Gene RTKB2 (M.brevicollis)
RTKB2
Species: M.brevicollis
Alias: RTKB2
External Links:
Annotation:
Sequence
Protein domains of RTKB2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| TNFR | RTKB2.AA | TNFR | 478-519 | 28 | 9.8e-05 | 22.97 | SMART | 1-50 (50) | Show / Hide |
Range on Protein: 478-519 Range on HMM: 1-50/50 Sequence Identity: 28% (14 aa) CP--SSSYQDASNHLS--TSCKPKR-SSCSI---GYYISSDGGTTKNRVC |. |.. .||.. |.| | ..|. | | .... |.|.|| CKCQEGHYCHHWNHTHYEPHCLPCRHTRCPPEHMGQYMKQPCTATSNTVC |
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| GCC2_GCC3 | RTKB2.AA | GCC2_GCC3 | 424-453 | 31 | 0.023932 | 10.6 | Pfam | 1-30 (49) | Show / Hide |
Range on Protein: 424-453 Range on HMM: 1-30/49 Sequence Identity: 31% (10 aa) GTYHKTVK--CVSCESGKYQDSSSHLSTSCKS |||... |..|. | ||.... . ||.. GTYYNKGQNPCEPCPRGTYQNEEGQD--SCIP |
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| TNFR | RTKB2.AA | TNFR | 435-475 | 22 | 0.073762 | 5.38 | SMART | 1-50 (50) | Show / Hide |
Range on Protein: 435-475 Range on HMM: 1-50/50 Sequence Identity: 22% (11 aa) CE--SGKYQDSSSHLS--TSCKSKT--YCSA---GTYDANGGSNSANTNC |. | |.....|.. |.. . |. |.| .. || | CKCQEGHYCHHWNHTHYEPHCLPCRHTRCPPEHMGQYMKQPCTATSNTVC |
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| GCC2_GCC3 | RTKB2.AA | GCC2_GCC3 | 467-496 | 28 | 1.47389 | 4.78 | Pfam | 1-30 (49) | Show / Hide |
Range on Protein: 467-496 Range on HMM: 1-30/49 Sequence Identity: 28% (9 aa) GSNS-ANT-NCRTCPSSSYQDASNHLSTSCKP | . ... .| || .||. .. . ||.| GTYYNKGQNPCEPCPRGTYQNEEGQD--SCIP |
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| HYR | RTKB2.AA | HYR | 548-625 | 23 | 0.286904 | 6.2 | Pfam | 1-86 (86) | Show / Hide |
Range on Protein: 548-625 Range on HMM: 1-86/86 Sequence Identity: 23% (20 aa) TDVTPPELTLVANA---ILQFEAQTDTFAYPTVTATDTTGETITVTHTNNVHPD---TPN-SYDVTYSGKDSSGNVG-TLVVQITI .| ||| . . | ... .| ....||||. |.. .. . . .| . ...||| |..|| . | ....|. VDTTPPTVENCPNNIFRTVELGTSTVNVFWTEPTATDNSGDIQANLISRTAQPGDFFPVGEQTTVTYTFQDNAGNQADTCTFTVTV |
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| HYR | RTKB2.AA | HYR | 710-731 | 52 | 0.040775 | 8.99 | Pfam | 1-23 (86) | Show / Hide |
Range on Protein: 710-731 Range on HMM: 1-23/86 Sequence Identity: 52% (12 aa) VDTTPPTI-TLVQGINMTVEAGS |||||||. . .| ||| |. VDTTPPTVENCPNNIFRTVELGT |
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| HYR | RTKB2.AA | HYR | 770-782 | 46 | 4.177083 | 2.37 | Pfam | 64-76 (86) | Show / Hide |
Range on Protein: 770-782 Range on HMM: 64-76/86 Sequence Identity: 46% (6 aa) TVEYTATDSSDNR ||.||..|.. |. TVTYTFQDNAGNQ |
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| CCP | RTKB2.AA | CCP | 795-847 | 23 | 1.1e-08 | 36.09 | SMART | 1-79 (79) | Show / Hide |
Range on Protein: 795-847 Range on HMM: 1-79/79 Sequence Identity: 23% (19 aa) CGAVP----FSNATASAST----------AIYGDIVAFACPAGTYLSG-----------SARLTCTISRNFSDLP----PSC |. | |.. . |. ||| | . |. | .|.| |...||. . |. | |.| CP-PPPHIDPENGYVTCSNSQFTSTFKDTYSYGDTVTYSCNPGYTLIGGRQPEKSQEYHSSTITCQNN--WSPPPWGPLPTC |
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| EB | RTKB2.AA | EB | 883-896 | 35 | 0.302508 | 7.74 | Pfam | 46-59 (59) | Show / Hide |
Range on Protein: 883-896 Range on HMM: 46-59/59 Sequence Identity: 35% (5 aa) CSCDVNFILSNATC |.|. .|...| .| CQCPEGFTQHNGRC |
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| EGF | RTKB2.AA | EGF | 849-897 | 10 | 0.305287 | 3.18 | SMART | 1-32 (32) | Show / Hide |
Range on Protein: 849-897 Range on HMM: 1-32/32 Sequence Identity: 10% (6 aa) PCPLNTARAQDNHAEATCQ--------PCGPYMATAGLGNHDCSCD-VNFILSNATCQ .| |. | . | | ... .|. ECA-------------PCHHGGCEQHGTCI---------SYTC-CPGPGYTG---RCE |
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| GCC2_GCC3 | RTKB2.AA | GCC2_GCC3 | 847-879 | 35 | 0.558776 | 6.15 | Pfam | 11-42 (49) | Show / Hide |
Range on Protein: 847-879 Range on HMM: 11-42/49 Sequence Identity: 35% (12 aa) CVPCPLNTARAQDNHAEATCQPCGPY-MATAGLG |.||| .| |.. .| ||.|. . |.. | CEPCPRGTY--QNEEGQDSCIPCPPGKTTTDYPG |
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| GCC2_GCC3 | RTKB2.AA | GCC2_GCC3 | 892-903 | 33 | 27.022846 | 0.67 | Pfam | 7-18 (49) | Show / Hide |
Range on Protein: 892-903 Range on HMM: 7-18/49 Sequence Identity: 33% (4 aa) SNATCQACPSGF ....|..|| |. GQNPCEPCPRGT |
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| EB | RTKB2.AA | EB | 1047-1059 | 23 | 16.660943 | 1.58 | Pfam | 47-59 (59) | Show / Hide |
Range on Protein: 1047-1059 Range on HMM: 47-59/59 Sequence Identity: 23% (3 aa) TCPDDLVVVGDAC .||. .. ... | QCPEGFTQHNGRC |
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| EGF_CA | RTKB2.AA | EGF_CA | 1152-1194 | 32 | 2.7e-10 | 34.93 | Pfam | 1-53 (53) | Show / Hide |
Range on Protein: 1152-1194 Range on HMM: 1-53/53 Sequence Identity: 32% (17 aa) DIDECVASS-FAC---SPNASCINTDGGFICE---CNDNST---QYNAVLHSC |.||| . | . |..||||.|.| |. | |. . |.. . | DVDECADGTHHMCGDPHRNTWCINTIGSFECVNQDCMDGYEMISENNCDGTNC |
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| EGF_CA | RTKB2.AA | EGF_CA | 1152-1195 | 29 | 1.1e-09 | 39.41 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 1152-1195 Range on HMM: 1-34/34 Sequence Identity: 29% (14 aa) DIDECVASSFACSPNA---SCINTDGGFICECNDNSTQYNAVLHSCV ||||| |.... ||| .|.. | | . | ..|. DIDEC-----PCQNGGPTGTCIN-PGSYRC-CPPGYT------RHCE |
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| EGF | RTKB2.AA | EGF | 1155-1195 | 19 | 0.001381 | 19.16 | SMART | 1-32 (32) | Show / Hide |
Range on Protein: 1155-1195 Range on HMM: 1-32/32 Sequence Identity: 19% (9 aa) ECVASSFACSPN-----ASCINTDGGFICECN-DNSTQYNAVLHSCV || |... . || .. | | . | .|. ECA----PCHHGGCEQHGTCI----SYTC-CPGPGYTG------RCE |
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| EB | RTKB2.AA | EB | 1163-1194 | 24 | 0.077617 | 9.83 | Pfam | 30-59 (59) | Show / Hide |
Range on Protein: 1163-1194 Range on HMM: 30-59/59 Sequence Identity: 24% (9 aa) CS---PNASC--INTDGGFICECNDNSTQYNAVLHSC |. ....| .| .|.|... || | . | CQAMWGGSHCHSMN----GTCQCPEGFTQHNGR---C |
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| EGF | RTKB2.AA | EGF | 1156-1188 | 25 | 0.282601 | 7.33 | Pfam | 1-36 (36) | Show / Hide |
Range on Protein: 1156-1188 Range on HMM: 1-36/36 Sequence Identity: 25% (9 aa) CVASSFACSPNASCINTDGGFICECNDN---STQYN | |. .. |..|.||. |.| |. . CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR |
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| EGF | RTKB2.AA | EGF | 1227-1292 | 14 | 0.306521 | 3.16 | SMART | 1-32 (32) | Show / Hide |
Range on Protein: 1227-1292 Range on HMM: 1-32/32 Sequence Identity: 14% (10 aa) ICSAEHSVYSPELATPKNLAVAFFKPCVA----PNSNCTVTGPNDDVMSCVCA-TGYMGDAQTGINSVGCQ |. || .. |. .| |. ||.| |. ECA----------------------PCHHGGCEQHGTCI-------SYTC-CPGPGYTG---------RCE |
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| EGF | RTKB2.AA | EGF | 1260-1282 | 26 | 31.277002 | 0.5 | Pfam | 14-36 (36) | Show / Hide |
Range on Protein: 1260-1282 Range on HMM: 14-36/36 Sequence Identity: 26% (7 aa) CTVTGPNDDVMSCVCATG---YMGDA |. |. . .| |. | | |. CVDTP---GGYTCQCPPGYLGYTGKR |
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| EGF | RTKB2.AA | EGF | 1295-1325 | 38 | 3.4e-08 | 30.43 | Pfam | 1-36 (36) | Show / Hide |
Range on Protein: 1295-1325 Range on HMM: 1-36/36 Sequence Identity: 38% (14 aa) CNRN--PCQFGGECVVSRYGPRCLCPAG---LSGAT || | ||. .|.|| .. |..| || | .| . CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR |
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| EGF | RTKB2.AA | EGF | 1294-1327 | 30 | 1.1e-05 | 26.07 | SMART | 1-32 (32) | Show / Hide |
Range on Protein: 1294-1327 Range on HMM: 1-32/32 Sequence Identity: 30% (12 aa) HCNRNPCQFG-----GECVVSRYGPRCLCP-AGLSGATCS | ||. | |.|. ...| || .| .| .| ECA--PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE |
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| EGF_CA | RTKB2.AA | EGF_CA | 1296-1327 | 32 | 0.001874 | 2.53 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 1296-1327 Range on HMM: 1-34/34 Sequence Identity: 32% (12 aa) NRN--PCQFGG---ECVVSRYGPRCLCPAGLSGATCS . . ||| || |. . || ||.| . .| DIDECPCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE |
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| EGF_2 | RTKB2.AA | EGF_2 | 1295-1326 | 25 | 0.001916 | 14.26 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 1295-1326 Range on HMM: 1-29/29 Sequence Identity: 25% (9 aa) CNRNPCQF-GGECVVSRYGP--RCLCPAG-LSGATC | |. .| |. . . .| |. | .|..| C----CNGHHGTCNNQ---GCGKCQCDDGWWQGDHC |
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| EGF | RTKB2.AA | EGF | 1333-1371 | 24 | 0.000107 | 18.76 | Pfam | 1-36 (36) | Show / Hide |
Range on Protein: 1333-1371 Range on HMM: 1-36/36 Sequence Identity: 24% (11 aa) CNG---RCSGRGTCTPGAASPDLDPATSEYACTCDEG---FAGTD || |...|||... ..| | | .| ..| . CNPNNNPCHHHGTCVDTP---------GGYTCQCPPGYLGYTGKR |
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| EGF | RTKB2.AA | EGF | 1332-1373 | 22 | 0.001325 | 19.22 | SMART | 1-32 (32) | Show / Hide |
Range on Protein: 1332-1373 Range on HMM: 1-32/32 Sequence Identity: 22% (11 aa) ACNGRCSGR-----GTCTPGAASPDLDPATSEYACTCD-EGFAGTDCN | |. |||. | | | .|. | | ECA-PCHHGGCEQHGTCI-------------SYTC-CPGPGYTG-RCE |
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| EGF_2 | RTKB2.AA | EGF_2 | 1333-1372 | 26 | 0.005137 | 12.92 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 1333-1372 Range on HMM: 1-29/29 Sequence Identity: 26% (12 aa) CNGRCSG-RGTCT-PGAASPDLDPATSEYA---CTCDEG-FAGTDC | |.| .||| . . | || | . | .| C---CNGHHGTCNNQ--------------GCGKCQCDDGWWQGDHC |
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| EGF_CA | RTKB2.AA | EGF_CA | 1359-1372 | 24 | 8.471272 | 1.94 | Pfam | 29-53 (53) | Show / Hide |
Range on Protein: 1359-1372 Range on HMM: 29-53/53 Sequence Identity: 24% (6 aa) YACT---CDEGFA--------GTDC . |. |..|. || | FECVNQDCMDGYEMISENNCDGTNC |
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| Kinase | RTKB2.AA | RTKB | 1450-1712 | 67 | 4.7e-203 | 680.85 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 1450-1712 Range on HMM: 1-264/264 Sequence Identity: 67% (178 aa) VRLGEELGHGAFGEVFQAWIRNSYSGKVRRCAAKTLKPDVSFEHRQDFLSEMTVMKEIGAHPNVIGIIGHCLRETPQILLVELAEFGNMRDYLRGCRATQ |.|||.||.||||||||||.||..... ..||||.|||..|.|.||||.||||||||.|.||||||||||||...|.||||||.|.||.||||| |||.| VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRASQ ENPQTIRVDQMADFCLQIARGMAFLEQKNVIHRDLAARNVLVDKNFECKISDFGLARSIEGGEYKTTATKLPVKWMAPESLKSRIYTTKS-DVWSFGVTM .|||.....|..|||.|||.|||||.|.|||||||.|||||||....|||.|||.||.|....|.||.|.||.|||||||...||||||| ||||||||| HNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVTM WEIFSLGGTPYKEHQNRDVLSFLESGHRLPSPRQAPVEFDDIARMCWVLEASDRPSFSELVDLL |||||||||||....|.|....||||||||.|||.|...|.|..|||..||..||.|.||||.. WEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF |
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| Kinase | RTKB2.AA | TyrKc | 1450-1712 | 37 | 5.5e-128 | 432.4 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1450-1712 Range on HMM: 1-280/280 Sequence Identity: 37% (110 aa) VRLGEELGHGAFGEVFQAWIRNSYSGKVRRCAAKTLKPDVSFEHRQDFLSEMTVMKEIG-AHPNVIGIIGHCLRE-------TPQILLVELAEFGNMRDY ..||..||.||||||... . . .| |.||.| |.||..|. .|...| |||.. ..| |. . | ...|... |. .|| ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY LRGCRATQENPQTIRVDQMADFCLQIARGMAFLEQKNVIHRDLAARNVLVDKNFECKISDFGLARSIEGG-------EYKTT----ATK--LPVKWMAPE || .| . . .... .||.|||.||..|..||.|||||||||.||..|. .|||||||.| |. . .|... .| ||..||||| LRKHRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE SLKSRIYTTKSDVWSFGVTMWEIFSLGGTPYKE-----HQNRDVLSFLESGHRLPSPRQ--------APVEFDDIARMCWVLEASDRPSFSELVDLL ... ...|||||||||||.|||||..|..|| . |..|. ....|.|.| | .| | .| ..|| ...|||.|||..... CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | RTKB2.AA | Pkinase_Tyr | 1450-1712 | 42 | 2e-123 | 418.66 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 1450-1712 Range on HMM: 1-270/270 Sequence Identity: 42% (116 aa) VRLGEELGHGAFGEVFQAWIRNSYSGKVRRCAAKTLKPDVSFEH--RQDFLSEMTVMKEIGAHPNVIGIIGHCL-RETP--QILLVELAEFGNMRDYLRG ...|..||.||||||... . . ... .| |.||.. . |. |.||..|. .||..| |||.. .| |. .. | .. .|... |...|||| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK CRATQENPQTIRVDQMADFCLQIARGMAFLEQKNVIHRDLAARNVLVDKNFECKISDFGLARSI-EGGEY--KTTATKLPVKWMAPESLKSRIYTTKSDV | |..| . . .. ..|.|||.||..||.|| |||||||||.||..|. .||.|||||| | . ..| |.. .|||.||||||... ...|||||| HR---EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV WSFGVTMWEIFSLGGTP-YKEHQNRDVLSFL-ESGHRLPSPRQAPVEFDDIARMCWVLEASDRPSFSELVDLL |||||.|||||..|..| |.. | .|. .. |.|.|.| |. .| | |. ..|| ...|||.|||.. | WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | RTKB2.AA | TK | 1450-1712 | 24 | 6.6e-119 | 400.46 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 1450-1712
Range on HMM: 1-486/486
Sequence Identity: 24% (117 aa)
VRLGEELGHGAFG---EVFQAWIRN--SYSGKV-------------------RRCAAKTLKPD--VSFEHRQD--------------FLSEMTVMKE-IG
..||..||.|.|| ||.... |. . ||. ..| |.||.. | | ..| ...|| .|.. .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
AHPNVIGIIGHCLRE------------TPQILLVELAEFGN----MRDYLRGCRATQENPQT--------------------------------------
|||.. ..|.|... | ....|... |. ||||| || . ..|
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------IRVDQMADFCLQIARGMAFLEQK------NVIHRDLAARNVLVDKNFE-----------CKISDFG---
. . |. .|.|||.||..|..| |..||||||||.||..| |||.|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-----LARSIEGGEYKTTAT--------------------------KLPVKWMAPESLKSRI---------YTTKSDVWSFGVTMWEIFSLG-GTPYKEH
||| |. ... .... |||..|||||.|..|. .|||||||||||.|||||..| ...| ..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
QN---------RDVLSFLESG--------------HRLPSPRQAP--------------VEFDDIARMCWVLEASDRPSFSELVDLL
| ..|. .|..| .|.| | ..| |..|. ..|| ....|||.||.|.. |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | RTKB2.AA | UTK | 1450-1712 | 34 | 1.5e-100 | 340.32 | In-house | 1-296 (296) | Show / Hide |
Range on Protein: 1450-1712 Range on HMM: 1-296/296 Sequence Identity: 34% (103 aa) VRLGEELGHGAFGEVFQAWIRN-SYSGKVRRCAAKTLK--PDVSFEHR--QDFLSEMT---VMKEIGAHPNVIGIIGHCLRETPQILLVELAEFGNMRDY |.||..||.||||||. | .. |. ... ..| |... | .|.. ||. | . .|| ||||.. .| |..| | ....|..| |..|.| VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY LRGCRATQE-NPQTIRVDQMADFCLQIARGMAFLEQKNVIHRDLAARNVLVDKN-------FECKISDFG---LARSIE---------GGEYKTT--ATK || .| |.. .| . .|. .....|||||..|......||||||||.||... |||.||| ..| . . .| . ... LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR LPVKWMAPESLKSR-IYTTKSDVWSFGVTMWEIFSLGGTPYKEHQNRDVLSFLESG--HRLPSPRQAPVEFDDIARMCWVLEASDRPSFSELVDLL .|..|||||.| .. .|||||||||||..|||.. | .||... |..|. ... | .|.|.|.. | . .. . || . ..||.| .||. . WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | RTKB2.AA | TK-Unique | 1450-1712 | 37 | 7.1e-97 | 328.14 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 1450-1712 Range on HMM: 1-294/294 Sequence Identity: 37% (109 aa) VRLGEELGHGAFGEVFQAWIRN--SYSGKVRRCAAKTLKPDVSFEHRQDFLSEMTVMKEIGAHPNVIGIIGHCLRET-PQILLVELAEFGNMRDYLRGCR ...|...| ||||.|. . ... ..| .. | |.|| ..... .||||.| .|||.|.|||.. ..| | . . |. .. | .. || ..||| || LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR AT-----------------QENPQT--IRVDQMADFCLQIARGMAFLEQ--KNVIHRDLAARNVLVDKNFECKISDFGLARSIE-GGEYKTTAT--KLPV . . |.| | ... |. |||.||..|.. |...||||.|||||. ...|||.|||.|| .. .|.| .. . ..|. PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI KWMAPESLK--SRIY-TTKSDVWSFGVTMWEIFSLGGTPYKEHQNRDVLSFLESGHRLPSPRQA-PVEFDDIARMCWVLEASDRPSFSELVDLL .|||||||| ..| |||||||||||.|||||.||..|| . ..|.. .. |.|.| | . . |. . . || .|...||||..... | RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | RTKB2.AA | Fer | 1450-1713 | 33 | 1.8e-84 | 286.96 | In-house | 1-283 (283) | Show / Hide |
Range on Protein: 1450-1713
Range on HMM: 1-283/283
Sequence Identity: 33% (97 aa)
VRLGEELGHGAFGEVFQA--WIRNSYSGKVR----RCAAKTLKPD-VSFEHRQDFLSEMTVMKEIGAHPNVIGIIGHCLRETPQILLVELAEFGNMRDYL
| ||. || ||||||... .. .... .. |..| . .. | ...|. |. .|. ||||. ..| | | | .. |.. |. ..||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL
RGCRATQENPQ-TIRVDQMADFCLQIARGMAFLEQKNVIHRDLAARNVLVDK-NFECK--ISDFGLARS--IEGGEYKTT--ATKLPVKWMAPESLKSRI
..|.. |. ... ..|.|.|.||..|..||.||||.||||.|..| ....| |||||..| .| || |.|.|..|.|||.....|
------KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGI
YTTKSDVWSFGVTMWEIFSLGGTPYKE----HQNRDV-----LSFLESGHRLPSPRQAPVEFDDIAR-MCWVLEASDRPSFSELVDLLA
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YSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
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| Kinase | RTKB2.AA | Src | 1450-1712 | 38 | 2.1e-84 | 286.69 | In-house | 1-255 (255) | Show / Hide |
Range on Protein: 1450-1712 Range on HMM: 1-255/255 Sequence Identity: 38% (102 aa) VRLGEELGHGAFGEVFQAWIRNSYSGKVRRCAAKTLKPDVSFEHRQDFLSEMTVMKEIGAHPNVIGIIGHCLRETPQILLVELAEFGNMRDYLRGCRATQ ..| ..|| | ||||... . |.. | |||||. . ..|| | .||. |.... . | .| | |. . |. |||. . IKLCRKLGQGQFGEVWMGY----WNGNT-KVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----D ENPQTIRVDQMADFCLQIARGMAFLEQKNVIHRDLAARNVLVDKNFECKISDFGLARSIEGG--EY-KTTATKLPVKWMAPESLKSRIYTTKSDVWSFGV . ..... | |. |.|.|||.||..|.||||||||||||..| ||. |||||| |. . || . |.|.||.||| . . .|.||||||||. GEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGI TMWEIFSLGGTPYKEHQNRDVLSFLESGHRLPSPRQAPVEFDD-IARMCWVLEASDRPSFSELVDLL ..||.. | .||. .|..|| .| | |.| |.. | |. . | ..|| .. .|| | | . | LLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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| Kinase | RTKB2.AA | InsR | 1450-1714 | 37 | 4.3e-75 | 251.64 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 1450-1714 Range on HMM: 1-278/278 Sequence Identity: 37% (105 aa) VRLGEELGHGAFGEVFQAWIRNSYSGKVRR---CAAKTLKPDVSFEHRQDFLSEMTVMKEIGAHPNVIGIIGHCLRETPQILLVELAEFGNMRDYLRGCR . |. |.| |.|| | .. .. . | || ||.. . | . | .||.| ||||. .| .|. | | | | |. . |. ..|||. | IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCH-HVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRR ATQE--NPQTI------RVDQMADFCLQIARGMAFLEQKNVIHRDLAARNVLVDKNFECKISDFGLARSIEGGEY--KTTATKLPVKWMAPESLKSRIYT .| || . ||| .|. |||.|. |. .|||||.|| .|.. | .|| |||..| | | | . .||| |||||||| ..| PEEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGVFT TKSDVWSFGVTMWEIFSLGGTPYKEHQNRDVLSFL-ESGHRLPSPRQAPVEFDDIARMCWVLEASDRPSFSELVDLLAD |.|||||||| .||. .|| || . | || . | | | | .. .||| ..||.| .....| | THSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD |
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| Kinase | RTKB2.AA | KIN6 | 1494-1712 | 37 | 1.4e-71 | 235.82 | In-house | 61-305 (305) | Show / Hide |
Range on Protein: 1494-1712 Range on HMM: 61-305/305 Sequence Identity: 37% (93 aa) RQDFLSEMTVMKEIGAHPNVIGIIGHCLRETPQILLVELAEFGNMRDYLRGCR--------------ATQENP--QT---IRVDQMADFCLQIARGMAFL ..||. | || | || .. | . |.||. . .. ||| . ||. . || .. | ||. || .| HHDFMHEIAFMKQLGHHPHLVNMLGCVTNSYKPCLVVEYCCHMDLLKYLRNRCQYMMNLDDLGINYHCPDENSRYDDMMCIRHKDLYMFAWQICDGMEYL EQKNVIHRDLAARNVLVDKNF---ECKISDFGLAR--SIEGGEYKTTATK-LPVKWMAPESLKSRIYTTKSDVWSFGVTMWEIFSLGGTPYKEHQ-NRDV .|| ||||||||||||.. ||||||||.| |.. . . ||.||||||.|| . .||||||||| |.|.||||. || | | .. HSKNCIHRDLAARNVLVTEGCRMKTCKISDFGLCRYPYMDQFQYTSKGGRYLPIKWMAPECLKHYEFSYKSDVWSFGVLMFEMFSLGDVPYPEMQRPTEM LSFLESGHRLPSPRQAPVEFDDIARMCWVLEASDRPSFSELVDLL . ...|| |. | .| |. || . || .||| |.|. .. IEHHRSGRRPKHPKWCPEEIYDIMQSCWQEKPDDRPEFNEMRMQF |
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| Kinase | RTKB2.AA | FGFR | 1566-1712 | 47 | 1.4e-68 | 232.9 | In-house | 144-293 (293) | Show / Hide |
Range on Protein: 1566-1712 Range on HMM: 144-293/293 Sequence Identity: 47% (71 aa) QIARGMAFLEQKNVIHRDLAARNVLVDKNFECKISDFGLARSIEGGEY--KTTATKLPVKWMAPESLKSRIYTTKSDVWSFGVTMWEIFSLGGTPYKEHQ |.|||| .|. . .|||||||||||| ... ||.|||||| | .| ||| ||.||||||.| .|.||..|||||.|| .|||. .||.|| QVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIP -NRDVLSFLESGHRLPSPRQAPVEFDDIARMCWVLEASDRPSFSELVDLL . ..| .|||. | . . | . . || ....||.| .||. | SVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL |
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| Kinase | RTKB2.AA | VEGFR | 1563-1712 | 48 | 3.4e-64 | 219.58 | In-house | 178-332 (332) | Show / Hide |
Range on Protein: 1563-1712 Range on HMM: 178-332/332 Sequence Identity: 48% (75 aa) FCLQIARGMAFLEQKNVIHRDLAARNVLVDKNFECKISDFGLARS-IEGG-EYKTTAT--KLPVKWMAPESLKSRIYTTKSDVWSFGVTMWEIFSLGGTP . .|.|||| ||. ...|||||||||.|.. | ||.||||||. | . |.. .|| |||||||. ..|||.|||||.|| .|||||||| | YSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSP YKEHQ-NRDVLSFLESGHRLPSPRQAPVEFDDIARMCWVLEASDRPSFSELVDLL | | . . ..| .| |. | .. | .| || | ||.||||| | YPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL |
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| Kinase | RTKB2.AA | S_TKc | 1450-1717 | 21 | 1.7e-45 | 158.39 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1450-1717 Range on HMM: 1-231/231 Sequence Identity: 21% (60 aa) VRLGEELGHGAFGEVFQAWIRNSYSGKVRRCAAKTLKPDVSFEHRQDFLSEMTVMKEIGAHPNVIGIIGHCLRETPQILLVELAEF--GNMRDYLRGCRA ......|.||||.|.... .. |..| | .| .....|. ..|. |||.. ..... . . |... |...||.. .. YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR TQENPQTIRVDQMADFCLQIARGMAFLEQKNVIHRDLAARNVLVDKNFECKISDFGLARSIEGGEYKTTATKLPVKWMAPESLKSRIYTT-KSDVWSFGV . ... . . . .. ||....... ....||||| |.|.|. . ||.|||||| . | .|||| | |.. |.|.||.|. -HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC TMWEIFSLGGTPYKEHQNRDVLSFLESGHRLPSPRQAPVEFDDIARMCWVLEASDRPSFSELVD----LLADIVL ...| .. | .|. | .. . . |. |. | |.. . ..||. |. .. . ILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | RTKB2.AA | Pkinase | 1450-1712 | 20 | 5.3e-35 | 124.84 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 1450-1712 Range on HMM: 1-293/293 Sequence Identity: 20% (62 aa) VRLGEELGHGAFGEVFQAWIRNSYSGKVRRCAAKTLKPDVSFE--HRQDFL-SEMTVMKEIGAHPNVIGIIGHCLRETPQILLVELAEFG----NMRDYL ..|. .| |.||.|... ... . | |..| . . ...... || .||.. |||.. ... . ... . |..| | ||. YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI RGCRATQENPQTI--RVDQMADFCLQIARGMAFLEQKNVIHRDLAARNVLVDKNFEC----KISDFGLARSIEGGEYKTTATKLPV---KWMAPESLK-S .. .. .. .. ....||.||.... ....||||| |.|.|.| .. ||.|||||. .. . . . .. .. .|||| .. . ST-----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGG RIYTTKSDVWSFGVTMWEIFSLGGTPYKEH-----QNRDVLSFLESGHRLPSPRQAP---------------------VEFDDIARMCWVLEASDRPSFS . |..|.|.||.|....| .. | .|...| . ... .. | .|..... . |. |. . |. . ..||.. QYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE ELVDL--L ... . QILQHPWF |
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| Kinase | RTKB2.AA | FGFR | 1450-1546 | 38 | 1e-19 | 63.87 | In-house | 1-100 (293) | Show / Hide |
Range on Protein: 1450-1546 Range on HMM: 1-100/293 Sequence Identity: 38% (38 aa) VRLGEELGHGAFGEVFQAWIR---NSYSGKVRRCAAKTLKPDVSFEHRQDFLSEMTVMKEIGAHPNVIGIIGHCLRETPQILLVELAEFGNMRDYLRGCR ||. || |.||.| | .. | | | || . . . | ||| .|| || |.|.| .| | | | .||... || ||.|| | LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR |
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| Kinase | RTKB2.AA | VEGFR | 1450-1552 | 32 | 3.1e-10 | 34.97 | In-house | 1-108 (332) | Show / Hide |
Range on Protein: 1450-1552 Range on HMM: 1-108/332 Sequence Identity: 32% (36 aa) VRLGEELGHGAFGEVFQAW---IRNSYSGKVRRCAAKTLKPDVSFEHRQDFLSEMTVMKEIGAHPNVIGIIGHCLR---ETPQILLVELAEFGNMRDYLR .|| ||.|||| | .| || . . .. | | ||. . .||. ... || | || | | | || |||. .||| LKLGKMLGRGAFGQVHEASAFGIRKMETCTT--VAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLR GCRAT-QENP | . ..| TKRMYFVPYP |
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| Kinase | RTKB2.AA | KIN6 | 1450-1465 | 43 | 0.007586 | 5.01 | In-house | 1-16 (305) | Show / Hide |
Range on Protein: 1450-1465 Range on HMM: 1-16/305 Sequence Identity: 43% (7 aa) VRLGEELGHGAFGEVF . . ||||||. |. IHKDHKLGHGAFCNVY |
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