Gene RTKM2 (M.brevicollis)
RTKM2
Species: M.brevicollis
Alias: RTKM2
External Links:
Annotation:
Sequence
Protein domains of RTKM2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | RTKM2.AA | RTKM | 85-347 | 87 | 7.1e-233 | 779.92 | In-house | 1-263 (263) | Show / Hide |
Range on Protein: 85-347 Range on HMM: 1-263/263 Sequence Identity: 87% (231 aa) VTVLDSIASTPFGRLRTGYLKPMDKNRSGRGMSILVSSLKEHSALQVRDAFMAEASILKRIGRSCHPSIASLVGLCFHSQPLYIVQEGCEQGFLATMLRD |...|.|..|||||||||||||||||.|||.|.|||..|||||||||||||||||||||||||.||||||||||.||||||||||||.|||||||||||| VFISDRITATPFGRLRTGYLKPMDKNHSGRCMPILVNCLKEHSALQVRDAFMAEASILKRIGRDCHPSIASLVGVCFHSQPLYIVQEDCEQGFLATMLRD CRGSGNMEESVSKADLANMCQKVMSAVEFLHGSSVLLMTLNGFTVMVDAHREPRIAVLGRDPNLDGDRFLQRWLAPEAVESKGYSMAADMYSFGVLMWEI ||||.||||||||||||||||||||||||||.||||||||||||||.|.||||||.||||||||..|||.|||||||||||..||||||||||||||||| CRGSQNMEESVSKADLANMCQKVMSAVEFLHDSSVLLMTLNGFTVMMDVHREPRIVVLGRDPNLHFDRFIQRWLAPEAVESRSYSMAADMYSFGVLMWEI WSLGATPYAQVSDDKVPLQITSQHLLPCPPGCPPSAFDLMRQCWEYRPSARPTAPRMSAECTS |.||||||.||||||||.||||||||||||||||.|.|||||||.|.|||||||.|||||||| WTLGATPYVQVSDDKVPIQITSQHLLPCPPGCPPAAYDLMRQCWNYYPSARPTAQRMSAECTS |
|||||||||
| Kinase | RTKM2.AA | TK | 85-345 | 16 | 2.5e-59 | 197.2 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 85-345
Range on HMM: 1-486/486
Sequence Identity: 16% (81 aa)
VTVLDSIASTPFG---RLRTGYLKPMDKNRSGRG------------------MSILVSSLKEHSALQVRDAFM-------------AEASILKRIG--RS
.|... . . || . . | ......... |. . | |||..| . .. |. .||...|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
CHPSIASLVGLCFHS------------QPLYIVQEGCEQGF----LATMLRDCRGSGNMEES--------------------------------------
|| | .|.| |... .|..|| | .. | | . ||.||. .. |..
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------VSKADLANMCQKVMSAVEFLHGS------SVLLMTLNGFTVMVDAHRE-----------PRIAVLG---
.. ..| ||. . .. |.|| . . | ..|. . .|| |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-------RDPNLD-------------------------------GDRFLQRWLAPEAVESKG---------YSMAADMYSFGVLMWEIWSLG-ATPYAQV
|| . | |... ||.|||..... .. . |..|||||||||...| ...| ..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
SD---------DKVPLQITSQ--------------HLLPCPPGCP--------------PSAFDLMRQCWEYRPSARPTAPRMSAEC
|. . | .... . .|.||.|| . .|||.|||.| |. ||| . .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
|
|||||||||
| Kinase | RTKM2.AA | TK-Unique | 85-337 | 24 | 2e-37 | 126.64 | In-house | 1-286 (294) | Show / Hide |
Range on Protein: 85-337 Range on HMM: 1-286/294 Sequence Identity: 24% (72 aa) VTVLDSIASTPFGRLRTGYLKPMDKNRSGRGMSILVSSLKEHSALQVRDAFMAEASILKRIGRSCHPSIASLVGLCFHSQ-PLYIVQEGCEQGFLATMLR ..|.|.| .. || .| ... . ... ...| ||... .. ...|. |....| .| .|| | ...| | |. | .|. | |..| | . || LEVGDVIGEGAFGQVWRGEVWGIW-KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELG--DHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR DCR-------------------GSGNMEESVSKADLANMCQKVMSAVEFLHG--SSVLLMTLNGFTVMVDAHREPRIAVLGRDP---------NLDG-DR || .....|..| ||.. . . .. |.|.. . ..| |.. . . |. .|. . . .. | TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGR FLQRWLAPEAVE--SKGY-SMAADMYSFGVLMWEIWSLGATPYAQVSDDKVPLQITSQHLLPCPPGC-PPSAFDLMRQCWEYRPSARPT ||.|||. . | .. | .||||||||| .|||.|| ....... .|. . .| |..| .. . ||..|| . |. ||. IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPS |
|||||||||
| Kinase | RTKM2.AA | UTK | 256-345 | 36 | 4.6e-35 | 117.41 | In-house | 204-296 (296) | Show / Hide |
Range on Protein: 256-345 Range on HMM: 204-296/296 Sequence Identity: 36% (34 aa) RWLAPEAVESK-GYSMAADMYSFGVLMWEIWSLGATPYAQVSDDKVPLQITSQ--HLLPCPPGCPPSAFDLMRQCWEYRPSARPTAPRMSAEC || ||||. . .. . |..||||..||||. |..||. |...| .|.. . ...|||..|| . ..||..||.| |. ||..... .. RWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
|||||||||
| Kinase | RTKM2.AA | RTKB | 123-345 | 29 | 8.4e-34 | 111.34 | In-house | 36-264 (264) | Show / Hide |
Range on Protein: 123-345 Range on HMM: 36-264/264 Sequence Identity: 29% (69 aa) LKEHSALQVRDAFMAEASILKRIGRSCHPSIASLVGLCFHSQPLYIVQEGCEQGFLATMLRDCRGSGNMEESVSKADLANMCQKVMSAVEFLHGSSVLLM || .. |..| .| ..| .| || .. ..| |.. |. . | || |.| || ||.| | . | |. | . . ||| |. LKPGASYEERQDFCSEMTVMKELGW--HPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRASQHNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHR TLNGFTVMVDAHREPRIAVL-------GRDPNLDGDRFLQRWLAPEAVESKGYSMAA-DMYSFGVLMWEIWSLGATPYAQVSDDKVPLQITSQHLLPCPP | . |.|| .. .|. ... . .|. .|.||| ... |. | |||| |||| |||.|||.| . . | | || | DLCARNVLVDQQLHCKICDFGMAREIDHECYETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPR GCPPSAFDLMRQCWEYRPSARPTAPRMSAEC |. |...|..|| ...||. . . .. QMPQAADHIMQMCWQMEAQHRPDFDELVDAF |
|||||||||
| Kinase | RTKM2.AA | Pkinase_Tyr | 256-337 | 42 | 1.3e-31 | 107.74 | Pfam | 179-262 (270) | Show / Hide |
Range on Protein: 256-337 Range on HMM: 179-262/270 Sequence Identity: 42% (36 aa) RWLAPEAVESKGYSMAADMYSFGVLMWEIWSLGATP-YAQVSDDKVPLQI-TSQHLLPCPPGCPPSAFDLMRQCWEYRPSARPT .|.|||. . .. . | .||||||||| ..|..| |. .|. | .| . . .|||..||. |||.|||.| |. ||| KWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPT |
|||||||||
| Kinase | RTKM2.AA | Abl | 118-345 | 27 | 2e-30 | 98.33 | In-house | 27-252 (252) | Show / Hide |
Range on Protein: 118-345 Range on HMM: 27-252/252 Sequence Identity: 27% (66 aa) ILVSSLKEHSALQVRDAFMAEASILKRIGRSCHPSIASLVGLCFHSQPLYIVQEGCEQGFLATMLRDCRGSGNMEESVSKADLANMCQKVMSAVEFLHGS . | .||| ...| . |..|| |.| . || . |.| | . | ||. | .| | ||.| .|... | | .. |....| VAVKTLKED-TMEVHE-FLKEAAIMKEM---KHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLREC-----DREELPAVVLLYMATQIASGMSYLEKR SVLLMTLNGFTVMVDAHREPRIAVLGRDPNLDGD--------RFLQRWLAPEAVESKGYSMAADMYSFGVLMWEIWSLGATPYAQVSDDKVPLQITSQHL . . | .| |. ..| | . .| .| .| |||.. . .|. .|.. ||||.||| | .|| . .| .. . HFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYPGIDLSHVYHKLEKGYR LPCPPGCPPSAFDLMRQCWEYRPSARPTAPRMSAEC . |.||||. ..||||||..... ||. . . MERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM |
|||||||||
| Kinase | RTKM2.AA | Frk | 135-337 | 28 | 3.9e-25 | 83.8 | In-house | 41-248 (260) | Show / Hide |
