Gene 10070 (M.brevicollis)

10070

Species: M.brevicollis
Alias: 10070
External Links:
Annotation:

Classification

Group: TK-assoc
Family: SH2
Subfamily: Unique

Sequence

Name Sequence Type Origin Length Description Download
10070.AA Protein None 1565 None Fasta, JSON

Protein domain

Protein domains of 10070.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RasGEF_N 10070.AA RasGEF_N 312-357 21 7.8e-11 36.73 Pfam 1-46 (104) Show / Hide 
Range on Protein: 312-357
Range on HMM: 1-46/104
Sequence Identity: 21% (10 aa)

IVVGGSKQRLLSLLL-QGQSLGDTNYIRDFFMCFRMFISSTEVFQFL
.| ||. ..|.  ..   ..  |.... .|....|.|... |....|
QVKGGTLEKLVEHCTHHHFHDPDPTFVETFLLTYRSFTTP-ELLEKL
RasGEF 10070.AA RasGEF 547-763 27 8.5e-39 138.75 Pfam 1-204 (204) Show / Hide 
Range on Protein: 547-763
Range on HMM: 1-204/204
Sequence Identity: 27% (65 aa)

QEINVDLICDVMTKLDHED-FCHIDAVNLLQENWRKGENRD-------EMLVNRITQRFNQFNNWVLTILLTEPDVRERAQNLEKLIQLIDRFDENQNLH
.... . |   .| ...|  || |.   .|. .| |  ..|          ..|....||.. ||| |  |.|.|...||. ..| |.. . . | .|..
LDFDPEEIARQLTLIEWELWFCAIHPRECLDCAWTKC-EKDKKHRTHNSPNIERMINHFNHLSNWVATEILSEEDPKKRAKVIKKWIKIAQHCRELNNFN

GVFAVISALSHPAVRRLVRTWELVGDTWRFYFNTMEKLLSPSDNRAKYR--SRLK---GFFSAGTVRQPAYGFATSRRCQLPT-MPFVGIFCQDVLFCEQ
...|.||.|.|... || .|||.|    .  |. .|||.||..| ..||   .||   .                    | |   ||.|.. .|  | ..
SMMAIISGLNHSPIYRLKKTWEKVPKKYKKTFEELEKLMSPEKNFKNYRHDEALKGKCK-----------------HNPQKPCFIPFFGVYLKDLTFIHE

GNP-DRIKLSVAEPDIPSENDQELIHFYKH-RA
||| | |.              .|| | |. | 
GNPKDFINNGT-----------KLINFEKRFRM
RasGEF 10070.AA RasGEF 546-821 24 7.3e-38 133.03 SMART 1-261 (261) Show / Hide 
Range on Protein: 546-821
Range on HMM: 1-261/261
Sequence Identity: 24% (71 aa)

HQEINVDLICDVMTKLDHEDFCHIDAVNLLQENWRKGENRDEM-----LVNRITQRFNQFNNWVLTILLTEPD--VRERAQNLEKLIQLIDRFDENQNLH
   .. . .   .| .|.| ||.|.   .|.  | . . . ..      . |...|||.  ||| |  |....  ...||| .|| ||  . . | .|..
FLHFDPWELAEQLTLMDWELFCKIHPFECLDCVWHHCHKKSPSHLCPQNIHRFIRRFNCVSNWVATMILKCTTMHPKKRAQVIEKWIQVAKHCRELNNFN

GVFAVISALSHPAVRRLVRTWELVGDTWRFYFNTMEKLLSPS-DNRAKYRSRLKGFF-SAGTVRQPAYGFATSRRCQLPTMPFVGIFCQDVLFCEQGNPD
...|..|||......||  ||| |    . .|  ...|..|| .|  .|| .|| .  ..                | |..|| |.. .| .| . ||||
SMMAIMSALQSSPIYRLKKTWEHVPHKYKKLFEELCELMDPSERNYKNYREHLKSCNWMP--------------NQQPPCIPFFGVYLKDLTFIHEGNPD

RIKLSVAEPDIPSENDQELIHFYKHRAVGKLLEHLREFQR--TPYTVSHLPLATPQNLTIARWFLQH---QKSISRS--ECMNISLKLEEPS
 ..              .||.| | | ... . ..| .|   ..|.. . .       .  .|.||.     ...    |... ||..| ..
WLENHT----------KNLINFEKRRMMFNIIREIRQWQSACQHYNFQPNH-------MDIQWWLQQWRYLDHLPEENDEQYQLSLRIEPRV
SH2 10070.AA SH2 1025-1083 33 2.2e-22 67.56 Pfam 21-81 (81) Show / Hide 
Range on Protein: 1025-1083
Range on HMM: 21-81/81
Sequence Identity: 33% (21 aa)

PNGAFVLRPSTSQPGCFALSVKFND---QVTHYLVERLTDGKFSFKDSDRAFLTLRDLIVHY
|.|.|..|.| |.||...|||....   .|.|| . |. .|..   . .. | .| .|. ||
PDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHK-FCSLQELVEHY
SH2 10070.AA SH2 1010-1089 35 4e-15 57.49 SMART 10-87 (87) Show / Hide 
Range on Protein: 1010-1089
Range on HMM: 10-87/87
Sequence Identity: 35% (29 aa)

RDRAMAKLTNLDHPVPNGAFVLRPSTSQPGCFALSVKFNDQVTHYLVERLTDGKFSFKD-SDRAFLTLRDLIVHYCIFPTE
|. | ..| |     |.|.|..|.| |.||...|||.....| ||...|. |||... . ..| | .| .|. ||   |  
REEAEQLLKNP--GMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 10070.AA SH2 1128-1202 34 1.5e-23 70.97 Pfam 1-78 (81) Show / Hide 
Range on Protein: 1128-1202
Range on HMM: 1-78/81
Sequence Identity: 34% (27 aa)

WFFGDISRAEAEAQLSK-HSRPGLFLVRTSSTGKDNFALSFLDDE--CVITHVLITFVDDLGFCLDGKPCADTLFDLV
|..|.|||.||| .| .   ..| |||| |.. .  ..||..||   ....|  | . |. |... |... ..| .||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELV
SH2 10070.AA SH2 1126-1211 30 4e-21 77.42 SMART 1-87 (87) Show / Hide 
Range on Protein: 1126-1211
Range on HMM: 1-87/87
Sequence Identity: 30% (27 aa)

QPWFFGDISRAEAEAQLSKH-SRPGLFLVRTSSTGKDNFALSFLDDECVITHVLITFVDDLGFCLDG--KPCADTLFDLVKICSTPEQD
|||..|.|||.|||. | ..  ..| |||| |.. .  ..||. ..   . | .|   || ....|.  ... ..| .||   ... . 
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG