22411

Species: M.brevicollis
Alias: 22411
External Links:
Annotation:

Classification

Group: TK-assoc
Family: SH2
Subfamily: SH2-R

Sequence

Name Sequence Type Origin Length Description Download
22411.AA Protein None 3929 None Fasta, JSON

Protein domain

Protein domains of 22411.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

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Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
TIG 22411.AA TIG 32-124 28 6.8e-15 52.77 Pfam 1-82 (82) Show / Hide
Range on Protein: 32-124
Range on HMM: 1-82/82
Sequence Identity: 28% (27 aa)

AYITDITP-RQVGYKGGQHITIRGVGFDREGQEGATTVYVGTDVCETIAYYSSDTQIVCVMPEVTVVESYLAVTVSLWVAGGAMGSTAICETSC
  ||.|.|  .   .||..|||.| .|   ..   |..|.|.. | .|  ..|.|||||. |..|      . |... |  .  .|.. .  . 
PTITSISPNTTGPPSGGTTITITGQNF--GNDS-DTKCYFGGTPCTVI--WWSSTQIVCTTPPHT------PGTHNVSV-VNGQWSSNPTTFTY

IPT 22411.AA IPT 31-119 25 0.000725 20.09 SMART 1-111 (111) Show / Hide
Range on Protein: 31-119
Range on HMM: 1-111/111
Sequence Identity: 25% (28 aa)

NAYITDITPRQVGYKGGQ-HITIRGVGFDREGQEGATTVYVG----TDVCETIAY-YS---SDTQIVCVMPEVTV---VESYLAV----TVSLWVAGGAM
.  ||.| |..    ||  .|||.|  ||  .|.   .| ||    .  |. .   |.   |.|||||..|. ..     .   |    .|..   .. .
DPVITRIHPNCGPCSGGTERITICGKNFDSDIQVRFVRVNVGGRVWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSPIPGQVPVRVTQEVQF-CNDNVR

GS-------TAI
..       |  
TQLSWPQPFTYV

TIG 22411.AA TIG 134-223 26 6.2e-05 19.07 Pfam 1-82 (82) Show / Hide
Range on Protein: 134-223
Range on HMM: 1-82/82
Sequence Identity: 26% (25 aa)

PTISESQ--LAAPP--GGNVTLIG-YLRGITADEFELRLNGTLLETAYESDDVISTSSWNTGRYDAVVPSMTAGYYNVSFLVNRQDSSWGAGFSA
|||.  .    .||  | ..|..| .. |... .   ...||   . . |.. |           ...|. |.| .|||. || | ||..  |. 
PTITSISPNTTGPPSGGTTITITGQNF-GNDS-DTKCYFGGTPCTVIWWSSTQI----------VCTTPPHTPGTHNVSV-VNGQWSSNPTTFTY

TIG 22411.AA TIG 243-304 19 1.8e-05 20.87 Pfam 1-60 (82) Show / Hide
Range on Protein: 243-304
Range on HMM: 1-60/82
Sequence Identity: 19% (12 aa)

PVVSALSA-SAAGTLGGALLTVYGDGFDADACVENNVVSVAGVNCVPVACTNTEITCRLEAVV
|.....|  . . . || ..|..|..|  .    .. . . |..|...  ..|.|.|.. ...
PTITSISPNTTGPPSGGTTITITGQNF--GNDS-DTKCYFGGTPCTVIWWSSTQIVCTTPPHT

IPT 22411.AA IPT 242-338 15 0.003626 13.28 SMART 1-111 (111) Show / Hide
Range on Protein: 242-338
Range on HMM: 1-111/111
Sequence Identity: 15% (18 aa)

HPVVSALSASAAGTLGGA-LLTVYGDGFDADACVENNVVSVA------GVNCVPVAC------TNTEITCRLEAVVGV--PESDLPRGLAGSIFSNSLGT
 ||..... . .   ||  ..|..|  ||.  ...  .|.|       .|.| ..          |.|.|.. .  .   . .. |  . ....  . ..
DPVITRIHPNCGPCSGGTERITICGKNFDS--DIQVRFVRVNVGGRVWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSPIPGQVPVRVTQEVQFCNDNV

WTP-APAEVFNFT
 |   . . | ..
RTQLSWPQPFTYV

TIG 22411.AA TIG 820-911 24 2.1e-12 44.32 Pfam 1-82 (82) Show / Hide
Range on Protein: 820-911
Range on HMM: 1-82/82
Sequence Identity: 24% (23 aa)

AQAVDAVGP-LTGPVAGNLLLNIAGTGFPASPAENNVTVGGQPCVVQSAQPDSLTCILPPAWSDLDTREADLNGTLNATIVING--EAFTNDFVY
 . .... |  |||..|. .. | |..|  .. .. ...||.||.| .  .....|..||.           .||.| .. .||     ...| |
PT-ITSISPNTTGPPSGGTTITITGQNFGNDS-DTKCYFGGTPCTVIWWSSTQIVCTTPPHT----------PGTHNVSV-VNGQWSSNPTTFTY

TIG 22411.AA TIG 732-819 23 2.4e-12 44.15 Pfam 1-82 (82) Show / Hide
Range on Protein: 732-819
Range on HMM: 1-82/82
Sequence Identity: 23% (21 aa)

PSINTVSNSGDP-SVLAV--ADIVTISGAGFGLDEAAIAVTFNDIPASIVQVSDTEVICEVPHISAGPINIELIRAHVGRAANHDATAWTY
|.|. .|    | .   .   ...||.| .|| |   . ..|...|. .. .|.|...|..| ...|..|. . .     . ... |  ||
PTITSIS----PNTTGPPSGGTTITITGQNFGNDS-DTKCYFGGTPCTVIWWSSTQIVCTTPPHTPGTHNVSV-VNG---QWSSNPTTFTY

IPT 22411.AA IPT 731-820 16 0.015046 6.56 SMART 1-111 (111) Show / Hide
Range on Protein: 731-820
Range on HMM: 1-111/111
Sequence Identity: 16% (19 aa)

NPSINTVSNSGDPSVLAVA--D-IVTISGAGFGLDEAAIAVTFN------DIPASIVQV------SDTEVICEVPHISA---GPINIEL---IRAHVGRA
.|.|     . .|.   ..  . ..|| |  |. |   . |..|        |......      |.|. .|..|...    .|.. ..    .. . . 
DPVIT----RIHPNCGPCSGGTERITICGKNFDSDIQVRFVRVNVGGRVWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSPIPGQVPVRVTQEVQF-CN

ANHDA-----TAWTYA
.| ..       .|| 
DNVRTQLSWPQPFTYV

IPT 22411.AA IPT 823-912 16 0.017414 5.87 SMART 4-111 (111) Show / Hide
Range on Protein: 823-912
Range on HMM: 4-111/111
Sequence Identity: 16% (19 aa)

VDAVGPLTGPVAGNL-LLNIAGTGFPASPAENNVTVG------GQPCVVQSA------QPDSLTCILPPAWSDLDTREADLNGTL----NATIVINGEAF
. .. | .||..|.  .. | |. | ..  .  |.|.      ..|| .|..       . ...| .||.    . .  . ....    .. . .|..  
ITRIHPNCGPCSGGTERITICGKNFDSDIQVRFVRVNVGGRVWEVPCTFQPWDYHGKDSQTQIVCCTPPY--HNQSP-IPGQVPVRVTQEVQF-CNDNVR

T-----NDFVYD
|      .| | 
TQLSWPQPFTYV

TIG 22411.AA TIG 917-940 28 1.760906 3.99 Pfam 1-25 (82) Show / Hide
Range on Protein: 917-940
Range on HMM: 1-25/82
Sequence Identity: 28% (7 aa)

PVLTAVTP-SAIPSAVTTLVTLAGS
|..|...| .  |..  |..|. |.
PTITSISPNTTGPPSGGTTITITGQ

TIG 22411.AA TIG 1028-1118 23 1.8e-07 27.63 Pfam 3-82 (82) Show / Hide
Range on Protein: 1028-1118
Range on HMM: 3-82/82
Sequence Identity: 23% (22 aa)

VTAISP-ARFGTAGGARITITGAGFGQLVNSVGVEAKNVSGSNVPCLVDYVSDSQVECVMAEATGEAHDCELELQINGFVARCSPGTCVVDF
.|.||| ..  ..|| .||||| .|     . .     .   ..|| | ..|..|..|.  ..| .    .. . .||    .|....   .
ITSISPNTTGPPSGGTTITITGQNF-----GNDS-DTKCYFGGTPCTVIWWSSTQIVCTTPPHT-PG-THNVSV-VNG---QWSSNPTTFTY

IPT 22411.AA IPT 1025-1115 21 0.014301 6.8 SMART 1-111 (111) Show / Hide
Range on Protein: 1025-1115
Range on HMM: 1-111/111
Sequence Identity: 21% (24 aa)

NHRVTAISPARFGTAGGA-RITITGAGFGQLVNSVGVEAK-NVSGS-NVPCLVDYV------SDSQVECVMAEATG---EAHDCEL----ELQINGFVAR
. ..|.|.| .   .||  ||||.|  |.  .... |. . .     .||| .. .      |..| .|.. ....    . . ..    |.|. .   |
DPVITRIHPNCGPCSGGTERITICGKNFDSDIQVRFVRVNVGGR-VWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSPIPGQVPVRVTQEVQFCNDNVR

C-----SPGTCV
      .| | |
TQLSWPQPFTYV

TIG 22411.AA TIG 1128-1203 23 3e-06 23.71 Pfam 1-82 (82) Show / Hide
Range on Protein: 1128-1203
Range on HMM: 1-82/82
Sequence Identity: 23% (20 aa)

PS-------TERPSVGWGDVVTLTTERV---WGNPSVTVGGVPAVVQSYSETAVTFEVPALSAGAHDVALAVAPYGRASGMASLGY
|.       |. |. | |...|.| .       ......||.|..| . |.| .....|....| |.| . |   .. |.  .. |
PTITSISPNTTGPPSG-GTTITITGQNFGNDS-DTKCYFGGTPCTVIWWSSTQIVCTTPPHTPGTHNVSV-VNG-QWSSNPTTFTY

TIG 22411.AA TIG 1205-1295 14 2.8e-07 26.98 Pfam 1-82 (82) Show / Hide
Range on Protein: 1205-1295
Range on HMM: 1-82/82
Sequence Identity: 14% (14 aa)

LSVDGLSQ-LSGSVAGGSRVVLVGEGFPTDPTALAVSFVHAGSGNNARRAAVLSTNMTLAEVVIPYLINEGTAHSETYELALTVTN-----SSTFQI
.... .|   .|...||..... |..| .|.  . . |  .   ..       ... |. ....| ..      ..|... . | .     ..||..
PTITSISPNTTGPPSGGTTITITGQNFGNDS-DTKCYFGGTPCTVI-------WWSSTQIVCTTPPHT------PGTHNVSV-VNGQWSSNPTTFTY

TIG 22411.AA TIG 1327-1391 36 1.2e-15 55.34 Pfam 1-69 (82) Show / Hide
Range on Protein: 1327-1391
Range on HMM: 1-69/82
Sequence Identity: 36% (26 aa)

PVLTAIQP-TTGAA--GTVLTLTGSNF---FAEPRVHIAGVACTVLTANSSLVTCTVGEVRGGSHLVEVEV
|..|.|.| ||| .  ||..|.||.||     ...... |..||| . .|....||. .. .|.| | | |
PTITSISPNTTGPPSGGTTITITGQNFGNDS-DTKCYFGGTPCTVIWWSSTQIVCTTPPHTPGTHNVSV-V

IPT 22411.AA IPT 1326-1404 18 3.4e-05 24.51 SMART 1-111 (111) Show / Hide
Range on Protein: 1326-1404
Range on HMM: 1-111/111
Sequence Identity: 18% (21 aa)

TPVLTAIQPTTGAAG--T-VLTLTGSNFFA---EPRVHIA------GVACTVLTA------NSSLVTCTVGEVRG---GSHLVEV----EVTPFGMAMGI
 || |.|.|..| .   | ..|..|.|| .   ...| .       .|.||.. .      ...  .|.... ..   .   |.|    ||   ... . 
DPVITRIHPNCGPCSGGTERITICGKNFDSDIQVRFVRVNVGGRVWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSPIPGQVPVRVTQEVQF-CNDNVR

H--------TFA
         |. 
TQLSWPQPFTYV

TIG 22411.AA TIG 1407-1487 22 1.6e-12 44.77 Pfam 1-82 (82) Show / Hide
Range on Protein: 1407-1487
Range on HMM: 1-82/82
Sequence Identity: 22% (19 aa)

ATVDSMSP-AIASYAGGTLVTLHGHGF-GPADAVSITVGTKSCDVVNTTYNQVLCRAPEVLTPLAVAYYAHVE-PVVLPGTMSY
 |..| || . .. .|||..|..|..| . .  .....|.  |.|. .. .|. |..|.. .        . .  .. |.| .|
PTITSISPNTTGPPSGGTTITITGQNFGNDS-DTKCYFGGTPCTVIWWSSTQIVCTTPPHTPGTHNVSV-VNGQWSSNPTTFTY

IPT 22411.AA IPT 1406-1499 15 5.7e-07 30.4 SMART 1-111 (111) Show / Hide
Range on Protein: 1406-1499
Range on HMM: 1-111/111
Sequence Identity: 15% (18 aa)

TATVDSMSPAIASYAGGT-LVTLHGHGFGP-ADAVSITVG------TKSCDVVNTTY------NQVLCRAPEVLTPLAVAYYAHVEPVVLPGTMSYEQLL
  .. ...|  .. .||| ..|..|. |..  . ....|.      . .| .... |      .| .|..|. ... .    .   || ......   . 
DPVITRIHPNCGPCSGGTERITICGKNFDSDIQVRFVRVNVGGRVWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSP---IPGQVPVRVTQEVQF-CND

DRDYS-------TYV
... .       |||
NVRTQLSWPQPFTYV

TIG 22411.AA TIG 1603-1614 38 13.639823 0.98 Pfam 1-13 (82) Show / Hide
Range on Protein: 1603-1614
Range on HMM: 1-13/82
Sequence Identity: 38% (5 aa)

PVVTRIHP-AALP
|..|.|.| .  |
PTITSISPNTTGP

TIG 22411.AA TIG 1648-1732 25 6.8e-16 56.17 Pfam 1-82 (82) Show / Hide
Range on Protein: 1648-1732
Range on HMM: 1-82/82
Sequence Identity: 25% (23 aa)

PEVNAIRP-TWGTALGGTKITVLGLGL---TAVSSVTINTYPCSDISVVSDSLITCVTTRRSTLTALSVEVEVDDGSIAVNQPTARFRY
| ...| | |.|.. |||.||. | ..   . .........||  | ..|...|.|.|   ..   ..| | |..   . .  . .|.|
PTITSISPNTTGPPSGGTTITITGQNFGNDS-DTKCYFGGTPCTVI-WWSSTQIVCTTPPHTPG-THNVSV-VNG---QWSSNPTTFTY

IPT 22411.AA IPT 1647-1733 22 2e-06 28.95 SMART 1-111 (111) Show / Hide
Range on Protein: 1647-1733
Range on HMM: 1-111/111
Sequence Identity: 22% (25 aa)

TPEVNAIRPTWGTALGGT-KITVLGLGLTA---VSSVTIN------TYPCSDIS--VV---SDSLITCVTTRRS----TLTALSV----EVEVDDGSIAV
 |.. .| |..| . |||  ||. |  . .   | .|..|      . ||. ..  .    |.. |.|.|   .    .     |    || . ...   
DPVITRIHPNCGPCSGGTERITICGKNFDSDIQVRFVRVNVGGRVWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSPIPGQVPVRVTQEVQF-CNDNVR

NQ--PTARFRYM
 |  .. .|.|.
TQLSWPQPFTYV

G8 22411.AA G8 1740-1822 42 2.6e-29 108.48 Pfam 1-94 (137) Show / Hide
Range on Protein: 1740-1822
Range on HMM: 1-94/137
Sequence Identity: 42% (40 aa)

NTWVNDEPPIEGDTVVIPADQVVLMDVT---PPKLFLLLV-QGQLIFEDM---QDLELHASYIWVQGG--LLEVGTEDVPF--QHRATITLYGD
.|| |   |..|| |.||| . ||.||    .||.  ...  ||||| |    ....|.| .||..||   |..|||..|.  ||..||||.|.
STWQNGKVPQPGDNVTIPAGYTVLLDVNSIQTPKYKQIIIWEGQLIFADNRDGRNITLRAHWIWIMGGGFRLHIGTEECPYAWQHKITITLHGR

G8 22411.AA G8 1863-1881 47 0.011392 13.08 Pfam 119-137 (137) Show / Hide
Range on Protein: 1863-1881
Range on HMM: 119-137/137
Sequence Identity: 47% (9 aa)

GVIDIHGIPRRRTWTKVAQ
| |..|| ... |||| |.
GTIELHGKQPHTTWTKLAA

G8 22411.AA G8 2584-2699 31 2.6e-17 68.61 Pfam 7-137 (137) Show / Hide
Range on Protein: 2584-2699
Range on HMM: 7-137/137
Sequence Identity: 31% (41 aa)

TLPLAGDQVEIGVRMYVVMNIN---PPAFSHMDI-AGKLQFDDS---DDRMLEANTISVWG---ELQVGSSGKPF--EHEGVVRLHGQRTSDSLIIDDTH
..| .|| | |     |.. .|   .| ..   |  |.| |.|.    .  |.|. | ..|   .|..|. . |.  .|.  . |||. ..  .|.|.  
KVPQPGDNVTIPAGYTVLLDVNSIQTPKYKQIIIWEGQLIFADNRDGRNITLRAHWIWIMGGGFRLHIGTEECPYAWQHKITITLHGREDDTDFIQDNGP

FLGNKVMAVL--GTVSMYG-QPRTAWVRLAA
  |||| .|   ||....| ||.| | .|||
YMGNKVIGVMNGGTIELHGKQPHTTWTKLAA

SH2 22411.AA SH2 3748-3831 17 0.000754 6.68 SMART 1-87 (87) Show / Hide
Range on Protein: 3748-3831
Range on HMM: 1-87/87
Sequence Identity: 17% (16 aa)

NDYWHPKLSAAQAQEIIMD--KPQGTFLLYGRKP----VILCVKTGKNTARHDALEFHGDLGFRIQMKREQPFHGDLSTLIAYYAEPREG
  . | ..| ..|... .   .| |.||.  . .     .|.|... .  .|  ..  .| ...|.     . . .|  |...|  .. |
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-GKVKHYRIRRNDDGKYYIDET-WRRKFPSL-ELVNHYQHNPLG