Gene RTKE5 (M.brevicollis)

RTKE5

Species: M.brevicollis
Alias: RTKE5
External Links:
Annotation:

Classification

Group: TK
Family: RTKE

Sequence

Name Sequence Type Origin Length Description Download
RTKE5.AA Protein None 1915 None Fasta, JSON
RTKE5.kin_dom Protein Kinase Domain None 284 None Fasta, JSON
RTKE5.kin_dom2 Protein Kinase Domain None 89 None Fasta, JSON

Protein domain

Protein domains of RTKE5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
TNFR_c6 RTKE5.AA TNFR_c6 496-534 30 0.001081 16.05 Pfam 1-41 (41) Show / Hide 
Range on Protein: 496-534
Range on HMM: 1-41/41
Sequence Identity: 30% (13 aa)

CAVG-TFSDAPGA-TSCNTCDSCGT-GEYVARGCILTENVIC
|. | |..| ..    |. | .|   |.|. . |  |.|  |
CPPGKTYTD-WNHVPHCLSCTRCHPMGQYMVQPCTWTQNTVC
TNFR_c6 RTKE5.AA TNFR_c6 536-558 37 0.082957 9.61 Pfam 18-41 (41) Show / Hide 
Range on Protein: 536-558
Range on HMM: 18-41/41
Sequence Identity: 37% (9 aa)

SCSSCAE-GDPVVTACTAYADTLC
||..| . |  .|  ||.  .| |
SCTRCHPMGQYMVQPCTWTQNTVC
Kinase RTKE5.AA RTKE 965-1100 25 7e-47 157.98 In-house 160-293 (293) Show / Hide 
Range on Protein: 965-1100
Range on HMM: 160-293/293
Sequence Identity: 25% (41 aa)

AMARDVYETQSYIQTN-----KLNRD---GADKMDTWADGVGSSLGLLGATQAEKLRFLSPEALDDNHFSSSSDVFAFGVLLWEVLLAETM-FKGESRPR
...||.| .| |.|..     ..  .   |                         .|...||...|.|||..|||.|.|.|.|||.....| ........
GLSRDMYLGQEYMQCYYRIKTRRWMPTTWG------------------------SRRWWAPEVWKDQHFSFKSDVWAYGCLCWEVWNNGQMPYAHMDDQQ

IAQRIRTHNMP------------ALPVKYSTFAD-VYSHLVDRVPARRPSFDNLYFML
..|||....||            |.||.....|| .........|..||.|..||.|.
FMQRIVQCQMPSGGHLGDHEPVHAPPVHCPPWADRLMQWCLCINPEHRPNFAQLYQMW
Kinase RTKE5.AA TK 1012-1100 20 2.9e-18 57.1 In-house 349-486 (486) Show / Hide 
Range on Protein: 1012-1100
Range on HMM: 349-486/486
Sequence Identity: 20% (28 aa)

LRFLSPEALDDNH---------FSSSSDVFAFGVLLWEVL-LAETMFKG-ESR---------PRIAQRIRT---------------HNMPALPVKY----
.| ..||.|.|..         |.. |||..||||.||.. ...... |  |            . ...|.               . ||. |       
IRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMR

----------STFADVYSHLVDRVPARRPSFDNLYFML
            ..|.     .. |..||.|. |. .|
YRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RTKE5.AA CTKA 1013-1100 37 9.2e-16 49.31 In-house 199-290 (290) Show / Hide 
Range on Protein: 1013-1100
Range on HMM: 199-290/290
Sequence Identity: 37% (35 aa)

RFLSPEALDDNHFSSSSDVFAFGVLLWEVL-LAETMFKGESRPRIAQRIRTHNMPALPVKYSTFADVYSHLVDR----VPARRPSFDNLYFML
|  .||||  . ||. |||.||||||||..  .|. . . |   . | .  | | .|||  .  ..|  |.        |. ||.|  |  ||
RWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAYTSHGMRRLPVPRNC-PQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase RTKE5.AA UTK 1016-1042 46 5.5e-12 37.31 In-house 207-234 (296) Show / Hide 
Range on Protein: 1016-1042
Range on HMM: 207-234/296
Sequence Identity: 46% (13 aa)

SPEALDDN-HFSSSSDVFAFGVLLWEVL
.||||... .|...|||..|||..||..
APEALTHHTRFTTKSDVWSFGVVCWEIW
Kinase RTKE5.AA RTKC 1016-1042 59 7.5e-11 31.92 In-house 175-201 (261) Show / Hide 
Range on Protein: 1016-1042
Range on HMM: 175-201/261
Sequence Identity: 59% (16 aa)

SPEALDDNHFSSSSDVFAFGVLLWEVL
.||||||. || .||| |||.|. |..
APEALDDRKFSEKSDVWAFGILMYEIY
Kinase RTKE5.AA Fer 1013-1101 19 1e-10 32.83 In-house 183-283 (283) Show / Hide 
Range on Protein: 1013-1101
Range on HMM: 183-283/283
Sequence Identity: 19% (20 aa)

RFLSPEALDDNHFSSSSDVFAFGVLLWEVLL-AETMFKG--------ESR-PRIAQRIRTHNMPALP-VKYSTFADVYS-HLVDRVPARRPSFDNLYFML
| |.||....  .|. .||..|||..||.   ... . |        . . ..... |.  .|. .|    .... .   .  .. |  ||... .. .|
RWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKL

L
 
K
Kinase RTKE5.AA TKL 1012-1100 18 1.6e-10 34.08 In-house 237-364 (364) Show / Hide 
Range on Protein: 1012-1100
Range on HMM: 237-364/364
Sequence Identity: 18% (24 aa)

LRFLSPEALDDN----------------HFSSSSDVFAFGVLLWEVLLAETMFK-GESRPRI---------AQRIRTHNMPALP------------VKY-
.|...||.|...                 .| ..||..||..|||.|  .. ..   ..|.|         ....   . | .|                
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCP

STFADVYSHLVDRVPARRPSFDNLYFML
  ...   .  |  |  ||||. .   |
PSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase RTKE5.AA TK-Unique 1008-1042 34 2.7e-10 31.81 In-house 196-233 (294) Show / Hide 
Range on Protein: 1008-1042
Range on HMM: 196-233/294
Sequence Identity: 34% (13 aa)

QAEKLRFLSPEALD--DNHF-SSSSDVFAFGVLLWEVL
.   .| ..||.|   .... .. ||| .||||.||..
GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIF
Kinase RTKE5.AA Pkinase_Tyr 1015-1042 42 8e-10 33.89 Pfam 181-208 (270) Show / Hide 
Range on Protein: 1015-1042
Range on HMM: 181-208/270
Sequence Identity: 42% (12 aa)

LSPEALDDNHFSSSSDVFAFGVLLWEVL
..||.. .. |.. ||| .||||.||..
MAPECINYGKFTTKSDVWSFGVLMWEIF
Kinase RTKE5.AA Eph 1017-1042 46 4.8e-08 22.98 In-house 179-204 (264) Show / Hide 
Range on Protein: 1017-1042
Range on HMM: 179-204/264
Sequence Identity: 46% (12 aa)

PEALDDNHFSSSSDVFAFGVLLWEVL
|||.   .|.|.|||  .|...|||.
PEAIAYRKFTSASDVWSYGIVMWEVM
Kinase RTKE5.AA Pkinase 1012-1100 12 6.4e-07 25.56 Pfam 175-293 (293) Show / Hide 
Range on Protein: 1012-1100
Range on HMM: 175-293/293
Sequence Identity: 12% (15 aa)

LRFLSPEALD-DNHFSSSSDVFAFGVLLWEVLLAETMFKGE-------SRPRIAQRIRTHNMPALPVKY--------------------STFADVYSHLV
.....|| .  ... ....|....|..|.|.|. .. |.|.        . .|... .. ..   | ..                    ... |. . . 
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

DRVPARRPSFDNLYFM--L
.. |..||... .     .
CKDPKKRPTAEQILQHPWF
Kinase RTKE5.AA Src 1017-1041 48 1.1e-05 15.28 In-house 169-193 (255) Show / Hide 
Range on Protein: 1017-1041
Range on HMM: 169-193/255
Sequence Identity: 48% (12 aa)

PEALDDNHFSSSSDVFAFGVLLWEV
|||.. ..|.  |||  ||.||.|.
PEAINYGRFTIKSDVWSFGILLTEI
Kinase RTKE5.AA Src 1083-1100 33 0.016555 4.28 In-house 238-255 (255) Show / Hide 
Range on Protein: 1083-1100
Range on HMM: 238-255/255
Sequence Identity: 33% (6 aa)

VDRVPARRPSFDNLYFML
... | .|| |. |.  |
WHKDPEQRPTFEYLQWFL
Kinase RTKE5.AA RTKC 1087-1100 35 0.063144 2.0 In-house 248-261 (261) Show / Hide 
Range on Protein: 1087-1100
Range on HMM: 248-261/261
Sequence Identity: 35% (5 aa)

PARRPSFDNLYFML
|. ||.|. . . |
PHDRPTFSEVVHWL
Kinase RTKE5.AA TK-Unique 1085-1100 37 0.192945 0.88 In-house 279-294 (294) Show / Hide 
Range on Protein: 1085-1100
Range on HMM: 279-294/294
Sequence Identity: 37% (6 aa)

RVPARRPSFDNLYFML
..|  ||||. . ..|
WEPEERPSFRQIKHRL
Kinase RTKE5.AA Pkinase_Tyr 1087-1100 35 0.64446 3.73 Pfam 257-270 (270) Show / Hide 
Range on Protein: 1087-1100
Range on HMM: 257-270/270
Sequence Identity: 35% (5 aa)

PARRPSFDNLYFML
|..||.|  .. .|
PEDRPTFSEIHEQL
Kinase RTKE5.AA RTKE 1352-1637 49 1.5e-179 602.82 In-house 1-293 (293) Show / Hide 
Range on Protein: 1352-1637
Range on HMM: 1-293/293
Sequence Identity: 49% (146 aa)

LQFVRVLGSGQFGEVWLASMPAHAHSSPNYSSKETAAATSKREVMLVAVKRLLNDECLHEFEQELAIMMKIRHANLVRMLFVVQEKQHRALVLEYLDGGA
|.|.|.||||.||||||..||.||| |||| ||||......|....||||.|.|.||.|||.||...|.|..|.|.|..|.|||.|||...|.||..||.
LTFMRALGSGEFGEVWLMTMPNHAH-SPNY-SKETISSEQQRSTRQVAVKTLHNHECHHEFVQEMTMMCKLHHPNVVHLLHVVQMKQHFMMVYEYMPGGQ

LDSWLQGQ-SKPPSEERTRHILHSIACGMLELQRLGMVHRDLAARNVLCDAQMQVVKVADYGLSRSTRVGKDDEQAYYKFKTRRPMP-----VRWMAPEV
|..|||.. ..|.|.|...|.||..||||..|.|||.|||||.|.||.|......||||||||||....|....|.||..||||.||     .||.||||
LEDWLQDHHGRPTSHEDQIHCLHQVACGMSFLERLGIVHRDLCAHNVYCCRCWNDVKVADYGLSRDMYLGQEYMQCYYRIKTRRWMPTTWGSRRWWAPEV

LKTQKFTVATDVFSFGVLVGEVLTQAELPLAHLNDESLMLRITDCVK-SGGYGG--RPLHAPPVKAPAWVSQIMVDCTLFDAAARPDFADLVVRL
.|.|.|....||...|.|..||......|.||..|...|.||..|.. |||..|  .|.|||||..|.|....|..|. .....||.||.|....
WKDQHFSFKSDVWAYGCLCWEVWNNGQMPYAHMDDQQFMQRIVQCQMPSGGHLGDHEPVHAPPVHCPPWADRLMQWCLCINPEHRPNFAQLYQMW
Kinase RTKE5.AA TK 1352-1637 19 1.1e-80 270.12 In-house 1-486 (486) Show / Hide 
Range on Protein: 1352-1637
Range on HMM: 1-486/486
Sequence Identity: 19% (93 aa)

LQFVRVLGSGQFG---EVWLASMPAHAHSSPNYSSKETAAA------TSKREVMLVAVKRLL--NDECLHEFEQ--------------ELAIMMKIR---
......||.||||   ||... .  .  . ........          .. ... |||| |   ...   ||..              |...|.. .   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMT-VTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSL

--HANLVRMLFVVQEK------------QHRALVLEYLDGGA----LDSWLQGQSKPPSE----------------------------------------
  | |.||.. |. ..            ..  .|.|| ..|     |...|.  ... ..                                        
GHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

-----------ERTRHILHS-----------------------IACGMLELQRL------GMVHRDLAARNVLCDAQMQ----------VVKVADYGLS-
           . | . |..                       |||||  | ..      ..|||||||||.| . ...          |.|.||.||| 
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----RSTRVGKDD---------------------EQAYYKFKTRRPMPVRWMAPEVLK---------TQKFTVATDVFSFGVLVGEVLTQA-ELPLAHL
     .. ....||                     .|.||. .... .|.||||||.|.         . ||| ..||.|||||. |..| . | .   .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

ND------ESLMLRITDCVKSGGY---------GGRPLHAPPVKAP--------------AWVSQIMVDCTLFDAAARPDFADLVVRL
..      .  .  . .....||          |.|   ..|. .|              . . ..| .|  .|.. ||.|..|. .|
SNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RTKE5.AA Pkinase_Tyr 1352-1637 28 2.6e-70 238.75 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1352-1637
Range on HMM: 1-270/270
Sequence Identity: 28% (87 aa)

LQFVRVLGSGQFGEVWLASMPAHAHSSPNYSSKETAAATSKREVMLVAVKRLLN----DE-CLHEFEQELAIMMKI-RHANLVRMLFVVQ-EKQH--RAL
..| ..||.|.||||... .                    . . . |||| | .    .. |. .| .|..||... .| |.||.. |.  ....    .
ITFGKKLGEGAFGEVYKGTWKG----------------DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYI

VLEYLDGGALDSWLQGQ---SKPPSEERTRHILHSIACGMLELQRLGMVHRDLAARNVLCDAQMQVVKVADYGLSRSTRVGKDDEQAYY-KFKTRRPMPV
|.||  .| |.. |. .    .|.. ..  .. . ||.||  | . ...||||||||.| . .. |||..| ||.|        .  || . ..  ..|.
VMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFGLARDI-----YNDDYYYRKRGGGKLPI

RWMAPEVLKTQKFTVATDVFSFGVLVGEVLTQAELP-LAHLNDESLMLRI-TDCVKSGGYGGRPLHAPPVKAPAWVSQIMVDCTLFDAAARPDFADLVVR
.|||||.... |||...|| |||||  |..|  | |  . . .| .. .|  |       |.|   ..| ..|. . ..| .|  .|.. || |.... .
KWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED-------GYR--MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQ

L
|
L
Kinase RTKE5.AA TyrKc 1352-1637 27 1.6e-59 204.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 1352-1637
Range on HMM: 1-280/280
Sequence Identity: 27% (87 aa)

LQFVRVLGSGQFGEVWLASMPAHAHSSPNYSSKETAAATSKREVMLVAVKRLLNDECLHEFEQELAIMMKI--RHANLVRMLFVVQEK-------QHRAL
... ..||.|.||||... .                        . |||| | .|  . .| .|. ||.|.  .| |.||.. |. ..       .   .
ITLGKKLGEGAFGEVYKGTWK-----------------------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMI

VLEYLDGGALDSWLQGQSKPPSEERTRHILHSIACGMLELQRLGMVHRDLAARNVLCDAQMQVVKVADYGLSRSTRVG---KDDEQAYYKFKT--RRP--
|.|| ..|.|.. |.   .  . .   .. . |||||  | . . .||||||||.| ...  .||..| ||||    .      .. ||. |.   .   
VMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTM

MPVRWMAPEVLKTQKFTVATDVFSFGVLVGEVLTQAELPLAH-----LNDESLMLRITDCVKSGGYGGRPLH-----APPVKAPAWVSQIMVDCTLFDAA
.|.||||||.... ||| ..||.||||.  |..|  . |        .... ..     .||.|..  .| .        | .|. . ||| .|  .|..
LPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVI----EYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWHEDPE

ARPDFADLVVRL
 || |.... ..
DRPTFSEIHECF
Kinase RTKE5.AA UTK 1352-1637 29 1.2e-55 188.89 In-house 1-296 (296) Show / Hide 
Range on Protein: 1352-1637
Range on HMM: 1-296/296
Sequence Identity: 29% (94 aa)

LQFVRVLGSGQFGEVWLASM-PAH-----AHSSPNYSSKETAAATSKR---EVMLVAVKRLLNDECLHEFEQELAIMMKIR-HANLVRML-FVVQEKQHR
.|. | ||.|.|||| .|.  ..      .. .    ... .| ....   ..|. |               ||..|.. . | |..|..  ..||..  
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEAR--------------ELQMMKQFHWHPNVLRLVGVCTQEEP-W

ALVLEYLDGGALDSWLQGQSKPPS-------EERTRHILHSIACGMLELQRLGMVHRDLAARNVLCDAQ------MQVVKVADYG---LSRSTRVGK---
..|.||  .| |.| |. ... |        ...  .    ||.||  | . | |||||||||.| ...      |.|.|.||.|   .||  ||.    
MIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSR--RVNTFHF

---DDEQAYYKFKTRRPMPVRWMAPEVLKTQ-KFTVATDVFSFGVLVGEVLTQAELPLAHLNDESLMLRITDCVKSGGYGGRPLHAPPVKAPAWVSQIMV
   ..|. ||.   ....|.||||||.|  . .|| ..||.||||.. |..| . || ...... . .....       ||| ....|   |. | ..|.
SNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCN-------GGRYRMPCPWDCPHPVYRLMH

DCTLFDAAARPDFADLVVRL
.|   | . |||| ||| ..
RCWHYDPQERPDFEDLVQQM
Kinase RTKE5.AA TKL 1358-1637 19 1.1e-42 148.1 In-house 1-364 (364) Show / Hide 
Range on Protein: 1358-1637
Range on HMM: 1-364/364
Sequence Identity: 19% (75 aa)

LGSGQFGEVWLASMPAHA---HSSPNYSSKETAAATSKREVMLVAVKRLLNDECL-----------------------------HEFEQELAIMMKIRHA
.||| ||||. .    .                   | .    ||||..  ...                               ..|.|. .| ..|| 
IGSGGFGEVYKGKWRGWGGKCP--------------S-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHP

NLVRMLFVVQEKQH-------------RALVLEYLDGGALDSWLQGQSKPPSEERTRHILHSIACGMLELQRLG--------MVHRDLAARNVLCDAQMQ
|.|... .... ..              ..| || .|| | . |.        ... .. ..||.||  |   .        ..||||  .|.| |  ..
NIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWT

V-------------VKVADYGLSRSTRVGKDDEQA-----------YYKFKTRRPM-PVRWMAPEVLKTQ----------------KFTVATDVFSFGVL
.             .|..|.||||.    ....              .. .| ..    ||||||||. |                ... ..||.|||..
NVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIV

VGEVLTQAELPLAHLNDESLMLR--ITDCVKSGGYGGRPLHAP-----------PVKAPAWVSQIMVDCTLFDAAARPDFADLVVRL
  |.||  . | .... .. ...  . .  .  .. |...  |           .  .|  ....| ||   |. .|| | ... ||
LWEILTRCR-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase RTKE5.AA S_TKc 1352-1641 20 9.4e-40 139.31 SMART 1-231 (231) Show / Hide 
Range on Protein: 1352-1641
Range on HMM: 1-231/231
Sequence Identity: 20% (61 aa)

LQFVRVLGSGQFGEVWLASMPAHAHSSPNYSSKETAAATSKREVMLVAVKRLLNDECLHEFEQELAIMMKIRHANLVRMLFVVQEKQHRALVLEYLDG--
 ...|..|.| ||.|...                           .||.|..        ...|..|..| .| |.|... | |. .|  .|.||.||  
YEILRKIGKGAFGKVYKCRHKK--------------------TGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDL

GALDSWLQGQSKPP-----SEERTRHILHSIACGMLELQRLGMVHRDLAARNVLCDAQMQVVKVADYGLSRSTRVGKDDEQAYYKFKTRRPMPVRWMAPE
| | . .. . ...     .| ..|.... |.|..  . ..| .||||   |.|.|    ..|..| ||.|                |       .||||
GDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL--------------TTFCGTPWYMAPE

VLKTQKFTV-ATDVFSFGVLVGEVLTQAELPLAHLNDESLMLRITDCVKSGGYGGRPLHAPPVKAPAWVSQIMVDCTLFDAAARPDFADLVV-----RLS
||   ...  . |. |.|... | |.  . |     .. .|...                     .  . ...  |  .| . ||   ..       .. 
VL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

PFT
|. 
PWF
Kinase RTKE5.AA CTKA 1475-1637 38 1.1e-37 124.1 In-house 140-290 (290) Show / Hide 
Range on Protein: 1475-1637
Range on HMM: 140-290/290
Sequence Identity: 38% (63 aa)

IACGMLELQRLGMVHRDLAARNVLCDAQMQVVKVADYGLSRSTRVGKDDEQAYYKFKTRRPMPVRWMAPEVLKTQKFTVATDVFSFGVLVGEVLTQAELP
|| ||  |  .|.||||||.||.|   |  ..|.|| |..|      . |  ||    .| ||||||||| |.. ||. | ||..||||. |... .|.|
IAAGMNYLAEMGFVHRDLACRNCLL-GQYCHIKIADFGHGRT----LRTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKP

LAHLNDESLMLRITDCVKSGGYGGRPLHAPPVKAPAWVSQIMVDCTLFDAAARPDFADLVVRL
 .|. |    . .   . |.|   | |  .|  .|  .   |  |  |  ..|| |. |   |
WRHMSD----QEVCQAYTSHGM--RRLP-VPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase RTKE5.AA TK-Unique 1352-1569 27 5.4e-35 118.15 In-house 1-234 (294) Show / Hide 
Range on Protein: 1352-1569
Range on HMM: 1-234/294
Sequence Identity: 27% (69 aa)

LQFVRVLGSGQFGEVWLASMPAHAHSSPNYSSKETAAATSKR-EVMLVAVKRLLNDECLHEFEQELAIMMKIR-HANLVRMLFVVQEKQ-HRALVLEYLD
| . .|.|.|.||.|| . .                .  .|.  | ....|. ..|.   .| .|...|...  | |.|..| . ....    ...||. 
LEVGDVIGEGAFGQVWRGEVWGIW------------KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCP

GGALDSWLQ----GQSKP-------------PSEERTR--------HILHSIACGMLELQRLGM--VHRDLAARNVLCDAQMQVVKVADYGLSRSTRVGK
.| |.. |.    ... .             |.. ||         |..  |||||  |... .  |||||.|||||      |.|..|.|..| ..   
CGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE-DKVCKICDFGMARDVYT--

DDEQAYYKFKTRRPMPVRWMAPEVLK--TQKF-TVATDVFSFGVLVGEVLT
  ...| . ... ..|.||||||.||  .. . |  .|| |||||  |..|
--NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase RTKE5.AA Fer 1352-1638 26 1.7e-34 114.95 In-house 1-283 (283) Show / Hide 
Range on Protein: 1352-1638
Range on HMM: 1-283/283
Sequence Identity: 26% (82 aa)

LQFVRVLGSGQFGEVWLASMPAHAHSSPNYSSKETAAATSKREVML------------VAVKRL----LNDECLHEFEQELAIMMK-IRHANLVRMLFVV
  .  .||.| ||||...                      . ....            |.||..    ...| . || .|  ||..   | | |.   | 
VTLGKKLGEGAFGEVYKGR---------------------R-TLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVC

QEKQHRALVLEYLDGGALDSWLQGQSK--PPSEERTRHILHSIACGMLELQRLGMVHRDLAARNVLCDAQMQVVK--VADYGLSRSTRVGKDDEQAYYKF
. .|   .|.|. .||.||| |.  ..   .  |. | ... .||||  |   ...|||.||||.| ..   ..|  ..| |.|| ..... |    || 
VDEQPIMIVMEFCNGGSLDSYLKKNKNKTVSDNEKIR-MCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYD----YKM

K-TRRPMPVRWMAPEVLKTQKFTVATDVFSFGVLVGEVLTQAE-LPLA--HLNDESLMLRIT--DCVKSGGYGGRPLHAPPVKAPAWVSQIMV-DCTLFD
| . . .|.||.|||...|  .. .|||.||||.  |. | ..  ...  |     . .  .  ...|    .|.. . .|  .|  . |||  .|   |
KEKACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPH-G---MKMTNVKKQARKWIIKKGYM-MPMPNHMPPEIMQIMMKQCWQKD

AAARPDFADLVVRLS
   || ..... .| 
PEDRPTMKEICQKLK
Kinase RTKE5.AA Src 1398-1569 36 4e-32 106.4 In-house 26-195 (255) Show / Hide 
Range on Protein: 1398-1569
Range on HMM: 26-195/255
Sequence Identity: 36% (64 aa)

VAVKRLLNDE-CLHEFEQELAIMMKIRHANLVRMLFVVQEKQHRALVLEYLDGGALDSWLQ--GQSKPPSEERTRHILHSIACGMLELQRLGMVHRDLAA
|||| |  .    . | ||  || | || .||... |. ..     | ||   | |  .|.  |. .  . ..   .   .| ||  | .  ..||||||
VAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAA

RNVLCDAQMQVVKVADYGLSRSTRVGKDDEQAYYKFKTRRPMPVRWMAPEVLKTQKFTVATDVFSFGVLVGEVLT
|||| . .  |.|||| || | . .. |||   |  ..   .|..|.||| .  ..||. .|| |||.|  |. |
RNVLVGENN-VCKVADFGLARLIKED-DDE---YCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVT
Kinase RTKE5.AA Eph 1352-1569 32 3.1e-31 102.09 In-house 1-205 (264) Show / Hide 
Range on Protein: 1352-1569
Range on HMM: 1-205/264
Sequence Identity: 32% (72 aa)

LQFVRVLGSGQFGEVWLASMPAHAHSSPNYSSKETAAATSKREVMLVAVKRL---LNDECLHEFEQELAIMMKIRHANLVRMLFVVQEKQHRALVLEYLD
..  .|.|.|.||||    . .       . .             .||.| |     .    .|  | .||    | | .|   ||   .    | || .
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVD-------------PVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYME

GGALDSWLQGQSKPPSEERTRHILHSIACGMLELQRLGMVHRDLAARNVLCDAQMQVVKVADYGLSRSTRVGKDDE--QAYYKFKTRRPMPVRWMAPEVL
 |.|||.|  .    .  .   .|  || ||  |  .. |||||||||.| ...  | ||.|.||||  .   ||.   | |  .  .  |.|| |||..
NGSLDSFLRQHDGQFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNL-VCKVSDFGLSRVLE---DDPSVEATYTTRGGK-IPIRWTAPEAI

KTQKFTVATDVFSFGVLVGEVLT
   ||| | || |.|... ||..
AYRKFTSASDVWSYGIVMWEVMS
Kinase RTKE5.AA Pkinase 1352-1590 22 9.7e-30 106.23 Pfam 1-233 (293) Show / Hide 
Range on Protein: 1352-1590
Range on HMM: 1-233/293
Sequence Identity: 22% (59 aa)

LQFVRVLGSGQFGEVWLASMPAHAHSSPNYSSKETAAATSKREVMLVAVKRLLNDECLHEFEQ------ELAIMMKIRHANLVRMLFVVQEKQHRALVLE
....|..||| ||.|...      .                    .||||..  ..  ....|      |..|| ...| | ||.. ....|.|  .|.|
YHIGRKIGSGSFGCVYKCHHKGTGK--------------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVME

YLDGG----ALDSWLQ-GQSKPP--SEERTRHILHSIACGMLELQRLGMVHRDLAARNVLCDAQMQV---VKVADYGLSRSTRVGKDDEQAYYKFKTRRP
|..||     | ....  ....   ||.  ....  |..|.  . . | .||||   |.|.| ....   ||..| ||..  .         |  ..   
YCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---------Y-NNS-MT

MPV---RWMAPEVLK-TQKFTVATDVFSFGVLVGEVLTQAELPLAHL------NDESLMLRITDC
 ..   ..|||||..  |. . . |..|.|... |.|.  ..|  .       ..  .. || ..
TFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGP
Kinase RTKE5.AA RTKC 1443-1574 39 1.1e-28 91.72 In-house 79-207 (261) Show / Hide 
Range on Protein: 1443-1574
Range on HMM: 79-207/261
Sequence Identity: 39% (52 aa)

VLEYLDGGALDSWLQGQSKPPSEERTRHILHSIACGMLELQRLGMVHRDLAARNVLCDAQMQVVKVADYGLSRSTRVGKDDEQAYYKFKTRRPMPVRWMA
|||..  |.| | |    . . . . |  .  .| ||     .| .|||.|||||| .. .   |||| || |      | . |||       .|||| |
VLEFCERGSLKSYLMNNPDCTEHQKVRFCYQ-CASGMEHIHSFGFIHRDVAARNVLLSSDLT-CKVADFGLARESPCNDDSHEAYYRSRSGN-LPVRWTA

PEVLKTQKFTVATDVFSFGVLVGEVLTQAELP
|| |  .||. ..|| .||.|  |..|.||.|
PEALDDRKFSEKSDVWAFGILMYEIYTKAEMP
Kinase RTKE5.AA Src 1352-1369 55 3.5e-07 20.42 In-house 1-18 (255) Show / Hide 
Range on Protein: 1352-1369
Range on HMM: 1-18/255
Sequence Identity: 55% (10 aa)

LQFVRVLGSGQFGEVWLA
....| ||.||||||| .
IKLCRKLGQGQFGEVWMG
Kinase RTKE5.AA RTKC 1603-1637 28 3e-06 16.55 In-house 227-261 (261) Show / Hide 
Range on Protein: 1603-1637
Range on HMM: 227-261/261
Sequence Identity: 28% (10 aa)

APPVKAPAWVSQIMVDCTLFDAAARPDFADLVVRL
..| . .. |  .| || . ....||.| ..| .|
PCPEDCHKEVYDMMMDCWMHTPHDRPTFSEVVHWL
Kinase RTKE5.AA Eph 1604-1637 38 9.8e-05 11.68 In-house 231-264 (264) Show / Hide 
Range on Protein: 1604-1637
Range on HMM: 231-264/264
Sequence Identity: 38% (13 aa)

PPVKAPAWVSQIMVDCTLFDAAARPDFADLVVRL
||.  |.   |.| ||   | . || |...|  |
PPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase RTKE5.AA TK-Unique 1614-1637 29 0.004037 6.75 In-house 271-294 (294) Show / Hide 
Range on Protein: 1614-1637
Range on HMM: 271-294/294
Sequence Identity: 29% (7 aa)

QIMVDCTLFDAAARPDFADLVVRL
..|  |.  ..  ||.|.... ||
NLMKSCWQWEPEERPSFRQIKHRL
Kinase RTKE5.AA CTKA 1352-1369 27 0.013608 4.37 In-house 1-18 (290) Show / Hide 
Range on Protein: 1352-1369
Range on HMM: 1-18/290
Sequence Identity: 27% (5 aa)

LQFVRVLGSGQFGEVWLA
..    .|.|..|.|  |
HCIMFKIGEGHYGQVFRA