Gene Y43C5B.2 (Nematode worm)

Y43C5B.2

Species: Nematode worm
Alias: Y43C5B.2, aSWK460
External Links:
Annotation:

Classification

Group: TK
Family: Fer

Sequence

Name Sequence Type Origin Length Description Download
Y43C5B.2.AA Protein None 245 None Fasta, JSON

Protein domain

Protein domains of Y43C5B.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 Y43C5B.2.AA SH2 16-103 30 3.5e-25 90.9 SMART 1-87 (87) Show / Hide 
Range on Protein: 16-103
Range on HMM: 1-87/87
Sequence Identity: 30% (29 aa)

EPYYHGFLPREDVKTVLKNN----GDFVIRISEPQAGSPRSNILSVMHCVPPMEEEIKHYVIKTKG-DKIFIEK---VSFLSIPEMVEWHLTKKES
.|.|||...||..   |||.    |||..| ||.   .|.. .|||..      ...|||.|.... .| .|.    ..| |. |.|... . . .
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSES---NPGDYVLSVRWK-----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 Y43C5B.2.AA SH2 18-97 29 1.3e-18 56.46 Pfam 1-81 (81) Show / Hide 
Range on Protein: 18-97
Range on HMM: 1-81/81
Sequence Identity: 29% (25 aa)

YYHGFLPREDVKTVLKN----NGDFVIRISEPQAGSPRSNILSVMHCVPPMEEEIKHYVIKTKGDK--IFIEKVSFLSIPEMVEWH
.|||...|...   |.|    .|.|..| || . |.     |||..  |  ....|||.|.. ...    .... | |..|.|| .
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGD---YTLSVRDDGP--GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
Kinase Y43C5B.2.AA Fer 126-195 55 5.7e-31 102.79 In-house 1-77 (283) Show / Hide 
Range on Protein: 126-195
Range on HMM: 1-77/283
Sequence Identity: 55% (43 aa)

IEPLKKLGEGAFGEVMMG--TMKFRKGGKSVQ--VAIKQAKL--SNLTKEQIKEFMGEARVMRS-LSHPHVVRFYGV
..  |||||||||||  |  |.|. ||...|.  ||.|..|.  . .||||||||| |||.||. ..||.||.||||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGV
Kinase Y43C5B.2.AA Pkinase_Tyr 126-195 45 4e-25 85.7 Pfam 1-72 (270) Show / Hide 
Range on Protein: 126-195
Range on HMM: 1-72/270
Sequence Identity: 45% (33 aa)

IEPLKKLGEGAFGEVMMGTMKFRKGGKSVQVAIKQAKLSNLTKEQ--IKEFMGEARVMRSL-SHPHVVRFYGV
|. .|||||||||||..||.|  .... ..||.|     . ..||  ...|| ||..|..| .||..||.|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGV
Kinase Y43C5B.2.AA TK 126-195 27 2.2e-20 64.34 In-house 1-111 (486) Show / Hide 
Range on Protein: 126-195
Range on HMM: 1-111/486
Sequence Identity: 27% (30 aa)

IEPLKKLGEGAFG---EVMMG---------------------TMKFRKGGKSVQVAIKQAKL--SNLTKEQIK-------------EFMGEARVMRS--L
|. .||||||.||   ||..|                     ..|..|.|. ..||.|. |.  ..  .|..              |.. |. .|..  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

SHPHVVRFYGV
 ||..||.|||
HHPNIVRLYGV
Kinase Y43C5B.2.AA UTK 126-196 29 4.3e-18 58.51 In-house 1-79 (296) Show / Hide 
Range on Protein: 126-196
Range on HMM: 1-79/296
Sequence Identity: 29% (23 aa)

IEPLKKLGEGAFGEVMMGTMKF-RKGGKSVQVAIKQAKLSNLTKEQIK---EFMGEAR---VMRSLS-HPHVVRFYGVP
......||.|||||| ... .. .  .. ..||.|... .  .  .     .|| |||   .|  .. ||.|.|..||.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVC
Kinase Y43C5B.2.AA Ack 126-195 40 4.7e-17 54.09 In-house 1-70 (266) Show / Hide 
Range on Protein: 126-195
Range on HMM: 1-70/266
Sequence Identity: 40% (29 aa)

IEPLKKLGEGAFGEVMMGTMKFRKGGKSVQVAIKQAKLSNLTKE-QIKEFMGEARVMRSLSHPHVVRFYGV
|  ..|||.| || |  |. .   |||..|||.|  .  ...    . .|. |. .| || |||.|| |||
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGV
Kinase Y43C5B.2.AA Axl 130-195 45 5.2e-15 49.4 In-house 5-69 (267) Show / Hide 
Range on Protein: 130-195
Range on HMM: 5-69/267
Sequence Identity: 45% (30 aa)

