Gene RTKE3 (M.brevicollis)

RTKE3

Species: M.brevicollis
Alias: RTKE3
External Links:
Annotation:

Classification

Group: TK
Family: RTKE

Sequence

Name Sequence Type Origin Length Description Download
RTKE3.AA Protein None 1214 None Fasta, JSON
RTKE3.kin_dom Protein Kinase Domain None 272 None Fasta, JSON
RTKE3.kin_dom2 Protein Kinase Domain None 215 None Fasta, JSON

Protein domain

Protein domains of RTKE3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ldl_recept_a RTKE3.AA Ldl_recept_a 298-316 47 5.2e-05 18.05 Pfam 21-41 (41) Show / Hide 
Range on Protein: 298-316
Range on HMM: 21-41/41
Sequence Identity: 47% (10 aa)

HQFCDGYRHCADGSDE--FMC
.. ||| . |.|||||    |
SWVCDGDPDCHDGSDEWPENC
LDLa RTKE3.AA LDLa 280-318 26 0.000237 13.01 SMART 1-47 (47) Show / Hide 
Range on Protein: 280-318
Range on HMM: 1-47/47
Sequence Identity: 26% (13 aa)

ANRAP----APCLNDRSVTFETHQFCDGYRHCADGSDE------FMCEP
  ..       | | |      .. |||.  |.|||||        |..
TCPPDHPNQFQCGNGR--CIPKSWVCDGDNDCGDGSDEWPFFDPENCPQ
Kinase RTKE3.AA RTKE 479-712 33 1.8e-117 396.54 In-house 58-293 (293) Show / Hide 
Range on Protein: 479-712
Range on HMM: 58-293/293
Sequence Identity: 33% (84 aa)

AFRNRRRLNCLHQHRHILNFAGYSTMKDGFILIYDMSNYTQLADVLRLD--APNPKESALICQRQVAEACSFLDSLGIVHRNLGAHSVFCVGDITEVRLA
.|   ... |. .|...........||..|...|......||.|.|. .  .|...|....|..|||...|||..||||||.|.||.|.|......|..|
EFVQEMTMMCKLHHPNVVHLLHVVQMKQHFMMVYEYMPGGQLEDWLQDHHGRPTSHEDQIHCLHQVACGMSFLERLGIVHRDLCAHNVYCCRCWNDVKVA

NITTARDVYLSQEYVARTIVNEATMASATAMGSSDTHDEFSKQLAKRFWSAEVWSDQIFSTKSDVYAYGQLCWQVYNKGQLPYPGMSLQSIALHVQQGTP
.....||.||.|||..............|..|            ..|.|..|||.||.||.||||.|||.|||.|.|.||.||..|. |.......|...
DYGLSRDMYLGQEYMQCYYRIKTRRWMPTTWG------------SRRWWAPEVWKDQHFSFKSDVWAYGCLCWEVWNNGQMPYAHMDDQQFMQRIVQCQM

P------------SVRAIPSEHARRLILQCLRIKPESRPNFACVAFEV
|            .........|.||. .||.|.||.|||||  ..  
PSGGHLGDHEPVHAPPVHCPPWADRLMQWCLCINPEHRPNFAQLYQMW
Kinase RTKE3.AA TK 489-712 14 7.8e-33 106.83 In-house 99-486 (486) Show / Hide 
Range on Protein: 489-712
Range on HMM: 99-486/486
Sequence Identity: 14% (55 aa)

LHQHRHILNFAGYSTMKDG------------FILIYDMSNYTQ----LADVLRLDAPNPKESALI-----------------------------------
| .| .|... |..| ...            ....  . ..      | | ||   |. ....                                     
LGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQ

----------------------------------------CQRQVAEACSFLDSL------GIVHRNLGAHSVFCVGDIT----------EVRLANIT--
                                        . .|.|.....| |.      ..|||.| |. .    . .           ...|     
DYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------TARDVYLSQEYVARTIVNEATMASA----TAMGSSDTHDEFSKQLAKRFWSAEVWSDQI---------FSTKSDVYAYGQLCWQVYNKG-QLPY
       |||.| ...|....    ....       . ... .... . .|  |  . |.. |..         |.|||||...| |.| ..  | . .|
RQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDP-WQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYY

PGMSL---------QSIALHVQQG--------------TPPSV-RAIPS-------------EHARRLILQCLRIKPESRPNFACVAFEV
.|||          | .  ....|               ..      |.             |   .|..|| . .|| ||.|. .  . 
GGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RTKE3.AA UTK 486-712 22 1.7e-17 56.38 In-house 63-296 (296) Show / Hide 
Range on Protein: 486-712
Range on HMM: 63-296/296
Sequence Identity: 22% (57 aa)

LNCLHQHRHILNFAGYSTMKDGFILIYDMSNYTQLADVLRLDAPNP--------KESALICQRQVAEACSFLDSLGIVHRNLGAHSVFCVGD------IT
. ..| |...|.. |. |   ...... .     |...||  .|.|        ... | . ...|.. ..| | |.|||.| |  ..   .       .
MKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMM

EVRLANIT---TARDVY---------LSQEYVA--RTIVNEATMASATAMGSSDTHDEFSKQLAKRFWSAEVWSDQ-IFSTKSDVYAYGQLCWQVYNKGQ
 ...|.      .|.|.          |..| |  ....  . ||                         |.  ..  |.|||||...| .|| ..  |.
VCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMA------------------------PEALTHHTRFTTKSDVWSFGVVCWEIWTWGR

LPYPGMSLQSIALHVQQG---TPPSVRAIPSEHARRLILQCLRIKPESRPNFACVAFEV
||||||| . ... |  |    .|. .. | .   || ..| .  |. ||.|  .  ..
LPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVY-RLMHRCWHYDPQERPDFEDLVQQM
Kinase RTKE3.AA Fer 628-713 23 9.9e-15 46.7 In-house 188-283 (283) Show / Hide 
Range on Protein: 628-713
Range on HMM: 188-283/283
Sequence Identity: 23% (23 aa)

EVWSDQIFSTKSDVYAYGQLCWQVYNKGQLPYPG----MSLQSI-----ALHVQQGTPPSVRAIPSEHARRLIL-QCLRIKPESRPNFACVAFEVE
|.|.. |.|.|.||...| .|| ....|. ||||    | .  .     .  .. | ..       .  ..... ||   .|| ||... .  ...
ETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase RTKE3.AA Pkinase_Tyr 628-712 29 1.6e-13 46.42 Pfam 184-270 (270) Show / Hide 
Range on Protein: 628-712
Range on HMM: 184-270/270
Sequence Identity: 29% (26 aa)

EVWSDQIFSTKSDVYAYGQLCWQVYNKGQLP-YPGMSLQSIALHV-QQGTPPSVRAIPSEHARRLILQCLRIKPESRPNFACVAFEV
|.... .|.|||||...| |.| ..  |. | ||||| . .  .. ..|         ..   .|..|| . .|| || |. .  . 
ECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase RTKE3.AA Tie 634-712 32 1.1e-12 34.26 In-house 189-267 (267) Show / Hide 
Range on Protein: 634-712
Range on HMM: 189-267/267
Sequence Identity: 32% (26 aa)

IFSTKSDVYAYGQLCWQVYNKGQLPYPGMSLQSIALHVQQGTPPSVRAIPSEHARRLILQCLRIKPESRPNFACVAFEV
.. |||||..|| | |..   |  || ||    .  .. ||          .    |. || | .|  || || .| ..
VYTTKSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase RTKE3.AA Src 633-710 32 2.4e-10 31.29 In-house 175-255 (255) Show / Hide 
Range on Protein: 633-710
Range on HMM: 175-255/255
Sequence Identity: 32% (26 aa)

QIFSTKSDVYAYGQLCWQVYNKGQLPYPGMSLQSIALHVQQG-TPPSVRAIPSEHARRLILQCLRIKPESRPNFACVA--F
. |..||||  .| | . .  .|. |||||. .    .|..|   |  .  | |   ...||| . .|| || |.     .
GRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase RTKE3.AA Frk 635-716 26 3.3e-09 27.72 In-house 179-260 (260) Show / Hide 
Range on Protein: 635-716
Range on HMM: 179-260/260
Sequence Identity: 26% (22 aa)

FSTKSDVYAYGQLCWQVYNKGQLPYPGMSLQSIALHVQQGTPPSVRAIPSEHARRLILQCLRIKPESRPNFACVAFEVERCS
|..||||...| |   .   |..|||||  . .   |..|      .   ..   ..|.| . .|. || |  . . .|   
FTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase RTKE3.AA TK-Unique 628-712 28 7e-09 26.88 In-house 206-294 (294) Show / Hide 
Range on Protein: 628-712
Range on HMM: 206-294/294
Sequence Identity: 28% (25 aa)

