DCLK2

Species: Mouse
Alias: DCAMKL2, 6330415M09Rik, DCLK2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: CAMK
Family: DCAMKL

Sequence

Name Sequence Type Origin Length Description Download
DCLK2.AA Protein None 772 None Fasta, JSON
DCLK2.NA RNA None 4063 None Fasta, JSON
DCLK2.kin_dom Protein Kinase Domain None 258 None Fasta, JSON

Protein domain

Protein domains of DCLK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DCX DCLK2.AA DCX 67-158 44 1.3e-44 155.46 SMART 1-96 (96) Show / Hide
Range on Protein: 67-158
Range on HMM: 1-96/96
Sequence Identity: 44% (43 aa)

SEKKAKKARFYRNGDRYFKGLVFAISNDR-FRSFDALLIELTR-SLSDNVNLPQGVRTIYTIDGSRKVTSLDELLEG-ESYVCASNE-PFRKVDYT
...|.|. .||||||..||| ...|.... |.|||.|| ..|. .|......|.|||.|||.||...||||||. .| ..|||.... .|..|||.
HHWKPKRICFYRNGDPFFKGVRLVINRKWQFKSFDHLLQDVTQTKLHVKMDCPHGVRHIYTTDGRHRVTSLDEFEDGDDFYVCCCTNEKFKPVDYD

DCX DCLK2.AA DCX 89-153 52 4.7e-35 125.98 Pfam 1-68 (68) Show / Hide
Range on Protein: 89-153
Range on HMM: 1-68/68
Sequence Identity: 52% (36 aa)

FAISNDRFRSFDALLIELTRSLSDNVNLPQG-VRTIYTIDGSRKVTSLDE-LLEGESYVCA-SNEPFR
......||..||||| ..|.||.|.|.||.| ||.||| ||...|||||| |..|..|||. .||.|.
MVVNRRRFKTFDALLDDITESLHDKVQLPFGAVRKIYTPDGGHRVTSLDEFLQDGGCYVCCCGNERFK

DCX DCLK2.AA DCX 191-279 31 1.2e-36 129.0 SMART 1-96 (96) Show / Hide
Range on Protein: 191-279
Range on HMM: 1-96/96
Sequence Identity: 31% (30 aa)

DFIKPKLVTVIRSGVKPRKAVRILLNKKT-AHSFEQVLTDITE---AIKLDSG-VVKRLCTLDG-KQVTCLQDFFGDDDVFIACGPE-KYRYAQDD
.. ||| ....|.|....|.||...|.|. ..||...|.|.|.   ..|.|.. .|... |.|| ..||.|..|...||....|. . | .....|
HHWKPKRICFYRNGDPFFKGVRLVINRKWQFKSFDHLLQDVTQTKLHVKMDCPHGVRHIYTTDGRHRVTSLDEFEDGDDFYVCCCTNEKFKPVDYD

DCX DCLK2.AA DCX 213-274 30 2.2e-24 88.56 Pfam 1-68 (68) Show / Hide
Range on Protein: 213-274
Range on HMM: 1-68/68
Sequence Identity: 30% (21 aa)

ILLNKKTAHSFEQVLTDITE----AIKLDSGVVKRLCTLDG-KQVTCLQDFFGDDDVFIAC-GPEKYR
...|......|...|.||||    ...|..| |....|.|| ..|| |..|. |......| | |...
MVVNRRRFKTFDALLDDITESLHDKVQLPFGAVRKIYTPDGGHRVTSLDEFLQDGGCYVCCCGNERFK

Kinase DCLK2.AA DCAMKL 409-666 64 1.7e-217 684.01 In-house 1-279 (279) Show / Hide
Range on Protein: 409-666
Range on HMM: 1-279/279
Sequence Identity: 64% (180 aa)

