Gene UTK20 (M.brevicollis)
UTK20
Species: M.brevicollis
Alias: UTK20
External Links:
Annotation:
Sequence
Protein domains of UTK20.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | UTK20.AA | UTK | 1564-1849 | 26 | 1e-93 | 317.64 | In-house | 1-296 (296) | Show / Hide |
Range on Protein: 1564-1849 Range on HMM: 1-296/296 Sequence Identity: 26% (81 aa) IALRAELSRSAFGALREGAMQNTA----KTFEGQAKLVVCSMGETVPARHKA-LVLAETR---VLGSLE-HRHIMQLLGVVVAEQPTLIAWRCDCEGTLR ..|...| . ||| ... .. . . . .... ..... |. . .. |.| ... .. |.....|.||...|.|..|.... ..| || VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEP--YPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR DLLRSATREAGDAELALPLVHRLDFVVQASRALQYLHSCGISHEAVAAKKFFVDDSR-------SIRIAALGRRGGNLQHRATRERSFSVSSVQSGFDNL ..||............| | .||..... .|..|||||||. | .||. ..|...| ...|| .| ||| ...|. ... ||. ....... SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFG-RGG-MSRRVNTFH-FSN---RYWESYY ETSRQFDTDVMQWMAPEVLTGQTDPSFANDVYRLGIFWWEMLTFAREPFEGLALPALTASVCNGD--RPNRPPLLGDTLWRIVQACWSPEPQDRPNIEDV ......| ..|||||.|| .|......||. .|...||..|..| |..|.. ......||||. |...|. .....|....|| ..||.||..||. YMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDL GQQA || VQQM |
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| Kinase | UTK20.AA | TK | 1564-1849 | 13 | 3.9e-35 | 114.67 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 1564-1849
Range on HMM: 1-486/486
Sequence Identity: 13% (68 aa)
IALRAELSRSAFG---ALREG---------------------AMQNTAKTFEGQAKLVVCSMGETVPARHKAL--------------VLAETRVLGS--L
| | .| . .|| ..| . | . . . .. | . .. . . ..| .. . .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
EHRHIMQLLGVVVAE------------QPTLIAWRCDCEGT----LRDLLRSATREAGDAELA-------------------------------------
.| .| .|.||.. . .| .| . . | ||| ||. ... . .
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------LPLVHRLDFVVQASRALQYLHSC------GISHEAVAAKKFFVDDSRS-----------IRIAALG---
|.. ..| . .|......||||. .. | .|| |... ..|| |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-------RRGGN-LQHRATRERS-------FSVSSVQSGFDNLETSRQFDTDVMQ---------WMAPEVLTGQT--------DPSFANDVYRLGIFWWE
|. .. ....... |. . . . ..| |||||.|.... . . ||. .|.. ||
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFE-----------D-DP-WQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWE
MLTFAREPFEG-LA-------------LPALTA----------SVCNGDRPNRPPLLGD-------------TLW-RIVQACWSPEPQDRPNIEDVGQQA
..|...||. | . . |.. .| .. |. .||. | ... .. | ||...|.|||. ... .|
IFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | UTK20.AA | TK-Unique | 1760-1849 | 24 | 1.3e-15 | 50.36 | In-house | 202-294 (294) | Show / Hide |
Range on Protein: 1760-1849 Range on HMM: 202-294/294 Sequence Identity: 24% (23 aa) WMAPEVLT--GQTDPSFANDVYRLGIFWWEMLTFAREPFEGLALPALTASVCNGDRPNRPPLL-GDTLWRIVQACWSPEPQDRPNIEDVGQQA |||||.| ... . .||. .|.. ||..|. |. |. . . . .|.|...|. ... . . ||. ||..||..... .. WMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | UTK20.AA | TyrKc | 1564-1849 | 19 | 6e-14 | 2.88 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1564-1849
Range on HMM: 1-280/280
Sequence Identity: 19% (65 aa)
IALRAELSRSAFGALREGAMQNTAKTFEGQAKLVV---CSMGETVPARHKALVLAETRVLGSL--EHRHIMQLLGVVVAE-------QPTLIAWRCDCEG
| | .| . ||| ..| . . | . .. .. . | |.. .| .| .| .|.||.. . .| .| . |
ITLGKKLGEGAFGEVYKGTWK-----------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG
TLRDLLRSATREAGDAELALPLVHRLDFVVQASRALQYLHSCGISHEAVAAKKFFVDDSRSIRIAALG--RRGGNL--------QHRAT---RERS-FSV
|.| ||. .. |.. . |.| .|... .|||| .. | || |.. . ..|. | | ... |.. ... . .
DLKDYLRKHRPK-------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI
SSVQSGFDNLETSRQFDTDVMQWMAPEVLTGQTDP--SFANDVYRLGIFWWEMLTFAREPFEG-----LALPALTASVCNGDRPNRPPL--------LGD
|||||.. . ... ||. |. ||..|. .| .| . . . | .|.|. .|| |
---------------------RWMAPECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPD
TLWRIVQACWSPEPQDRPNIEDVGQQA
. .| . || .| |||. ... ..
EMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | UTK20.AA | Fer | 1760-1850 | 24 | 1e-12 | 39.72 | In-house | 184-283 (283) | Show / Hide |
Range on Protein: 1760-1850 Range on HMM: 184-283/283 Sequence Identity: 24% (25 aa) WMAPEVLTGQTDPSFANDVYRLGIFWWEMLTFAREPFEG---------LALPALTASVCNGDRPNRPPLLGDTLWRIVQ-ACWSPEPQDRPNIEDVGQQA |.|||... . |.. ||. |. || | . ||..| .. .| . ...| .. |. ... .|. || .| |||. .. |. WLAPETWQTGI-YSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKL E . K |
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| Kinase | UTK20.AA | TKL | 1759-1849 | 25 | 4.7e-12 | 39.7 | In-house | 238-364 (364) | Show / Hide |
Range on Protein: 1759-1849 Range on HMM: 238-364/364 Sequence Identity: 25% (32 aa) QWMAPEVLTGQT---------------DPSFANDVYRLGIFWWEMLT----FAREPFEGLALP----ALTASVCNGD-RPNRP------------PLLGD .||||||| ||. . | . ||| || .||.|| .. .|.. . . . ||. || .| | . RWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPP TLWRIVQACWSPEPQDRPNIEDVGQQA . .. | ||...|..||. ... .. SMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | UTK20.AA | Abl | 1758-1849 | 26 | 2.3e-11 | 33.64 | In-house | 162-252 (252) | Show / Hide |
Range on Protein: 1758-1849 Range on HMM: 162-252/252 Sequence Identity: 26% (24 aa) MQWMAPEVLTGQTDPSFANDVYRLGIFWWEMLTFAREPFEGLALPALTASVCNGDRPNRPPLLGDTLWRIVQACWSPEPQDRPNIEDVGQQA ..| ||| | .. | ||. |. ||. |. |. |. | . .| | .||. . ......|| .. ||| ... .. IKWTAPESLAYNKF-SSKSDVWAFGVLLWEIATYGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM |
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| Kinase | UTK20.AA | Dicty4 | 1760-1851 | 36 | 5.8e-11 | 32.98 | In-house | 183-277 (277) | Show / Hide |
Range on Protein: 1760-1851 Range on HMM: 183-277/277 Sequence Identity: 36% (35 aa) WMAPEVLTGQTDPSFANDVYRLGIFWWEMLTFAREPFE--GLALPALTASVCN-GDRPNRPPLLGDTLWRIVQACWSPEPQDRPNIEDVGQQ--AEE ||||||. .| . | ||| || ||.|| ||. . .. . ..||| . || |. . . . .| ||...|| || | . |. |. WMAPEVMMHQPYNEKA-DVYSFGIVLWEILT-RQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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| Kinase | UTK20.AA | RTKD | 1760-1851 | 30 | 3.9e-10 | 30.66 | In-house | 172-262 (262) | Show / Hide |
Range on Protein: 1760-1851 Range on HMM: 172-262/262 Sequence Identity: 30% (28 aa) WMAPEVLTGQTDPSFANDVYRLGIFWWEMLTFAREPFEGLALPALTASVCNGDRPNRPPLLGDTLWRIVQACWSPEPQDRPNIEDVGQQAEE | ||||| | | || ..| .| | |. |.... ..| .| | || .|.. ||. .|..|| . | | .. WCAPEVLE-EHKFSQASDVWSWAVFVYEIWTQAQLPYRDMHNQKVWHYVIQGYRLTRPMQCPRDIWALMMDCWAEDPKERPRMCQVVDQMTK |
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| Kinase | UTK20.AA | Pkinase_Tyr | 1760-1852 | 25 | 4.2e-10 | 34.84 | Pfam | 180-270 (270) | Show / Hide |
Range on Protein: 1760-1852 Range on HMM: 180-270/270 Sequence Identity: 25% (24 aa) WMAPEVLTGQTDPSFANDVYRLGIFWWEMLTFAREP-FEGLALPALTASV-CNGDRPNRPPLLGDTLWRIVQACWSPEPQDRPNIEDVGQQAEEV |||||.. . . ||. |. .||..|. ..| ..|. . . . .| | .|.. | . .. . || ..|.||| ... |. WMAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI---HEQL |
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| Kinase | UTK20.AA | Frk | 1758-1853 | 28 | 4.4e-10 | 30.77 | In-house | 166-260 (260) | Show / Hide |
Range on Protein: 1758-1853 Range on HMM: 166-260/260 Sequence Identity: 28% (27 aa) MQWMAPEVLTGQTDPSFANDVYRLGIFWWEMLTFAREPFEGLALPALTASVCNGDRPNRPPLLGDTLWRIVQACWSPEPQDRPNIEDVGQQAEEVR ..| ||| . ||. || |..|. | |. |. | .| | .|| .|. |.. || .|. || | . . |. IKWTAPEAAN-YNKFTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF |
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| Kinase | UTK20.AA | Src-Echino1 | 1758-1849 | 30 | 3.5e-09 | 27.49 | In-house | 161-252 (252) | Show / Hide |
Range on Protein: 1758-1849 Range on HMM: 161-252/252 Sequence Identity: 30% (29 aa) MQWMAPE-VLTGQTDPSFANDVYRLGIFWWEMLTFAREPFEGLALPALTASVCNGDRPNRPPLLGDTLWRI-VQACWSPEPQDRPNIEDVGQQA ..| ||| .| |. ||. || ||.|| | |..|. .. | .| | .. | |. . . || .|| || | . . IKWTAPEAALYGRF--TIKSDVWSFGILMTEMVTFGRYPYPGMMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF |
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| Kinase | UTK20.AA | Abl | 1614-1719 | 30 | 3.2e-08 | 23.01 | In-house | 43-142 (252) | Show / Hide |
Range on Protein: 1614-1719 Range on HMM: 43-142/252 Sequence Identity: 30% (32 aa) LAETRVLGSLEHRHIMQLLGVVVAEQPTLIAWRCDCEGTLRDLLRSATREAGDAELALPLVHRLDFVVQASRALQYLHSCGISHEAVAAKKFFVDDSRSI |.| .. ..|. ..||||| | | | | | | | ||.. || || | | | . ...|| . | .||. | . . . LKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDRE------ELPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIV RIAALG ..| | KVADFG |
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| Kinase | UTK20.AA | S_TKc | 1564-1847 | 17 | 8.1e-08 | -62.25 | SMART | 1-220 (231) | Show / Hide |
Range on Protein: 1564-1847
Range on HMM: 1-220/231
Sequence Identity: 17% (50 aa)
IALRAELSRSAFGALREGAMQN-----TAKTFEGQAKLVVCSMGETVPARHKALVLAETRVLGSLEHRHIMQLLGVVVAEQPTLIAWRCDCE-GTLRDLL
. .. . ||| . . . | .. | ..| . | .| .|..| . . .. || |.|.|..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYI
RSATREAGDAELALPLVHRLDFVVQASRALQYLHSCGISHEAVAAKKFFVDDSRSIRIAALGRRGGNLQHRATRERSFSVSSVQSGFDNLETSRQFDTDV
.. |. .. .| | .. | .||.|.|| || | . ..|. | |. | .| .
KKRGRHGLR--FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------------------------TTFC
--MQWMAPEVLTGQTDPSF-ANDVYRLGIFWWEMLTFAREPFEGLALPALTASVCNGDRPNRPPLLGDTLWRIVQACWSPEPQDRPNIEDVGQ
.|||||| .. . |.. .|. .|||. . ||. . .. .. . .. ... |. .|..|| . .. |
GTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQ
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| Kinase | UTK20.AA | Src-Echino1 | 1573-1720 | 20 | 2.7e-05 | 13.73 | In-house | 2-142 (252) | Show / Hide |
Range on Protein: 1573-1720
Range on HMM: 2-142/252
Sequence Identity: 20% (31 aa)
SAFGALREGAMQNTAK-TFEGQAKLVVCSMGETVPARHKALVLAETRVLGSLEHRHIMQLLGVVVAEQPTLIAWRCDCEGTLRDLLRSATREAGDAELAL
. .| . . | ..| ... | . | .| ||| |. . |. |.|. | ..| | . .| |.| |.. . .
RMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKT--MSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKR------GKCKHV
PLVHRLDFVVQASRALQYLHSCGISHEAVAAKKFFVDDSRSIRIAALGR
. .| . ..|| | . | .||. |.. ..|| .|.
KMTTLIDMGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGL
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| Kinase | UTK20.AA | Frk | 1614-1719 | 23 | 2.9e-05 | 13.82 | In-house | 42-143 (260) | Show / Hide |
Range on Protein: 1614-1719 Range on HMM: 42-143/260 Sequence Identity: 23% (25 aa) LAETRVLGSLEHRHIMQLLGVVVAEQPTLIAWRCDCEGTLRDLLRSATREAGDAELALPLVHRLDFVVQASRALQYLHSCGISHEAVAAKKFFVDDSRSI |.| ... .| | ..|| | |.| .| .|.| . |.. ... . . .| | . || | | .||. |... .. LREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKG----RQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNIC RIAALG .|| | KIADFG |
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| Kinase | UTK20.AA | TKL | 1651-1697 | 20 | 0.000542 | 10.28 | In-house | 123-163 (364) | Show / Hide |
Range on Protein: 1651-1697 Range on HMM: 123-163/364 Sequence Identity: 20% (11 aa) GTLRDLLRSATREAGDAELALPLVHRLDFVVQASRALQYLHSCG--------ISH |.|...| . .|.... ...|...||||.. | | GSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIH |
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| Kinase | UTK20.AA | Pkinase_Tyr | 1614-1643 | 26 | 0.003251 | 11.51 | Pfam | 51-84 (270) | Show / Hide |
Range on Protein: 1614-1643 Range on HMM: 51-84/270 Sequence Identity: 26% (9 aa) LAETRVLGSL-EHRHIMQLLGVVV-AEQP--TLI ..| ... .| | .| .|.||.. ..| .| MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYI |
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| Kinase | UTK20.AA | TK-Unique | 1614-1703 | 19 | 0.003932 | 6.79 | In-house | 51-162 (294) | Show / Hide |
Range on Protein: 1614-1703 Range on HMM: 51-162/294 Sequence Identity: 19% (22 aa) LAETRVLGSLE-HRHIMQLLGVVVAEQ-PTLIAWRCDCEGTLRDLLRSATRE-----------------AGDAELA-LPLVHRLDFVVQASRALQYLHS- | | ... .| | .| |.||. . . |..|.. |.|...||. .. . ... . . . | .| ....||.| LKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQ -CGISHEAVAAK ..| | ..|. RKKIVHRDLCAR |
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| Kinase | UTK20.AA | RTKD | 1673-1702 | 33 | 0.00941 | 5.22 | In-house | 102-131 (262) | Show / Hide |
Range on Protein: 1673-1702 Range on HMM: 102-131/262 Sequence Identity: 33% (10 aa) LVHRLDFVVQASRALQYLHSCGISHEAVAA . ||. . . . ..| ||| |. | .|| NQHRFRMARDVAMGLAYLHFRGCCHRDIAA |
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| Kinase | UTK20.AA | Fer | 1601-1643 | 22 | 0.018733 | 4.3 | In-house | 42-86 (283) | Show / Hide |
Range on Protein: 1601-1643 Range on HMM: 42-86/283 Sequence Identity: 22% (10 aa) MGETVPARH-KALVLAETRVLGS-LEHRHIMQLLGVVVAEQPTLI . .... . .. ...|.|.. . . | .. .. || | ||| .| CKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMI |
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| Kinase | UTK20.AA | Fer | 1670-1692 | 26 | 0.216393 | 0.63 | In-house | 107-129 (283) | Show / Hide |
Range on Protein: 1670-1692 Range on HMM: 107-129/283 Sequence Identity: 26% (6 aa) ALPLVHRLDFVVQASRALQYLHS .... ..... ||.. ..|||| TVSDNEKIRMCYQAACGMEYLHS |
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| Kinase | UTK20.AA | Pkinase_Tyr | 1651-1692 | 26 | 0.417089 | 4.37 | Pfam | 92-129 (270) | Show / Hide |
Range on Protein: 1651-1692 Range on HMM: 92-129/270 Sequence Identity: 26% (11 aa) GTLRDLLRSATREAGDAELALPLVHRLDFVVQASRALQYLHS | |.| ||. . . .|.. . |.. .| .....||.| GDLLDYLRKHR----EDKQPLTMKDLLQMCWQIAKGMEYLES |
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