EVWS--DQIF-STKSDVYAYGQLCWQVYNKGQLPYPGMSLQSIALHVQQGTPPSVRAIP-SEHARRLILQCLRIKPESRPNFACVAFEV
|. .  .... .|||||...| | | .   |. |||||.  .|  ....|  . ...   |.  . |. .|.. .||.||.|. .... 
ESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase RTKE3.AA TKL 635-712 20 5.4e-07 21.23 In-house 266-364 (364) Show / Hide 
Range on Protein: 635-712
Range on HMM: 266-364/364
Sequence Identity: 20% (20 aa)

FSTKSDVYAYGQLCWQVYNKGQLPYP-GMSLQSI---------ALHVQQGTPPSVRAIPSE------------HARRLILQCLRIKPESRPNFACVAFEV
.|.|.|||..| . | ..   . ||   .. . |         .. .. | .| .  |...            . ..|. .|   .||.||.| ..  . 
YSEKCDVYSFGIVLWEILTRCR-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase RTKE3.AA CTKA 635-663 44 0.000127 11.3 In-house 211-239 (290) Show / Hide 
Range on Protein: 635-663
Range on HMM: 211-239/290
Sequence Identity: 44% (13 aa)

FSTKSDVYAYGQLCWQVYNKGQLPYPGMS
||. |||.|.| | | .   | .|. .||
FSCASDVWAFGVLLWEIMSMGEKPWRHMS
Kinase RTKE3.AA Pkinase 636-708 14 0.000497 15.33 Pfam 190-287 (293) Show / Hide 
Range on Protein: 636-708
Range on HMM: 190-287/293
Sequence Identity: 14% (14 aa)

STKSDVYAYGQLCWQVYNKGQLPYPGM------SLQSIALHVQQGTPPSVRAIPS--------------------EHARRLILQCLRIKPESRPNFACV
..|.|....| ....... |..|.||       . . .   . .. ... .  ..                    | .. .|  ||. .|..||.....
GPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI
Kinase RTKE3.AA TK-Unique 541-565 40 0.001783 7.99 In-house 139-165 (294) Show / Hide 
Range on Protein: 541-565
Range on HMM: 139-165/294
Sequence Identity: 40% (11 aa)

QVAEACSFLDS--LGIVHRNLGAHSVF
|.| . ..| |   .||||.| |. |.
QIACGMEYLASQRKKIVHRDLCARNVL
Kinase RTKE3.AA TKL 478-559 15 0.002184 8.07 In-house 68-166 (364) Show / Hide 
Range on Protein: 478-559
Range on HMM: 68-166/364
Sequence Identity: 15% (17 aa)

FAFRNRRRLNCLHQ--HRHILNFAGYSTMKDG-------------FILIYDMSNYTQLADVLRLDAPNPKESALICQ--RQVAEACSFLDSLG-------
| |. .. ......  | .|. | ||..  ..             . ....      | ..|           ..|.  ...| ....| | .       
FRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKP

-IVHRNL
 |.||.|
PIIHRDL
Kinase RTKE3.AA Frk 541-594 32 0.025128 3.46 In-house 106-160 (260) Show / Hide 
Range on Protein: 541-594
Range on HMM: 106-160/260
Sequence Identity: 32% (18 aa)

QVAEACSFLDSLGIVHRNLGAHSVFCVGDITEVRLANITTARDVYLSQE--YVART
|||    .|.|   .|| | |  |  ||.   ...|    || .   .|  | .|.
QVAAGMAYLESQNYIHRDLAARNVL-VGEHNICKIADFGLARVLMKDNEDIYESRH
Kinase RTKE3.AA CTKA 540-561 36 0.066003 2.03 In-house 138-159 (290) Show / Hide 
Range on Protein: 540-561
Range on HMM: 138-159/290
Sequence Identity: 36% (8 aa)

RQVAEACSFLDSLGIVHRNLGA
.|.|   ..| ..|.||| | .
MQIAAGMNYLAEMGFVHRDLAC
Kinase RTKE3.AA Pkinase_Tyr 540-559 35 0.52914 4.02 Pfam 118-137 (270) Show / Hide 
Range on Protein: 540-559
Range on HMM: 118-137/270
Sequence Identity: 35% (7 aa)