YRIGKVIGDGNFAVVKECVDRYTG-KEFALKI-----------------IDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATDLFLVMELVKGG
|.||..|||||||||.||..| || ...|.||                 |||.||.||||.|.|||||....|||.||.|.|...|.|...||||.|.||
YQIGRIIGDGNFAVVHECRHRETGDHKYAMKIRYQSTLQFSFPSKFFQQIDKRKCKGKEHMIDNEVSIMQKIKHPHIIQLYEHWDTETHYYLVMEYVQGG

DLFDAITSSTKYTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAETGYGLKV
|||||||..||.||||...|...|..||.|||...||||||||||||||...||.|||||.|||||..|.|   ||||||||||||||||..|||||.||
DLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFGLACHVNGDFGPLYTVCGTPTYVAPEILMETGYGCKV

DVWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEILSHPWV
|.||||||.||||||||||||..| ||.|||||..||.|||.||||||.||||.|||.||||..|.|.||..|..||||
DIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISDSAKDLISHMLQVDPEKRYTAEQIMQHPWV

Kinase DCLK2.AA CAMK1 409-666 42 3.1e-138 404.48 In-house 1-276 (276) Show / Hide
Range on Protein: 409-666
Range on HMM: 1-276/276
Sequence Identity: 42% (119 aa)

YRIGKVIGDGNFAVVKECVDRYT---GKEFALKIID-KAKCCGKE----HLIENEVSILRRV---KHPNIIMLVEEMETATDLFLVMELVKGGDLFDAIT
| .||.|| | |..|..|... |   ||..|.|.|| |    .|.     ..|||..|...|   .||||| . |  |. ... ||||||.||.||| | 
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

SSTKYTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLK--LGDFGLATVVE-G--PLYTVCGTPTYVAPEIIAE---TGYGLKVDV
  ..|||.| .  . ... |. |.||. |||||.|||||| .. .|    .|  . ||||.. .. .   ..|.|||| |||||...    ..|. ..|.
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLL-YYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDM

WAAGVITYILLCGFPPFRSEN-NLQEDLFDQILAGKLEFPAPYWDNITDS-AKELISQMLQVNVEARCTAGEILSHPWV
| .||||||||||.||| .|| . .  ||..|. ...||| |.|||| |. ||..|..|| |. . | |. ..| |||.
WSIGVITYILLCGYPPFYDENVDNE--LFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI

Kinase DCLK2.AA CAMK 414-666 25 1.1e-126 410.49 In-house 1-425 (425) Show / Hide
Range on Protein: 414-666
Range on HMM: 1-425/425
Sequence Identity: 25% (110 aa)

VIGDGNFAVVKECVDRYTG------------KEFALKIIDKAKCCG---------------------------KEHLIENEVSILRR-------VKHPNI
..| |.|..||.|... |.            ...| ||||| |  .                           ... ...|..|...       ..||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IMLVEEME------------TATD--------LFLVM---ELVKGG----DLFDAITSSTK---------------YTERDGSAMVYNLANALRYLHSLS
| | | .|            | ..        ...||   |.. ||    |||| |.. ..               .|||. . ..  .. |..|.||. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDIKPENLLVCEYPDGT-------------KSLKLGDFGLATVVEG--------------------------PLYTVCGTPTYVA-PEIIA------
|||||.||||.|...  |..               .|. |||.|.....                          ...|.|||| |.| ||..       
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------ETGYGLKVDVWAAGVITYILLCGFPPFRSENN-----------LQEDLFDQILAGKLEFPAPY------------WDNITDS--------AK
        ...|| |.|.|..|||.||.|||.|||.....            ...|| .|..|| .|| ||            ||.|.|.        .|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

ELISQMLQVNVEARCTAGEILSHPWV
 ||..||||. | | |. ..|.|||.
DLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase DCLK2.AA RAD53 409-666 36 1.4e-124 373.16 In-house 1-305 (305) Show / Hide
Range on Protein: 409-666
Range on HMM: 1-305/305
Sequence Identity: 36% (113 aa)

YRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDK-------AKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETA-TDLFLVMELVKGGDLFDAITSST
| ..|..| |||..||..... |.. .| |||||        .  .|.  ..||| ||....||.|| . .  .|. .....|.||. ||.||. | |. 
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK

K----YTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGT--------------KSLKLGDFGLATVVEGP--LYTVCGTPTYVAPEIIAE
.    ..| .. .  | . .|..|||.. |.|||.|||| |  .. ...               ..|. ||||. .|.    . | ||||.|||||.|. 
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITS

---------------TGYGLKVDVWAAGVITYILLCGFPPFRSENNLQ----EDLFDQILA-GKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEI
               .||. |||.| .|.|.||.|||.||| |.   |     .||.||.  ||..|| |||| |...|| ||..||.|..|.| |. |.
KGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPF-SDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEA

LSHPWV
|.||| 
LNHPWM

Kinase DCLK2.AA S_TKc 409-666 35 2.9e-103 350.26 SMART 1-231 (231) Show / Hide
Range on Protein: 409-666
Range on HMM: 1-231/231
Sequence Identity: 35% (97 aa)

YRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATDLFLVMELVKG--GDLFDAITSSTK-----
|.|...|| | |..|. |... ||...|.|||.          |..|..||.. .||||. | . ... ..|..|||.. |  ||||| | .  .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-YTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGL-KVDVWAAGVITYIL
 ..| .   ..| ...|| |.||. |.|||.||||.|..|       .|..|||||...    .|.|||| |.|||..   |||  |.|.|. |.| |..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEILS-------HPWV
||| |||.     .. .|..|.              ...||..|...||.. | | || |.|        |||.
LCGYPPFP----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase DCLK2.AA CAMK-Unique 409-666 27 6.9e-98 323.73 In-house 1-363 (363) Show / Hide
Range on Protein: 409-666
Range on HMM: 1-363/363
Sequence Identity: 27% (99 aa)

YRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDKAKCC-GKEHL------------------IENEVSILRRVKHPNIIMLVEE----METAT-------
|. ...||.||| .|.|| || |||..| |.. |..    | ..                   ..|..|...|.||||| |..      ....       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------DLFLVMELVKGGDLFDAITS--------------------STKYTE--RDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDG----
        ....|||.. ||||||.| .                     ....|  .| .  .  |. |. |.||..|||||.|.||..||. ..     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------TKSLKLGDFGLATVVE-GPLY----TVCGTPTYVAP--------------EIIAETGYGLKV----DVWAAGVITYILLCGFPPFRSENNLQ
         . .|| ||||.. ..    .    |.|||| |.||              |.|.. .|. ..    | |. |||.|..||| ||| .|..  
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

------EDLFDQILAGKL-EFPAPYWDN---ITDSAKELISQMLQVNVEARCTAGEILSHPWV
        .|. |..|.. .|. ..|.    |...|| .. . ..| .  | .| |.|.|.|.
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI

Kinase DCLK2.AA CAMKL 409-666 34 4.6e-95 303.81 In-house 1-297 (297) Show / Hide
Range on Protein: 409-666
Range on HMM: 1-297/297
Sequence Identity: 34% (105 aa)

YRIGKVIGDGNFAVVKECVD-RYTGKEFALKIIDKAKCCGKEHLIEN--------------EVSILRRVK---HPNIIMLVEEM-------ETATDLFLV
|||||..| |.|..|| ... |.||.. | ||||| |.. ...   |              |..|.....   ||||| | | .       || ....||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLV

MELVKGGD--LFDAITSS----TKYTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKS--LKLGDFGLATV---V----EGPLYTVCG
||.. ||.  ||| | .      . .|..   .   .  |. |.||. ||||||||||.|.    |  ..  .|. |||...    .    .  | | ||
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILL----DENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCG

TPTYVAPEIIAE--T-GYGLKVDVWAAGVITYILLCGFPPFRSENN------LQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGE
.| | ||||..   .  .| |||.|..||| | ..||  ||. ...       .  |. .|  |  ..| .|   .  ... ||..||||| | | |. .
SPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYH--VS-DCRDLIRKMLQVNPEKRPTIHQ

ILSHPWV
|..|||.
IMNHPWM

Kinase DCLK2.AA Pkinase 409-666 34 3.1e-93 320.86 Pfam 1-293 (293) Show / Hide
Range on Protein: 409-666
Range on HMM: 1-293/293
Sequence Identity: 34% (102 aa)

YRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDK--AKCCGKEHLIE-NEVSILRRVKHPNIIMLVEEMETATDLFLVMELVKGG----DLFDAIT--SS
|.||..|| |.|..|..|... |||..|.|||.|  .|.. .....  .|..|..|..||||. | . .|. ... .|||.. ||    |||| |.  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TKY--TERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLA----TVVEGPLYTVCGTPTYVAPEIIA-ETGYGLKVDVWAA
...  .|..   ..| .. .| |.|| .|.|||.||||.|. . ..   ..|..|||||    .   . ..|.|||| |.|||.|   ..|| |||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVITYILLCGFPPFRSE----NNLQEDLFDQILAGKLEFPAPYWDNIT-----------------DSAKELISQMLQVNVEARCTAGEILSHPWV
|.| |..||| |||...    |. |  ....|. ..|.|. |.|..|                  ...|..|. .|... . |.|| .|| |||.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase DCLK2.AA CDPK 409-666 36 3.5e-86 264.35 In-house 1-271 (271) Show / Hide
Range on Protein: 409-666
Range on HMM: 1-271/271
Sequence Identity: 36% (101 aa)

YRIGKVIGDGNFAVVKECVDR-YTGKEF-ALKIIDKAKCCGKEH-LI-ENEVSILRRVKHPNIIMLVEEMETATDLFLVME--LVKGGDLFDAITSSTKY
| |.||.| |.| .|. ....  |. |  | ||| | ..  ||   .  ||. ||.   ||||| . |  .     ..|||  ...||.||| |..  ..
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF

TERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGT---KSLKLGDFGLATVVE-------GPLYTVCGTPTYVAPEIIAETGYGLKVDVWAA
||.. .  .. . .|. | ||  |||||.||||.| .   |..   . .|. |.|...  .         ... ||||.|.|||..    |  |.|.| .
TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWSC

GVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEILSHPWV
||| |||||| |||  .|  ... ....  || .|  | ||.|.|.|| ||..||... . | .| ..| |||.
GVILYILLCGYPPFYGKN--DQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF

Kinase DCLK2.AA RSK 411-666 29 1.3e-85 290.68 In-house 1-278 (278) Show / Hide
Range on Protein: 411-666
Range on HMM: 1-278/278
Sequence Identity: 29% (83 aa)

IGKV--IGDGNFAVVKECVDRYTGKEFALKIIDKAKCCGK----EHLIENEVSILRRVK-HPNIIMLVEEMETATDLFLVMELVKGGDLFDAITSSTK--
.     .| | . ....|... ||...| |...||| . .    .|  . |..|| |.. ||.|. | .  .| . |.|.||...||.||. .       
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMT-ERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFG

-YTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATV--VE--GPLYTVCGTPTYVAPEIIA----ETGYGLKVDVWAA
  .|.. ..  .... |...||.. |.|||.|||| |  .   .  ..|| |||..     .  ....| |.|  |.|||...    . |..  .|.|  
CFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GVITYILLCGFPPFRS-ENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCT-----AGEILSHPWV
||. | .| |.|||.. . | .......|. ||. .. | |..... ||.||..||... . | .     | ||..||| 
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase DCLK2.AA MARK 409-666 35 6.2e-83 270.93 In-house 1-262 (262) Show / Hide
Range on Protein: 409-666
Range on HMM: 1-262/262
Sequence Identity: 35% (97 aa)

YRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDKAKCCG-KE-HLIENEVSILRRVKHPNIIMLVEEME--TATD-LFLVMELVKGGDLFDAITSS--TK
|...|.|| |..|.|| .... ||...|.||..| |    ..   .. |..|.....||||| | . .|  | .  ..|.||.. ||.|.| | .    .
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

YTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTK--SLKLGDFGLATVV-EGP-LYTVCGTPTYVAPEIIAETGYG-LKVDVWAAGVIT
 .|..  ..   .  |. |.|| .||||||||||.|.    |  .    |. |||... . .|  | | |||| | ||||.    |   |||.|. ||. 
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILI----DENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVL

YILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEILSHPWV
|...||  ||.  .. ...|. .||.|| ..|      . .... ||...|.|| | | |. ||..|||.
YFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH----VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM

Kinase DCLK2.AA RSK 409-666 33 1.4e-77 264.09 In-house 1-271 (271) Show / Hide
Range on Protein: 409-666
Range on HMM: 1-271/271
Sequence Identity: 33% (91 aa)

YRIGKVIGDGNFA---VVKECVDRYTGKEFALKIIDKAKCCGK-EHLIENEVSILRRVKHPNIIMLVEEMETATDLFLVMELVKGGDLFDAITSSTKYTE
| . ..|| | |    |.| |. . |....| |||.||.   |     |.|  ||| . ||.|. | .  .... ....|.. .|||||| .      .|
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

RDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLA---TVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDVWAAGVITYILLC
|. ..  ...|.|. ||||. ||||| |||| |. .      ..|. |||.|      .| |.| |.|  |.|||..   |..  .|.|  ||. |. | 
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

GFPPFRSENNLQEDLFDQIL---AGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTA-----GEILSHPWV
|..|| . ..  ......|.    |.. .  ..||.|.| ||.|...|| .. . | .|      .|..|||.
GCTPFQNKPR--DTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF

Kinase DCLK2.AA TyrKc 409-666 22 6.6e-15 18.36 SMART 1-280 (280) Show / Hide
Range on Protein: 409-666
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

YRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDKAKCCGKEHLIENEVSILRRV--KHPNIIMLVEEMETA-------TDLFLVMELVKGGDLFDAITSS
 . ||..| |.| .| ... .    . | | . . .    .  . .| .|....  .||||. |.    .          |..|||....||| | . ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

TK-YTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGP-------LYTVC----GTPT-----YVAPEIIAETG
 .  . .|   . .  |.  .||||  ..|||.   | || |        | .||||.  ..          | .     |. |       ||| | .  
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YGLKVDVWAAGVITY-ILLCGFPPFRS-EN--NLQEDLFDQILAG-KLEFPAPYWDN-----ITDSAKELISQMLQVNVEARCTAGEILSHPWV
.  | |||. ||  . |.  | .|    .      .... .. .|  .. |. .         .|   ....|  . . | |.|  ||  |   
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase DCLK2.AA Pkinase_Tyr 409-591 27 3e-14 48.87 Pfam 1-199 (270) Show / Hide
Range on Protein: 409-591
Range on HMM: 1-199/270
Sequence Identity: 27% (57 aa)

YRIGKVIGDGNFAVVKECVDR----YTGKEFALKIIDKAKCCGKEH-----LIENEVSILRRV-KHPNIIML---VE-EMETATDLFLVMELVKGGDLFD
 ..||..| |.| .|.... .     |. . | |.. |   . .|.     ... |..|..   .||||. |   .  . |    ...|||....||| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLD

AITS----STKYTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVV-EGPLY-TVCG---TPT-YVAPEIIAETGYG
   .      . |  |   | .  |... ||.|  ..|||.   | || |    ..  | .|||||  . .   | .. |    |    ||| |..  . 
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFT

LKVDVWA
 | |||.
TKSDVWS