Range on Protein: 135-337 Range on HMM: 41-248/260 Sequence Identity: 28% (61 aa) FMAEASILKRIGRSCHPSIASLVGLCFHSQPLYIVQEGCEQGFLATMLRDCRGSGNMEESVSKADLANMCQKVMSAVEFLHGSSVLLMTLNGFTVMVDAH |..|| |.|.. || . .| .| .|.||. | ..| | . |. . | ... | .| .| . . .| . | |.|. | FLREAQIMKKL---RHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKG---RQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEH REPRIAVLG--R---DPNL------DGDRFLQRWLAPEAVESKGYSMAADMYSFGVLMWEIWSLGATPYAQVSDDKVPLQITSQHLLPCPPGCPPSAFDL .|| | | | | || .| ||||.... ... .|..|||.|. || | ||. . . .| .. .|.||.||. ... NICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEI MRQCWEYRPSARPT | .||. | ||| MLECWHSDPMKRPT |
|||||||||
| Kinase | RTKM2.AA | Fer | 256-346 | 32 | 1.5e-24 | 80.62 | In-house | 183-283 (283) | Show / Hide |
Range on Protein: 256-346 Range on HMM: 183-283/283 Sequence Identity: 32% (33 aa) RWLAPEAVESKGYSMAADMYSFGVLMWEIWSLGATPYAQ--------VSDDKVPLQ-ITSQHLLPCPPGCPPSAFDLMR-QCWEYRPSARPTAPRMSAEC ||||||..... || . |..||||..||| . ||.||. . .. . |.. . .|.|...|| .| |||.. |. |||. . RWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKL T K |
|||||||||
| Kinase | RTKM2.AA | CTKA | 256-337 | 42 | 1.8e-23 | 75.6 | In-house | 199-282 (290) | Show / Hide |
Range on Protein: 256-337 Range on HMM: 199-282/290 Sequence Identity: 42% (36 aa) RWLAPEAVESKGYSMAADMYSFGVLMWEIWSLGATPYAQVSDDKVPLQITSQ--HLLPCPPGCPPSAFDLMRQCWEYRPSARPT || ||||. .| | | ..||||.||| | | .|.. || | .|| || |. || .| || | .||| RWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPT |
|||||||||
| Kinase | RTKM2.AA | Eph | 256-345 | 34 | 2.1e-22 | 71.93 | In-house | 175-264 (264) | Show / Hide |
Range on Protein: 256-345 Range on HMM: 175-264/264 Sequence Identity: 34% (31 aa) RWLAPEAVESKGYSMAADMYSFGVLMWEIWSLGATPYAQVSDDKVPLQITSQHLLPCPPGCPPSAFDLMRQCWEYRPSARPTAPRMSAEC || ||||. . .. | | |.|..|||. | | || |. .| | || |..||.. . || .||.. .. ||. . . RWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL |
|||||||||
| Kinase | RTKM2.AA | TyrKc | 85-348 | 23 | 6.5e-21 | 76.71 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 85-348 Range on HMM: 1-280/280 Sequence Identity: 23% (74 aa) VTVLDSIASTPFGRLRTGYLKPMDKNRSGRGMSILVSSLKEHSALQVRDAFMAEASILKRIG-RSCHPSIASLVGLCFHS-------QPLYIVQEGCEQG .| .. . . ||. . | .| . | .|||.. | .|| ||.|....| . || | |.| | .. .||.|| | .. | ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA----REDFMREARIMCKLGGH--HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG FLATMLRDCRGSGNMEESVSKADLANMCQKVMSAVEFLHGSSVLLMTLNGFT--------VMVDAHREPRIA------VLGRD-------PNLD-----G | ||..|. .. .|| ..| . . |.|| .. ..|.. . .|. .. | . | DLKDYLRKHRPK------LCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG DR--FLQRWLAPEAVESKGYSMAADMYSFGVLMWEIWSLGATPYAQ-----VSDDKVPLQITSQHLLPCPPG--------CPPSAFDLMRQCWEYRPSAR . . ||.|||. . .. . | .||||.|||| ..|..|| .|.. | .. . . .|.|| ||. ...|.|||.. |. | GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR PTAPRMSAECTSL || . . PTFSEI---HECF |
|||||||||
| Kinase | RTKM2.AA | UTK | 124-216 | 26 | 1.8e-14 | 45.9 | In-house | 39-136 (296) | Show / Hide |
Range on Protein: 124-216 Range on HMM: 39-136/296 Sequence Identity: 26% (26 aa) KEHSALQVRD---AFMAEAS---ILKRIGRSCHPSIASLVGLCFHSQPLYIVQEGCEQGFLATMLRDCRGSGN-MEESVSKADLANMCQKVMSAVEFLHG ....| | .. || || ..|. .||... |||.|. ..|..|| | .|.| |...||..| . . ...... .. |. . .....||. HHADAQQEPEPYPDFMEEARELQMMKQFH--WHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHS |
|||||||||
| Kinase | RTKM2.AA | S_TKc | 85-349 | 16 | 3.4e-12 | 1.92 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 85-349 Range on HMM: 1-231/231 Sequence Identity: 16% (50 aa) VTVLDSIASTPFGRLRTGYLKP---------MDKNRSGRGMSILVSSLKEHSALQVRDAFMAEASILKRIGRSCHPSIASLVGLCFHSQPLYIVQEGCEQ ..|. | . ||. . .. | .. . .. | .|||. || | | . . . . ||.| | |.. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDG --GFLATMLRDCRGSGN---MEESVSKADLANMCQKVMSAVEFLHGSSV---------LLMTLNGFTVMV----DAHREPRIAVLGRDPNLDGDRFLQ-- | | ........ |. . | . . ... . .|.|..| . .|.. .... | . . | DLGDLFDYIKKRGRHGLRFPFPE-H----ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL--------------TTFCGTP RWLAPEAVESKGYSM-AADMYSFGVLMWEIWSLGATPYAQVSDDKVPLQITSQHLLPCPPGCPPSAFDLMRQCWEYRPSARPTAPRMSAEC-----TSLA ..||| . ||. ..|..|.|....| . | .|. .| . .... .|.| |..|.|... |. |||| ... WYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP-------QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | RTKM2.AA | Pkinase_Tyr | 122-215 | 33 | 1.6e-10 | 36.26 | Pfam | 35-128 (270) | Show / Hide |
Range on Protein: 122-215 Range on HMM: 35-128/270 Sequence Identity: 33% (33 aa) SLKEHSALQV--RDAFMAEASILKRIGRSCHPSIASLVGLCF-HSQP--LYIVQEGCEQGFLATMLRDCRGSGNMEESVSKADLANMCQKVMSAVEFLH .|||.. . |..||.||.|.| .|. || | .|.| | ...| .||| | .. | | . ||. | . ..... || .||. . .. |.|. MLKEGAMHEQNCREDFMREAKIMKQLGH--HPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR---EDKQPLTMKDLLQMCWQIAKGMEYLE |
|||||||||
| Kinase | RTKM2.AA | Pkinase | 256-339 | 18 | 8.8e-10 | 35.67 | Pfam | 176-285 (293) | Show / Hide |
Range on Protein: 256-339 Range on HMM: 176-285/293 Sequence Identity: 18% (21 aa) RWLAPEAVE-SKGYSMAADMYSFGVLMWEIWSLGATPYAQV------SDDKVPLQITS-QHLLPCPPGCP-------------------PSAFDLMRQCW ...||| . ...|. ..||.|.|....| . | .|. . ..... .| . . ..| |. ... |... |. WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL EYRPSARPTAP .. |. ||||. CKDPKKRPTAE |
|||||||||
| Kinase | RTKM2.AA | Eph | 85-183 | 31 | 1.5e-05 | 14.46 | In-house | 1-96 (264) | Show / Hide |
Range on Protein: 85-183 Range on HMM: 1-96/264 Sequence Identity: 31% (31 aa) VTVLDSIASTPFGRLRTGYLKPMDKNRSGRGMS-ILVSSLKEHSALQVRDAFMAEASILKRIGRSCHPSIASLVGLCFHSQPLYIVQEGCEQGFLATMLR ... .| . || .. | ||. .. | . .. . . ||. .. . | | .||||. | || | | | |.|. || | | | | . || IKIEKVIGAGEFGEVCCGRLKLPSGKREVW-VDPVAIKTLKAGYTEKQRWDFLSEASIM---GQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLR |
|||||||||
| Kinase | RTKM2.AA | CTKA | 122-186 | 32 | 0.002712 | 6.76 | In-house | 41-104 (290) | Show / Hide |
Range on Protein: 122-186 Range on HMM: 41-104/290 Sequence Identity: 32% (22 aa) SLKEHSALQVRDAFMAEASILK--RIGRSCHPSIASLVGLCFHSQPLYIVQEGCEQGFLATMLRDCR .||.| | || .|| .| || . |.|.| ..|.. . | | | || || MLKDHATEEDRRAFLHEAFVLSSEHFH---HPNVLRLLGVCTQHKPWHMIMEHMQYGDLHCYLRACR |
|||||||||