RQVAEACSFLDSLGIVHRNL
.|.|.....| | ...|| |
WQIAKGMEYLESKNCIHRDL
Kinase RTKE3.AA RTKE 921-1188 48 9.80000000001e-168 563.54 In-house 1-293 (293) Show / Hide 
Range on Protein: 921-1188
Range on HMM: 1-293/293
Sequence Identity: 48% (144 aa)

LTFVRALGQGEFGQVSLMTLR----------------EGGSTRQVAVKLLLEAQHHKEYVAEVTMLSKMHHPNLMGLVHTTVTAEGHPGMVLEYMPQGSL
|||.||||.||||.|.|||..                ...||||||||.|.....|.|.|.|.||..|.||||...|.|...... |..||.||||.|.|
LTFMRALGSGEFGEVWLMTMPNHAHSPNYSKETISSEQQRSTRQVAVKTLHNHECHHEFVQEMTMMCKLHHPNVVHLLHVVQMKQ-HFMMVYEYMPGGQL

EGWLQAR-GTRVSHEDLLLIAHQVAMGMNELARLGIVHRDLAARNVLIGRCLN-VKVADFGLSRVMQLGRDDSDAYYRIKTRQPMP-----LRWMAPESI
|.|||.. |...||||.....||||.||..|.|||||||||.|.||...||.| |||||.||||.|.||......|||||||..||     .||.|||..
EDWLQDHHGRPTSHEDQIHCLHQVACGMSFLERLGIVHRDLCAHNVYCCRCWNDVKVADYGLSRDMYLGQEYMQCYYRIKTRRWMPTTWGSRRWWAPEVW

LSRKCDVRSDVWSYGCLCVEMWSGGELPYARLKDAEVLERLVAALQ---GHLKDGAVVLASPSRCPAGISDLIQSCLCINPELRLGFALLVQRT
........||||.|||||.|.|..|..|||...|.....|.|.. .   |||.|...|.|.|..||. ...|.|.|||||||.|  || |.|..
KDQHFSFKSDVWAYGCLCWEVWNNGQMPYAHMDDQQFMQRIVQCQMPSGGHLGDHEPVHAPPVHCPPWADRLMQWCLCINPEHRPNFAQLYQMW
Kinase RTKE3.AA TK 921-1188 20 4.5e-84 281.62 In-house 1-486 (486) Show / Hide 
Range on Protein: 921-1188
Range on HMM: 1-486/486
Sequence Identity: 20% (101 aa)

LTFVRALGQGEFG---QVSLMTLREG-----------------------GSTRQVAVKLLLE--AQHHKEYVA--------------EVTMLSKMH----
.|... ||.|.||   .| . ..|..                       | . .|||| | |  |.. .|  .              |. ....|.    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLMGLVHTTVTAE-----------GHPGMVLEYMPQGS----LEGWLQARGTR--------------------------------------------
 |||.  |.   .  |           ... .|.|||| |.    |  .|...  .                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VSHEDLLLIAHQVAMGMNELARL------GIVHRDLAARNVLIGRCLN-----------VKVADFGLSR
                               .. ..|| ...|.| ||  |...      ..|||||||||.|.|. ..           .|.|||||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

VMQ--LGRDDS-------------------------DAYYRIKTRQPMPLRWMAPESILSRK---------CDVRSDVWSYGCLCVEMWSGG-ELPYARL
..   | ||.                          ..||| ...  .|.||||||....|.         .   |||||.|.|. |... | | .|  .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

KD---------AEVLERLVAALQ----GHLKD---GAVVLASPSRCP--------------AGISDLIQSCLCINPELRLGFALLVQRT
 .         .||.|.|.. ..    | | .   .   .. |  ||              . . ||.|.|   .|| |  |. |... 
SNQDVWKDGDNQEVMEYLRRGGRLCRSG-L-NEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RTKE3.AA TyrKc 921-1188 30 2.5e-72 247.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 921-1188
Range on HMM: 1-280/280
Sequence Identity: 30% (90 aa)

LTFVRALGQGEFGQVSLMTLREGGSTRQVAVKLLLEAQHHKEYVAEVTMLSKM--HHPNLMGLVHTTVTAE------GHPGMVLEYMPQGSLEGWLQARG
.|. . || |.||.| . |..     .||||| | |   ...   |  ...|   ||||.  |.   .. .      . . .|.|||| |.|   |....
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

TRVSHEDLLLIAHQVAMGMNELARLGIVHRDLAARNVLIGRCLNVKVADFGLSRVMQLG---RDDSDAYYRI----KTRQPMPLRWMAPESILSRKCDVR
 .....||| ...|.| ||. |.. ...||||||||.|.|. . ||..||||||    .      |. |||      .. ..|.||||||.|  .|.   
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

SDVWSYGCLCVEMWSGGELPYAR-----LKDAEVLERLVAALQGHLKDGAVVLASPSR--------CPAGISDLIQSCLCINPELRLGFALLVQRT
|||||.| .. |. . |. ||       ....||.|.. .            .  |          ||. . .....|   .|| |  |. .... 
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY---------RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase RTKE3.AA Pkinase_Tyr 921-1188 32 4.2e-71 241.44 Pfam 1-270 (270) Show / Hide 
Range on Protein: 921-1188
Range on HMM: 1-270/270
Sequence Identity: 32% (91 aa)

LTFVRALGQGEFGQVSLMTLR--EGGSTRQVAVKLLLE---AQH--HKEYVAEVTMLSKM-HHPNLMGLVHTTVTAEGH--PGMVLEYMPQGSLEGWLQA
.|| . ||.|.||.| . |..  ... . .|||| | |    ..  ...  .|. ..... ||||.  |.   .  ...  . .|.|||| |.|   |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---GTRVSHEDLLLIAHQVAMGMNELARLGIVHRDLAARNVLIGRCLNVKVADFGLSRVMQLGRDDSDAYY-RIKTRQPMPLRWMAPESILSRKCDVRS
.   . .....||| ...|.|.||. |.. ...||||||||.|... . ||..||||.| .      .| || | ..  ..| .|||||.|  .|. . |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-----YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKS

DVWSYGCLCVEMWSGGELP-YARLKDAEVLERL-VAALQGHLKDGAVVLASPSRCPAGISDLIQSCLCINPELRLGFALLVQRT
||||.| |. |. . || | |. ....||.|..     .         .. |  ||. | ||...|   .|| |  |. .... 
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR---------MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase RTKE3.AA UTK 921-1188 30 1.6e-65 223.07 In-house 1-296 (296) Show / Hide 
Range on Protein: 921-1188
Range on HMM: 1-296/296
Sequence Identity: 30% (92 aa)

LTFVRALGQGEFGQVSLMTLREGG---STRQVAVKLLL---EAQHHKE---YVAEVT----MLSKMH-HPNLMGLVHTTVTAEGHPGMVLEYMPQGSLEG
. . | ||||.||.|.......      . .|||| .     ||. .|   .. | .    |... | |||...||. ..|.|. . .|.|||..|.|  
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVG-VCTQEEPWMIVTEYMENGDLRS

WLQ-------ARGTRVSHEDLLLIAHQVAMGMNELARLGIVHRDLAARNVLIGRC-------LNVKVADFG---LSRVMQ-----LGRDDSDAYYRIKTR
 |.       |... .. ...|  | ..| ||. |.. |.|||||||||.|...        . .|.||||   .|| ..       |.... ||.   .
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSN-RYWESYYYMAQHQ

QPMPLRWMAPESILSR-KCDVRSDVWSYGCLCVEMWSGGELPYARLKDAEVLERLVAALQGHLKDGAVVLASPSRCPAGISDLIQSCLCINPELRLGFAL
...|.||||||.. .. .    |||||.| .| |.|..| |||. . ...|......            ...| .||. . .| ..|   .|. |  |  
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGR-------YRMPCPWDCPHPVYRLMHRCWHYDPQERPDFED

LVQRT
|||. 
LVQQM
Kinase RTKE3.AA TK-Unique 921-1188 26 1.7e-54 186.29 In-house 1-294 (294) Show / Hide 
Range on Protein: 921-1188
Range on HMM: 1-294/294
Sequence Identity: 26% (82 aa)

LTFVRALGQGEFGQVSLMTLREGG---STR-QVAVKLLL-EAQHHK--EYVAEVTMLSKMH-HPNLMGLVHTTVTAEGHPGMVLEYMPQGSLEGWLQARG
|.. . .|.|.||||   .....    . . .||||.|  .|. ..  ..  |  |...   |||.  ..  ... .. . ...||.|.|.|.. |. ..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

TR-------------------------VSHEDLLLIAHQVAMGMNELAR--LGIVHRDLAARNVLIGRCLNVKVADFGLSR-VMQLGRDDSDAYYRIKTR
                           .| .||. .| |.|.||. ||.   .||||||.|||||... ...|..|||..| |.        .| .....
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-----NGVYSMMCSQ

QPMPLRWMAPESIL--SRKC-DVRSDVWSYGCLCVEMWSGGELPYARLKDAEVLERLVAALQGHLKDGAVVLASPSRC-PAGISDLIQSCLCINPELRLG
...|.|||||||..   . .   .|||||.|.|  |. . |. || ........|.. .          . .  |. | .  .  |..||.. .|| |  
GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDG---------YRMPQPEHCCSHEMYNLMKSCWQWEPEERPS

FALLVQRT
|. ...| 
FRQIKHRL
Kinase RTKE3.AA Src 921-1188 31 2.8e-51 172.44 In-house 1-255 (255) Show / Hide 
Range on Protein: 921-1188
Range on HMM: 1-255/255
Sequence Identity: 31% (87 aa)

LTFVRALGQGEFGQVSLMTLREGGSTRQVAVKLLLEAQ-HHKEYVAEVTMLSKMHHPNLMGLVHTTVTAEGHPGMVLEYMPQGSLEGWLQ--ARGTRVSH
....| |||| || |   . .    . .|||| | ... . . . .|   . |. |..|  | .  .. |     | ||| .|||  .|.   .| ... 
IKLCRKLGQGQFGEVWMGYWNG---NTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQL-YAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHL

EDLLLIAHQVAMGMNELARLGIVHRDLAARNVLIGRCLNVKVADFGLSRVMQLGRDDSDAYYRIKTRQPMPLRWMAPESILSRKCDVRSDVWSYGCLCVE
..|. .| ||| ||. | .  ..||||||||||.|  . .||||||| |... . ||    |  ..   .| .|.||| |. ..  . |||||.| |  |
PQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED-DD---EYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

MWSGGELPYARLKDAEVLERLVAALQGHLKDGAVVLASPSRCPAGISD-LIQSCLCINPELRLGFALLVQRT
. . |  ||   . .|||... .            .  |. ||. . . ... | .  || |  |. | .  
IVTYGRVPYPGMTNHEVLQQVERGY---------RMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase RTKE3.AA S_TKc 921-1192 22 1.4e-48 168.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 921-1192
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

LTFVRALGQGEFGQVSLMTLREGGSTRQVAVKLLLEAQHHKEYVAEVTMLSKMHHPNLMGLVHTTVTAEGHPGMVLEYMPQ--GSLEGWLQARGTR----
 ...| .|.| ||.| . . ..  . |.||.| .      .    |. .|.| ||||.  |  . ..  .|  ||.||...  |.|   .. ||..    
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-VSHEDLLLIAHQVAMGMNELARLGIVHRDLAARNVLIGRCLNVKVADFGLSRVMQLGRDDSDAYYRIKTRQPMPLRWMAPESILSRKCDV-RSDVWSYG
  .  .   ...|.. ... . ..||.||||   |.|. .  ..|..||||.|..              | .   . .|||| .   . .  ..|.|| |
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

CLCVEMWSGGELPYARLKDAEVLERLVAALQGHLKDGAVVLASPSRCPAGISDLIQSCLCINPELRLGFALLVQRT-----RPEV
|.  || . |. |.    .........                    .    |.|. ||. .|| |..   . |.       | .
CILYEMLC-GYPPFP--QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RTKE3.AA TKL 927-1188 19 3.8e-45 156.32 In-house 1-364 (364) Show / Hide 
Range on Protein: 927-1188
Range on HMM: 1-364/364
Sequence Identity: 19% (75 aa)

