Gene N5 (M.brevicollis)
N5
Species: M.brevicollis
Alias: N5
External Links:
Annotation:
Sequence
Protein domains of N5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| MYSc | N5.AA | MYSc | 1-723 | 33 | 2.3e-227 | 762.53 | SMART | 1-771 (771) | Show / Hide |
Range on Protein: 1-723 Range on HMM: 1-771/771 Sequence Identity: 33% (272 aa) MSGFEQ--THDLASSESLDETRLSNALEARYGADMIYTYVGDILVAVNPYRML-PLYTPAVQRKYM-----NMLQRSAQPPHLYAIADAAYNQMSRNATP | .. ..|.. . | | . . |. || |.|||| |....|||||..| |.||| | ..|. . .|. |||..||||.||..| .. MNPPKFEGVDDMCMLTYLNEPAVLHNLKKRYMNDQIYTYIGPVCIAVNPYKQLPPIYTPDVIKQYRNRKFDDGKHRYEMPPHIFAIADNAYRNMLNDKEN QVAVISGESGAGKTESTKHFIRQIMEVSSRGVGAGAGDEDDGGERKRHPIEAKIMACNPVLEAFGNAQTVMNDNSSRFGKFVELKFNNLGQVFGASMSHY | .|||||||||||.||. .. . ||. . ..| .|...||.||||||| || |.|||||||..|. |.. | . ||....| QCIIISGESGAGKTENTKKIMQYLAAVSG----------------QVERVEQQILQSNPILEAFGNAKTVRNNNSSRFGKYMEIHFDEKGKICGAKIENY LLEKARVVSQGTGERNFHIFELLLEG-TSNNLGRYHLD----GYDNFRYLAS---------------RDEDKARLAQEWKE----VQDAFPGIGFTTDDL |||| |||.| ||||.||| |..| . . . ..||. . ....||. ... |.|.|| .. |. .||. .. LLEKSRVVYQNKGERNYHIFYQLCAGASEEQKQEFHLKPFSHNPEDYHYLNQGGHYWNNKRHQSQCFTVD-GIDDAEEFKETCEQTCNAMRVMGFSEEEQ ECVNKIIAAILLLGQLEFKEGGN--GEDAE----IVDPKPLNHAAELLGVSAEKLRVGFMTNKLVLGSE---TIYKPLNVQKSSESRDAVSKAVYDRMFE | . .|.||||.|| .||..|.| ...|. . |.. |. |.|||||..|.|. . . |.. | | .| |||||. . .||| .||.|.|.| EWIFRIVAAILHLGNIEFEQGRNQYDNQAVCSEKVKDEEELQNACELLGVDPEDLEKWLTHRKMKTGHEGGTWITKPLNVEQAIYARDALAKAIYSRLFD WLVTKIDMMLCPAEARLEDTYTIGILDIFGFEDFKNNGFDQICINLANESLHKFFNTHIFASELEEYAAEGIDGASVLFT--DNGEILNLFFDR---PDG |.| .| . ..|.||.|||.||| |..|.| | ||| .|| | .||| |.| .| ||| .|||. . |. || ....| . | | WIVKRINQSM--------HNYFIGVLDIYGFEIFEHNSFEQFCINYCNEKLQQFFNHHMFKLEQEEYQREGIEWTFIDFFMYDNQPCCDLIEKKGKRPMG LFAVLDEETNF---PSATDKTLMTKL-----EQQMERHTPFEM------------NKGGYAFAIQHYAGPITYQGTGLLDKNKDPLPNRMSESMTDASNP .|. ||||..| |..||.|.. || |....|. |. ..| ..| |.|||| .||. .|.|.||||.|. . . | .|| IFSLLDEECMFHAQPKGTDQTFLEKLNKQDYHQHHKNHPHFSKPHKSHRCCKPKKRMGRTHFIIKHYAGDVTYNVEGWLEKNKDTLFDDLIQLMQSSKNP LAQLLFKP--DFVKRTRGDAAGGDIDGAKSKKGKGKGKQGPK------KGINTVSTGFRISLEKLMERMNRCKPHFVRCIKPN---LAKXXESAMVMKQL . . ||.. | ..|... . . ...|. .| | | ||.. |. .|..||| .| | ||..|||||| .. .. .|. || FIKQLFPEYEDQTSQTPQEKSS-QGKNKSRRKKR-M-MQM-KKTCMQKKRFPTVGFQFK-QLNELMETLNSCHPHYIRCIKPNEEKKPWDFDDDLVLHQL KYTGMLQTIEIRKDGYPNRPSFKQFIDTYRGAVFDFTKPMDYTSANCTRILQK---AEEKQREVAAANKLTGKT-----AHLDKWIVAKTKVFLKYWHQD .. |.| .| ||. |.|.| .. | |. . . .| .|. .. .. .|. .| ..|.. . |.. . |||||... .| RCCGVLENIRIRRAGFPYRWPYQEFYQRYK-------MLCPPTWPNWGNPWKNQLFGDPKKACEAILQQLGE-YIQHQNWDPDMYQFGKTKVFFRNPGQL -ILDNFYRP |. .. FHLEEMRER |
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| Myosin_head | N5.AA | Myosin_head | 7-653 | 34 | 1e-204 | 691.16 | Pfam | 1-715 (765) | Show / Hide |
Range on Protein: 7-653
Range on HMM: 1-715/765
Sequence Identity: 34% (253 aa)
THDLASSESLDETRLSNALEARYG-ADMIYTYVGDILVAVNPYRMLPLYTPAVQRKYMNMLQRSAQPPHLYAIADAAYNQMSRNATPQVAVISGESGAGK
. |.. . | |. . ..|. || .|.||||.|.....||||. ||.||. . .|.. |. |||..||||.|| .| . . .| .|.|||||||
VEDMVMLTYLNEPSVLHNLKKRYMTGDLIYTYSGHFCISVNPYKQLPIYTQDMIQEYRGKH-RYEMPPHIFAIADEAYRHMRHDRENQCIIICGESGAGK
TESTKHFIRQIMEVSSRGVGAGAGDEDDGGERKRHPIEAKIMACNPVLEAFGNAQTVMNDNSSRFGKFVELKFNNLGQV----FGASMSHYLLEKARVVS
||.||. .. . ||... | . ..| .| . ||.|||||||.|. |.|||||||. |. |. |.. |. ...||||| |||
TENTKYVMQYFASVSGSNPG-----------VNMGRVEQQILQSNPILEAFGNAKTTRNNNSSRFGKYMEIHFDKTGKINPTAVGGNIENYLLEKSRVVY
QGTGERNFHIFELLLEGTSNNL--GRYHLD--GYDNFRYLASRD---EDKA----RLAQEWKEVQDAFPGIGFTTDDLECVNKIIAAILLLGQLE-FKEG
| .|||||||| || |.| . .||. . ....|| . .. |.| .....|. |||| . . . .|.||||.||... ||..
QTPGERNFHIFYQLLAGASQQEEKKELHLTSADPKDYHYLNQSGTNPCYTVDDGIDDAEEFQHTRNAMDIIGFTHEEQRSIFRIVAAILHLGNMKGFKQD
GNGEDAEIVDPKP-LNHAAELLGVSAEKLRVGFMTNKLVLG----SETIYKPLNVQKSSESRDAVSKAVYDRMFEWLVTKIDMMLCPAE-----------
.|.| |.. | . .. ..||.||..|... .... ... | .|.. ||.|..... .|||..|| |.||| |.|..| . .| .
QNEEQAVVDDTEEICEIICELMGVDPEEFEKWLCYRRIKTGGGKRREWVTKPQNCEQAMYARDALAKAIYSRMFDWIVNRINQAICHKTQNTDDSDGQAA
----------------ARLEDTYTIGILDIFGFEDF-KNNGFDQICINLANESLHKFFNTHIFASELEEYAAEGIDGASVLF-TDNGEILNLFFD-RPDG
| . |.||.|||.||| | ..|.|.| ||| .|| | .||| |.| .| ||| .|||. . . .|| . .| .|.|
QWDDTVSITVVDVPDPAFDKRNYFIGVLDIYGFEIFCEKNSFEQFCINYCNEKLQQFFNHHMFKLEQEEYVREGIQWTFIDYGFDNQPCCDLIEKKKPMG
LFAVLDEETNFPSATDKTLMTKLEQQM-ERHT--PF-EMN--------KGGYAFAIQHYAGPITYQGTGLLDKNKDPLPNRMSESMTDASN-PLAQLLFK
... ||||..|| |||.|. || |. . | | . . .| .|.| |||| ..|. .| |.||||||.. ..|.|. ... |. | ||.
ILSLLDEECWFPKATDQTFLQKLYQTHSSKHPRLHFAQKPGRFYKRHRQGNTHFIIKHYAGDVWYNCEGWLEKNKDPLFDDLIELMWCSWDNPFMQELFP
P-----------DFVKRTRGDAAGGDIDGAKSKKGKGKGKQGPKKGI-NTVSTGFRISLEKLMERMNRC---KPHFVRCIKPNLA---KXXESAMVMKQL
. || . . . . .. .. |..||||| || . ||. |. .. .||. .. | ||.||||||| . .. ||. ||
DWEWAEWAHMQIDFEADFHEEEFK----RRYNRNGCQKGKQGKKKWFMQTVWFQFKEQCNHLMKWLYQCAWWHPHYVRCIKPNENKQPWQFDNSMVLHQL
KYTGMLQ-TIEIRKDGYPNRPSFKQFIDTYR
.. |.| .| |. |.|.|. . | ||
RCNGVLEINIRICRAGFPYRWTYDEFFQRYR
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| IQ | N5.AA | IQ | 723-745 | 52 | 0.000207 | 21.9 | SMART | 1-23 (23) | Show / Hide |
Range on Protein: 723-745 Range on HMM: 1-23/23 Sequence Identity: 52% (12 aa) PMDAAAVRIQAWTRRYLAQLRFY | .||..|||| |.||| |. RMHRAAIIIQAWWRGYLARKRYK |
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| IQ | N5.AA | IQ | 725-745 | 47 | 0.000222 | 18.06 | Pfam | 1-21 (21) | Show / Hide |
Range on Protein: 725-745 Range on HMM: 1-21/21 Sequence Identity: 47% (10 aa) DAAAVRIQAWTRRYLAQLRFY .||..|||| |.||| .. HRAAIKIQAWWRGYLARKHYR |
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| SH2 | N5.AA | SH2 | 864-947 | 38 | 2.5e-29 | 104.68 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 864-947 Range on HMM: 1-87/87 Sequence Identity: 38% (34 aa) YPWFHGLISRADAENFLRD--EDPGTFLVRVSER-ANGYGLSFKYNKRSRHYKISLSPAGGYKVVG-SSEDFPTLAELVEYFGSNPLS .||.|| |||..||. |. .|.|||| ||. ...| ||...... .||.| .. |.| . . ... ||.| |||... |||. QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG |
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| SH2 | N5.AA | SH2 | 866-941 | 41 | 5.9e-28 | 83.9 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 866-941 Range on HMM: 1-81/81 Sequence Identity: 41% (34 aa) WFHGLISRADAENFLRD--EDPGTFLVRVSER-ANGYGLSFKYNK---RSRHYKISLSPAGGYKVVGSSEDFPTLAELVEYF |.|| |||..||. |. .|||||| ||. ..| ||.... | .||.| . ||| . | |..|.||||.. WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHK-FCSLQELVEHY |
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| SH2 | N5.AA | SH2 | 1013-1062 | 29 | 0.000211 | 14.75 | Pfam | 1-52 (81) | Show / Hide |
Range on Protein: 1013-1062 Range on HMM: 1-52/81 Sequence Identity: 29% (16 aa) YIRGKLSREQTEDELRK-MGDDGHFVVRLKSQKDNQIVYALSYSAEG---VFYH .. ||.||.. |. |.. . || |.|| . . .. |.|| .| ...| WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGD--YTLSVRDDGPGDRVKH |
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| SH2 | N5.AA | SH2 | 1011-1098 | 22 | 0.000713 | 6.94 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 1011-1098 Range on HMM: 1-87/87 Sequence Identity: 22% (20 aa) PSYIRGKLSREQTEDELRKM-GDDGHFVVRLKSQKDNQIVYALSYSAEGVFYHHLLMRAKGRPFTLND-RNLRVDYLEDAIEKFQDRVYP . |..|||. |. |.. . || |.|| .. | |.||. .| ..| .. | . . . . . . . . | . .. .| . QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSES--NPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG |
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