RTKB1

Species: M.brevicollis
Alias: RTKB1
External Links:
Annotation:

Classification

Group: TK
Family: RTKB

Sequence

Name Sequence Type Origin Length Description Download
RTKB1.AA Protein None 1697 None Fasta, JSON
RTKB1.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of RTKB1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
CCP RTKB1.AA CCP 495-553 19 3e-08 34.64 SMART 1-79 (79) Show / Hide
Range on Protein: 495-553
Range on HMM: 1-79/79
Sequence Identity: 19% (17 aa)

CEPLT---APMDGNAQF----------EVYGGISMAFFSCNAGFNMLG-----------NPELYCRYNEEEGAAQWSAPV----PTC
|  .    .|. |  ..          . |   . . .||| |. . |           .....|  |       || |.    |||
CP-PPPHIDPENGYVTCSNSQFTSTFKDTYSYGDTVTYSCNPGYTLIGGRQPEKSQEYHSSTITCQNN-------WSPPPWGPLPTC

Sushi RTKB1.AA Sushi 515-553 28 2.1e-05 22.04 Pfam 31-65 (65) Show / Hide
Range on Protein: 515-553
Range on HMM: 31-65/65
Sequence Identity: 28% (12 aa)

SMAFFSCNAGFNMLGN--PELYCRYNEEEGAAQWSAPVPT-C
|.. ..|..|. | |.  ... |        .||. |.|| |
SKVYYECDPGYQMMGQGSNTITC-------NGQWTPPFPTPC

CCP RTKB1.AA CCP 558-613 21 0.00414 13.3 SMART 1-79 (79) Show / Hide
Range on Protein: 558-613
Range on HMM: 1-79/79
Sequence Identity: 21% (18 aa)

CDVD-----VDVNVVESSA-------TNGGRYPSTLTSSCRSGYTPSGG----------DTRRTCSTSGTYMGTP----LTC
|.       ..   |..|         .  .| .|.| ||..|||..||           ...||  .    ..|     ||
CP-PPPHIDPENGYVTCSNSQFTSTFKDTYSYGDTVTYSCNPGYTLIGGRQPEKSQEYHSSTITCQNN--WSPPPWGPLPTC

Sushi RTKB1.AA Sushi 558-613 21 0.02003 11.44 Pfam 1-65 (65) Show / Hide
Range on Protein: 558-613
Range on HMM: 1-65/65
Sequence Identity: 21% (15 aa)

CD-VDVD--VNVV-ESSAT------NGGRYPSTLTSSCRSGYTPSGGDT-RRTCSTSGTYMGT-PLT-C
|. .  |  ..   . ..|      |  .. |... .|..||...| .. ..||  .|.  .. | | |
CPFDPPDPNIPHGHVIHTTKWRCYRN-YQFGSKVYYECDPGYQMMGQGSNTITC--NGQWTPPFP-TPC

CCP RTKB1.AA CCP 618-670 20 4.4e-07 30.79 SMART 1-79 (79) Show / Hide
Range on Protein: 618-670
Range on HMM: 1-79/79
Sequence Identity: 20% (17 aa)

CGDVP----SDGATPN----------ATTATYGDAVAYTCPAGTHMTG-----------DAVLTCTASGAFSALP----PSC
|.  |     . .. .           .| .||| | |.|. | ...|            ...||...   |  |    |.|
CP-PPPHIDPENGYVTCSNSQFTSTFKDTYSYGDTVTYSCNPGYTLIGGRQPEKSQEYHSSTITCQNN--WSPPPWGPLPTC

Sushi RTKB1.AA Sushi 618-670 22 1.6e-05 22.42 Pfam 1-65 (65) Show / Hide
Range on Protein: 618-670
Range on HMM: 1-65/65
Sequence Identity: 22% (15 aa)

CGDVPSD-------GATPNA-----TTATYGDAVAYTCPAGTHMTGD--AVLTCTASGAFSALPPS-C
|...|.|         ...      .   .|. | |.| .| .| |.  ...||  .|  . ..|. |
CPFDPPDPNIPHGHVIHTTKWRCYRN-YQFGSKVYYECDPGYQMMGQGSNTITC--NGQWTPPFPTPC