KKLGEGAFGEVMMGTMKFRKGGKSVQVAIKQAKLSNLTKEQIKEFMGEARVMRSLSHPHVVRFYGV
| |||| || || | .|    | .|.||.|  |. ..|. .| ||. ||  |.  .||.|.|  ||
KMLGEGEFGSVMEGQLK-QEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGV
Kinase Y43C5B.2.AA InsR 126-195 32 2.7e-14 44.3 In-house 1-72 (278) Show / Hide 
Range on Protein: 126-195
Range on HMM: 1-72/278
Sequence Identity: 32% (24 aa)

IEPLKKLGEGAFGEVMMG-TMKFRKGGKSV--QVAIKQAKLSNLTKEQIKEFMGEARVMRSLSHPHVVRFYGV
|. ....|.|.|| |  |    . .....   ..|||  ...   .| | ||  || ||    . |||| .||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERI-EFLNEASVMKEFNCHHVVRLLGV
Kinase Y43C5B.2.AA FAK 126-195 26 5.6e-14 43.06 In-house 1-92 (285) Show / Hide 
Range on Protein: 126-195
Range on HMM: 1-92/285
Sequence Identity: 26% (25 aa)

IEPLKKLGEGAFGEVMMGTMKFRKG-----------------------GKSVQVAIKQAKLSNLTKEQIKEFMGEARVMRSLSHPHVVRFYGV
|.. ...||| ||.|  |.    |.                          .|||||  |  . ....  .|| || .|. . |||.|.  |.
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCK-KCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGI
Kinase Y43C5B.2.AA Src 126-195 35 6.2e-14 43.68 In-house 1-62 (255) Show / Hide 
Range on Protein: 126-195
Range on HMM: 1-62/255
Sequence Identity: 35% (25 aa)

IEPLKKLGEGAFGEVMMGTMKFRKGGKSVQVAIKQAKLSNLTKEQIKEFMGEARVMRSLSHPHVVRFYGV
|  ..|||.| |||| ||. .     ....||.|  |  ..  |.   |  || .| .|.|...|. | |
IKLCRKLGQGQFGEVWMGYWN-----GNTKVAVKTLKPGTMSPEA---FLQEAQIMKKLRHEKLVQLYAV
Kinase Y43C5B.2.AA TK-Unique 126-195 27 8.3e-14 44.1 In-house 1-72 (294) Show / Hide 
Range on Protein: 126-195
Range on HMM: 1-72/294
Sequence Identity: 27% (20 aa)

IEPLKKLGEGAFGEVMMGTMKFRKGGKSVQ-VAIKQAKLSNLTKEQIKEFMGEARVMRSLS-HPHVVRFYGV
.| ....||||||.|  |... .... . | ...  .   |.|... ..|. |...|..|  ||..|...|.
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGC
Kinase Y43C5B.2.AA Eph 126-195 36 1.3e-13 41.91 In-house 1-72 (264) Show / Hide 
Range on Protein: 126-195
Range on HMM: 1-72/264
Sequence Identity: 36% (27 aa)

IEPLKKLGEGAFGEVMMGTMKFRKGGKSV---QVAIKQAKLSNLTKEQIKEFMGEARVMRSLSHPHVVRFYGV
|   | .|.| ||||  |..| ..| . |    ||||  | .   |... .| .|| .|   .||...|  ||
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRW-DFLSEASIMGQFDHPNIIRLEGV
Kinase Y43C5B.2.AA Pkinase 126-205 24 2.3e-12 44.78 Pfam 1-78 (293) Show / Hide 
Range on Protein: 126-205
Range on HMM: 1-78/293
Sequence Identity: 24% (20 aa)

IEPLKKLGEGAFGEVMMGTMKFRKGGKSVQVAIKQAKLSNLTKEQIKEFMG--EARVMRSLSHPHVVRFYGVPRRRVNVALC
.. ..|.|.|.||.|     | .. | . .||.|. |...  ... ..     |...|..|.||..||.|.. ... .. ..
YHIGRKIGSGSFGCV----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMV
Kinase Y43C5B.2.AA TyrKc 126-244 14 1.9e-05 -134.54 SMART 1-280 (280) Show / Hide 
Range on Protein: 126-244
Range on HMM: 1-280/280
Sequence Identity: 14% (42 aa)

IEPLKKLGEGAFGEVMMGTMKFRKGGKSVQVAIKQAKLSNLTKEQIKEFMGEARVMRSL--SHPHVVRFYGVPRRR-----------VNVALCR--SLNE
|. .|||||||||||. ||.|       .|||.|  | .      ...|| |||.|..|  .||..||.||| .             . . ..   .|..
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLAKCH---------------------------------------------------------------------RK-----LR----------------
.| |..                                                                     ||      .                
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

---------------------CATPFFV---------------------------------CMSVNWLSVL--------------NELRVFL
                     ...|                                    |..    ..               .|.. ..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF