Gene BMPR1 (Sea Urchin)

BMPR1

Species: Sea Urchin
Alias: Spk330, SPU_016272, SpAlk3/6, BMPR1
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: STKR
Subfamily: STKR1

Sequence

Name Sequence Type Origin Length Description Download
BMPR1.AA Protein None 665 None Fasta, JSON
BMPR1.kin_dom Protein Kinase Domain None 211 None Fasta, JSON

Protein domain

Protein domains of BMPR1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Activin_recp BMPR1.AA Activin_recp 17-106 23 5.3e-22 74.59 Pfam 1-121 (121) Show / Hide 
Range on Protein: 17-106
Range on HMM: 1-121/121
Sequence Identity: 23% (28 aa)

LYCY-CDEH-------CPEITRN-----NTCYPSP--------GGWCFAQIQAGEDG--VEHETPIRSYGCLAPEEDGGL---MQCKG----QLSNHRIS
| || |...       |.|   |     .||   |        .|.|.. .   .|.  .|. . ...|||. ..|....   ..||.      ..||..
LKCYFCNGYWEYDYQICHENENNFEIPVHTCETHPDKMCFYCYDGQCYVSWEYNDDEEDTEQHQRMHMYGCWSLNENCPQCHPFMCKSYKHTHSPPHRHG

RTVYC-CNDEPNCNLKLNPTL
....| |...  || .|.|..
HNHECWCCETDYCNRNLTPPP
Kinase BMPR1.AA Type1 210-422 66 1.7e-188 515.84 In-house 1-215 (290) Show / Hide 
Range on Protein: 210-422
Range on HMM: 1-215/290
Sequence Identity: 66% (142 aa)

VQLIRKIGKGRYGEVWKAKWRGENVAVKIYFTAEEASWFRETDIYQTVLMRHTSILSFIAADIRGSGAYTQLFLITEYHEWGSLYDFLNVNILDSQSMLR
.|.|..||||||||||..|||||||||||.|...|.||||||.|||||.|||..||.|||||....|..|||.|||.|||.|||||.|| ..|| |.|||
IQMIECIGKGRYGEVWRGKWRGENVAVKIFFSRDERSWFRETEIYQTVMMRHENILGFIAADMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLDTQQMLR

LAYSAANGLAHLHTEICGMQ--GKPAIAHRDVKSSNIMVRKNGTCMIADMSLAARFLSEGNEIDLGQNTRLGTTRYLPPEVLDNVLMSNTFDAFKMADMY
||||.|.||||||.||.|.|  |||||||||.|| ||||.|||.|.|||..|| |. .. ..||.|||.|.||.||..|||||. .. |.|...||||.|
LAYSCACGLAHLHMEIFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIGQNPRVGTKRYMAPEVLDETMNMNCFESYKMADIY

SFGMVLWEIARRCVT
|||.|.|||||||..
SFGLVMWEIARRCEV
Kinase BMPR1.AA Type1 424-655 61 1.3e-186 510.61 In-house 57-290 (290) Show / Hide 
Range on Protein: 424-655
Range on HMM: 57-290/290
Sequence Identity: 61% (145 aa)

GFIAADIRGSGAYTQLFLITEYHEWGSLYDFLNVNILDSQSMLRLAYSAANGLAHLHTEICGMQ--GKPAIAHRDVKSSNIMVRKNGTCMIADMSLAARF
||||||....|..|||.|||.|||.|||||.|| ..|| |.|||||||.|.||||||.||.|.|  |||||||||.|| ||||.|||.|.|||..|| |.
GFIAADMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLDTQQMLRLAYSCACGLAHLHMEIFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRH

LSEGNEIDLGQNTRLGTTRYLPPEVLDNVLMSNTFDAFKMADMYSFGMVLWEIARRCVTRGIVEECQLPFYDAVPMDPSIQDMMRVVVIERRRPDIPNRW
 .. ..||.|||.|.||.||..|||||. .. |.|...||||.||||.|.|||||||.. ||||. |||.|| ||.|||. || .|| ... || |||||
QQDTDQIDIGQNPRVGTKRYMAPEVLDETMNMNCFESYKMADIYSFGLVMWEIARRCEVGGIVEDYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRW

SGDDILRTISKVMSECWNQNPAARVTSLRVKKTL
. ....|...|.|.||| |||.|| |.||.||||
QSHPCMRHMAKLMKECWYQNPHARHTALRIKKTL
Kinase BMPR1.AA STKR 210-420 56 1.7e-146 476.12 In-house 1-228 (312) Show / Hide 
Range on Protein: 210-420
Range on HMM: 1-228/312
Sequence Identity: 56% (128 aa)

VQLIRKIGKGRYGEVWKAKWRG----ENVAVKIYFTAEEASWFRETDIYQTVLMRHTSILSFIAADIRGS-GAYTQLFLITEYHEWGSLYDFLNVNILDS
.|||. |||||||||||.||||    |.|||||.....|.||||||.||||..||| .||.|||||...  | .||..|||||||.|||.|.|. ...| 
IQLIECIGKGRYGEVWKGKWRGNGEKETVAVKIFPSRDEQSWFRETEIYQTPMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTIDW

QSMLRLAYSAANGLAHLHTEIC--GMQ--GKPAIAHRDVKSSNIMVRKNGTCMIADMSLAARFLSEGNEIDLG-------QNTRLGTTRYLPPEVLDNVL
..|.|.|.|.|.||||||.||.  |.|  .|||||||| ||.||.|...|||.|||. || |. .. |.||..       |||. || ||..|||||. .
HEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDGAM

MSNTFDA-FKMADMYSFGMVLWEIARRC
. . |.  ||..|||..|.|.|||||||
NFQCFESAFKRMDMYAMGLVMWEIARRC
Kinase BMPR1.AA STKR 424-655 50 5.9e-144 467.81 In-house 61-312 (312) Show / Hide 
Range on Protein: 424-655
Range on HMM: 61-312/312
Sequence Identity: 50% (128 aa)

GFIAADIRGS-GAYTQLFLITEYHEWGSLYDFLNVNILDSQSMLRLAYSAANGLAHLHTEIC--GMQ--GKPAIAHRDVKSSNIMVRKNGTCMIADMSLA
.|||||...  | .||..|||||||.|||.|.|. ...| ..|.|.|.|.|.||||||.||.  |.|  .|||||||| ||.||.|...|||.|||. ||
QFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTIDWHEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLA

ARFLSEGNEIDLG-------QNTRLGTTRYLPPEVLDNVLMSNTFDA-FKMADMYSFGMVLWEIARRCVTRG------IVEECQLPFYDAVPMDPSIQDM
 |. .. |.||..       |||. || ||..|||||. .. . |.  ||..|||..|.|.||||||| . |      ||.| |.|||| ||..||. ||
MRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDGAMNFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDM

MRVVVIERRRPDIPNRWS-GDDILRTISKVMSECWNQNPAARVTSLRVKKTL
  ||...|.|| |||||.  .. .| ..|.| ||| ..|.|| |.|.||||.
QKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWDHDPEARLTALCVKKTM
Kinase BMPR1.AA Type2 210-420 42 2.7e-77 254.72 In-house 1-233 (315) Show / Hide 
Range on Protein: 210-420
Range on HMM: 1-233/315
Sequence Identity: 42% (99 aa)

VQLIRKIGKGRYGEVWKAKWRGE-----NVAVKIYFTAEEASWFRETDIYQT-VLMRHTSILSFIAADIR---GSGAYTQLFLITEYHEWGSLYDFLNVN
 ||.  |||||.|.||||.| ..      |||||.  .. .||  | |||.. ..|.| .||.||.|. |   . .   .. |.||.|. |||.|.|  .
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVKIFPEQDKQSWQNEKDIYSLPYHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQH

ILDSQSMLRLAYSAANGLAHLHTEIC-GMQ---GKPAIAHRDVKSSNIMVRKNGTCMIADMSLAARFLSEGNE--------IDLGQNTRLGTTRYLPPEV
..|  ...|.| |.|.||||||.||  . |    ||.||||| ||.|. |. ..|| |||  || ||    ..         |.   .  || ||  |||
TIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPEV

LD-NVLMSNTFDAFKMADMYSFGMVLWEIARRC
|.  |   .  |||| .|||..| ||||.. ||
LEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRC
Kinase BMPR1.AA TKL 216-421 27 4.1e-74 252.53 In-house 1-287 (364) Show / Hide 
Range on Protein: 216-421
Range on HMM: 1-287/364
Sequence Identity: 27% (81 aa)

IGKGRYGEVWKAKWRG----------ENVAVKIYFT-------------------------AEEASWFRETDIYQTVLMR---HTSILSFIAADIRGS--
||.|..|||.|.||||          . ||||.. .                         ..||||||.. ......|.   |  |..|........  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------GAYTQLFLITEYHEWGSLYDFLNVNILDSQSMLRLAYSAANGLAHLHTEIC--GMQGKPAIAHRDVKSSNIMVRKNGT--------------C
       |  .||....||.. |||...|.      . ..|.|...| |...||...   ..  ||.|.||| ||.||.| .|.|              |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

MIADMSLAARFLSEGNEIDLG---------------QNTRLGTTRYLPPEVLDNVLMSNT----------FDAFKMADMYSFGMVLWEIARRCV
 |.|. |. ..  .||  | .                .|. ||.|...||||.. .  .           |.... .|.||||.|||||. ||.
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR
Kinase BMPR1.AA TKL 425-655 26 9.8e-70 237.98 In-house 90-364 (364) Show / Hide 
Range on Protein: 425-655
Range on HMM: 90-364/364
Sequence Identity: 26% (76 aa)

FIAADIRGS---------GAYTQLFLITEYHEWGSLYDFLNVNILDSQSMLRLAYSAANGLAHLHTEIC--GMQGKPAIAHRDVKSSNIMVRKNGT----
|........         |  .||....||.. |||...|.      . ..|.|...| |...||...   ..  ||.|.||| ||.||.| .|.|    
FMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSN

----------CMIADMSLAARFLSEGNEIDLG---------------QNTRLGTTRYLPPEVLDNVLMSNT----------FDAFKMADMYSFGMVLWEI
          | |.|. |. ..  .||  | .                .|. ||.|...||||.. .  .           |.... .|.||||.|||||
YMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI

ARRCVTRGIVEECQ-LPFYDAVPMDPSIQDMMRVVVIERRRPDIPNRWSG-------DDILRTISKVMSECWNQNPAARVTSLRVKKTL
. ||.        . .|... ...|| ...|. .|. ...|| ||..|.        .|... ..| | .||...| .| . ....|.|
LTRCR------PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase BMPR1.AA Type2 425-655 37 3.5e-63 207.36 In-house 64-315 (315) Show / Hide 
Range on Protein: 425-655
Range on HMM: 64-315/315
Sequence Identity: 37% (95 aa)

FIAADIR---GSGAYTQLFLITEYHEWGSLYDFLNVNILDSQSMLRLAYSAANGLAHLHTEIC-GMQ---GKPAIAHRDVKSSNIMVRKNGTCMIADMSL
||.|. |   . .   .. |.||.|. |||.|.|  ...|  ...|.| |.|.||||||.||  . |    ||.||||| ||.|. |. ..|| |||  |
FICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQHTIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGL

AARFLSEGNE--------IDLGQNTRLGTTRYLPPEVLD-NVLMSNTFDAFKMADMYSFGMVLWEIARRCVTRG---IVEECQLPFYDAVPMD-PSIQDM
| ||    ..         |.   .  || ||  ||||.  |   .  |||| .|||..| ||||.. ||   .    | | |.||   |    ||. ||
AMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPEVLEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRCTDHYPDDEVPEYQMPFEEEVGQHDPSFEDM

MRVVVIERRRPDIPNRWS-GDDILRTISKVMSECWNQNPAARVTSLRVKKTL
  .|| .|.|| .|. |. .  . | .   . .|| . . || |.. |.  .
QELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDCWDHDAEARLTAQCVQERM
Kinase BMPR1.AA Pkinase 210-417 25 7.3e-31 110.2 Pfam 1-206 (293) Show / Hide 
Range on Protein: 210-417
Range on HMM: 1-206/293
Sequence Identity: 25% (58 aa)

VQLIRKIGKGRYGEVWKAKWRGEN--VAVKIYFTAEEASWFRET-----DIYQTVLMRHTSILSFIAADIRGSGAYTQLFLITEYHEWG----SLYDFLN
 ...||||.| .|.|.|....|..  |||||    .| ||...|      |.    ..|  |. .. .  .     . . ...||.| |    .|.|.. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

---VNIL--DSQSMLRLAYSAANGLAHLHTEICGMQGKPAIAHRDVKSSNIMVRKNGTC----MIADMSLAARFLSEGNEIDLGQNTRLGTTRYLPPEVL
    . .  . .   . .|  . ||...| .         | |||.|..||.. .||..     |.|  ||. |    .  .   .|. || .|..|||.
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVI

DNVLMSNTFDAFKMADMYSFGMVLWEIA
         .  . .||.|.| .|.| .
R-----GGQYYGPKVDMWSCGCILYEML
Kinase BMPR1.AA MLK 210-356 24 1.1e-29 100.28 In-house 1-176 (291) Show / Hide 
Range on Protein: 210-356
Range on HMM: 1-176/291
Sequence Identity: 24% (45 aa)

VQLIRKIGKGRYGEVWKAKWRGEN-----VAVKIYF-------TAEEASWFRETDIYQTVLMRHTS----ILSFIAADIRGSGAYTQ-LFLITEYHEWGS
 |. ..||.| .|.|||..||...     ||||...        ... .|  |.....   ..|      |  | .. ..    ... .....|| | ||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQ----PPCHFCIVMEYCEGGS

LYDFLNVN---------------ILDSQSMLRLAYSAANGLAHLHTEICGMQGKPAIAHRDVKSSNIMVR------KNGTCMIAD
||..|. .               . | ..... |.  |.|.. ||     .. ...| ||| ||.||..       ..||. |.|
LYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLH-----SMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICD
Kinase BMPR1.AA TKL-Unique 212-425 30 5.3e-28 95.94 In-house 1-230 (290) Show / Hide 
Range on Protein: 212-425
Range on HMM: 1-230/290
Sequence Identity: 30% (73 aa)

LIRKIGKGRYGEVWKAKWRGENVAVKIYFTAEEASWFRETD-IYQTV----LMR-HTSILSFIAADIRGSGAYTQLFLITEYHEWGSLYDFLN-------
 . ||| | ||.| |.||||. ||.|. .  .| | .....  .  |      . |  |. .... .    .  ......|| . ||||| |.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

----VNILDSQSMLRLAYSAANGLAHLHTEICGMQGKPAIAHRDVKSSNIMVRKN-----GTCMIADMSLAARFLSEGNEIDLGQN------TRLGTTRY
     . |. | ....|  .| |. .||...     .| |.||| ||||. |  |         |.| .| ..|.|  |.  .. .      ||.|..|.
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCE-----PP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGL-SKFNSKINKMTNNEHKGTRNQTRCGSFRW

LPPEVLDNVLMSNTFDAFKMADMYSFGMVLWEIARRCVTRGF
..|||| ..   ....  . .| ||||.|||||| |..|. .
MAPEVLRMNF--CQYS--EKSDVYSFGIVLWEIATRKITKTY
Kinase BMPR1.AA Pkinase 439-655 18 2.3e-25 90.76 Pfam 75-293 (293) Show / Hide 
Range on Protein: 439-655
Range on HMM: 75-293/293
Sequence Identity: 18% (47 aa)

LFLITEYHEWG----SLYDFLN---VNIL--DSQSMLRLAYSAANGLAHLHTEICGMQGKPAIAHRDVKSSNIMVRKNGTC----MIADMSLAARFLSEG
. ...||.| |    .|.|..     . .  . .   . .|  . ||...| .         | |||.|..||.. .||..     |.|  ||. |    
IYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---

NEIDLGQNTRLGTTRYLPPEVLDNVLMSNTFDAFKMADMYSFGMVLWEIARRCVTRGIVEECQLPFYDAVPMDPSIQDMMRVVVIERRRPDIPNRWSGDD
.  .   .|. || .|..|||.         .  . .||.|.| .|.| . .           .||....  ...  |.| ...  ...|   ...  ..
Y-NNS-MTTFCGTPWYMAPEVIR-----GGQYYGPKVDMWSCGCILYEMLCGR----------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCS

IL-----------------RTISKVMSECWNQNPAARVTSLRVKKT--L
|                  ..  .... |....|. | |   ...   .
ISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase BMPR1.AA TKL-Unique 438-581 31 6.4e-21 70.64 In-house 74-228 (290) Show / Hide 
Range on Protein: 438-581
Range on HMM: 74-228/290
Sequence Identity: 31% (53 aa)

QLFLITEYHEWGSLYDFLN-----------VNILDSQSMLRLAYSAANGLAHLHTEICGMQGKPAIAHRDVKSSNIMVRKN-----GTCMIADMSLAARF
......|| . ||||| |.            . |. | ....|  .| |. .||...     .| |.||| ||||. |  |         |.| .| ..|
NMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCE-----PP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGL-SKF

LSEGNEIDLGQN------TRLGTTRYLPPEVLDNVLMSNTFDAFKMADMYSFGMVLWEIARRCVTR
.|  |.  .. .      ||.|..|...|||| ..   ....  . .| ||||.|||||| |..|.
NSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF--CQYS--EKSDVYSFGIVLWEIATRKITK
Kinase BMPR1.AA TK 210-416 15 1.2e-18 58.45 In-house 1-387 (486) Show / Hide 
Range on Protein: 210-416
Range on HMM: 1-387/486
Sequence Identity: 15% (62 aa)

VQLIRKIGKGRYG---EVWKAKWRGEN---------------------------VAVKIYF---TAEEASWFR-----------------ETDIYQTVLM
..|..|.|.| .|   ||.|..|||.|                           ||||.     .....  |                  |  . .  | 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHTSILSFIAADIRGSG--------AYTQLFLITEYHEWGS----LYDFLNVN-----------------------------------------------
.|  |......  .| .        .   . ...|| . |.    | |.|  .                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------ILDSQSMLRLAYSAANGLAHLHTEIC-GMQGKPAI---AHRDVKSSNIMVRKNGT-----------CMIA
                              .|. . .|  .. .|.|...||   | .      |    |||.   |..| .|..           | ||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEF------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIA

DMSLA-------ARFLSEGNEIDLGQNTRLGT-----------------------TRYLPPEVLD-NVLMSN--TFDAFKMADMYSFGMVLWEI
|  |.       || . .. .    .. . |.                        |...||.|. .|  .   .       |..||| ..|||
DFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase BMPR1.AA S_TKc 210-479 20 3.2e-15 46.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 210-479
Range on HMM: 1-231/231
Sequence Identity: 20% (58 aa)

VQLIRKIGKGRYGEVWKAKWRG--ENVAVKIYFTAEEASWFRETDIYQTVLMRHTSILSFIAADIRGSGAYTQLFLITEYHEW--GSLYDFLNVNI----
 ...|||||| .|.|.|.....  . ||.||       .  || .| .    .|  |  .. .        . |....|| .   |.|.|..  .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LDSQSMLRLAYSAANGLAHLHTEICGMQGKPAIAHRDVKSSNIMVRKNGTCMIADMSLAARFLSEGNEIDLGQNTRLGTTRYLPPEVLDNVLMSNTF
   ..     ...|  ...|...|           | |||.| .||.. .  . .|.|  ||...           .|  ||  |..||||         
RFPFPE-HARFYMYQICCALEYCHSH-G-------IIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---------

DAFK-MADMYSFGMVLWEIARRCVTRGFIAADIRGSGAYTQLFLITEYHEWGSLYDFLNVNILDSQSMLRLAYSAANG-------LAHL
   |  .|..|.| .|.| . ..               . ..| .       .. ||.. ..|.     |.    |            .
GYGKCKCDWWSCGCILYEMLCGYPPFP----------QMQMMFKKIG---SPEAKDFIR-KCLQKDPEKRPTA-EALQDEWDIKCHPWF
TGF_beta_GS BMPR1.AA TGF_beta_GS 180-208 62 3.8e-15 52.83 Pfam 1-29 (29) Show / Hide 
Range on Protein: 180-208
Range on HMM: 1-29/29
Sequence Identity: 62% (18 aa)

ETLSELLEKSSASGSGSGLPLLVQRTIAK
.|.....|... ||||||||||||||||.
KTMQDMMEDFCTSGSGSGLPLLVQRTIAR
GS BMPR1.AA GS 180-210 58 4.3e-15 57.37 SMART 1-31 (31) Show / Hide 
Range on Protein: 180-210
Range on HMM: 1-31/31
Sequence Identity: 58% (18 aa)

ETLSELLEKSSASGSGSGLPLLVQRTIAKQV
.|.....| .. ||||||||||||||.|.|.
KTMHDMMEDTCTSGSGSGLPLLVQRTVARQI
Kinase BMPR1.AA Pkinase_Tyr 210-322 23 1.3e-14 50.14 Pfam 1-128 (270) Show / Hide 
Range on Protein: 210-322
Range on HMM: 1-128/270
Sequence Identity: 23% (31 aa)

VQLIRKIGKGRYGEVWKAKWR------GENVAVKIY--FTAEE----ASWFRETDIYQTVLM-RHTSILSFIAADI-RGS-GAYTQLFLITEYHEWGSLY
.....|.|.| .|||.|..|.      .  ||||.    . .|    .. .||  |  .  . .|  |...... . .|  .   |.....|| . |.|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQ--LGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLL

DFLNVN-----ILDSQSMLRLAYSAANGLAHLH
|.|  .      |. . .|  ..  |.|...|.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE
Kinase BMPR1.AA Dicty4 302-417 33 5.3e-14 43.27 In-house 106-211 (277) Show / Hide 
Range on Protein: 302-417
Range on HMM: 106-211/277
Sequence Identity: 33% (41 aa)

LDSQSMLR---LAYSAANGLAHLHTEICGMQGKPAIAHRDVKSSNIMVRKNGTCMIADMSLAARFLSEGNEIDLGQ--NTRLGTTRYLPPEVLDNVLMSN
||.  ..|   .| .|| |...||. .      | | ||| ||.|..| || .  ..|  |....     ..|...   |  ||. .  ||    |.|..
LDWPLIKRAMRMAFDAARGMNWLHCCN------PVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMK---KHEDHKDNQMTACGTPCWMAPE----VMMHQ

TFDAFKMADMYSFGMVLWEIA
 ..    || ||||.|||||.
PYN--EKADVYSFGIVLWEIL
Kinase BMPR1.AA Dicty4 460-575 33 5.3e-14 43.27 In-house 106-211 (277) Show / Hide 
Range on Protein: 460-575
Range on HMM: 106-211/277
Sequence Identity: 33% (41 aa)

LDSQSMLR---LAYSAANGLAHLHTEICGMQGKPAIAHRDVKSSNIMVRKNGTCMIADMSLAARFLSEGNEIDLGQ--NTRLGTTRYLPPEVLDNVLMSN
||.  ..|   .| .|| |...||. .      | | ||| ||.|..| || .  ..|  |....     ..|...   |  ||. .  ||    |.|..
LDWPLIKRAMRMAFDAARGMNWLHCCN------PVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMK---KHEDHKDNQMTACGTPCWMAPE----VMMHQ

TFDAFKMADMYSFGMVLWEIA
 ..    || ||||.|||||.
PYN--EKADVYSFGIVLWEIL
Kinase BMPR1.AA TyrKc 210-655 14 1e-13 -0.94 SMART 1-280 (280) Show / Hide 
Range on Protein: 210-655
Range on HMM: 1-280/280
Sequence Identity: 14% (69 aa)

VQLIRKIGKGRYGEVWKAKWRGENVAVKIYF-TAEEASWFRETDIYQTVLM--RHTSILSFIAADIRGSGAY---TQLFLITEYHEWGSLYDFLNVNILD
..|..|.| | .|||.|..|. ..||||     | ..   ||  |        .|  |. .... . ... .    .|....|| ..|.| |.|  .  .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCK--LGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

SQSMLRLAYSAANGLAHLHTEICGMQGKPAIAHRDVKSSNIMVRKNGTCMIADMSLAARFLSEGNEIDLGQNTRLGTTRYLPPEVLDNVLMSNTFDAFKM
                                                                                                    
----------------------------------------------------------------------------------------------------

ADMYSFGMVLWEIARRCVTRGFIAADIRGSGAYTQLFLITEYHEWGSLYDFLNVNILDSQSMLRLAYSAANGLAHLHTEICGMQGKPAIAHRDVKSSNIM
                                                        |  . .|  .. .|.| ..||           . |||    |..
--------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCL

VRKNGTCMIADMSLAARFLSEG-------NEIDLGQ--NTR-LGTTRYLPPEVLDNVLMSNTFDAFKMADMYSFGMVLWEIARRCVTRGIVEECQLPFYD
| .|.|. |.|  | .|.. ..         ..  .  ... .   | ..||..    . ..|      | .||| ..||         |   .| | ..
VGENHTVKISDFGL-SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYGKFT--TKSDVWSFGVCMWE---------IFTYGQQPYPG

AVPMDPSIQDMMRVVVIERRRPDIPNRWSGDDI-----LRTISKVMSECWNQNPAARVTSLRVKKTL
 . .. | |.... |   .|.|  ||      .        . ..|..||. .|. | |   ... .
MIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase BMPR1.AA HH498 280-416 24 1e-12 36.21 In-house 77-219 (284) Show / Hide 
Range on Protein: 280-416
Range on HMM: 77-219/284
Sequence Identity: 24% (39 aa)

QLFLITEYHEWGSLYDFL--------------NVNI-----LDSQSMLRLAYSAANGLAHLHTEICGMQGKPAIAHRDVKSSNIMVRKNGTCMIADMSLA
|. ..|.| . |||.  |              ...      .| || ....   |.|   ||        |. | |||  | || . ..|   .||    
QFAIVTQYCDNGSLFSILNTIPIGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSL-----KHPIIHRDLNSHNILIHEDGHAVVADFGE-

ARFLSEGNEIDLGQNTR-LGTTRYLPPEVLD-NVLMSNTFDAFKMADMYSFGMVLWEI
 ||. .  .  .   |   |  |.  |||   .   |      . .| .|..|..||.
SRFVCDMHDDNM---TKQPGNLRWMAPEVFSQCQKYS------IKVDVFSYAMCIWEM
Kinase BMPR1.AA HH498 438-574 24 1e-12 36.21 In-house 77-219 (284) Show / Hide 
Range on Protein: 438-574
Range on HMM: 77-219/284
Sequence Identity: 24% (39 aa)

QLFLITEYHEWGSLYDFL--------------NVNI-----LDSQSMLRLAYSAANGLAHLHTEICGMQGKPAIAHRDVKSSNIMVRKNGTCMIADMSLA
|. ..|.| . |||.  |              ...      .| || ....   |.|   ||        |. | |||  | || . ..|   .||    
QFAIVTQYCDNGSLFSILNTIPIGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSL-----KHPIIHRDLNSHNILIHEDGHAVVADFGE-

ARFLSEGNEIDLGQNTR-LGTTRYLPPEVLD-NVLMSNTFDAFKMADMYSFGMVLWEI
 ||. .  .  .   |   |  |.  |||   .   |      . .| .|..|..||.
SRFVCDMHDDNM---TKQPGNLRWMAPEVFSQCQKYS------IKVDVFSYAMCIWEM
Kinase BMPR1.AA Dicty4-Unclassified 302-417 31 1.1e-11 36.32 In-house 106-202 (263) Show / Hide 
Range on Protein: 302-417
Range on HMM: 106-202/263
Sequence Identity: 31% (37 aa)

LDSQSMLRLAYSAANGLAHLHTEICGMQGKPAIAHRDVKSSNIMVRKNGTCMIADMSLAARFLSEGNEIDLGQN-TRLG-TTRYLPPEVLDNVLMSNTFD
||.   .. | . | |..||||          . |||.|||||.. |.    |||. ..        .||  .| |  . | .   ||    .||   . 
LDDTLIIKYAFDIAQGMQHLHTR--------NFIHRDIKSSNILMDKHFNIKIADFGISR-------VIDFNFNMTTIAGTPKWESPE----CLMHESYN

AFKMADMYSFGMVLWEIA
    .| ||..|.|.| |
--QKSDVYSYAMMLYELA
Kinase BMPR1.AA Dicty4-Unclassified 460-575 31 1.1e-11 36.32 In-house 106-202 (263) Show / Hide 
Range on Protein: 460-575
Range on HMM: 106-202/263
Sequence Identity: 31% (37 aa)

LDSQSMLRLAYSAANGLAHLHTEICGMQGKPAIAHRDVKSSNIMVRKNGTCMIADMSLAARFLSEGNEIDLGQN-TRLG-TTRYLPPEVLDNVLMSNTFD
||.   .. | . | |..||||          . |||.|||||.. |.    |||. ..        .||  .| |  . | .   ||    .||   . 
LDDTLIIKYAFDIAQGMQHLHTR--------NFIHRDIKSSNILMDKHFNIKIADFGISR-------VIDFNFNMTTIAGTPKWESPE----CLMHESYN

AFKMADMYSFGMVLWEIA
    .| ||..|.|.| |
--QKSDVYSYAMMLYELA
Kinase BMPR1.AA MLK 438-514 26 5.2e-11 34.55 In-house 84-176 (291) Show / Hide 
Range on Protein: 438-514
Range on HMM: 84-176/291
Sequence Identity: 26% (26 aa)

QLFLITEYHEWGSLYDFLNVN---------------ILDSQSMLRLAYSAANGLAHLHTEICGMQGKPAIAHRDVKSSNIMVR------KNGTCMIAD
......|| | ||||..|. .               . | ..... |.  |.|.. ||     .. ...| ||| ||.||..       ..||. |.|
HFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLH-----SMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICD
Kinase BMPR1.AA Dicty4 210-238 51 3.1e-08 23.76 In-house 1-29 (277) Show / Hide 
Range on Protein: 210-238
Range on HMM: 1-29/277
Sequence Identity: 51% (15 aa)

VQLIRKIGKGRYGEVWKAKWRGENVAVKI
 .   .|||| .||| |..|||  ||||.
INIEQRIGKGSFGEVYKGTWRGKEVAVKK
Kinase BMPR1.AA HH498 210-237 46 1.5e-07 19.6 In-house 1-28 (284) Show / Hide 
Range on Protein: 210-237
Range on HMM: 1-28/284
Sequence Identity: 46% (13 aa)

VQLIRKIGKGRYGEVWKAKWRGENVAVK
.   .||| | .|.| | .||. .||||
IEFHEKIGSGSFGKVYKGEWRNKIVAVK
Kinase BMPR1.AA TK 439-574 15 4.5e-07 18.95 In-house 130-387 (486) Show / Hide 
Range on Protein: 439-574
Range on HMM: 130-387/486
Sequence Identity: 15% (40 aa)

LFLITEYHEWGS----LYDFLNVN----------------------------------------------------------------------------
. ...|| . |.    | |.|  .                                                                            
WMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCK

-ILDSQSMLRLAYSAANGLAHLHTEIC-GMQGKPAI---AHRDVKSSNIMVRKNGT-----------CMIADMSLA-------ARFLSEGNEIDLGQNTR
 .|. . .|  .. .|.|...||   | .      |    |||.   |..| .|..           | |||  |.       || . .. .    .. .
HQLTMHQLL-MCWQIACGMEYLHSKNCEF------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYG

LGT-----------------------TRYLPPEVLD-NVLMSN--TFDAFKMADMYSFGMVLWEI
 |.                        |...||.|. .|  .   .       |..||| ..|||
TGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase BMPR1.AA Dicty4-Unclassified 210-238 44 2e-06 18.27 In-house 1-29 (263) Show / Hide 
Range on Protein: 210-238
Range on HMM: 1-29/263
Sequence Identity: 44% (13 aa)

VQLIRKIGKGRYGEVWKAKWRGENVAVKI
.|  . ||||   .| |  |.| .||||.
IQIDQFIGKGHFSKVHKGNWKGKDVAVKK
Kinase BMPR1.AA MLK 404-416 53 0.000215 11.3 In-house 217-229 (291) Show / Hide 
Range on Protein: 404-416
Range on HMM: 217-229/291
Sequence Identity: 53% (7 aa)

ADMYSFGMVLWEI
.|..|.|.||||.
CDVWSWGVVLWEM
Kinase BMPR1.AA MLK 562-574 53 0.000215 11.3 In-house 217-229 (291) Show / Hide 
Range on Protein: 562-574
Range on HMM: 217-229/291
Sequence Identity: 53% (7 aa)

ADMYSFGMVLWEI
.|..|.|.||||.
CDVWSWGVVLWEM
Kinase BMPR1.AA TK 633-655 30 0.000239 9.64 In-house 464-486 (486) Show / Hide 
Range on Protein: 633-655
Range on HMM: 464-486/486
Sequence Identity: 30% (7 aa)

VMSECWNQNPAARVTSLRVKKTL
.| .||. .|. | |   ... |
LMQQCWHYDPEDRPTFSQLHEQL
Kinase BMPR1.AA MLK 608-655 29 0.001673 8.17 In-house 249-291 (291) Show / Hide 
Range on Protein: 608-655
Range on HMM: 249-291/291
Sequence Identity: 29% (14 aa)

VVIERRRPDIPNRWSGDDILRTISKVMSECWNQNPAARVTSLRVKKTL
|. .. || ||.      . . ..| |..||||.|. | ..  . . |
VAYNGLRPPIPST-----CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase BMPR1.AA Pkinase_Tyr 438-480 25 0.002362 11.98 Pfam 81-128 (270) Show / Hide 
Range on Protein: 438-480
Range on HMM: 81-128/270
Sequence Identity: 25% (12 aa)

QLFLITEYHEWGSLYDFLNVN-----ILDSQSMLRLAYSAANGLAHLH
|.....|| . |.|.|.|  .      |. . .|  ..  |.|...|.
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE
Kinase BMPR1.AA TKL-Unique 623-645 17 0.046628 3.27 In-house 258-280 (290) Show / Hide 
Range on Protein: 623-645
Range on HMM: 258-280/290
Sequence Identity: 17% (4 aa)

GDDILRTISKVMSECWNQNPAAR
....   ... . .||...|  |
PNHCPKEYRDLIQQCWHHDPSQR
Kinase BMPR1.AA Pkinase_Tyr 632-645 35 1.624582 2.37 Pfam 247-260 (270) Show / Hide 
Range on Protein: 632-645
Range on HMM: 247-260/270
Sequence Identity: 35% (5 aa)

KVMSECWNQNPAAR
..| .||...|. |
DLMKQCWHYDPEDR
Kinase BMPR1.AA Pkinase_Tyr 405-416 58 2.019388 2.05 Pfam 196-207 (270) Show / Hide 
Range on Protein: 405-416
Range on HMM: 196-207/270
Sequence Identity: 58% (7 aa)

DMYSFGMVLWEI
| .||| ..|||
DVWSFGVLMWEI
Kinase BMPR1.AA Pkinase_Tyr 563-574 58 2.019388 2.05 Pfam 196-207 (270) Show / Hide 
Range on Protein: 563-574
Range on HMM: 196-207/270
Sequence Identity: 58% (7 aa)

DMYSFGMVLWEI
| .||| ..|||
DVWSFGVLMWEI