LGQGEFGQVSLMTLREGG------STRQVAVKLLL----------------------------EAQHHKEYVAEVT-MLSKMHHPNLMGLVHTTVTAEG-
.|.| ||.|   ..|  |      . . |||| .                             ||.. ..   |.. |.|. .|||.  ..      .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------HPGMVLEYMPQGSLEGWLQARGTRVSHEDLLLIAHQVAMGMNELARLG--------IVHRDLAARNVLIGRCLN--------------V
           ....| ||.| |||.  |.       .. .. .|...| ||| |   .        |.||||  .|.|. . ..              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KVADFGLSRVMQLGRDDSDAYYR------------IKTRQPMPLRWMAPESILSR----------------KCDVRSDVWSYGCLCVEMWSGGELPYARL
|..||||||.|.   ...|  .              . .|   .|||||| .                   . . ..||.|.| .  |. .. . ||. .
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYYDY

KDAEVL-------ERLVAALQG-----------HLKDGAVVLASPSRCPAGISDLIQSCLCINPELRLGFALLVQRT
.  ...       .  .... |           |.     .   .. || ....|.| |   .|| |. |  ...| 
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH---K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase RTKE3.AA Frk 921-1192 31 4e-43 147.14 In-house 1-260 (260) Show / Hide 
Range on Protein: 921-1192
Range on HMM: 1-260/260
Sequence Identity: 31% (87 aa)

LTFVRALGQGEFGQVSLMTLREGGSTRQVAVKLLLE-AQHHKEYVAEVTMLSKMHHPNLMGLVHTTVTAEGHPGMVLEYMPQGSLEGWLQ---ARGTRVS
. ..| || | ||.|          |  |||| |   .   .....|  .. |. || |. | .   | |    .. | | .|||  .||    .| .. 
IQLIRRLGSGQFGEVWEGLWNN---TTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQL-YAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQ

HEDLLLIAHQVAMGMNELARLGIVHRDLAARNVLIGRCLNVKVADFGLSRVMQLGRDDSDAYYRIKTRQPMPLRWMAPESILSRKCDVRSDVWSYGCLCV
 . |. .| ||| ||  |     .||||||||||.|  . .|.||||| ||.     |    |  ..   .|..| ||| . . |  ..|||||.| |  
MQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMK---DNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLT

EMWSGGELPYARLKDAEVLERLVAALQGHLKDGAVVLASPSRCPAGISDLIQSCLCINPELRLGFALLVQRTRPEV
|.   | .||. . .||||. . .            .  |. ||  . .... |   .|. |  |  |  .     
EIITYGRMPYPGMTNAEVLQMVDHGYR---------MPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase RTKE3.AA CTKA 1024-1188 37 4.3e-41 135.73 In-house 137-290 (290) Show / Hide 
Range on Protein: 1024-1188
Range on HMM: 137-290/290
Sequence Identity: 37% (63 aa)

AHQVAMGMNELARLGIVHRDLAARNVLIGRCLNVKVADFGLSRVMQLGRDDSD-AYYRIKTRQPMPLRWMAPESILSRKCDVRSDVWSYGCLCVEMWSGG
| |.| ||| || .|.||||||.||.|.|.   .|.||||..|       ..   || .  .  || |||||| .   |    ||||..| |  |. |.|
AMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTL-----RTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMG

ELPYARLKDAEVLERLVAALQGHLKDGAVVLASPSRCPAGISDLIQSCLCINPELRLGFALLVQRT
|.|.... | ||    . |  .|   |   |  |  ||  .  . | |.   |  |  |. |    
EKPWRHMSDQEV----CQAYTSH---GMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase RTKE3.AA Pkinase 921-1182 22 2.2e-36 129.76 Pfam 1-285 (293) Show / Hide 
Range on Protein: 921-1182
Range on HMM: 1-285/293
Sequence Identity: 22% (67 aa)

LTFVRALGQGEFGQVSLMTLREGGSTRQVAVKLLLEAQHHKEYV------AEVTMLSKMHHPNLMGLVHTTVTAEGHPGMVLEYMPQG----SLEGWLQ-
....| .|.| ||.| . . .  |   .|||| .     ...        .|. .. ...|||   | ..  . ..|. ||.||.. |    .|  ... 
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST

ARGTRV--SHEDLLLIAHQVAMGMNELARLGIVHRDLAARNVLIGRCLNV----KVADFGLSRVMQLGRDDSDAYYRIKTRQPMPLRWMAPESIL-SRKC
 |....  | ...  .. |.. |.. . . ||.||||   |.|| .  ..    |..||||.....    .| .. .  |.     ..|||| |. ... 
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTP-----WYMAPEVIRGGQYY

DVRSDVWSYGCLCVEMWSGGELPYARL----KDAEVLERLVAALQGHLKDGAVVLASPS--------------RCPAGISDLIQSCLCINPELRLGFA
. ..|.||.||.. || . |..|.       . .. .....  ... |.     . |.|              . .    |.| .||| .|. |....
GPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE
Kinase RTKE3.AA Tie 1013-1188 35 2.7e-33 98.19 In-house 109-267 (267) Show / Hide 
Range on Protein: 1013-1188
Range on HMM: 109-267/267
Sequence Identity: 35% (62 aa)

TRVSHEDLLLIAHQVAMGMNELARLGIVHRDLAARNVLIGRCLNVKVADFGLSRVMQLGRDDSDAYYRIKTRQPMPLRWMAPESILSRKCDVRSDVWSYG
. .| . .|  |  || ||. |.. ...||||||||.|..  .  |.|||||||        .|  |  ||   .| |||| ||.       .|||||||
STLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSR--------GDEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYG

CLCVEMWSGGELPYARLKDAEVLERLVAALQGHLKDGAVVLASPSRCPAGISDLIQSCLCINPELRLGFALLVQRT
 |  |. | |  ||  .  ||. |.|    .         .  |  |   . ||.. |    |  |  || .. . 
VLLWEIVSLGGTPYCGMTCAELYEKLPQGYR---------MEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase RTKE3.AA Fer 995-1189 27 8.1e-32 105.71 In-house 87-283 (283) Show / Hide 
Range on Protein: 995-1189
Range on HMM: 87-283/283
Sequence Identity: 27% (56 aa)

VLEYMPQGSLEGWLQARGTR-VSHEDLLLIAHQVAMGMNELARLGIVHRDLAARNVLIGR-CLNVK--VADFGLSRVMQLGRDDSDAYYRIK-TRQPMPL
|.|....|||.  |.  . . ||  ... ...|.| ||. |   ...|||.||||.|..   ...|  ..|||.||    .  |    |. | . . .| 
VMEFCNGGSLDSYLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYD----YKMKEKACKVPI

RWMAPESILSRKCDVRSDVWSYGCLCVEMWSGGELPYAR----LKDAEVLERLVAALQGHLKDGAVVLASPSRCPAGISDLIQ-SCLCINPELRLGFALL
||.|||.. .. .   .||||.|..| |  . |. ||.     .| ..| ...... .    ..   .  |...|  |  ..  .|   .|| |  .. .
RWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWII----KKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEI

VQRTR
.|. .
CQKLK
Kinase RTKE3.AA Tie 929-1004 31 2.4e-07 17.72 In-house 1-79 (267) Show / Hide 
Range on Protein: 929-1004
Range on HMM: 1-79/267
Sequence Identity: 31% (25 aa)

QGEFGQVSLMTLREGGSTRQVAVKLLLEA---QHHKEYVAEVTMLSKM-HHPNLMGLVHTTVTAEGHPGMVLEYMPQGSL
 | ||||   ...  |   .||.| . |    . |.... |. .. |. ||||.. ||       |   . .|| | | |
EGNFGQVMKAMIKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLV-GACEHRGYLYVAIEYAPYGNL
Kinase RTKE3.AA CTKA 921-1010 26 1e-05 15.0 In-house 1-102 (290) Show / Hide 
Range on Protein: 921-1010
Range on HMM: 1-102/290
Sequence Identity: 26% (27 aa)

LTFVRALGQGEFGQVSLMTLREGGS--------TRQVAVKLLLEA---QHHKEYVAEVTMLS--KMHHPNLMGLVHTTVTAEGHPGMVLEYMPQGSLEGW
.     .| | .|||    |.             . |||| | .       ... .|. .||  ..|||| ..|.   .| .  . |. |.|. | |   
HCIMFKIGEGHYGQVFRAWLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLL-GVCTQHKPWHMIMEHMQYGDLHCY

LQA
|.|
LRA
Kinase RTKE3.AA Fer 921-952 28 0.278773 0.25 In-house 1-38 (283) Show / Hide 
Range on Protein: 921-952
Range on HMM: 1-38/283
Sequence Identity: 28% (11 aa)

LTFVRALGQGEFGQVSLMT-----LREGGST-RQVAVK
 |.   || | || | . .     ....... ..||||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVK