Gene RTKE2 (M.brevicollis)

RTKE2

Species: M.brevicollis
Alias: RTKE2
External Links:
Annotation:

Classification

Group: TK
Family: RTKE

Sequence

Name Sequence Type Origin Length Description Download
RTKE2.AA Protein None 1350 None Fasta, JSON
RTKE2.kin_dom Protein Kinase Domain None 263 None Fasta, JSON
RTKE2.kin_dom2 Protein Kinase Domain None 240 None Fasta, JSON

Protein domain

Protein domains of RTKE2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 RTKE2.AA LRR_1 164-186 29 0.004492 15.07 Pfam 1-26 (26) Show / Hide 
Range on Protein: 164-186
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

QLERLDLSN-N--KLE-YVHELAAQSL
.|..||||. |  .|. .... .  .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP RTKE2.AA LRR_TYP 162-185 41 0.009808 16.31 SMART 1-24 (24) Show / Hide 
Range on Protein: 162-185
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

FQQLERLDLSNNKLEYVHELAAQS
  .|..||||||.|. ... | |.
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP RTKE2.AA LRR_TYP 186-207 37 0.078036 8.93 SMART 1-24 (24) Show / Hide 
Range on Protein: 186-207
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

LYSLKYLNLSHNLLSRL--YAIHL
| .|. |.||.| |..|   | . 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 RTKE2.AA LRR_1 188-207 26 0.460515 7.94 Pfam 1-26 (26) Show / Hide 
Range on Protein: 188-207
Range on HMM: 1-26/26
Sequence Identity: 26% (7 aa)

SLKYLNLSH-N--LLS-RLYAI--HL
.|..|.||. |   |.  .     .|
NLQHLDLSGCNCCNLTGHIPPSCFNL
LRR_1 RTKE2.AA LRR_1 212-234 18 0.820806 7.05 Pfam 1-26 (26) Show / Hide 
Range on Protein: 212-234
Range on HMM: 1-26/26
Sequence Identity: 18% (5 aa)

QLDTLDVRF-N--PIQ-EIRSDLLISA
.| .||..  |  ... .| .. . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LDLa RTKE2.AA LDLa 289-327 27 0.000847 8.02 SMART 1-47 (47) Show / Hide 
Range on Protein: 289-327
Range on HMM: 1-47/47
Sequence Identity: 27% (13 aa)

EETLN----LTCSDNSNTITNFQYCDGVQDCDNGWDE-----FECCQL
. . .     .|. |.. | . . |||. || .| ||      | |  
TCPPDHPNQFQCG-NGRCIPKSWVCDGDNDCGDGSDEWPFFDPENCPQ
Kinase RTKE2.AA RTKE 558-797 31 1.6e-132 446.57 In-house 1-286 (293) Show / Hide 
Range on Protein: 558-797
Range on HMM: 1-286/293
Sequence Identity: 31% (89 aa)

QGFMTLSSTRKCYS------------------------GVYLP-AFPTTEEQPNVERALVEARLLLCLQQHANVLKVHHLASDDRVQILLYEEIQQGPLD
..||..........                        ..... ....|..........|......|...|.||....|...........||....|.|.
LTFMRALGSGEFGEVWLMTMPNHAHSPNYSKETISSEQQRSTRQVAVKTLHNHECHHEFVQEMTMMCKLHHPNVVHLLHVVQMKQHFMMVYEYMPGGQLE

VALAQY--KVTQAQGREICL-KVASACSFLESMGIVHRNLGAHSIYACSDITDVRLAGFGLSRDVYFTEEYMTKN-AAASQLAPD-----RRFWSPEVWQ
..|...  ..|.......|| .||...||||..|||||.|.||..|.|....||..|..|||||.|...|||... .........     ||.|.||||.
DWLQDHHGRPTSHEDQIHCLHQVACGMSFLERLGIVHRDLCAHNVYCCRCWNDVKVADYGLSRDMYLGQEYMQCYYRIKTRRWMPTTWGSRRWWAPEVWK

DGNFSFKSDVFAFGRFFWQVYNNGQMPYKEMPERQFVSASVTNALP------------ALPVVEDPLAQRLIEACLRTQPRSRPRF
|..|||||||.|.|...|.|.|||||||..|...||....|....|            |.||...|.|.||...||...|..||.|
DQHFSFKSDVWAYGCLCWEVWNNGQMPYAHMDDQQFMQRIVQCQMPSGGHLGDHEPVHAPPVHCPPWADRLMQWCLCINPEHRPNF
Kinase RTKE2.AA TK 590-804 12 6.4e-37 120.76 In-house 87-486 (486) Show / Hide 
Range on Protein: 590-804
Range on HMM: 87-486/486
Sequence Identity: 12% (51 aa)

ALVEARLLLC--LQQHANVLKVHHLASDD------------RVQILLYEEIQQGP----LDVALAQYKVTQAQGRE------------------------
...|.. ..|  | .| |... .   ...            .  ... |  . |     |.  | . . .  .  .                        
EEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY

----------------------------------------------------ICLKVASACSFLESM------GIVHRNLGAHSIYACSDITD-------
                                                    .|. .|.....|.|.      ..|||.| |. .  ... ..       
SHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGC

---VRLAGFG--------LSRDVYFTEEYMTKNAAASQLAPDR---------------------RFWSPEVWQ---------DGNFSFKSDVFAFGRFFW
   ...| ||        |.||.|  ..| .|.     . . .                     |  .||...         .| |. ||||..|| . |
GPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMW

QVYNNG-QMPYKEMPE---------RQFVSASVT---------------NALPALPVVED-------------PLAQRLIEACLRTQPRSRPRFGYDTKL
 .. .| ...| .|.          ....   ..               . .|. |   |             .. ..|.  | . .|. ||.|    . 
EIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQ

T
 
L
Kinase RTKE2.AA UTK 593-754 22 9.5e-25 81.6 In-house 56-244 (296) Show / Hide 
Range on Protein: 593-754
Range on HMM: 56-244/296
Sequence Identity: 22% (44 aa)

EAR---LLLCLQQHANVLKVHHLASDDRVQILLYEEIQQGPLDVALA---------QYKVTQAQGREICLKVASACSFLESMGIVHRNLGAHSIYACSD-
|||   .. ... | |||.. .. ...   ....|  ..| |.  |          .  .|  |  . .. .|.. ..|.|.|.|||.| |  .. ... 
EARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHR

-----ITDVRLAGFG---LSRDVY---------FTEEYMTKNAAA------SQLAPDRRFWSPEVWQDG-NFSFKSDVFAFGRFFWQVYNNGQMPYKEM
      .....|.||   .||.|.         ....||  .. .      .          ||.  ..  |..||||..|| . | .. .|..||..|
MMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMA----------PEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGM
Kinase RTKE2.AA TK-Unique 652-760 29 2.3e-13 42.58 In-house 140-249 (294) Show / Hide 
Range on Protein: 652-760
Range on HMM: 140-249/294
Sequence Identity: 29% (34 aa)

VASACSFLES--MGIVHRNLGAHSIYACSDITDVRLAGFGLSRDVYFTEEYMTKNAAASQLAPDRRFWSPEVWQ--DGNF-SFKSDVFAFGRFFWQVYNN
.|.. ..|.|  ..||||.| |. .   ..   . ...||..|||| ...|...    ||     |  .||. .  .|.. . |||| .|| . | .  .
IACGMEYLASQRKKIVHRDLCARNV-LLTEDKVCKICDFGMARDVYTNGVYSMM---CSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTL

GQMPYKEMPERQFV
|..|| .|| ....
GACPYPGMPWKDIM
Kinase RTKE2.AA Frk 647-797 25 4.3e-11 34.33 In-house 102-249 (260) Show / Hide 
Range on Protein: 647-797
Range on HMM: 102-249/260
Sequence Identity: 25% (40 aa)

EICLKVASACSFLESMGIVHRNLGAHSIYACSDITDVRLAGFGLSRDVYFTEE--YMTKNAAASQLAPDRRFWSPEVWQDGNFSFKSDVFAFGRFFWQVY
..  .||.   .|||.  .|| | |  .    .   ...| ||| | .   .|  | ..  |   .    ..  ||  .   |. ||||..||     . 
DMAAQVAAGMAYLESQNYIHRDLAARNVL-VGEHNICKIADFGLARVLMKDNEDIYESRHGARFPI----KWTAPEAANYNKFTIKSDVWSFGILLTEII

NNGQMPYKEMPERQFVSASVTN-ALPALPVVEDPLAQRLIEACLRTQPRSRPRF
  |.|||  | ... .     .  .|  |  .  | . ..| | . .|. || |
TYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLE-CWHSDPMKRPTF
Kinase RTKE2.AA TKL 648-797 18 4.3e-09 28.91 In-house 137-357 (364) Show / Hide 
Range on Protein: 648-797
Range on HMM: 137-357/364
Sequence Identity: 18% (40 aa)

ICLKVASACSFLESMG--------IVHRNLGAHSIYACSDIT-------------DVRLAGFGLSRDVYFT-EEYMTKNA---------AASQLAPDR--
..| .|.....| ||.        |.||.|  . |   .. |             .. .. |||||..  . .  .|...          .... . .  
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

-RFWSPEV---------W-------QDGNFSFKSDVFAFGRFFWQVYNNGQMPYKEMPERQFV---------SASVTNA-LPALP------------VVE
 |. .|||         .       . . .| |.||..||  .| ..   . ||...|... .         .  . .   | .|               
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDC

DPLAQRLIEACLRTQPRSRPRF
.|   .|.. |  . |..|| |
PPSMKKLMQDCWDHDPEKRPSF
Kinase RTKE2.AA Abl 651-751 32 1.4e-08 24.18 In-house 105-199 (252) Show / Hide 
Range on Protein: 651-751
Range on HMM: 105-199/252
Sequence Identity: 32% (33 aa)

KVASACSFLESMGIVHRNLGAHSIYACSDITDVRLAGFGLSRDVYFTEEYMTKNAAASQLAPDRRFWSPEVWQDGNFSFKSDVFAFGRFFWQVYNNGQMP
..||. |.||.   .|| | |      ..   |..| |||.|    ...  |  | |       ..  ||      || ||||.|||   | .   |  |
QIASGMSYLEKRHFIHRDLAARNCL-VGEHHIVKVADFGLAR--MMKDDTYTAHAGAKFPI---KWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSP

Y
|
Y
Kinase RTKE2.AA CTKA 657-797 27 1e-06 18.0 In-house 145-283 (290) Show / Hide 
Range on Protein: 657-797
Range on HMM: 145-283/290
Sequence Identity: 27% (40 aa)

SFLESMGIVHRNLGAHSIYACSDITDVRLAGFGLSRDVYFTE-EYMTKNAAASQLAPDRRFWSPEVWQDGNFSFKSDVFAFGRFFWQVYNNGQMPYKEMP
..| .||.||| | .  .   .  . . .| ||..|    ||  | .     . . |  |  .||  . | ||  |||.|||   | .   |  |.  | 
NYLAEMGFVHRDLACRNCLLGQYCH-IKIADFGHGR-TLRTESQYYY--VSSQRVMP-VRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMS

ERQFVSASVTN---ALPALPVVEDPLAQRLIEACLRTQPRSRPRF
 .  . |       .||  .   . |   . . |..  |  || |
DQEVCQAYTSHGMRRLPVPRNCPQVLYH-CMQECWKFEPNQRPTF
Kinase RTKE2.AA Src 719-803 29 5.7e-05 12.76 In-house 169-255 (255) Show / Hide 
Range on Protein: 719-803
Range on HMM: 169-255/255
Sequence Identity: 29% (26 aa)

PEVWQDGNFSFKSDVFAFGRFFWQVYNNGQMPYKEMPERQFVSASVTNA--LPALPVVEDPLAQRLIEACLRTQPRSRPRFGY-DTKL
||  . |.|. ||||  ||   . .   |..||. |  .. |   | .   .|  . . | | ....  | . .|. || | |   .|
PEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHE-VLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase RTKE2.AA DDR 648-737 31 6.1e-05 13.22 In-house 139-230 (306) Show / Hide 
Range on Protein: 648-737
Range on HMM: 139-230/306
Sequence Identity: 31% (30 aa)

ICLKVASACSFLESMGIVHRNLGAHSIYACSDITDVRLAGFG--LSRDVYFTEEYMTKN--AAASQLAPDRRFWSPEVWQDGNFSFKSDVFAFG
||  .||.  .|||| .||| | . ..    . . .. . ||  .||  |  . |         .. .|  |. ..|    | |. |||| |||
ICTQIASGMKYLESMNFVHRDLATRNCLVGKEYH-IKICDFGTVMSRNLYSQDYYRVEGFTGRQRHHMP-IRWMAWESILLGKFTTKSDVWAFG
Kinase RTKE2.AA Pkinase_Tyr 718-760 34 7e-05 17.15 Pfam 182-225 (270) Show / Hide 
Range on Protein: 718-760
Range on HMM: 182-225/270
Sequence Identity: 34% (15 aa)

