Gene TKL5 (Sea Urchin)

TKL5

Species: Sea Urchin
Alias: Spk331, TKL5, SpTKL1c, SPU_011521
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: TKL-Sp1

Sequence

Name Sequence Type Origin Length Description Download
TKL5.AA Protein None 408 None Fasta, JSON
TKL5.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of TKL5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TKL5.AA TKL-Sp1 144-404 82 4.5e-239 756.08 In-house 1-263 (263) Show / Hide 
Range on Protein: 144-404
Range on HMM: 1-263/263
Sequence Identity: 82% (216 aa)

LDMGPVVGKGQFGVVHRASWRGTPVAVKKISIMGSRKDEIEKEVAIHRRATHPNIVQMMALGYQGKEAFLVMQFIEGPSLYTIIFPDRDDVEIPLDWAKK
|||||||||||||||||||||||||||||||.||||||||||||||||||.|||||||||||||||||||||||||||||.|.||||||||.||||||||
LDMGPVVGKGQFGVVHRASWRGTPVAVKKISMMGSRKDEIEKEVAIHRRACHPNIVQMMALGYQGKEAFLVMQFIEGPSLHTVIFPDRDDVKIPLDWAKK

LRISREVLQAVTFMHGYNILHLDIKPANVLVDSATLRPYICDLGLAHIKNRNHMSQSS--VNMKGTPSFMPPEALGPKKPGYRHTNKHDIWSVAGTLVEL
..||.||||||||||..||||||||||||.|..||.|||||||||||||||||||||.  |||.|||..||||......||.||.|||||||||.|.|||
MQISCEVLQAVTFMHACNILHLDIKPANVMVERATRRPYICDLGLAHIKNRNHMSQSTSMVNMRGTPCHMPPEMVQKQEPGWRHPNKHDIWSVACTFVEL

YSMKRLWGNSMDPISLMVLILTGQIDKPESLTAVDPRVQKILEPCFKRKPEERPSASGLLDQF
||||||||.||....||..|||||..|||.||.|||.|||||||||..|||.||||..|||||
YSMKRLWGDSMEFMALMRRILTGQMSKPEILTKVDPKVQKILEPCFDQKPEKRPSAEDLLDQF
Kinase TKL5.AA TKL 150-404 18 4.1e-62 212.67 In-house 1-364 (364) Show / Hide 
Range on Protein: 150-404
Range on HMM: 1-364/364
Sequence Identity: 18% (71 aa)

VGKGQFGVVHRASWRG----------TPVAVKKISIMGSRK----------------------------DEIEKEVAIHRRATHPNIVQMMALGYQGKE-
.|.| ||.|... |||          ..|||||.... . .                            ...|.|. ...|  ||||||.|.   ...  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------AFLVMQFIEGPS-LYTIIFPDRDDVEIPLDWAKKLRISREVLQAVTFMHGYN--------ILHLDIKPANVLVDS-------------
             ..||....| | |....            | ...|..... ... ..|  |        |.| |.|..|.|||.             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPN

ATLRPYICDLGLAHIKNR---NHMSQSSVN--------------MKGTPSFMPPEALGPKKP------------GYRHTNKHDIWSVAGTLVELYSMKRL
|. .. |||.||.  ...   . .......                ||| .|.||.|  . .            |.  . |.|..| .  | |... .| 
ADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP

WG-NSMDPISLM-------VLILTGQIDKPES-----------LTAVDPRVQKILEPCFKRKPEERPSASGLLDQF
.  . ..|. ..       ...   .   |              . ..|.. |... | . .||.|||.. .|...
YYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase TKL5.AA Pkinase 144-404 21 8.3e-45 159.51 Pfam 1-293 (293) Show / Hide 
Range on Protein: 144-404
Range on HMM: 1-293/293
Sequence Identity: 21% (65 aa)

LDMGPVVGKGQFGVVHRASWRGTP--VAVKKISIMGSRKDEIEK-----EVAIHRRATHPNIVQMMALGYQGKEAFLVMQFIEGP----SLYTIIFPDRD
.  | ..|.| ||.| .. ..||.  ||||.|.  . .... .      |..|..|  |||||..    . ...  .|| . ||     .|...|     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

DVEIPL--DWAKKLRISREVLQAVTFMHGYNILHLDIKPANVLVDSATLRP----YICDLGLAHIKNRNHMSQSSVNMKGTPSFMPPEALGPKKPGYRHT
. . ..  ..    .. ...|... ..|  .|.| |.||.|.|.|  .  .     ||| |||  .. .  ..      ||| .|.|| .     |  ..
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR---GGQYYG

NKHDIWSVAGTLVELYSMKRLWGNS-----MDPISLMVLILTGQIDKPESLT------------------AVDPRVQKILEPCFKRKPEERPSASGLLDQ
 | |.||.  .| |... . .. ..     .|.. ....|. .... ... .                  ....  ..... |....|..||.|  .|  
PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--F
  |
PWF
Kinase TKL5.AA S_TKc 144-404 23 5.1e-44 153.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 144-404
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)

LDMGPVVGKGQFGVVHRASWRG--TPVAVKKISIMGSRKDEIEKEVAIHRRATHPNIVQMMALGYQGKEAFLVMQFIEG--PSLYTIIFPDRD---DVEI
 ... ..||| ||.|... ...    ||.|.|.      . |..|..|...  |||||..    .  .. ..|| ...|   .|...|   .    .. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PLDWAKKLRISREVLQAVTFMHGYNILHLDIKPANVLVDSATLRPYICDLGLAHIKNRNHMSQSSVNMKGTPSFMPPEALGPKKPGYRHTN-KHDIWSVA
|  .|.  .. .....|. ..|  .|.| |.||.|.|.|.   .  ||| ||| .            . ||| .|.|| |        ..  | |.||. 
PE-HAR--FYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL---------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCG

GTLVELYSMKRLWGNSMDPISLMVLILTGQIDKPESLTAVDPRVQKILEPCFKRKPEERPSASGLLD---------QF
 .| |... . ..    ..  .. .|.             .| .  ... |... ||.||.|  .|           |
CILYEMLCGYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TKL5.AA STE 144-405 20 1.7e-32 112.08 In-house 1-359 (359) Show / Hide 
Range on Protein: 144-405
Range on HMM: 1-359/359
Sequence Identity: 20% (77 aa)

LDMGPVVGKGQFGVVHRASWR-----------------GTPVAVKKISIMGSR------------------KDEIEKEVAIHRRAT--HPNIVQMMALGY
..   ..||| ||.|..|  .                 |. .|.|....  ..                  ...|.||. |...    |||||.     .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

QG-------KEAFLVMQFIEGPSLYTIIF-----PDRDD------VEIPLDWAKKLRISREVLQA-VTFMHGYNILHLDIKPANVLVDSATLRPYICDLG
..        | ...| ...| ||  ||      .....        .| .. ..  | |..|..   . |  .| | ||||||.|.        .|| |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAY--ICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFG

LAHIKNRN--------------HMSQSSVNMKGTPSFMPPEALGPKKPGYR---HTNKHDIWSVAGTLVELYSMKRLWGNSMDPISLMVLILTGQ-----
.. . . .               |.| .  . ||| .| || . . . | |   .. | ||||.  |..|.   |  | . | | . | .|....     
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHD-MHPMRAMFMIPFNYHMQQQ

--------IDKPESLTAVD-------------------PRVQKILEPCFKRKPEERPSASGLLD---QFN
         . |   . ..                   |  .  .. |... |..||.|| ||     | 
FEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase TKL5.AA CAMK 149-334 16 2.3e-29 91.19 In-house 1-320 (425) Show / Hide 
Range on Protein: 149-334
Range on HMM: 1-320/425
Sequence Identity: 16% (57 aa)

