHENILAFFASDMTSRQ-
.|.|..|||. |.|.|           .||||.|.|                          .| ||||..|.. ..|   |||.||. | .... ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

--------SCTQLWLIMEYHERGSLYDYLNRHVLDARQMCRLALTACSGLVHLHTEIT--CNNSKPAIAHRDIKTKNILVKRNLT--------------C
        ...||...|||...|||..||.       |.||.|| ...|. .||....  |   ||.|.|||.|.|||||..|.|              |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

CIADLGLAVLHTQREDNIDMG---------------TNTRVGTKRYMAPELLEETMDVRC----------FESFKRVDVYAFGLVMWEIARRCEVGGMVA
.|.|.||.  ..|.... |..               |.|..||.|.||||.|...|. ..          || ....|||.||.|.|||. ||.      
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----P

DYKPPFFEYVPSDPSFDDMRKVACIEKLRPNIPNRWTN-------NTVLTSMAKLMKECWCPTASARHTSLRVKKTL
 |..|... ...|| |..| ...| ..||| ||..| |       .....||.|||..|| . ...| . ....|.|
YYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ALK2.AA Pkinase 139-426 21 1e-57 202.87 Pfam 1-293 (293) Show / Hide 
Range on Protein: 139-426
Range on HMM: 1-293/293
Sequence Identity: 21% (69 aa)

INLLQQVGKGRYGEVWMGTWQGDT--VAVKIFSSIDEKSWFRET-----EIYNTVMLRHENILAFFASDMTSRQSCTQLWLIMEYHERG----SLYDYLN
. .....|.| .|.|. ....|.   |||||..  .||||...|     ||.   .|.|.||. .. . ..     . ....|||.| |    .|.||. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

---RHVL--DARQMCRLALTACSGLVHLHTEITCNNSKPAIAHRDIKTKNILVKRNLTC----CIADLGLAVLHTQREDNIDMGTNTRVGTKRYMAPELL
   . ..  . .. .. ..  ..|| ..| .         | |||.|  |||...| ..    .|.| ||| ..       .  ..|..|| .|||||..
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVI

EETMDVRCFESFKRVDVYAFGLVMWEIARRCEVGGMVADYKPPFFEYVPSDPSFDDMRKVACIEKLRPNIPNRWTNNTVL-----------------TSM
       . .  ..||....|....| . .           ||| . .  ... .|.... |  . .|.  .... ...                   ..
R-----GGQYYGPKVDMWSCGCILYEMLCGR----------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

AKLMKECWCPTASARHTSLRVKKT--L
 ...| |.|.  . | |   ...   .
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ALK2.AA TKL-Unique 141-409 26 9.6e-36 123.58 In-house 1-273 (290) Show / Hide 
Range on Protein: 141-409
Range on HMM: 1-273/290
Sequence Identity: 26% (82 aa)

LLQQVGKGRYGEVWMGTWQGDTVAVKIFSSIDEKSWFRETE-IYNTV----MLR-HENILAFFASDMTSRQSCT-------QLWLIMEYHERGSLYDYLN
 .  .| | ||.|  |.| |. ||.|.|.   |.| .....  .| |    .|. |.||. ..       . |.       .. ..||| ..|||||.|.
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYM-------GYCMDHQVYPPNMCIVMEYCPGGSLYDVLH

-----------RHVLDARQMCRLALTACSGLVHLHTEITCNNSKPAIAHRDIKTKNILVKRN-----LTCCIADLGLAVLHTQREDNIDMGTN-----TR
            . |.  |. ..|. . .|. .||....     | |.|||.|..|.|| .|     .   |.| ||. . ... ...  . .     ||
QNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEP-----P-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTR

VGTKRYMAPELLEETMDVRCFESFKRVDVYAFGLVMWEIARRCEVGGMVADYKPPFFEYVPSDPSFDDMRKVACI--EKLRPNIPNRWTNNTVLTSMAKL
.|. |.||||.|.       .   . .|||.|| |.|||| |.        || |. ..     ...  ....    |..|| |||..       .  .|
CGSFRWMAPEVLRMNF----CQYSEKSDVYSFGIVLWEIATRK----ITKTYKKPYQGM-----DQEQWCEMVHYMEENYRPPIPNHC-----PKEYRDL

MKECW
...||
IQQCW
Kinase ALK2.AA MLK 139-345 27 7.4e-31 104.33 In-house 1-229 (291) Show / Hide 
Range on Protein: 139-345
Range on HMM: 1-229/291
Sequence Identity: 27% (66 aa)

INLLQQVGKGRYGEVWMGTWQGDT-----VAVKIFS-------SIDEKSWFRETEIYNTVMLRHEN----ILAFFASDMTSRQSCTQLWLIMEYHERGSL
|.... .|.| .|.|| |.|.. .     ||||..        . .. .|  |.|..   .|.|.|    | .| .   .. |.  .. ..||| | |||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYG---VCLQPPCHFCIVMEYCEGGSL

YDYLNRH---------------VLDARQMCRLALTACSGLVHLHTEITCNNSKPAIAHRDIKTKNILVKR------NLTCCIADLGLAVLHTQREDNIDM
|..|.                 | |  .. . ||   .|.  ||     .. ...| |||.| .|||. .      ..|. |.| |..   .|...|  |
YNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLH-----SMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNM-M

GTNTRVGTKRYMAPELLEETMDVRCFESFKRVDVYAFGLVMWEI
.   . || ..|||| ..     ||    . .||. .|.|.||.
S---NAGTYAWMAPEVIQQ---FRCEKYSEKCDVWSWGVVLWEM
Kinase ALK2.AA S_TKc 139-427 19 1.8e-26 95.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 139-427
Range on HMM: 1-231/231
Sequence Identity: 19% (61 aa)

INLLQQVGKGRYGEVWMGTWQG--DTVAVKIFSSIDEKSWFRETEIYNTVMLRHENILAFFASDMTSRQSCTQLWLIMEYHER--GSLYDYLNRHV----
  .|...||| .|.|. ... .    ||.|| .    ..  || .|      .|.||  .. .  .     . |...||| .   |.|.||. ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LDARQMCRLALTACSGLVHLHTEITCNNSKPAIAHRDIKTKNILVKRNLTCCIADLGLAVLHTQREDNIDMGTNTRVGTKRYMAPELLEETMDVRCF
   ..  . ....   |..| ..|       |.  | |||.|  |||. .  .  |.| ||| .            .| .||  |||||.|         
RFPFPE-HARFYMYQICCALEYCH-------SH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---------

ESFK--RVDVYAFGLVMWEIARRCEVGGMVADYKPPFFEYVPSDPSFDDMRKVACIEKLRPNIPNRWTNNTVLTSMAKLMKECWCPTASARHTSLRVKK-
 ..   ..|....| ...| . .          .|||          . | |. .                   ..  ... |..   . | |   . . 
-GYGKCKCDWWSCGCILYEMLCG----------YPPFP-------QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQD

-------TLM
         .
EWDIKCHPWF
Kinase ALK2.AA TK 139-320 14 1.4e-23 75.27 In-house 1-359 (486) Show / Hide 
Range on Protein: 139-320
Range on HMM: 1-359/486
Sequence Identity: 14% (54 aa)

INLLQQVGKGRYG---EVWMGTWQGD---------------------------TVAVKIFS---SIDEKSWFR-----------------ETEIYNTVML
| |... |.| .|   ||..|.|.|.                           .||||.     . ...  |                  | .. .  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHENILAFFA-SDMTSRQSCTQ-------LWLIMEYHERGS----LYDYLNRHV----------------------------------------------
.|.||. ... .     ..|.        ....||| . |.    | ||| ..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDARQMCRLALTACSGLVHLHTE---ITCNNSKPAI---AHRDIKTKNILVKRNLT-----------CC
                               |. .|..  .. ...|. .||              |    |||. . |.|| .|..           | 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEF--------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCK

IADLGLA------VLHTQREDNIDMGTNTRVGTK------------------------RYMAPELLEE
||| ||.            .|     .... ...                        |.|||| |..
IADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLND
Kinase ALK2.AA STE 139-346 20 2.1e-23 79.57 In-house 1-262 (359) Show / Hide 
Range on Protein: 139-346
Range on HMM: 1-262/359
Sequence Identity: 20% (58 aa)

INLLQQVGKGRYGEVWMGTWQ-----------------GDTVAVKIFSSIDEKS---------------WFRE---TEIYNTVMLR--HENILAFFASDM
  .....||| .|.|  .                    |. .|.|. .  ....                 ..    ||     ..  |.||  .. . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TS---RQSCTQLWLIMEYHERGSLYDYLNR---------------HVLDARQMCRLALTACSG-LVHLHTEITCNNSKPAIAHRDIKTKNILVKRNLTCC
      .....||..||| . ||| | ...               |...  | .. .   . | | .||           | |||||  |||.     . 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--------IIHRDIKPANILL-----VK

IADLGLAVLHTQREDNI----------DMG--TNTRVGTKRYMAPELLEE-TMDVRCFESFK----RVDVYAFGLVMWEIA
..| |..   |.  .||          .|.  .|| |||  .|||| ..  . . |     |    ..|.. .|....| |
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R----DKGYDTKCDIWSLGCTIIEMA
Kinase ALK2.AA Pkinase_Tyr 139-345 26 2.6e-23 79.57 Pfam 1-207 (270) Show / Hide 
Range on Protein: 139-345
Range on HMM: 1-207/270
Sequence Identity: 26% (61 aa)

INLLQQVGKGRYGEVWMGTWQ------GDTVAVKIF--SSIDE---KSWFRETEIYNTVML-RHENILAFFASDM-TSRQSCTQLWLIMEYHERGSLYDY
| .... |.| .|||..|||       . .||||.   .. .|   .  | . |.     | .|.||. . .  .  ....  |....||| . |.|.||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDY

LNRH-----VLDARQMCRLALTACSGLVHLHTEITCNNSKPAIAHRDIKTKNILVKRNLTCCIADLGLAVLHTQREDNI-DMGTNTRVGTKRYMAPELLE
| .|      |.  ...  ..  ..|. .|.       ||. . |||. ..|.||..|... |.| ||| .. . .|.   ......    . |||| . 
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLE-------SKN-CIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGK-LPIKWMAPECIN

ETMDVRCFESFKRVDVYAFGLVMWEI
.      | .    ||..|| .||||
YGK----FTT--KSDVWSFGVLMWEI
Kinase ALK2.AA CAMK 144-319 18 3.1e-23 71.1 In-house 1-293 (425) Show / Hide 
Range on Protein: 144-319
Range on HMM: 1-293/425
Sequence Identity: 18% (56 aa)

QVGKGRYGEVWMGTWQGDT--------------VAVKIFS-------------------------------SIDEKSWFRETEIYNTVM-----LRHENI
. |.|..|.|  ..   .|              ||.|| .                                 |.|. .|| || ...      |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LAFFASDMTSRQ--------SCTQ--------LWLIM---EYHERG----SLYDYLNRH----------------VLDARQMCRLALTACSGLVHLHTEI
. ..    ....        . ..        ....|   || . |     |.||. .|                 .. |. .|.    ||.. ..|   
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH-

TCNNSKPAIAHRDIKTKNILVKRN-----------------LTCCIADLGLAVLHTQREDNI-------------------DMGTNTRVGTKRYMA-PEL
        |.|||.|  |||.  |                  .  |.| |.|   .. |.|                    .   .|..||  ||| ||.
-------NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEV

LE
|.
LN
Kinase ALK2.AA TyrKc 139-426 24 2.5e-17 57.51 SMART 1-280 (280) Show / Hide 
Range on Protein: 139-426
Range on HMM: 1-280/280
Sequence Identity: 24% (75 aa)

INLLQQVGKGRYGEVWMGTWQGDTVAVKIFSSIDEKSWFRETEIYNTVML--RHENILAFFASDMTS-RQSC---TQLWLIMEYHERGSLYDYL--NRHV
| |... | | .|||. |||   .||||   .  ..   || .|    .|  .|.||.....  ... |.      .|...||| . |.| |||  .|. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMC--KLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LDARQMCRLALTACSGLVHLHTEITCNNSKPAIAHRDIKTKNILVKRNLTCCIADLGLAVLHTQR------EDNIDMGT--NTR-VGTKRYMAPELLEET
|  ....  .. ...|  .||           . |||. . |.||..|.|. |.| ||.  ..        .| ... .  ... .   | |||| .   
LCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---

MDVRCFESFKRVDVYAFGLVMWEIARRCEVGGMVADYKPPFFEYVPSDPSFDDMRKVACIEKLRPNIPN-----RWTNNTVLTSMAKLMKECWCPTASAR
 . ..| .    ||..|| .||||  ...       |  . ..    . | .....     . .|  ||          .  . | ..||.||   .. |
-NYGKFTTK--SDVWSFGVCMWEIFTYGQQ-----PYPGMIQQ----MMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPEDR

HTSLRVKKTL
 |   ... .
PTFSEIHECF
TGF_beta_GS ALK2.AA TGF_beta_GS 113-137 68 3.1e-14 49.84 Pfam 5-29 (29) Show / Hide 
Range on Protein: 113-137
Range on HMM: 5-29/29
Sequence Identity: 68% (17 aa)

DLFDHSNTSGSGSGLPYLVQRTVAR
|..... |||||||||.|||||.||
DMMEDFCTSGSGSGLPLLVQRTIAR
Kinase ALK2.AA Dicty4 214-409 29 1e-13 42.31 In-house 81-256 (277) Show / Hide 
Range on Protein: 214-409
Range on HMM: 81-256/277
Sequence Identity: 29% (61 aa)

MEYHERGSLYDYLNR--------HVLDARQMCR---LALTACSGLVHLHTEITCNNSKPAIAHRDIKTKNILVKRNLTCCIADLGLAVLHTQREDNIDMG
.||  .|.||  |.           ||   . |   .|. |  |. .||.      . | | |||.|. |.||  |..  ..|.||. .    ||. | .
TEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC------CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKD-N

TNTRVGTKRYMAPELLEETMDVRCFESF-KRVDVYAFGLVMWEIARRCEVGGMVADYKPPFF-EYVPSDPSFDDMRKVACIEKLRPNIPNRWTNNTVLTS
. | .||  .|||| .        ....   .||| ||.| |||. | |          |.. .. |    ..  .   | .|||| ||.      ...|
QMTACGTPCWMAPEVM-------MHQPYNEKADVYSFGIVLWEILTRQE----------PYQKHHMP----YMQFVRAVCNKKLRPPIPDW-----CPPS

MAKLMKECW
 ..|...||
WKHLIQWCW
GS ALK2.AA GS 113-139 74 1.2e-12 49.27 SMART 5-31 (31) Show / Hide 
Range on Protein: 113-139
Range on HMM: 5-31/31
Sequence Identity: 74% (20 aa)

DLFDHSNTSGSGSGLPYLVQRTVARQI
|. ... |||||||||.||||||||||
DMMEDTCTSGSGSGLPLLVQRTVARQI
Kinase ALK2.AA Dicty4 139-168 56 5.5e-09 26.28 In-house 1-30 (277) Show / Hide 
Range on Protein: 139-168
Range on HMM: 1-30/277
Sequence Identity: 56% (17 aa)

INLLQQVGKGRYGEVWMGTWQGDTVAVKIF
||  |  ||| .|||  ||| |  ||||..
INIEQRIGKGSFGEVYKGTWRGKEVAVKKL
Kinase ALK2.AA TK 393-426 20 0.003108 5.84 In-house 453-486 (486) Show / Hide 
Range on Protein: 393-426
Range on HMM: 453-486/486
Sequence Identity: 20% (7 aa)

TNNTVLTSMAKLMKECWCPTASARHTSLRVKKTL
....  . .. ||..|| . .. | |   ... |
PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ALK2.AA TK 334-345 66 0.03211 2.38 In-house 376-387 (486) Show / Hide 
Range on Protein: 334-345
Range on HMM: 376-387/486
Sequence Identity: 66% (8 aa)

DVYAFGLVMWEI
||..|| .||||
DVWSFGVLMWEI
Kinase ALK2.AA MLK 400-426 29 0.215857 0.75 In-house 265-291 (291) Show / Hide 
Range on Protein: 400-426
Range on HMM: 265-291/291
Sequence Identity: 29% (8 aa)

SMAKLMKECWCPTASARHTSLRVKKTL
...||||.|| . .. | ..  . . |
HWKKLMKQCWNQDPHKRPSFRQIVQHL