SPEVWQDGNFSFKSDVFAFGRFFWQVYNNGQMP-YKEMPERQFV
.||....| |. |||| .||   | ..  |..| |..|.  ...
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVY
Kinase RTKE2.AA Pkinase_Tyr 647-669 34 0.004415 11.06 Pfam 115-137 (270) Show / Hide 
Range on Protein: 647-669
Range on HMM: 115-137/270
Sequence Identity: 34% (8 aa)

EICLKVASACSFLESMGIVHRNL
..|. .|.....|||....|| |
QMCWQIAKGMEYLESKNCIHRDL
Kinase RTKE2.AA Pkinase 688-795 13 0.549385 4.57 Pfam 156-282 (293) Show / Hide 
Range on Protein: 688-795
Range on HMM: 156-282/293
Sequence Identity: 13% (18 aa)

FGLSRDVYFTEEYMTKNAAASQLAPDRRFWSPEVWQ-DGNFSFKSDVFAFGRFFWQVYNNGQMPYKEM-----PERQFVSASVTNALPALPVVED-----
|||.. ..       .|  .. ..  ... .||| . .   . |.|....|  ...... |. |...       . ... . .  . .  .  ..     
FGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISY

----------------PLAQRLIEACLRTQPRSRP
                . .. .|. ||.  | .||
FFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
Kinase RTKE2.AA RTKE 1028-1296 50 9.20000000001e-172 576.92 In-house 1-293 (293) Show / Hide 
Range on Protein: 1028-1296
Range on HMM: 1-293/293
Sequence Identity: 50% (147 aa)

LTFVRKLGEGEFGEVNLMSMAN---------------QYGSTLQVAVKTLRDASLREDFMSEVTMMLKLHHPNLVGLLHTSQTTDGHLAMILEFMPGGSL
|||.|.||.||||||.||.|.|               |..||.|||||||........|..|.|||.||||||.|.|||..|... |..|..|.||||.|
LTFMRALGSGEFGEVWLMTMPNHAHSPNYSKETISSEQQRSTRQVAVKTLHNHECHHEFVQEMTMMCKLHHPNVVHLLHVVQMKQ-HFMMVYEYMPGGQL

EGWLEDR-GRSVSQTDLIYIAHQVASGMAELARLGIVHRDLAARNVLIGRALN-AKVADYGLSRTMAIGTESEECYYRIKTSRPMP-----VRWMAPSTI
|.||.|. ||..|..|.|...||||.||..|.|||||||||.|.||...|..| .|||||||||.|..|.|...|||||||.|.||     .||.||...
EDWLQDHHGRPTSHEDQIHCLHQVACGMSFLERLGIVHRDLCAHNVYCCRCWNDVKVADYGLSRDMYLGQEYMQCYYRIKTRRWMPTTWGSRRWWAPEVW

VDRKFTSESDVWSYGCLLCEMWSAGEMPFNDLDDQQVVERLLAAYA---GRVPENEPVLASPKSCPPLIDALIQSCLTVNGELRPNFIVLRRRT
 |..|...||||.||||..|.|..|.||....||||...|......   |.....|||.|.|..|||..|.|.|.||..|.|.||||. | ...
KDQHFSFKSDVWAYGCLCWEVWNNGQMPYAHMDDQQFMQRIVQCQMPSGGHLGDHEPVHAPPVHCPPWADRLMQWCLCINPEHRPNFAQLYQMW
Kinase RTKE2.AA TK 1028-1296 20 3.6e-88 295.61 In-house 1-486 (486) Show / Hide 
Range on Protein: 1028-1296
Range on HMM: 1-486/486
Sequence Identity: 20% (100 aa)

LTFVRKLGEGEFG---EVNLM------SMANQY----------------GSTLQVAVKTLR---DASLREDFM----------------SEVTMML--KL
.|...|||||.||   || .          ...                | . .||||.|.   ..| .| |.                .|  ||.  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHPNLVGLLHTSQTTD-----------GHLAMILEFMPGGS----LEGWLEDRGR---------------------------------------------
||||.| |.  .   .           ... ...|.||.|.    |  .| .. .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------SVSQTDLIY-------------------IAHQVASGMAELARL------GIVHRDLAARNVLIGRALN-----------AKVADYGLSRT
          .....||..                   ...|.|.||. |...      ..|||||||||.|.|. ..           .|.||.||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----MAIGTESE-----------------------ECYYRIKTSRPMPVRWMAPSTIV---------DRKFTSESDVWSYGCLLCEMWSAG-EMPFNDLD
    .|   .|.                       . ||| .... .|.||||| ..          ..|||..|||||.|.|. |... | |..  ...
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

D---------QQVVERLLAA-----YAGRVPEN----EPVLASPKSCP--------------PLIDALIQSCLTVNGELRPNFIVLRRRT
.         |.|.|.| .        |  . |       .. |. ||              .... |.|.|   . | ||.|  |... 
NQDVWKDGDNQEVMEYLRRGGRLCRS-G--L-NEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RTKE2.AA TyrKc 1028-1297 32 3.8e-75 256.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 1028-1297
Range on HMM: 1-280/280
Sequence Identity: 32% (96 aa)

LTFVRKLGEGEFGEVNLMSMANQYGSTLQVAVKTLRDASLREDFMSEVTMMLKL--HHPNLVGLLHTSQTT------DGHLAMILEFMPGGSLEGWLEDR
.|. .|||||.|||| .  .       .|||||.|.. . |||||.|  .| ||  ||||.| |.    .       .. | ...|.||.|.|   | ..
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

GRSVSQTDLIYIAHQVASGMAELARLGIVHRDLAARNVLIGRALNAKVADYGLSRTMAIG---TESEECYYRIKT--SRP--MPVRWMAPSTIVDRKFTS
.. ..  ||.....|.|.||. |.. ...||||||||.|.|. . .|..| ||||    .      .. ||| |.  ..   .|.||||| .| ..|||.
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

ESDVWSYGCLLCEMWSAGEMPFND-----LDDQQVVERLLAAYAGRVPENEPVLASPKS--------CPPLIDALIQSCLTVNGELRPNFIVLRRRTL
.|||||.| .. |. . |..|  .     ...|.|.|.. . |          .  |..        ||. .  ....|   . | ||.|  . .. .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY---------RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase RTKE2.AA Pkinase_Tyr 1028-1289 33 2.7e-73 248.84 Pfam 1-263 (270) Show / Hide 
Range on Protein: 1028-1289
Range on HMM: 1-263/270
Sequence Identity: 33% (93 aa)

LTFVRKLGEGEFGEVNLMSMA-NQYGSTLQVAVKTLRD---ASL--REDFMSEVTMMLKL-HHPNLVGLLHTSQTTDGH--LAMILEFMPGGSLEGWLED
.|| .|||||.|||| .  .   . . ...||||.|..    .   |||||.|. .| .| ||||.| |.      ...  . ...|.||.|.|   | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---GRSVSQTDLIYIAHQVASGMAELARLGIVHRDLAARNVLIGRALNAKVADYGLSRTMAIGTESEECYY-RIKTSRPMPVRWMAPSTIVDRKFTSES
.   .....  ||. ...|.|.||. |.. ...||||||||.|... . .|..| ||.|..      .. || | ... ..|..||||  | ..|||..|
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-----YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKS

DVWSYGCLLCEMWSAGEMP-FNDLDDQQVVERL-LAAYAGRVPENEPVLASPKSCPPLIDALIQSCLTVNGELRPNF
||||.| |. |. . ||.| . ......|.|..    |          .. |. ||. |  |...|   . | || |
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR---------MPCPENCPDEIYDLMKQCWHYDPEDRPTF
Kinase RTKE2.AA UTK 1028-1296 27 3.5e-67 228.87 In-house 1-296 (296) Show / Hide 
Range on Protein: 1028-1296
Range on HMM: 1-296/296
Sequence Identity: 27% (84 aa)

LTFVRKLGEGEFGEVNLMSMANQY--GSTLQVAVKTLR----DASLRE---DFMSEVT---MMLKLH-HPNLVGLLHTSQTTDGHLAMILEFMPGGSLEG
. . |.||.|.||||....  .    . ...||||...    .   .|   ||| | .   || ..| |||...|... .| .. .....|.|..|.|  
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGV-CTQEEPWMIVTEYMENGDLRS

WLEDRGR-------SVSQTDLIYIAHQVASGMAELARLGIVHRDLAARNVLIGRA-------LNAKVADYG---LSRTMA---IGTESEECYYRIKT-SR
 | . ..       ... ..... | ..|.||. |.. |.|||||||||.|...        . .|.||.|   .|| ..     . ..| ||  ..  .
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQD

PMPVRWMAPSTIVDR-KFTSESDVWSYGCLLCEMWSAGEMPFNDLDDQQVVERLLAA-YAGRVPENEPVLASPKSCPPLIDALIQSCLTVNGELRPNFIV
..|.|||||  .... .||. |||||.| .. |.|. | .|. .. ..||......  .          ...|..||  .  | ..| . . . ||.|  
RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGR--------YRMPCPWDCPHPVYRLMHRCWHYDPQERPDFED

LRRRT
|. . 
LVQQM
Kinase RTKE2.AA Src 1028-1296 33 6.9e-61 205.59 In-house 1-255 (255) Show / Hide 
Range on Protein: 1028-1296
Range on HMM: 1-255/255
Sequence Identity: 33% (92 aa)

LTFVRKLGEGEFGEVNLMSMANQYGSTLQVAVKTLRDASLR-EDFMSEVTMMLKLHHPNLVGLLHTSQTTDGHLAMILEFMPGGSLEGWLE--DRGRSVS
....||||.| ||||        .  . .||||||. ...  |.|  |   | || |..|| |.    . .     . |.|  |||  .|   ..||...
IKLCRKLGQGQFGEV----WMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEE-PIYIVTEYMSHGSLLDYLKKDGEGRHLH

QTDLIYIAHQVASGMAELARLGIVHRDLAARNVLIGRALNAKVADYGLSRTMAIGTESEECYYRIKTSRPMPVRWMAPSTIVDRKFTSESDVWSYGCLLC
 ..||..| |||.||| | .  ..||||||||||.|  . .|||| || | .  . . |   |  ..   .|..|.||  |  ..||  |||||.| || 
LPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED-DDE---YCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLT

EMWSAGEMPFNDLDDQQVVERLLAAYAGRVPENEPVLASPKSCPPLIDA-LIQSCLTVNGELRPNFIVLRRRT
|. . | .|    . ..|.... . |          .  |. ||. .   ... |     | || |  |.   
EIVTYGRVPYPGMTNHEVLQQVERGY---------RMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase RTKE2.AA TK-Unique 1028-1296 27 1.3e-59 204.25 In-house 1-294 (294) Show / Hide 
Range on Protein: 1028-1296
Range on HMM: 1-294/294
Sequence Identity: 27% (86 aa)

LTFVRKLGEGEFGEVNLMSMANQY---GSTLQVAVKTLR-DASLRE--DFMSEVTMMLKLH-HPNLVGLLHTSQTTDGHLAMILEFMPGGSLEGWLEDRG
|.. ...|||.||.|    . .     . . .||||.|. .|.. .  ||..|  || .|  |||.| .|  ....|.   .|.|..|.|.|.. |  ..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

RS-------------------------VSQTDLIYIAHQVASGMAELAR--LGIVHRDLAARNVLIGRALNAKVADYGLSR-TMAIGTESEECYYRIKTS
.                          .|  ||. .| |.|.||. ||.   .||||||.|||||... ...|..|.|..| ...     .. | .....
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-----NGVYSMMCSQ

RPMPVRWMAPSTIV--DRKF-TSESDVWSYGCLLCEMWSAGEMPFNDLDDQQVVERLLAAYAGRVPENEPVLASPKSC-PPLIDALIQSCLTVNGELRPN
 ..|.|||||  .   .. . |..|||||.|.|. |. . |..|...... ...|.. . |          .  |..| .. .  |..||.. . | ||.
GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGY---------RMPQPEHCCSHEMYNLMKSCWQWEPEERPS

FIVLRRRT
|  .. | 
FRQIKHRL
Kinase RTKE2.AA DDR 1028-1296 31 8.9e-58 198.27 In-house 1-306 (306) Show / Hide 
Range on Protein: 1028-1296
Range on HMM: 1-306/306
Sequence Identity: 31% (98 aa)

LTFVRKLGEGEFGEVNLMSMANQY-----GSTLQ--------VAVKTLRD---ASLREDFMSEVTMMLKLH-HPNLVGLLHTSQTTDGHLAMILEFMPG-
|.|| |.|||.|||| |    .       .. ..        ||||.||      .| ||..|.  |...  ||| | |.    |.|  . ||.|.|   
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVC-TQDEPYCMIMEYMENL

GSLEGWLEDRG---------R---------SVSQTDLIYIAHQVASGMAELARLGIVHRDLAARNVLIGRALNAKVADYG--LSRTMAIGTESEECYYRI
| |  ..  .          .         ..| . ..||. |.||||. |. . .||||||.||.|.|  ...|..| |  .|| .  .      |||.
GDLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQD-----YYRV

KT-----SRPMPVRWMAPSTIVDRKFTSESDVWSYGCLLCEMWS-AGEMPFNDLDDQQVVERLLAAYAGRVPENEPVLASPKSCPPLID-ALIQSCLTVN
       . .||.||||.  |.  |||. ||||. |  . || . . | |. .| | ||.| . . .  |   .. .|. |  ||  |   |. .| .. 
EGFTGRQRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFF--RHQGMQVYLPMPPMCPYEIYNQLMCRCWRRD

GELRPNFIVLRRRT
 . || |  . .  
QSQRPSFEEIHKFL
Kinase RTKE2.AA Frk 1028-1300 34 1.3e-53 184.14 In-house 1-260 (260) Show / Hide 
Range on Protein: 1028-1300
Range on HMM: 1-260/260
Sequence Identity: 34% (95 aa)

LTFVRKLGEGEFGEVNLMSMANQYGSTLQVAVKTLRDASLR-EDFMSEVTMMLKLHHPNLVGLLHTSQTTDGHLAMILEFMPGGSLEGWLE---DRGRSV
. ..|.|| | ||||       ..  |  ||||||.  ..  .||. |  .| || || |.  |.   | .  . .| | |  |||  .|    |.||..
IQLIRRLGSGQFGEV----WEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLI-QLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQC

SQTDLIYIAHQVASGMAELARLGIVHRDLAARNVLIGRALNAKVADYGLSRTMAIGTESEECYYRIKTSRPMPVRWMAPSTIVDRKFTSESDVWSYGCLL
  . |. .| |||.||| |     .||||||||||.|  .  |.||.|| | .      .|  |  ..   .|..| ||  .   |||  |||||.| ||
QMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMK---DNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILL

CEMWSAGEMPFNDLDDQQVVERLLAAYAGRVPENEPVLASPKSCPPLIDALIQSCLTVNGELRPNFIVLRRRTLPQV
 |.   | ||.  . ...|.. . . |  |.|.       |  ||. .  ... |  .. . || |  |. .     
TEIITYGRMPYPGMTNAEVLQMVDHGY--RMPQ-------PPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase RTKE2.AA CTKA 1028-1296 33 3.2e-51 170.27 In-house 1-290 (290) Show / Hide 
Range on Protein: 1028-1296
Range on HMM: 1-290/290
Sequence Identity: 33% (100 aa)

LTFVRKLGEGEFGEV---NLMSMAN----QYGSTLQVAVKTLRDAS---LREDFMSEVTMML--KLHHPNLVGLLHTSQTTDGHLAMILEFMPGGSLEGW
.    |.||| .|.|    ||        |      |||| |.|      |. |  |. .    ..|||| ..||    | .  . || |.|. | |   
HCIMFKIGEGHYGQVFRAWLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVC-TQHKPWHMIMEHMQYGDLHCY

LED-RGRS--------------------VSQTDLIYIAHQVASGMAELARLGIVHRDLAARNVLIGRALNAKVADYGLSRTMAIGTESEECYYRIKTSRP
|   |  .                    |.    .| | |.| ||  || .|.||||||.||.|.|.    |.|| |..||     ..|  || .  .| 
LRACRPADGQVCPARARRSIPRSFHPIEVHAHEQVYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTL----RTESQYYYVSSQRV

MPVRWMAPSTIVDRKFTSESDVWSYGCLLCEMWSAGEMPFNDLDDQQVVERLLAAYAGRVPENEPVLASPKSCPPLIDALIQSCLTVNGELRPNFIVLRR
|||||||| ..   ||.. ||||..| || |. | || |.  . || |..  ..    |       |  |..||  .  . | |.      || |  |.|
MPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAYTSHGMRR-------LPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQR

RT
  
ML
Kinase RTKE2.AA S_TKc 1028-1300 24 1.1e-47 165.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 1028-1300
Range on HMM: 1-231/231
Sequence Identity: 24% (69 aa)

LTFVRKLGEGEFGEVNLMSMANQYGSTLQVAVKTLRDASLREDFMSEVTMMLKLHHPNLVGLLHTSQTTDGHLAMILEFMPG--GSLEGWLEDRGRS---
 ...||.|.| ||.| .    .   .  .||.| ..     |....|. .. | ||||.| |. . |.  .|| |..|...|  |.|   ...|||    
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VSQTDLIYIAHQVASGMAELARLGIVHRDLAARNVLIGRALNAKVADYGLSRTMAIGTESEECYYRIKTSRPMPVRWMAPSTIVDRKFTS-ESDVWSY
   .  .  ....|...... . ..||.||||   |.|. .  . |..| ||.| .              |.      .|||  .   ...  ..|.|| 
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GCLLCEMWSAGEMPFNDLDDQQVVERLLAAYAGRVPENEPVLASPKSCPPLIDALIQSCLTVNGELRPNFIVLRRRT-----LPQV
||.| || . |. ||   ..|.. ....                    |...| .|. ||... | ||    . ..       | .
GCILYEMLC-GYPPFP--QMQMMFKKIG-------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RTKE2.AA Abl 1028-1296 33 1.2e-46 153.41 In-house 1-252 (252) Show / Hide 
Range on Protein: 1028-1296
Range on HMM: 1-252/252
Sequence Identity: 33% (91 aa)

LTFVRKLGEGEFGEVNLMSMANQYGSTLQVAVKTLRDASLR-EDFMSEVTMMLKLHHPNLVGLLHTSQTTDGHLAMILEFMPGGSLEGWLEDRGRS-VSQ
..   ||| | .|||   ..  ... |  ||||||.. ... ..|. |  .| ...||||| ||    | .    .| |||. | |  .| . .|. .. 
IMMKHKLGGGQYGEV-YEGVWKRHDCT--VAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVC-TREPPFYIITEFMCYGNLLDYLRECDREELPA

TDLIYIAHQVASGMAELARLGIVHRDLAARNVLIGRALNAKVADYGLSRTMAIGTESEECYYRIKTSRPMPVRWMAPSTIVDRKFTSESDVWSYGCLLCE
  |.|.| |.||||  | .   .|||||||| |.|     ||||.||.| |      ..  |  .     |..| ||  .   || | |||| .| || |
VVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMM------KDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWE

MWSAGEMPFNDLDDQQVVERLLAAYAGRVPENEPVLASPKSCPPLIDALIQSCLTVNGELRPNFIVLRRRT
.   |  |.  .| ..| ..|   |          .  |. ||| .  |.. |   .   || |  . ...
IATYGMSPYPGIDLSHVYHKLEKGYR---------MERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase RTKE2.AA TKL 1034-1296 20 1.1e-42 148.11 In-house 1-364 (364) Show / Hide 
Range on Protein: 1034-1296
Range on HMM: 1-364/364
Sequence Identity: 20% (76 aa)

LGEGEFGEVNLMSMANQYGST------LQVAVKTLRDAS-----------------------------LREDFMSEVTMMLKLHHPNLVGLLHTSQTTDG
.|.| ||||      .. |          ||||...  .                             .|. .  |. ||..|.|||.| ..  ..  ..
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

------------HLAMILEFMPGGSLEGWLEDRGRSVSQTDLIYIAHQVASGMAELARLG--------IVHRDLAARNVLIGRALN--------------
            .|... |..|||||.  |           .. .|...|.||. |   .        |.||||  .|.|. . ..              
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AKVADYGLSRTMAIGTESEEC-----------YYRIKTSRPM-PVRWMAPSTIVDR----------------KFTSESDVWSYGCLLCEMWSAGEMPFND
.|..|.||||.|   ....              .| .|...    |||||  . .                 ...  .||.|.| .|.|. .  . |. |
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYYD

LDDQQVV-------ERLLAAYAGRVPENEPVLAS------PKSCPPLIDALIQSCLTVNGELRPNFIVLRRRT
..  ...       .  .... |. |.  |.  .      ...||| .  |.| |   . | ||.|  .  | 
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase RTKE2.AA Pkinase 1028-1247 25 6.4e-35 124.55 Pfam 1-231 (293) Show / Hide 
Range on Protein: 1028-1247
Range on HMM: 1-231/293
Sequence Identity: 25% (61 aa)

LTFVRKLGEGEFGEVNLMSMANQYGSTLQVAVKTLRDASLREDFM------SEVTMMLKLHHPNLVGLLHTSQTTDGHLAMILEFMPGG----SLEGWLE
....||.|.| ||.| .    .      .||||...  . ....       ||. .|..|.||| | |... .. ..|. |..|...||    .|  ...
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIS

-DRGRSV--SQTDLIYIAHQVASGMAELARLGIVHRDLAARNVLIGRALNA----KVADYGLSRTMAIGTESEECYYRIKTSRPMPVRWMAPSTIV-DRK
 .|....  |  ... .. |...|.. . . ||.||||   |.|| .  .     |..| ||.. .   . . . .. .  ..    ..|||  |  ...
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTP----WYMAPEVIRGGQY

FTSESDVWSYGCLLCEMWSAGEMPFNDL------DDQQVVERLL
 ....|.||.||.| || . |. || .       |..|...| .
YGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIM