Gene BMPR2 (Sea Urchin)

BMPR2

Species: Sea Urchin
Alias: SPU_011711, BMPR2, Spk328
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: STKR
Subfamily: STKR2

Sequence

Name Sequence Type Origin Length Description Download
BMPR2.AA Protein None 982 None Fasta, JSON
BMPR2.kin_dom Protein Kinase Domain None 292 None Fasta, JSON

Protein domain

Protein domains of BMPR2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Activin_recp BMPR2.AA Activin_recp 27-97 24 1e-05 20.35 Pfam 48-121 (121) Show / Hide 
Range on Protein: 27-97
Range on HMM: 48-121/121
Sequence Identity: 24% (19 aa)

YTETFINI----SRLHQSLYIQGCWGNEAKSLNCNQENCTAHSKPSEYLVRTKN---QTSRIC-CCAGDYCNRNVSDAY
|. ...|       .||. . .|||  .  .  |  . | .  |     .. ..    ..  | || .||||||..  .
YVSWEYNDDEEDTEQHQRMHMYGCWSLNENCPQCHPFMCKSY-K----HTHSPPHRHGHNHECWCCETDYCNRNLTPPP
Kinase BMPR2.AA Type2 177-475 51 2.3e-213 711.15 In-house 1-315 (315) Show / Hide 
Range on Protein: 177-475
Range on HMM: 1-315/315
Sequence Identity: 51% (163 aa)

LKMMELVGQGRYCNVYRAALSEN-----EVAVKVFTGSSKQCYMNELDIMGLP-HMEHSNLLQYVGSGDR--MGEDGWVEHLLVVDMISKGSLMSYLREN
...|||.|.||...|..|....|     .||||.|. ..||...|| ||. || ||.|.|.||......|  ...|||.|..||.....||||..||...
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVKIFPEQDKQSWQNEKDIYSLPYHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQH

TYDWHTMCRLAQTTAAGLAHLHQVIDTQVG---LKPAVVHRDINSRNVLVNAEGNCVIGDFGFAMQVCGSSVVGEGD----GDNSTITDVGTVRYMSPEV
|.|||..||.|...|.||||||..|.....   .||...||||.|.||||.....|.|.|||.||..|.........    ||...|..|||.|||.|||
TIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPEV

LDGAVNLRDCECALKQVDVYALGLVVWEIAMRCKDLYPRDEMGNYQMPFEEQVGLH-PTFEDMQILVSRERKRPQFPDAWKQNSQALRSLKETIEDCWDH
|.||||..||..|.||.|.||.|||.||...||.|.||.||...|||||||.||.| |.|||||.||.|.|||||.||.||..... |.|.|||||||||
LEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRCTDHYPDDEVPEYQMPFEEEVGQHDPSFEDMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDCWDH

DAEARLTALCVEERI
||||||||.||.||.
DAEARLTAQCVQERM
Kinase BMPR2.AA STKR 177-475 44 2.1e-188 613.62 In-house 1-312 (312) Show / Hide 
Range on Protein: 177-475
Range on HMM: 1-312/312
Sequence Identity: 44% (138 aa)

LKMMELVGQGRYCNVYRAALSE----NEVAVKVFTGSSKQCYMNELDIMGLPHMEHSNLLQYVGSGDRMGEDGWVEHLLVVDMISKGSLMSYLRENTYDW
....|..|.|||..|... . .    ..||||.|   ..|....| .|. .|.|.| |.||.........|..|....|....  .|||. ||...|.||
IQLIECIGKGRYGEVWKGKWRGNGEKETVAVKIFPSRDEQSWFRETEIYQTPMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTIDW

HTMCRLAQTTAAGLAHLHQVID--TQVG-LKPAVVHRDINSRNVLVNAEGNCVIGDFGFAMQVCGSSVVGEGDG---DNSTITDVGTVRYMSPEVLDGAV
|.|||.|...| ||||||. |   .. .  |||..||||.|.|.||...|.|.|.|||.||...... ......   ||...|.|||.|||.|||||||.
HEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDGAM

NLRDCECALKQVDVYALGLVVWEIAMRCKDLYP---RDEMGNYQMPFEEQVGLHPTFEDMQILVSRERKRPQFPDAWKQNSQALRSLKETIEDCWDHDAE
|....|.|.|..|.||.||| ||||.||.|..|   ......|||||...|. ||.||||| .|.|.|.||..|..||.|..|.||...|.|.|||||.|
NFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWDHDPE

ARLTALCVEERI
||||||||....
ARLTALCVKKTM
Kinase BMPR2.AA Type1 177-475 35 6.5e-99 268.42 In-house 1-290 (290) Show / Hide 
Range on Protein: 177-475
Range on HMM: 1-290/290
Sequence Identity: 35% (107 aa)

LKMMELVGQGRYCNVYRAALSENEVAVKVFTGSSKQCYMNELDIMGLPHMEHSNLLQYVGSGDRMGEDGWVEHLLVVDMISKGSLMSYLRENTYDWHTMC
..|.| .|.||| .|.|.     .||||.|     . . .| .|     | | | |..... |. ... | . .|. |   .|||  || ..| | ..|.
IQMIECIGKGRYGEVWRGKWRGENVAVKIFFSRDERSWFRETEIYQTVMMRHENILGFIAA-DMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLDTQQML

RLAQTTAAGLAHLHQVIDTQV-GLKPAVVHRDINSRNVLVNAEGNCVIGDFGFAMQVCGSSVVGEGDGDNSTITDVGTVRYMSPEVLDGAVNLRDCECAL
||| ..| ||||||  |  .    |||. |||| |.|..|  .| |.|.|.| | .   ...  . |    . . |||.||| |||||   | .. | . 
RLAYSCACGLAHLHMEIFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRH--QQDTDQIDIG--QNPRVGTKRYMAPEVLDETMNMNCFE-SY

KQVDVYALGLVVWEIAMRCKDLYPRDEMGNYQMPFEEQVGLHPTFEDMQILVSRERKRPQFPDAWKQNSQALRSLKETIEDCWDHDAEARLTALCVEERI
| .|.|..||| |||| ||..      .  ||.|. . |   |.||||.  |  .. ||..| .| |.....|..    ..|| . ..||.||| .   .
KMADIYSFGLVMWEIARRCEVGG---IVEDYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRW-QSHPCMRHMAKLMKECWYQNPHARHTALRIKKTL
Kinase BMPR2.AA TKL 183-475 23 1.4e-81 277.3 In-house 1-364 (364) Show / Hide 
Range on Protein: 183-475
Range on HMM: 1-364/364
Sequence Identity: 23% (91 aa)

VGQGRYCNVYRAALSE----------NEVAVKVFTGSS-------------------------KQCYMNELDIMGLPHME---HSNLLQYVG--SGDRMG
.|.|... ||.. .            ..||||.|   .                         ... ...  .  . .|    | |..|..|     . |
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

E------DGWVEHLLVVDMISKGSLMSYLRENTYDWHTMCRLAQTTAAGLAHLHQVI---DTQVGLKPAVVHRDINSRNVLVNAEGN-------------
.      ..| .. .| . ...||| .||      || .||.|. .| |...||. .    |    ||...|||..|.|.||.  ..             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT----KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-CVIGDFGFAMQVCGSSVVGEG-----------DGDNSTITDVGTVRYMSPEVLDGAVNLRDC---------ECALKQVDVYALGLVVWEIAMRCKDLYP
 | |.|||..  ...|.    .           .... |.| .|| |.|.||||.|. |....         . . ...|||. |.| |||. ||.    
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----

RDEMGNYQ-MPFEEQVGLHPTFEDMQILVSRERKRPQFPDAWKQ------NSQALRSLKETIEDCWDHDAEARLTALCVEERI
      |. .|...... .| ||.|...|. ...||  |. |..      ......|.|. ..||||||.|.|...... .|.
-----PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase BMPR2.AA Pkinase 177-475 17 1.6e-28 101.98 Pfam 1-293 (293) Show / Hide 
Range on Protein: 177-475
Range on HMM: 1-293/293
Sequence Identity: 17% (60 aa)

LKMMELVGQGRYCNVYRAALSENE--VAVKVFTGSSKQCYMN-------ELDIMGLPHMEHSNLLQYVGSGDRMGEDGWVEHLLVVDMISKG----SLMS
..  . .|.| .  ||..    ..  ||||..  ... . ..       |. ||   .  | | ... ..  .   ....   .| .   .|    .|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--HPNIVRLYDWFED---KDHIY--MVMEYCEGGLYVMDLFD

YLR---ENTY--DWHTMCRLAQTTAAGLAHLHQVIDTQVGLKPAVVHRDINSRNVLVNAEGNC----VIGDFGFAMQVCGSSVVGEGDGDNSTITDVGTV
|..   ....  .... .. .  .. ||...|.           ..|||. . |.|.. .|..     |.|||.| |.         .. ..|.  .|| 
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTF--CGTP

RYMSPEVLDGAVNLRDCECALKQVDVYALGLVVWEIAMRCKDLYPRDEMGNYQMPFEEQVGLHPTFEDMQILVSRERKRPQFPDAWKQNSQAL-------
.||.|||      .|...   . ||....|....| . .               || ...  |..  |.. .. | ...|   | .. .|  .       
WYMAPEV------IRGGQYYGPKVDMWSCGCILYEMLCGR-------------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWH

---------RSLKETIEDCWDHDAEARLTALCVEER--I
         ...|. |..|.. | . |.|| .. .   .
FHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase BMPR2.AA S_TKc 177-476 16 9.3e-21 76.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 177-476
Range on HMM: 1-231/231
Sequence Identity: 16% (52 aa)

LKMMELVGQGRYCNVYRAALSE--NEVAVKVFTGSSKQCYMNELDIMGLPHMEHSNLLQYVGSGDRMGEDGWVEHLLVVDMISK--GSLMSYLRENT---
 ......|.| .  ||..   .   .||.|.      .  ..|..|.      | |. .. .. .        .  .| ....   |.|..|....    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----YDWHTMCRLAQTTAAGLAHLHQVIDTQVGLKPAVVHRDINSRNVLVNAEGNCVIGDFGFAMQVCGSSVVGEGDGDNSTITDVGTVRYMSPEVLDGA
    ..  . ..... .. .|...|.           ..|||.   |.|..   .  |.|||.| |.                | .||  ||.||||   
LRFPFPE-HARFYMYQICCALEYCHSH-G--------IIHRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPEVL---

VNLRDCECALKQVDVYALGLVVWEIAMRCKDLYPRDEMGNYQMPFEEQVGLHPTFEDMQILVSRERKRPQFPDAWKQNSQALRSLKETIEDCWDHDAEAR
          . .|....| ...| .   . ..|     ..|| |.  .                                 ...|. |. |.. | | |
------GYGKCKCDWWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG--------------------------------SPEAKDFIRKCLQKDPEKR

LTALCVE-------ERII
.|| . .          .
PTAEALQDEWDIKCHPWF
Kinase BMPR2.AA TK 177-363 12 1.5e-18 58.09 In-house 1-358 (486) Show / Hide 
Range on Protein: 177-363
Range on HMM: 1-358/486
Sequence Identity: 12% (47 aa)

LKMMELVGQGRYC---NVYRAALSEN---------------------------EVAVKVFT---GSSKQCYMN--------------ELDIMGLPH---M
... .  |.| ..    ||.. . .                            .||||. .   ..|..  .               |. .| . .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

EHSNLLQYVG-SGDRMGE------DGWVEHLLVVDMISKGS----LMSYLREN-----------------------------------------------
.| |... .| . .  .       ..    ..|. . ..|.    | .|||..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------TYDWHTMCR----------------LAQTTAAGLAHLHQVIDTQVGLKPAVVHRDINSRNVLVNAEGN-----------CVIGDFGF
             | | . |..                 ..  |.|...||.   .     . .||||.  ||.||. ...           | |.||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCE-F--IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGL

A------MQVCGSS----VVGEGDGDNSTITD-----------------VGTVRYMSPEVLD
.      .     |    .. .. |..  . .                    .|.|.||.|.
SRQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLN
Kinase BMPR2.AA TKL-Unique 179-394 24 1.2e-17 58.94 In-house 1-225 (290) Show / Hide 
Range on Protein: 179-394
Range on HMM: 1-225/290
Sequence Identity: 24% (60 aa)

MMELVGQGRYCNVYRAALSENEVAVKVFT------GSSKQCYMNELDIMGLPHME-HSNLLQYVG-SGDRMGEDGWVEHLLVVDMISKGSLMSYLR----
  ...|.| |..||..     .||.|.|        ...|   ||. .|     . | |...|.| . |     .  .  .|.. .. |||...|     
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKK--LHYHPNIVHYMGYCMDHQVYPP--NMCIVMEYCPGGSLYDVLHQNNN

-------ENTYDWHTMCRLAQTTAAGLAHLHQVIDTQVGLKPAVVHRDINSRNVLVNAE-----GNCVIGDFGFAMQVCGSSVVGEGDGDNSTI------
       ... ..  . ..|.  | |. .||  .      .| . |||. |.|.||. .      |  | |||..      .   . .. |...      
NNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCE------PP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLS-----KFNSKINKMTNNEHKGTRNQ

TDVGTVRYMSPEVLDGAVNLRDCECALKQVDVYALGLVVWEIAMRC
| .|. |.|.|||| .  .....     ..|||. | |.|||| |.
TRCGSFRWMAPEVLRMNFCQYSE-----KSDVYSFGIVLWEIATRK
Kinase BMPR2.AA TyrKc 177-475 19 3.2e-14 7.24 SMART 1-280 (280) Show / Hide 
Range on Protein: 177-475
Range on HMM: 1-280/280
Sequence Identity: 19% (63 aa)

LKMMELVGQGRYCNVYRAALSENEVAVKVFTGSSKQCYMNELDIMGLPHM--EHSNLLQYVGSGDRMGEDGW---VEHLLVVDMISKGSLMSYLRENT--
... .  | | .. ||.. ..  .||||.   ....  |.|. ||   .   .| |... .|     |.  .     ...|.   ..|.| .|||..   
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMC--KLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRKHRPK

YDWHTMCRLAQTTAAGLAHLHQVIDTQVGLKPAVVHRDINSRNVLVNAEGNCVIGDFGFAMQVCGSSVVGEGDGDNST----ITD-VGTVRYMSPEVLDG
  . ...  .   |.| ..||.           ..|||.  ||.||.... . |.||| .  .      || .   ..     .. .  .| |.||..  
LCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

AVNLRDCECALKQVDVYALGLVVWEIAMRCKDLYPRDE---MGNYQMPFEEQVGLHPTFEDM----QILVSRERKRPQFPDAWKQNSQALRSLKETIEDC
    .....  |  ||.. | . |||  ...  || ..   | |...    . |  .   .                 |         .   . . ...|
----NYGKFTTK-SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------F-------VCCPDEMYQIMKQC

WDHDAEARLTALCVEERI
|..|.| | |   . |..
WHEDPEDRPTFSEIHECF
Kinase BMPR2.AA UTK 177-393 23 5.9e-13 40.67 In-house 1-236 (296) Show / Hide 
Range on Protein: 177-393
Range on HMM: 1-236/296
Sequence Identity: 23% (61 aa)

LKMMELVGQGRYCNVYRAAL-------SENEVAVKVFT----GSSKQC----YMNELD---IMGLPHMEHSNLLQYVGSGDRMGEDGWVEHLLVVDMISK
.. ... |||.. .|..| .        |  |||||      .  ...     |.|     .|. .| .| |.|. ||   . .       ..|. . ..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFH-WHPNVLRLVGVCTQEEP-----WMIVTEYMEN

GSLMSYLRENTY------DWHTMCR---LAQTTAAGLAHLHQVIDTQVGLKPAVVHRDINSRNVLVNAEG-------NCVIGDFG---FAMQVCG--SSV
|.| |||| ..       .| |...    |   |.|...||.           .||||.  ||.||.. .        |.|.|||   .. .| .  .|.
GDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSC---------GFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSN

VGEGDGDNSTITDVGT--VRYMSPEVLDGAVNLRDCECALK---QVDVYALGLVVWEIAMR
  ... . .. ....   .| |.||.|. .          .   . ||...| |.||| ..
-RYWESYYYMAQHQDRWPIRWMAPEALTHHT---------RFTTKSDVWSFGVVCWEIWTW
Kinase BMPR2.AA AGC 303-384 17 6.9e-13 28.16 In-house 175-292 (395) Show / Hide 
Range on Protein: 303-384
Range on HMM: 175-292/395
Sequence Identity: 17% (23 aa)

VVHRD-INSRNVLVNAEGNCVIGDFGFAMQVCGSSVVGEGDGD-------------------------------------------NSTITDVG--TVRY
..||| .   |.| ...|.. . |||.. .. ..  .|.  ..                                           . | | .|  |  |
IIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQ-SQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEY

MSPEVLDGAVNLRDCECALKQVDVYA--LG
|.||.|             |..| ..  ||
MAPEIL-----------YGKACDWWSFGLG
Kinase BMPR2.AA STE 303-391 23 9.1e-13 41.53 In-house 173-262 (359) Show / Hide 
Range on Protein: 303-391
Range on HMM: 173-262/359
Sequence Identity: 23% (25 aa)

VVHRDINSRNVLVNAEGNCVIGDFGFAMQVCG---SSVVGEGDGDN---------STITDVGTVRYMSPEVLDG-AVNLRDCECALK----QVDVYALGL
..|||| . |.|.     . . |||.. |.     ..   . .. .          . |.|||  .|.|||...   . |      |    ..|.. ||.
IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANI-Q-S-NN-IIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R-----DKGYDTKCDIWSLGC

VVWEIA
...| |
TIIEMA
Kinase BMPR2.AA MLK 256-362 22 1.9e-11 36.06 In-house 92-205 (291) Show / Hide 
Range on Protein: 256-362
Range on HMM: 92-205/291
Sequence Identity: 22% (29 aa)

ISKGSLMSYLRENT---------------YDWHTMCRLAQTTAAGLAHLHQVIDTQVGLKP-AVVHRDINSRNVLVNA------EGNCVIGDFGFAMQVC
...||| ..|....               || . . . |   | |.. ||.       ..| ...|||..|.|.|. .      .|...| ||| .  ..
CEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHS-------MAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWH

GSSVVGEGDGDNSTITD-VGTVRYMSPEVL
 .        . .. ..  ||...|.|||.
QM--------C-TNMMSNAGTYAWMAPEVI
Kinase BMPR2.AA Pkinase_Tyr 177-327 21 4.1e-11 38.26 Pfam 1-156 (270) Show / Hide 
Range on Protein: 177-327
Range on HMM: 1-156/270
Sequence Identity: 21% (37 aa)

LKMMELVGQGRYCNVYRAALS------ENEVAVKVF---TGSS---KQCYMNELDIMGLPHM-EHSNLLQYVGSGDRMGEDGWVEHLLVVDMISKGSLMS
.....  |.| . .||.. .       . .||||.    . ..   ..  |.|. ||   ..  | |.....|   . || .  ....|.    .|.| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMK--QLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLD

YLREN-----TYDWHTMCRLAQTTAAGLAHLHQVIDTQVGLKPAVVHRDINSRNVLVNAEGNCVIGDFG
|||..       . ....  ..  |.|...|..            .|||.  ||.||. .. . |.|||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---------CIHRDLAARNCLVTENNVVKICDFG
Kinase BMPR2.AA STE 177-237 18 1.7e-05 15.47 In-house 1-98 (359) Show / Hide 
Range on Protein: 177-237
Range on HMM: 1-98/359
Sequence Identity: 18% (18 aa)

LKMMELVGQGRYCNVYRAALSENE-----------------VAVKVFT--------------------GSSKQCYMNELDIMGLPH-MEHSNLLQYVGS
.. .| .|.| .  ||.|.  .|                  .|.|.                       . .| ...|..||   . | | |  .| |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHM-HPNIVKYYGC
Kinase BMPR2.AA MLK 177-204 24 7.2e-05 12.97 In-house 1-33 (291) Show / Hide 
Range on Protein: 177-204
Range on HMM: 1-33/291
Sequence Identity: 24% (8 aa)

LKMMELVGQGRYCNVYRAALSENE-----VAVK
..  | .| | .. |...    ..     ||||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVK
Kinase BMPR2.AA TK 379-399 33 0.057373 1.52 In-house 376-396 (486) Show / Hide 
Range on Protein: 379-399
Range on HMM: 376-396/486
Sequence Identity: 33% (7 aa)

DVYALGLVVWEIAMRCKDLYP
||...| ..||| ....  |.
DVWSFGVLMWEIFTYGQEPYY
Kinase BMPR2.AA Pkinase_Tyr 450-475 26 0.949495 3.16 Pfam 245-270 (270) Show / Hide 
Range on Protein: 450-475
Range on HMM: 245-270/270
Sequence Identity: 26% (7 aa)

LKETIEDCWDHDAEARLTALCVEERI
. . . .||..|.| | |   . |..
IYDLMKQCWHYDPEDRPTFSEIHEQL