VVGKGQFGVVHRASWRGTP--------------VAVKKISI-----------------------------MGSRKDEIEKEVAIHRR-------ATHPNI
. |.|.||.|...  . |.              ||.| |.                               .. ......|..|...         ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQMMA------------LGY-QGKE--------AFLVM---QFIEGP----SLYTII---------FPDRDDVEIPLDWA-------KKL------RISR
...                |   .          ..||    ...|      |.  |         |            .       ...      |. |
IKLYEVYEDPHYFKNTND-YET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEF------------DQFDIVERGRFTEREARRYFR

EVLQAVTFMHGYNILHLDIKPANVLVDSAT----------------LRPYICDLGLAHIKNRNHM---------------------SQSSVNMKGTPSFM
 ...|| ..|  || |.|.|| |.|.|.                      |.| |.| ......                       |    . |||..|
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM

P-PEALGPK------------KPGYRHTNKHDIWSV
. || |  |            ||.|  . | |.||.
AAPEVLNGKGHCNMQNATDEEKPYY--GPKCDMWSC
Kinase TKL5.AA MLK 144-333 23 5e-29 97.91 In-house 1-221 (291) Show / Hide 
Range on Protein: 144-333
Range on HMM: 1-221/291
Sequence Identity: 23% (53 aa)

LDMGPVVGKGQFGVVHRASWRGTP-----VAVKKIS-------IMGSRKDEIEKEVAIHRRATHPN----IVQMMALGYQ-GKEAFLVMQFIEGPSLYTI
..   ..|.| ||.|... ||..      ||||..        .... ....|.|. . |.  |||    |.| ..   | ... ..||...|| |||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IFPDRDDVE---------IPLDWAKKLRISREVLQAVTFMHGYN---ILHLDIKPANVLVDS-----ATLRPYICDLGLAH-IKNR--NHMSQSSVNMKG
.   |.  .         .  | . .....  . ... . |      | | |.|. |.|.|      . .   ||| |... ....  |.||     ..|
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMS-----NAG

TPSFMPPEALGPKKPGYRHTNKHDIWS
|. .| ||..  .... . . | |.||
TYAWMAPEVIQ-QFRCEKYSEKCDVWS
Kinase TKL5.AA TKL-Unique 146-404 21 2.5e-28 97.11 In-house 1-290 (290) Show / Hide 
Range on Protein: 146-404
Range on HMM: 1-290/290
Sequence Identity: 21% (62 aa)

MGPVVGKGQFGVVHRASWRGTPVAVKKISI-MGSRKDEIE---KEVAIHRRAT-HPNIVQMMALGY----QGKEAFLVMQFIEGPSLYTIIF-----PDR
 . ..| | .|.| .. |||.|||.|....  .|......   .|| .  .   |||||. |.       . .. ..|| ...| |||  .         
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

DDVEIPLDWAKKLRISREVLQAVTFMHGYN--ILHLDIKPANVLVDSAT----LRPYICDLGLAHIKNRNHMSQSSVNMK---------GTPSFMPPEAL
   ...|........ . . |.  . | ..  |.|.|.|. |.|||..     ..  ||| ||.  |... ......|..         |..  |.|| |
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLS--KFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

GPKKPGYRHTNKHDIWSVAGTLVELYSMKR--LWGN---SMDPISLMVLILTGQIDKPESL-TAVDPRVQKILEPCFKRKPEERPSASGLLDQF
      .  ..| |..| .  | |... |.   .     .||....  .. .    ... . .   .. ..... |... |..||| .  .   
RMNF--CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase TKL5.AA MOS 144-278 28 1.2e-24 78.4 In-house 1-151 (299) Show / Hide 
Range on Protein: 144-278
Range on HMM: 1-151/299
Sequence Identity: 28% (44 aa)

LDMGPVVGKGQFGVVHRASWRGTPVAVKKIS----IMGSRKDEIEKEVAIHRRATHPNIVQMMALG---YQGKE--AFLVMQFIEGPSLYTIIF-----P
  .  . |.| || |  | ..|.||||| .     .    .     || . .|. |.|||. ||..     . .  .. .| .  . .|  .|      |
VCLCQMIGRGGFGSVWKAQYCGRPVAVKQVNKCTKNLKAMRRSFWAEVNY-LRLRHDNIVRVMAVSQRSPEDFNNLGTIIMECGGNQTLHQVIYEPTRHP

D--------RDDVEIPLDWAKKLRISREVLQAVTFMHGYNILHLDIKPANVLVDSAT
         |      |  .. ...|. |. |... |  ||||||.||||..||  |
PGDAGIIHCR-----MLILMHCCKYSLDVVNALQYCHHQNILHLDVKPANIIVDEGT
Kinase TKL5.AA Ciliate-E2 144-402 18 1.8e-24 80.88 In-house 1-361 (365) Show / Hide 
Range on Protein: 144-402
Range on HMM: 1-361/365
Sequence Identity: 18% (68 aa)

LDMGPVVGKGQFGVVHRASWRGTP--------------------VAVKK---ISIMGSRKDEIEKEVAIHR----------------RATHPNIVQMMAL
 .   . |.|.||.| ... . ..                    |..|.    ... . . .|..|  | |                .  ||||..|   
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

GY--QGKEAFLVMQFIEGPSLYT--IIFPDRDDVEIP----LDWAKKLRISREVLQ---------------AVTFMHGYN-ILHLDIKPANVLVDSATLR
 .  . .  .||| ...| .|.   ....   . ||.    ... . ..|....||               |. ..|  | |.| |||| |.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

PYICDLGLA-HIKNRNHMSQSSVNMK----------------------------GTPSFMPPEALGPKKP-----GYRHTNKHDIWSVAGTLVELYSMKR
. |.|.||.  ... | . .  . .|                            ||| .|.|| |. ||      . ... | ||||.  .| |. . |.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

LWGNSMDPISLMVLILTGQIDKPESLTA---------------VDPRVQKILEP----CFKRKPEERPS-ASGLLD
 .         .  |. ..|| |.                   ... .. ..      .....||.|.. .. .|.
PF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase TKL5.AA TAK1 144-315 27 1.8e-23 76.09 In-house 1-174 (284) Show / Hide 
Range on Protein: 144-315
Range on HMM: 1-174/284
Sequence Identity: 27% (50 aa)

LDMGPVVGKGQFGVVHRASWRGTPVAVKKIS-I----MGSRKDEIEKEVAIHRRATHPNIVQMMAL-GYQGKEAFLVMQFIEGPSLYTIIFPDRDDVEIP
 .   .|||| .||| .|.||.. .|||..  |     .. . .||.|.    |. ||||..   .    .. . ||| .... ||.  ..  ..  |  
IQNEHFVGKGTYGVVCKAKWRNKEIAVKRFEFIKYSSEECEQKNIEREIMQWSRVDHPNIIKLYGMYACHRQCQCLVMEYMDCGSLHNFLHGAKPKWEYT

LDWAKKLRISREVLQAVTFMHGYN---ILHLDIKPANVLVDSATLRPYICDLGLAHIKNRNHMSQSSVNMKGTPSFMPPEA
.. |   .  . . |.| ..|.     . | ||||.| |  .  .   ||| |..       |.|.  ...||. .| ||.
HAHA--MSWMHQCAQGVAYLHSMQPKPQIHRDIKPQNMLLCNKHRTLKICDFGTFC-----DMHQMMTCNRGTCRWMAPEV
Kinase TKL5.AA LISK-DD1 149-314 27 2e-22 78.03 In-house 1-201 (290) Show / Hide 
Range on Protein: 149-314
Range on HMM: 1-201/290
Sequence Identity: 27% (55 aa)

VVGKGQFGVVHRASWRGTPVAVKKISI--MGSRKDEIEK----EVAIHRR---ATHPNIVQMMALGYQ-------------GKEAFLVMQFIEGPSLYTI
  ||| || | .... |||||.|||..    . ... .|    |... .     .||||||    ..              . . ..|  ||||  |  .
EIGKGSFGKVYKGCYFGTPVAIKKIHKQPNDPNDPDYWKFMQREIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWY

IFP-DRDDV-------EIPLDWAKKLRISREVLQAVTFMHGYNILHLDIKPANVLVDSA---TLRPYICDLGLAHIKNRN--HMSQSSVNMKGTPSFMPP
..    ||         ||. | ....|.. . .|  . |  ||.| | |  | |||       |  .||.|.| . .        ..  . ||...|.|
LKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSKNIIHRDLKSKNILVDENGDSQWRIKVCDFGFARMFEQKKNQQNNRHMTICGTDNWMAP

E
|
E
Kinase TKL5.AA TyrKc 144-404 20 2.9e-14 8.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 144-404
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

LDMGPVVGKGQFGVVHRASWRGTPVAVKKISIMGSRKDEIEKEVAIHRRA--THPNIVQMMALGYQG-------KEAFLVMQFIEGPSLYTIIFPDRDDV
. .| . | |.||.|... |. ..||||..      . .. .|  | ..    |||||.. .   |.       .  ..|| . .. .|   .   |.. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

EIPLDWAKKLRISREVLQAVTFMHGYNILHLDIKPANVLVDSATLRPYICDLGLAHIKNRNHMSQ------SSVNMK----GTPS-----FMPPEALGPK
   | ....| ..  . .   . |  |. | |.   |.||..   .  |.| ||.    |.. .       ... .|    |. .      |.||..   
---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLS----RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---

KPGYRHTNKHDIWSVAGTLVELYSM-KRLWGNS----MDPISLMVLILTGQIDKPESL-------TAVDPRVQKILEPCFKRKPEERPSASGLLDQF
   .. | | |.||   .. |...  .  . .     |... .. .. .|   ..          .. |   | | . | ...||.||. | . ..|
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase TKL5.AA Pkinase_Tyr 144-220 26 6.6e-14 47.72 Pfam 1-91 (270) Show / Hide 
Range on Protein: 144-220
Range on HMM: 1-91/270
Sequence Identity: 26% (24 aa)

LDMGPVVGKGQFGVVHRASWR------GTPVAVKKI--SIMGSR--KDEIEKEVAIHRRA-THPNIVQMMALGY-QGKE--AFLVMQFIEG
. .| . |.|.||.|... |.      ..|||||..  . | .   ...  .|..| .    |||||....  . ||.    ..|| . ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPH
Kinase TKL5.AA MLK 376-404 20 0.02569 4.0 In-house 263-291 (291) Show / Hide 
Range on Protein: 376-404
Range on HMM: 263-291/291
Sequence Identity: 20% (6 aa)

DPRVQKILEPCFKRKPEERPSASGLLDQF
...  | .. | . .|..||| .  . ..
PEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase TKL5.AA TAK1 377-403 25 0.231571 0.24 In-house 258-284 (284) Show / Hide 
Range on Protein: 377-403
Range on HMM: 258-284/284
Sequence Identity: 25% (7 aa)

PRVQKILEPCFKRKPEERPSASGLLDQ
.|  .  . | .  ||.||| .     
KRIEQFMKCCWDDNPEKRPSMQECVKY
Kinase TKL5.AA Pkinase_Tyr 386-404 36 0.779594 3.45 Pfam 252-270 (270) Show / Hide 
Range on Protein: 386-404
Range on HMM: 252-270/270
Sequence Identity: 36% (7 aa)

CFKRKPEERPSASGLLDQF
| . .||.||. | .. |.
CWHYDPEDRPTFSEIHEQL