EGF_CA RTKB1.AA EGF_CA 702-719 22 14.455074 1.21 Pfam 27-53 (53) Show / Hide
Range on Protein: 702-719
Range on HMM: 27-53/53
Sequence Identity: 22% (6 aa)

GSHACS---CDVNYI------VSNGAC
||  |.   |. .|         ...|
GSFECVNQDCMDGYEMISENNCDGTNC

EGF_CA RTKB1.AA EGF_CA 977-1005 38 3e-10 34.79 Pfam 1-36 (53) Show / Hide
Range on Protein: 977-1005
Range on HMM: 1-36/53
Sequence Identity: 38% (14 aa)

DINECATST-SPC---SSDTMCVNTAGGFTCE---C
|..|||. |   |   . .| |.|| |.|.|.   |
DVDECADGTHHMCGDPHRNTWCINTIGSFECVNQDC

EGF_CA RTKB1.AA EGF_CA 977-1020 25 1.9e-08 35.3 SMART 1-34 (34) Show / Hide
Range on Protein: 977-1020
Range on HMM: 1-34/34
Sequence Identity: 25% (12 aa)

DINECATSTSPCSSDT---MCVNTAGGFTCECIDDSLQYNAVLMSCV
||.||     ||.       |.|  |...| | .          .|.
DIDEC-----PCQNGGPTGTCIN-PGSYRC-CPPGYT------RHCE

EGF RTKB1.AA EGF 981-1005 44 0.000154 18.23 Pfam 1-25 (36) Show / Hide
Range on Protein: 981-1005
Range on HMM: 1-25/36
Sequence Identity: 44% (11 aa)

CATSTSPCSSDTMCVNTAGGFTCEC
|.  ..||. .  ||.| ||.||.|
CNPNNNPCHHHGTCVDTPGGYTCQC

EGF RTKB1.AA EGF 980-1020 21 0.015953 15.63 SMART 1-32 (32) Show / Hide
Range on Protein: 980-1020
Range on HMM: 1-32/32
Sequence Identity: 21% (10 aa)

ECATSTSPCSSD-----TMCVNTAGGFTCECI-DDSLQYNAVLMSCV
|||    ||. .       |.    ..|| |  .          .|.
ECA----PCHHGGCEQHGTCI----SYTC-CPGPGYTG------RCE

EGF RTKB1.AA EGF 1071-1117 19 0.216689 4.88 SMART 1-32 (32) Show / Hide
Range on Protein: 1071-1117
Range on HMM: 1-32/32
Sequence Identity: 19% (10 aa)

ALAGFKPCVAS----NSNCTVSGPSDAVVSCVCA-TGYSGDAQTGANSIGCQ
  |   ||       .  |.         .| |.  ||.|          |.
ECA---PCHHGGCEQHGTCI-------SYTC-CPGPGYTG---------RCE

EGF RTKB1.AA EGF 1096-1107 33 8.626578 2.37 Pfam 22-36 (36) Show / Hide
Range on Protein: 1096-1107
Range on HMM: 22-36/36
Sequence Identity: 33% (5 aa)

SCVCATG---YSGDA
.| |. |   |.|. 
TCQCPPGYLGYTGKR

EGF RTKB1.AA EGF 1120-1150 36 6.6e-08 29.48 Pfam 1-36 (36) Show / Hide
Range on Protein: 1120-1150
Range on HMM: 1-36/36
Sequence Identity: 36% (13 aa)

CNPN--PCQFGGECEVSRRGARCKCAVG---LSGPT
||||  ||. .|.|  .. | .|.|..|    .|..
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR

EGF RTKB1.AA EGF 1119-1152 27 0.00021 21.88 SMART 1-32 (32) Show / Hide
Range on Protein: 1119-1152
Range on HMM: 1-32/32
Sequence Identity: 27% (11 aa)

YCNPNPCQFG-----GECEVSRRGARCKCA-VGLSGPTCS
 |   ||. |     |.|     . .| |.  | .| .| 
ECA--PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE

EGF_2 RTKB1.AA EGF_2 1120-1151 28 0.341193 7.22 Pfam 1-29 (29) Show / Hide
Range on Protein: 1120-1151
Range on HMM: 1-29/29
Sequence Identity: 28% (10 aa)

