Gene 25921 (M.brevicollis)
25921
Species: M.brevicollis
Alias: 25921
External Links:
Annotation:
Sequence
Protein domains of 25921.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| MYSc | 25921.AA | MYSc | 5-794 | 26 | 2.2e-197 | 662.91 | SMART | 1-771 (771) | Show / Hide |
Range on Protein: 5-794
Range on HMM: 1-771/771
Sequence Identity: 26% (232 aa)
IEPASLAATQDLTSLEELSSETICEALAARYAHDDIYTYVGDILVALNPFRNI-GIYSEAAHANYT------HTAGRDLAPHIFALADRAYSSLVSQNQS
.|. . ..|.. |. |. ..... | ||. | |||| |....|.||.... .||.. ...| . ...|||||.||.|| .. . ...
MNPPKFEGVDDMCMLTYLNEPAVLHNLKKRYMNDQIYTYIGPVCIAVNPYKQLPPIYTPDVIKQYRNRKFDDGKHRYEMPPHIFAIADNAYRNMLNDKEN
QVCVISGESGAGKTETSKYFLQHVIYLANHQRPGAAAFHDIHHRISQTSPILEAFGNASTSANANSSRFGKYLELKFDANCVLVGATLRHYLLEHSRTVA
| ..|||||||||||..|. .|. .... . ..| |. ||||||||| | | |||||||| |. ||.. ..|| ..|||| || |
QCIIISGESGAGKTENTKKIMQYLAAVSG-------QVERVEQQILQSNPILEAFGNAKTVRNNNSSRFGKYMEIHFDEKGKICGAKIENYLLEKSRVVY
GVTGERNYHVFYYMYAGLSASERAQLEL-P---DPNLHRFFGD------------EVPRLDDPEAAKAWQN----LQKSLHDVGLTQHAVHELQRILAAV
||||||.||...||.|. .. .. | | .| .. . ...|. |. ... ...... .|.. ... ||.||.
QNKGERNYHIFYQLCAGASEEQKQEFHLKPFSHNPEDYHYLNQGGHYWNNKRHQSQCFTVDGIDDAEEFKETCEQTCNAMRVMGFSEEEQEWIFRIVAAI
LHTGDIVIEQDSN--DDAQF-----DNVATVGRIASLLGVTLGSLAEALLKARIHIRGE---TYHRPHTQHEAELVVDALAKALYGHLFAWLMQNLDTLL
|| | | .||. | |... .. . ....||||. | ..|.. .. ..| ....|... .|. .||||||.|..|| |. ... . .
LHLGNIEFEQGRNQYDNQAVCSEKVKDEEELQNACELLGVDPEDLEKWLTHRKMKTGHEGGTWITKPLNVEQAIYARDALAKAIYSRLFDWIVKRINQSM
TPTQPATRTDLGIGILDIFGFENFERNSLEQLMINFANERLQFYFNEVKLCDMCIVLHECSRMYALNIFSNELQDLQAEGIGIDDLQFQ--DNLPTLLLF
... ||.|||.|||.||.||.||..||..||.|| .||. .| | .. |.||| . .| || |.. |
--------HNYFIGVLDIYGFEIFEHNSFEQFCINYCNEKLQQFFNHH-------------------MFKLEQEEYQREGIEWTFIDFFMYDNQPCCDLI
YGNK-PQPGLLQLLDEESRF---TSATDETLVVKLNNI-----LGSDPVYLT------------CKHADRFGVRHFAGTITYDVHGFLAKNRDPLSPAML
. . . .|.. |||||..| ..||.|.. |||. ... | . ... . |...|.||..||.|.|.| ||.|.|.. ..
EKKGKRPMGIFSLLDEECMFHAQPKGTDQTFLEKLNKQDYHQHHKNHPHFSKPHKSHRCCKPKKRMGRTHFIIKHYAGDVTYNVEGWLEKNKDTLFDDLI
EVLASGSNVVLEDMFGLGSDKFANESLPQSRAVSRQKRRSSSAALLLPAPGRRSGRASQSGSRYDLLPSQPSQTRLSNGSNEVGTRRGSAISLLNLMRPR
... | .| .. ..| ..|. .. .. .|. .| |. .. . .. .
QLMQSSKNPFIKQLFPEYEDQTSQTPQEKSS-QGKNKSRRKKR-M-MQM-K-------------------------------------------------
RSSYNITTAPPPVAETASATRRHLQASGSTTLSGRFATSLDELIERMQRCNPHFVRCIRSNAACEAKVFERALVLKQLNYTGVLETTRIRREGYSHRIVF
| . | .|.. .| .| ||.| . |.||..|||..| . .|.. ||| || . ||||. ||||.|...|. .
------------------KT--CMQKKRFPTVGFQFK-QLNELMETLNSCHPHYIRCIKPNEEKKPWDFDDDLVLHQLRCCGVLENIRIRRAGFPYRWPY
ADFVRRYRHIGF-AHTTHVK--------ANPEACRVILQAAEQ-------------------FLR-TQNEQAEQQKRRA
..|..||. . . . . . .||..|||. . |.| .. ..|..
QEFYQRYKMLCPPTWPNWGNPWKNQLFGDPKKACEAILQQLGEYIQHQNWDPDMYQFGKTKVFFRNPGQLFHLEEMRER
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| Myosin_head | 25921.AA | Myosin_head | 13-414 | 32 | 5.4e-127 | 433.0 | Pfam | 1-448 (765) | Show / Hide |
Range on Protein: 13-414
Range on HMM: 1-448/765
Sequence Identity: 32% (146 aa)
TQDLTSLEELSSETICEALAARYA-HDDIYTYVGDILVALNPFRNIGIYSEAAHANYTHTAGRDLAPHIFALADRAYSSLVSQNQSQVCVISGESGAGKT
. |.. |. |. ......| ||. | ||||.|......||.... ||.. . |. ...|||||.||.|| .... ..| ..|.||||||||
VEDMVMLTYLNEPSVLHNLKKRYMTGDLIYTYSGHFCISVNPYKQLPIYTQDMIQEYRGKHRYEMPPHIFAIADEAYRHMRHDRENQCIIICGESGAGKT
ETSKYFLQHVIYLANHQRPGAAAFHDIHHRISQTSPILEAFGNASTSANANSSRFGKYLELKFDANCVL----VGATLRHYLLEHSRTVAGVTGERNYHV
| .|| .|.. ... ... .. . . | |. ||||||||| | | ||||||||.|. ||. . . ||. ..|||| || | .||||.|.
ENTKYVMQYFASVSGSNPG--VNMGRVEQQILQSNPILEAFGNAKTTRNNNSSRFGKYMEIHFDKTGKINPTAVGGNIENYLLEKSRVVYQTPGERNFHI
FYYMYAGLSASE-RAQLELP--DPNLHRFFGD-E---VPRL-DDPEAAKAWQNLQKSLHDVGLTQHAVHELQRILAAVLHTGDIV-IEQDSNDD-AQFDN
||...||.|..| .. | | ||. .. . . | |. |...... .|.|. ... ||.||.|| | . .|| |.. | .|.
FYQLLAGASQQEEKKELHLTSADPKDYHYLNQSGTNPCYTVDDGIDDAEEFQHTRNAMDIIGFTHEEQRSIFRIVAAILHLGNMKGFKQDQNEEQAVVDD
VAT-VGRIASLLGVTLGSLAEALLKARIHIR----GETYHRPHTQHEAELVVDALAKALYGHLFAWLMQNLDTLLTPTQPA-------------------
. . .|..|.|| .... .|.. || .. |....| . .| .||||||.|. .| |. .. . . .. .
TEEICEIICELMGVDPEEFEKWLCYRRIKTGGGKRREWVTKPQNCEQAMYARDALAKAIYSRMFDWIVNRINQAICHKTQNTDDSDGQAAQWDDTVSITV
--------TRTDLGIGILDIFGFENF-ERNSLEQLMINFANERLQFYFNE
. . ||.|||.||| | |.||.||..||..||.|| .||.
VDVPDPAFDKRNYFIGVLDIYGFEIFCEKNSFEQFCINYCNEKLQQFFNH
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| Myosin_head | 25921.AA | Myosin_head | 469-752 | 20 | 1.4e-49 | 170.83 | Pfam | 484-715 (765) | Show / Hide |
Range on Protein: 469-752 Range on HMM: 484-715/765 Sequence Identity: 20% (61 aa) KPQPGLLQLLDEESRFTSATDETLVVKLNNIL-GSDP--VY-LTC--------KHADRFGVRHFAGTITYDVHGFLAKNRDPLSPAMLEVLASGSN-VVL |...|.| |||||..| |||.|.. ||.. . | .. . . | ..|.||...|.. |.| ||.|||.. ..|.. . .. . KKPMGILSLLDEECWFPKATDQTFLQKLYQTHSSKHPRLHFAQKPGRFYKRHRQGNTHFIIKHYAGDVWYNCEGWLEKNKDPLFDDLIELMWCSWDNPFM EDMFGLGSDKFANESLPQSRAVSRQKRRSSSAALLLPAPGRRSGRASQSGSRYDLLPSQPSQTRLSNGSNEVGTRRGSAISLLNLMRPRRSSYNITTAPP . | .. |. ..| . . . ... .... QELF--PDWEWAEWAHMQ----------------------------------------------------------------IDFEADFHEEEFKRRY-- PVAETASATRRHLQASGS-TTLSGRFATSLDELIERMQRC---NPHFVRCIRSNAACEAKVFERALVLKQLNYTGVLE-TTRIRREGYSHRIVFADFVRR ......... . . .|.. | .....|.. . | .||.||||. | ...|.. .|| || . |||| . ||.|.|...|.....|..| --NRNGCQKGKQGKKKWFMQTVWFQFKEQCNHLMKWLYQCAWWHPHYVRCIKPNENKQPWQFDNSMVLHQLRCNGVLEINIRICRAGFPYRWTYDEFFQR YR || YR |
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| SH2 | 25921.AA | SH2 | 885-970 | 30 | 5.2e-20 | 73.72 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 885-970 Range on HMM: 1-87/87 Sequence Identity: 30% (27 aa) YSWFHGLLDRTGADLLLED--TEDGTFLVRVCQA-YHGYALAMRTPTRTQHFKIELNTTTHCYAVSGHPELSFDSLNKLIQHFKQQPIG . |.|| ..| |. || .||.|||| .. .|.| .|. . .|..|. | . | . .... .|.|| |..|... |.| QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDD-GKYYIDETWRRKFPSL-ELVNHYQHNPLG |
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| SH2 | 25921.AA | SH2 | 887-964 | 32 | 1.5e-14 | 44.57 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 887-964 Range on HMM: 1-81/81 Sequence Identity: 32% (27 aa) WFHGLLDRTGADLLLED--TEDGTFLVRVCQAYH-GYALAMRTPT---RTQHFKIELNTTTHCYAVSGHPELSFDSLNKLIQHF |.|| . | | || .||||||| .. . .|.| |. | .|..| . . . | .| |.||. |..|. WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHK---FCSLQELVEHY |
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| SH2 | 25921.AA | SH2 | 1149-1238 | 25 | 5.2e-05 | 19.13 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 1149-1238 Range on HMM: 1-87/87 Sequence Identity: 25% (23 aa) PQWLRGRISRFDAERELRHRMHLDGIFLVREKAVTETQAVFALSLVYGRQIEHHLVIKTRD-GPWLLDNYPTEQMGNLNQFVDALSTVKDP .| |.||| .||. |... || ||||. . ..||. .. . .| .|.. | | . .| . .. .| . |. .. ... QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSES--NPGDYVLSVRWK-GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG |
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| SH2 | 25921.AA | SH2 | 1151-1210 | 34 | 0.002165 | 11.78 | Pfam | 1-61 (81) | Show / Hide |
Range on Protein: 1151-1210 Range on HMM: 1-61/81 Sequence Identity: 34% (22 aa) WLRGRISRFDAERELRHRMHLDGIFLVREKAVTETQAVFALSLVYGR---QIEHHLVIKTRDG | | ||| .||| |. . || ||||| . |. ..||.... ...| . .| .| WYHGKISRQEAERLLMNPGNPDGTFLVRE-SES-TPGDYTLSVRDDGPGDRVKHYRIQRTDNG |
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| Sam7 | 25921.AA | sam7 | 1309-1351 | 21 | 3.2e-05 | 16.54 | In-house | 1-51 (70) | Show / Hide |
Range on Protein: 1309-1351 Range on HMM: 1-51/70 Sequence Identity: 21% (11 aa) YSTEQVVQWLNMHDL---HRFAGQVRRKHI-----TGHRLRNMSDTALAEL ..|.|..|| .. ... . |. .| .| | .|.. |.|. WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEM |
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| Ank | 25921.AA | Ank | 1466-1498 | 45 | 2.4e-07 | 30.73 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 1466-1498 Range on HMM: 1-33/33 Sequence Identity: 45% (15 aa) DWKTPLFVAAENGHLEVVKLLLARGANPFKLSQ | ||| .|...||.||||.|| .||.. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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