Gene 27512 (M.brevicollis)

27512

Species: M.brevicollis
Alias: 27512
External Links:
Annotation:

Classification

Group: TK-assoc
Family: PTP
Subfamily: SHP

Sequence

Name Sequence Type Origin Length Description Download
27512.AA Protein None 389 None Fasta, JSON

Protein domain

Protein domains of 27512.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

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Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 27512.AA SH2 1-71 32 4.7e-25 75.39 Pfam 6-81 (81) Show / Hide 
Range on Protein: 1-71
Range on HMM: 6-81/81
Sequence Identity: 32% (25 aa)

MSGPDSEAALRE-RGEHGSFLVRASQSQPGRFALSVRCGD---AISHIIIRNNGGS-FDVGGGASFTDLTSLVEYY
.|. . |  |.. ....|.|||| |.|.|| ..||||...    . |..|.....  . ..|.  | .|  |||.|
ISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 27512.AA SH2 1-77 34 1.7e-19 72.05 SMART 8-87 (87) Show / Hide 
Range on Protein: 1-77
Range on HMM: 8-87/87
Sequence Identity: 34% (28 aa)

MSGPDSEAALRER-GEHGSFLVRASQSQPGRFALSVRCGDAISHIIIRNNG-GSFDVGG--GASFTDLTSLVEYYKRKPLV
.|. . |. |. . ...|.|||| |.|.|| ..||||... . |..|| |. |.. ...  . .| .|  ||..|.. ||.
ISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
PTPc 27512.AA PTPc 98-383 35 2.9e-110 373.56 SMART 1-308 (308) Show / Hide 
Range on Protein: 98-383
Range on HMM: 1-308/308
Sequence Identity: 35% (117 aa)

GFNEEFEQLQTMEHQHKF-------DRMEGARIENK--SKNRYK-NILPYDHTRVKLRNVP---DGVIGADYINANFINGEAPGTDKAYIASQGTMPDTV
||.|||| ||.|. . ..       .  .... ||.  .||||| .|..|||||||| . |   ..  | ||||||.|.|.  .  |.||. || .|.|.
GFWEEFERLQRMTPWDLMSNYDPCCSCTCACWPENREMDKNRYKCDIPCYDHTRVKLKPPPGESHCYEGSDYINANYIDGY--WRPKRYICTQGPLPHTI

ADFWQMIVEQNCRLVVMATNPVEK--------GKHKCTPYWPSSERRPARFGNYVVELLTEDNFD-AYTVRRMSVAVGEG---------DPREIYQYHYT
.|||.|. .|.|. .|| .|..||        |. ||  |||.    |  .|.. |... |.. .  ||.| ..|  ...         ..|....||||
EDFWRMVWQQKCHIIVMLCNCMEKCTENRDQNGREKCHQYWPDE---PMTYGHITVTCKSEEKCPDDYTMRTFEVTNTGCNCKYSMACSETRTVTHYHYT

SWPDHGVP-PEREFLQLIMKIRQHRDRLRKS-------------IPGLGPTLVHCRQVHANPRDQFQSAGIGRTGTFLVIDIVLDLIRHYGIDCDIDIQS
.|||||||   . ||..| ..|... .....              .  ||..|||            |||.||||||..|||....|..      .||  
NWPDHGVPESPDSFLDFIRQVRHWQSHSPNMYMNMVSSNSKYHHTCPTGPIVVHC------------SAGCGRTGTFCAIDIMCQQIEN------VDIFQ

IIHKLRGQRSGMIQTAAQYRFIYKAVMDYIQ
|. ..| || ||.||..||.|.|.....||.
IVKMMRNQRPGMVQTEEQYIFCYRCILEYIK
Y_phosphatase 27512.AA Y_phosphatase 125-380 40 1e-98 339.07 Pfam 1-243 (243) Show / Hide 
Range on Protein: 125-380
Range on HMM: 1-243/243
Sequence Identity: 40% (109 aa)

NKSKNRYKNILPYDHTRVKLRNVPDGVIGADYINANFINGEAP-GTDKAYIASQGTMPDTVADFWQMIVEQNCRLVVMATNPVEKGK-HK-CTPYWPS-S
||.|||||.|..||||||||  . .|  . ||||||.|.|  | .  ||||. || ||.|..|||.|. .|.|. .|| .|..|.|.  | | .|||.  
NKEKNRYKDIPCYDHTRVKLQPI-PGDEDSDYINANYIDG--PYWNPKAYICTQGPMPHTIEDFWRMVWQQKCTCIVMLCNCMEMGRDEKTCHQYWPDNK

ERRPARFGNYVVELLTEDNFDAYTVRRMSVAVGE---GDPREIYQYHYTSWPDHGVPPE--REFLQLIMKIRQHRDRLRKSIPGLG--PTLVHCRQVHAN
| .| ..|.. |..  |.  . |||| ..|   .   ...|....||||.|||||||.   . .|..| ..|...       |. |  |..|||      
EGQPMTYGDFQVTCVSEEHCPDYTVRTFEVTN-GDQKQETRTVTHYHYTNWPDHGVPESQPKSMLDFIRQVRKWQP-----NPDHGCPPIVVHCS-----

PRDQFQSAGIGRTGTFLVIDIVLDLIRHYGIDCDIDIQSIIHKLRGQRSGMIQTAAQYRFIYKAVMD
       ||.|||||| .|||......| |.    ||  |. ..| || ||.||..||.|.|.....
-------AGCGRTGTFCAIDIMCQQMEHEGTV---DIFQIVKHMRNQRPGMVQTEEQYIFCYQCILE
PTPc_motif 27512.AA PTPc_motif 259-380 33 6.2e-35 123.29 SMART 1-92 (92) Show / Hide 
Range on Protein: 259-380
Range on HMM: 1-92/92
Sequence Identity: 33% (42 aa)

EIYQYHYTSWPDH-----GVPPEREFLQLIMKIRQHRDRLRKSIPGLGPTLVHCRQVHANPRDQFQSAGIGRTGTFLVIDIVLDLIRHYGIDCDIDIQSI
....||||.||||     |||    .|..| ..|.             |..|||            |||.|||||| .||.....         .||  .
TVHHYHYTNWPDHVEKDSGVPE-DSILEFIRHVRK-------------PIVVHC------------SAGCGRTGTFCAIDMMMQQ---------VDIFQT

IHKLRGQRSGMIQTAAQYRFIYKAVMD
....| || ||.|| .||.|.|.....
VKEMRKQRPGMVQTEEQYIFCYRCILE