CNPNPCQF-GGECEVSRRG-ARCKCAVG-LSGPTC
|    |.  .| |. .  |  .|.|  |  .|..|
C----CNGHHGTCNNQ--GCGKCQCDDGWWQGDHC

EGF RTKB1.AA EGF 1157-1198 25 2.3e-05 25.06 SMART 1-32 (32) Show / Hide
Range on Protein: 1157-1198
Range on HMM: 1-32/32
Sequence Identity: 25% (12 aa)

ACDGRCNGH-----GTCTPGAASPDLDPATSEYECECD-EGFAGTDCE
 |.  |  .     |||.              |.| |  .|. |  ||
ECA-PCHHGGCEQHGTCI-------------SYTC-CPGPGYTG-RCE

EGF RTKB1.AA EGF 1158-1196 24 0.0001 18.86 Pfam 1-36 (36) Show / Hide
Range on Protein: 1158-1196
Range on HMM: 1-36/36
Sequence Identity: 24% (11 aa)

CDG---RCNGHGTCTPGAASPDLDPATSEYECECDEG---FAGTD
|.     |..||||...          ..|.|.| .|   ..| .
CNPNNNPCHHHGTCVDTP---------GGYTCQCPPGYLGYTGKR

EGF_2 RTKB1.AA EGF_2 1158-1197 31 0.000433 16.28 Pfam 1-29 (29) Show / Hide
Range on Protein: 1158-1197
Range on HMM: 1-29/29
Sequence Identity: 31% (14 aa)

CDGRCNG-HGTCT-PGAASPDLDPATSE-YECECDEG-FAGTDC
|   ||| ||||  .            .   |.|| | . | .|
C---CNGHHGTCNNQ------------GCGKCQCDDGWWQGDHC

EGF_CA RTKB1.AA EGF_CA 1184-1197 28 3.985041 2.97 Pfam 29-53 (53) Show / Hide
Range on Protein: 1184-1197
Range on HMM: 29-53/53
Sequence Identity: 28% (7 aa)

YECE---CDEGFA--------GTDC
.||.   |..|.         || |
FECVNQDCMDGYEMISENNCDGTNC

Kinase RTKB1.AA RTKB 1274-1536 73 2e-212 712.02 In-house 1-264 (264) Show / Hide
Range on Protein: 1274-1536
Range on HMM: 1-264/264
Sequence Identity: 73% (194 aa)

VRLGEKLGNGAFGEVFRAWIRNRHSGEERGCAAKTLKPGAPFEERQDFLSEMTVMKEIGAHPNVIGIIGHCLREEPYILLVELADLGNLRDYLRECRASR
|.||||||||||||||.||.||||...|. ||||.|||||..||||||.||||||||.|.||||||||||||..|||||||||..|||||||||.||||.
VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRASQ

SKPQSLHVSQMVDFCLQIASGMAFLEQKNVIHRDLAARNVLVGKKLECKISDFGLARNIEGEEYKTTATKLPVKWMAPESLADRIYTTKS-DVWSFGVTM
..||||...|.||||.|||.|||||.|.|||||||.||||||...|.|||.|||.||.|..|.|.||.|.||.|||||||.|.||||||| |||||||||
HNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVTM

WEIFSLGGTPYKEYRNGDVFNLLEKGYRLPTPRQAPAEADAIARMCWSLEAEDRPTFGELVDLL
|||||||||||..|||||.|..||.|.|||.|||.|..||.|..|||..||..||.| ||||..
WEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF

Kinase RTKB1.AA TyrKc 1274-1536 39 3.3e-129 436.45 SMART 1-280 (280) Show / Hide
Range on Protein: 1274-1536
Range on HMM: 1-280/280
Sequence Identity: 39% (116 aa)

VRLGEKLGNGAFGEVFRAWIRNRHSGEERGCAAKTLKPGAPFEERQDFLSEMTVMKEIG-AHPNVIGIIGHCLRE-------EPYILLVELADLGNLRDY
..||.|||.||||||...  .       . .| |.||..|    |.||..|. .|...|  |||.. ..| |. .       ||. ...|....|.|.||
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LRECRASRSKPQSLHVSQMVDFCLQIASGMAFLEQKNVIHRDLAARNVLVGKKLECKISDFGLARNIEGE-------EYKTT----ATK--LPVKWMAPE
||..|        | ......||.|||.||..|..||.|||||||||.|||... .|||||||.|.|. .       .|...     .|  ||..|||||
LRKHRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

SLADRIYTTKSDVWSFGVTMWEIFSLGGTPYKE-----YRNGDVFNLLEKGYRLPTPRQ--------APAEADAIARMCWSLEAEDRPTFGELVDLL
.. ....|||||||||||.|||||..|..|| .       | .|......|||.| |          .|.|   | ..||  ..|||||| |.....
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase RTKB1.AA Pkinase_Tyr 1274-1536 44 1.1e-128 436.48 Pfam 1-270 (270) Show / Hide
Range on Protein: 1274-1536
Range on HMM: 1-270/270
Sequence Identity: 44% (121 aa)

VRLGEKLGNGAFGEVFRAWIRNRHSGEERGCAAKTLKPGAPFEE--RQDFLSEMTVMKEIGAHPNVIGIIGHCL-REEP--YILLVELADLGNLRDYLRE
...|.||| ||||||...  .  .....  .| |.||.||  |.  |.||..|. .||..| |||..  .| |. ..||  ... .|.. .|.|.||||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

CRASRSKPQSLHVSQMVDFCLQIASGMAFLEQKNVIHRDLAARNVLVGKKLECKISDFGLARNI-EGEEY--KTTATKLPVKWMAPESLADRIYTTKSDV
 |   . .|.| .......|.|||.||..||.|| |||||||||.||.... .||.|||||| | . ..|  |.. .|||.||||||.......||||||
HR---EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

WSFGVTMWEIFSLGGTP-YKEYRNGDVFNLL-EKGYRLPTPRQAPAEADAIARMCWSLEAEDRPTFGELVDLL
|||||.|||||..|..| |..  | .|.... |.|||.| |. .|.|   . ..||  ..|||||| |..  |
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase RTKB1.AA TK 1274-1536 24 1.4e-124 419.77 In-house 1-486 (486) Show / Hide
Range on Protein: 1274-1536
Range on HMM: 1-486/486
Sequence Identity: 24% (121 aa)

VRLGEKLGNGAFG---EVFRAWIRNR---------------------HSGEERGCAAKTLKPGAPFEERQDFL----------------SEMTVMKE-IG
..||.||| |.||   ||.... |.|                     ..|..  .| |.||.|.. .... |.                .|| .|.. .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

AHPNVIGIIGHCLRE------------EPYILLVELADLGN----LRDYLRECRASRSKPQS--------------------------------------
 |||.. ..|.|...            ||.....|....|.    ||||||.||  ....|.                                      
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LHVSQMVDFCLQIASGMAFLEQK------NVIHRDLAARNVLVGKKLE-----------CKISDFG---
                               |.. |.. .|.|||.||..|..|      |..||||||||.|||...            |||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARNIEGEEYKTTAT--------------------------KLPVKWMAPESLADRI---------YTTKSDVWSFGVTMWEIFSLG-GTPYKEY
     ||| |. ... ....                          |||..|||||.|.||.         .|||||||||||.|||||..| ...| . 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

RN---------GDVFNLLEKG--------------YRLPTPRQAP--------------AEADAIARMCWSLEAEDRPTFGELVDLL
 |          .|...|..|              .|.| | ..|              .| . . ..||....|||||| .|.. |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase RTKB1.AA UTK 1274-1536 34 3.6e-102 345.72 In-house 1-296 (296) Show / Hide
Range on Protein: 1274-1536
Range on HMM: 1-296/296
Sequence Identity: 34% (102 aa)

VRLGEKLGNGAFGEVFRAWIRN-RHSGEERGCAAKTLKPGAPFEERQD----FLSEMT---VMKEIGAHPNVIGIIGHCLREEPYILLVELADLGNLRDY
|.||..|| ||||||..|  .. .  ..| ..| |.....|. .  ..    |. | .   .||    ||||.. .| |..||| ....|..  |.||.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRECRASRS-KPQSLHVSQMVDFCLQIASGMAFLEQKNVIHRDLAARNVLVGKK-------LECKISDFG---LARNIE---------GEEYKTT--ATK
|| .| .    | .|   |.......||.||..|......||||||||.||..        . |||.|||   ..|..          . .| .   ...
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

LPVKWMAPESLADR-IYTTKSDVWSFGVTMWEIFSLGGTPYKEYRNGDVFNLLEKG--YRLPTPRQAPAEADAIARMCWSLEAEDRPTFGELVDLL
.|..|||||.|...  .|||||||||||..|||.. | .||... | .|.  ...|  ||.| |.. |..   . . ||  . ..||.| .||. .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM

Kinase RTKB1.AA TK-Unique 1274-1536 37 6.2e-101 341.63 In-house 1-294 (294) Show / Hide
Range on Protein: 1274-1536
Range on HMM: 1-294/294
Sequence Identity: 37% (111 aa)

VRLGEKLGNGAFGEVFRAWIRN--RHSGEERGCAAKTLKPGAPFEERQDFLSEMTVMKEIGAHPNVIGIIGHCLRE-EPYILLVELADLGNLRDYLRECR
...|...| ||||.|.|. ...   |... .  | |.|| .| ....||||.|  .|||.|.|||.. ..| | .  ||  .. | .  |||..|||.||
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

AS-----------------RSKPQS--LHVSQMVDFCLQIASGMAFLEQ--KNVIHRDLAARNVLVGKKLECKISDFGLARNIE-GEEYKTTAT--KLPV
                   ..||.   .   ... |. |||.||..|..  |...||||.|||||.. ...|||.|||.|| .. ...| .. .  ..|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

KWMAPESLA--DRIY-TTKSDVWSFGVTMWEIFSLGGTPYKEYRNGDVFNLLEKGYRLPTPRQA-PAEADAIARMCWSLEAEDRPTFGELVDLL
.|||||||   ...| |||||||||||.|||||.||..|| .... |. .....|||.| | .  . |   . . ||..|.|.||.| .... |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL

Kinase RTKB1.AA Src 1274-1536 40 2.4e-94 319.72 In-house 1-255 (255) Show / Hide
Range on Protein: 1274-1536
Range on HMM: 1-255/255
Sequence Identity: 40% (109 aa)

VRLGEKLGNGAFGEVFRAWIRNRHSGEERGCAAKTLKPGAPFEERQDFLSEMTVMKEIGAHPNVIGIIGHCLREEPYILLVELADLGNLRDYLRECRASR
..| .|||.| ||||. .  ...        | ||||||    . ..|| |  .||.   |.... .   | .|||.    |.   |.| |||..    .
IKLCRKLGQGQFGEVWMGYWNGNTK-----VAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----D

SKPQSLHVSQMVDFCLQIASGMAFLEQKNVIHRDLAARNVLVGKKLECKISDFGLARNIE--GEEY-KTTATKLPVKWMAPESLADRIYTTKSDVWSFGV
.. ..||. | .|.  |.|.|||.||..|.|||||||||||||... ||. |||||| |.   .||   .  |.|.||.||| .  . .|.||||||||.
GEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGI

TMWEIFSLGGTPYKEYRNGDVFNLLEKGYRLPTPRQAPAEADA-IARMCWSLEAEDRPTFGELVDLL
 ..||.. | .||.  .| .|.  .|.|||.| |.. |.|    | ..||  ..|.||||  | . |
LLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL

Kinase RTKB1.AA FGFR 1274-1536 38 4e-92 312.37 In-house 1-293 (293) Show / Hide
Range on Protein: 1274-1536
Range on HMM: 1-293/293
Sequence Identity: 38% (113 aa)

VRLGEKLGNGAFGEVFRAWIR---NRHSGEERGCAAKTLKPGAPFEERQDFLSEMTVMKEIGAHPNVIGIIGHCLREEPYILLVELADLGNLRDYLRECR
  ||. || |.||.| .|      . .  .|   | | || ..  ..  |  ||| .|| || |.|.|  .| |  | |   .||..  |||||.||. |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

-----ASRSKP-----------QS--------LHVSQMVDFCLQIASGMAFLEQKNVIHRDLAARNVLVGKKLECKISDFGLARNIEGEEY--KTTATKL
     .... .           |         |   . | .  |.| || .|. . .||||||||||||.   . ||.|||||| |   .|  |||   |
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVKWMAPESLADRIYTTKSDVWSFGVTMWEIFSLGGTPYKEYR-NGDVFNLLEKGYRLPTPRQAPAEADAIARMCWSLEAEDRPTFGELVDLL
|.||||||.| ||.||..|||||.|| .|||. .||.||       . . .|  |.|.  | . . |   . . ||  ....|||| .||. |
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL

Kinase RTKB1.AA Fer 1274-1537 35 2.2e-91 309.88 In-house 1-283 (283) Show / Hide
Range on Protein: 1274-1537
Range on HMM: 1-283/283
Sequence Identity: 35% (103 aa)

VRLGEKLGNGAFGEVFRA------WIRNRHSGEERGCAAKTLKPGAPFEE-RQDFLSEMTVMKEIGAHPNVIGIIGHCLREEPYILLVELADLGNLRDYL
| ||.|||.||||||...          .| ..   .. |..|  .. .| ...|. |. .|.    ||||. ..| |  |.|. .. |... |.|..||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RECRASRSKPQSLHVSQMVDFCLQIASGMAFLEQKNVIHRDLAARNVLVGK-KLECK--ISDFGLARN--IEGEEYKTT--ATKLPVKWMAPESLADRIY
..  .      .. . . ...|.|.|.||..|..||.||||.||||.|..| |...|  |||||..|.   .|. ||    |.|.|..|.|||.. ..||
KKNKNK-----TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIY

TTKSDVWSFGVTMWEIFSLGGTPYKE----YRNGDV-----FNLLEKGYRLPTPRQAPAEADAIAR-MCWSLEAEDRPTFGELVDLLT
..|.|||||||..||||. | .|| .     ... |      .  .|||..| | ..| |   |   .||  . |||||. |..  | 
SPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK

Kinase RTKB1.AA SFK-Src 1274-1540 41 1.4e-86 256.54 In-house 1-259 (259) Show / Hide
Range on Protein: 1274-1540
Range on HMM: 1-259/259
Sequence Identity: 41% (112 aa)

VRLGEKLGNGAFGEVFRAWIRNRHSGEERGCAAKTLKPGAPFEERQDFLSEMTVMKEIGAHPNVIGIIGHCLREEPYILLVELADLGNLRDYLRECRASR
.|| .||| | ||.|..    |         | |||||||  .|   ||.|  |||    ||| |     |   ||     ||   | | |||.|     
IRLEKKLGSGQFGDVWKGRWNNTTE-----VAVKTLKPGAMSAE--EFLQEAQVMKKL-RHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEP----

SKPQSLHVSQMVDFCLQIASGMAFLEQKNVIHRDLAARNVLVGKKLECKISDFGLARNIEGEEY---KTTATKLPVKWMAPESLADRIYTTKSDVWSFGV
 . .|| . |.||   |.|.|||.|| .| .||||||||||||    ||. |||..| .. ..      .  | |.|| |||      . .||||||||.
-HGRSLRMPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGI

TMWEIFSLGGTPYKEYRNGDVFNLLEK--GYRLPTPRQAPAEADAIARMCWSLEAEDRPTFGELVDLLTDMI
 | ||  .|  ||    |  |   ...  |||.| |   | |  .| . ||  |..|||||. |   . |  
LMMEIVTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF

Kinase RTKB1.AA Eph 1274-1536 38 1.2e-78 263.8 In-house 1-264 (264) Show / Hide
Range on Protein: 1274-1536
Range on HMM: 1-264/264
Sequence Identity: 38% (103 aa)

VRLGEKLGNGAFGEVFRAWIRNRHSGEER---GCAAKTLKPGAPFEERQDFLSEMTVMKEIGAHPNVIGIIGHCLREEPYILLVELADLGNLRDYLRECR
... . .| | |||| .  .. .   .|      | |||| |..  .| ||||| ..|     |||.|   |   . .|   ..|  ..| | ..||.  
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQF-DHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHD

ASRSKPQSLHVSQMVDFCLQIASGMAFLEQKNVIHRDLAARNVLVGKKLECKISDFGLARNIEGEE-----YKTTATKLPVKWMAPESLADRIYTTKSDV
        ..| |.|     ||||| .|   | .||||||||.|| ..| ||.||||| | .| ..     | |.  | |..| ||| .| |..|. |||
G------QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDV

WSFGVTMWEIFSLGGTPYKEYRNGDVFNLLEKGYRLPTPRQAPAEADAIARMCWSLEAEDRPTFGELVDLL
||.|. |||. | |  || .  | || .  |.|||||.|.  |.    ..  ||  . ..||.| ..|  |
WSYGIVMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL

Kinase RTKB1.AA VEGFR 1387-1536 48 1.5e-62 214.14 In-house 178-332 (332) Show / Hide
Range on Protein: 1387-1536
Range on HMM: 178-332/332
Sequence Identity: 48% (75 aa)

FCLQIASGMAFLEQKNVIHRDLAARNVLVGKKLECKISDFGLARN-I-EGEEYKTTAT--KLPVKWMAPESLADRIYTTKSDVWSFGVTMWEIFSLGGTP
. .|.| || ||. ...|||||||||.|.  .   ||.||||||  |  .  |..     .|| |||||||. |..|||.|||||.|| .|||||||| |
YSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSP

YKEYR-NGDVFNLLEKGYRLPTPRQAPAEADAIARMCWSLEAEDRPTFGELVDLL
|     . . .| |  |||. .|  .. |   |   ||. | | ||.| |||  |
YPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL

Kinase RTKB1.AA S_TKc 1274-1540 23 7.7e-46 159.52 SMART 1-231 (231) Show / Hide
Range on Protein: 1274-1540
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)

VRLGEKLGNGAFGEVFRAWIRNRHSGEERGCAAKTLKPGAPFEERQDFLSEMTVMKEIGAHPNVIGIIGHCLREEPYILLVELADL--GNLRDYLRECRA
 ....|.| ||||.|.... ..      | .| | .|        .....|. ..|.   |||.. .....   . . .  |..|   |.|.||..... 
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

SRSKPQSLHVSQMVDFCLQIASGMAFLEQKNVIHRDLAARNVLVGKKLECKISDFGLARNIEGEEYKTTATKLPVKWMAPESLADRIYTT-KSDVWSFGV
 . ... ..  .   .. ||....... ....|||||   |.|. .  . ||.|||||| .       |       .|||| |    |.. |.|.||.|.
HG-LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

TMWEIFSLGGTPYKEYRNGDVFNLLEKGYRLPTPRQAPAEADAIARMCWSLEAEDRPTFGELVD-----LLTDMI
...| .. | .|.      ... ...|          . ||  . | |.  . |.|||  |.        .   .
ILYEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase RTKB1.AA Pkinase 1274-1536 19 1.9e-33 119.38 Pfam 1-293 (293) Show / Hide
Range on Protein: 1274-1536
Range on HMM: 1-293/293
Sequence Identity: 19% (61 aa)

VRLGEKLGNGAFGEVFRAWIRNRHSGEERGCAAKTLKPGAPFE--ERQDFL-SEMTVMKEIGAHPNVIGIIGHCLREEPYILLVELADLG----NLRDYL
 ..|.|.| |.||.|...    .| |...  | |..|     .  ...... ||  .||..  |||.. ... . ..  . .  |... |     | ||.
YHIGRKIGSGSFGCVYKC----HHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RECRASRSKPQSL--HVSQMVDFCLQIASGMAFLEQKNVIHRDLAARNVLVGKKLEC----KISDFGLARNIEGEEYKTTATKLPV---KWMAPESLA-D
.      ..  ..     .  ....||..|.... ....|||||   |.|. .. ..    ||.|||||. ..  . . . .. ..    .|||| .  .
ST-----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGG

RIYTTKSDVWSFGVTMWEIFSLGGTPYK------EYRNGDVFNLLEKGYRLPTPRQAP---------------------AEADAIARMCWSLEAEDRPTF
. |..|.|.||.|....| .. | .|..      . .. ..   . .| .|. ... .                      |.  . . |. .  ..|||.
QYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

GELVDL--L
 ...    .
EQILQHPWF

Kinase RTKB1.AA VEGFR 1274-1370 36 1.1e-13 48.19 In-house 1-101 (332) Show / Hide
Range on Protein: 1274-1370
Range on HMM: 1-101/332
Sequence Identity: 36% (37 aa)

VRLGEKLGNGAFGEVFRAWIRN-RHSGEERGCAAKTLKPGAPFEERQDFLSEMTVMKEIGAHPNVIGIIGHCLR---EEPYILLVELADLGNLRDYLREC
 .||  || |||| |  |   . | .   .  | | ||.||  .|    .||. ... || | ||    | |       |.   ||    ||| .|||  
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

R
|
R