Gene ball (Fruit Fly)
Sequence
Protein domains of ball.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | ball.AA | VRK | 47-307 | 50 | 1.1e-190 | 615.28 | In-house | 1-284 (284) | Show / Hide |
Range on Protein: 47-307 Range on HMM: 1-284/284 Sequence Identity: 50% (145 aa) WRIGPSIGVGGFGEIYAA----CKVGEKNYDAVVKCEP-HGNGPLFVEMHFYLRNAKLEDIKQFMQKHG------------LKSLGMPYILANGSVEVNG ||.|..||.||||.||.| ||..||....|||.|| |.|||||.|||||.|.||.|.|...|.||. |..||.||....|....|| WRLGKPIGQGGFGCIYLASPNTCKPCEKDAQYVVKIEPPHENGPLFTEMHFYQRAAKPEQIQKWMKKHKSLPAPQTHVLSRLPWLGIPYCWGFGYHDFNG EKHRFIVMPRYGSDLTKFLE-QNGKRLPEGTVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQAYLVDFGLASHFVTG----DFKPDPKKM ||.||.||||.|.||.|..| |||.|....||..||..||||..|.|.|.|||.|.||||||||.| ....|.||||.|||...... ..|.||... EKYRFMVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFE-KNPDQVYLVDYGLAYRYCPNGKHRQYKEDPRRC HNGTIEYTSRDAHLG-VPTRRADLEILGYNLIEWLGAELPWVTQKLLAVPPKVQKAKEAFMDNIGESLKTLFP-KGVPPPIGDFM ||||.|.||.|||.| .|.||.|||||||....||...|||........|.|||.||..|||||.|.....|| |.|...||..| HNGTCEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEKVQDAKQKFMDNIPEMMQKCFPWKQVCCEIGKYM |
|||||||||
| Kinase | ball.AA | CK1 | 47-324 | 26 | 1.4e-83 | 283.95 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 47-324 Range on HMM: 1-339/339 Sequence Identity: 26% (91 aa) WRIGPSIGVGGFG-EIYAAC----KVGEKN-----YDAVVKCEP-HGNGPLFVEMHFYLRNAKLEDIKQFMQ------KHGLK-SLGMPYILANGSVEVN |... || |||| .|| .. | . | ....|.|| . .|.....|..|.. .||...|.. . || .| ..|.|.. . . . WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKW-KASILKHKHFCKKHCGCPHPCMYWYHGEE GEKHRFIVMPRYGSDLTKFLE---QNGKRLPEGTVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEK------------GGAAQAYLVDFGLAS-HF .......||...| .| .... ...... .|....|||||.. .|||..|..| |.|..|...|... . . | |..|||.| . DDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKY V--------------TGDFKPDP----KKMHNG-TIEYTSRDAHLGVP-TRRADLEILGYNLIEWLGAE--LPWVTQKLLAVPPK---VQKAKEAFMDNI . |. .| . || . | |..|.|...|||.. .|| ||. ..| ||||| . ||| | | | |.|.|..|.|. RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKP-KDHQVEKMKYEFIDEK GESLKTLFPKG-----VPPPIGDFMKYVSKLTHNQEPDYDKC |.. ..... .|. ..|||...|.. .|||.. KMSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
|||||||||
| Kinase | ball.AA | CK1-D | 159-324 | 34 | 2.5e-21 | 71.88 | In-house | 96-261 (261) | Show / Hide |
Range on Protein: 159-324 Range on HMM: 96-261/261 Sequence Identity: 34% (59 aa) TVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQAYLVDFGLASHFVTGD----FKPDPKKMHNGTIEYTSRDAHLGVP-TRRADLEILGYN || || ||. .|.|.. ..| |.| | |.|| | | |..||||| .. .| || | | |.|. || ||| ||| TVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNM-VYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYV LIEWLGAELPWVTQKLLAVPPKVQKAKEAFMDNIGESLKTLFPKGVPPPIGDFMKYVSKLTHNQEPDYDKC |. . ||| | | |. | || . ...|| || | ..| |. .| .. ||| LMYFNRGSLPW--QGLKAA-TKRQKYERICEKKMSTKIDTLC-KGYPSEFQQYMNYCRNLKFDDKPDYCYL |
|||||||||
| Kinase | ball.AA | CK1-A | 159-324 | 30 | 6.7e-18 | 59.71 | In-house | 96-261 (261) | Show / Hide |
Range on Protein: 159-324 Range on HMM: 96-261/261 Sequence Identity: 30% (53 aa) TVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQAYLVDFGLASHFVTGDFKPD----PKKMHNGTIEYTSRDAHLGVP-TRRADLEILGYN || || ||. |.| ...| |.| | |.|... . .|.||||| .. . | ||. | | .||||. .|| |.| .|| TVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGR-HCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYV LIEWLGAELPWVTQKLLAVPPKVQKAKEAFMDNIGESLKTLFPKGVPPPIGDFMKYVSKLTHNQEPDYDKC .. . ..||| | . | | || . ... | || | .|.|. .| ...||| MMYFNRGKLPW--QGMKAM-TKKQKYEKISEKKMSTPIEQLC-KGFPAEFCMYMNYCRNLRFEEQPDYMYL |
|||||||||
| Kinase | ball.AA | TTBKL | 133-214 | 28 | 9e-16 | 49.8 | In-house | 75-161 (288) | Show / Hide |
Range on Protein: 133-214 Range on HMM: 75-161/288 Sequence Identity: 28% (25 aa) RFIVMPRYGSDLTKFLEQNGKR--LPEGTVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGG---AAQAYLVDFGLASHFVT .|.|| | .| . .. . . .||..|..|| |.. ..||..|..| |.| .|. .|... . ||.|||.| ... NFMVMTLCGPNLQDLRKMMPNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAW |
|||||||||
| Kinase | ball.AA | Worm6 | 133-324 | 23 | 3.6e-15 | 51.14 | In-house | 78-279 (279) | Show / Hide |
Range on Protein: 133-324 Range on HMM: 78-279/279 Sequence Identity: 23% (48 aa) RFIVMPRYGSDLTKFLEQN-GKRLPEGTVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGL----EKGGAAQAYLVDFGLAS--HFVTGDF-KPDPK-K ..|||. .| .| . .... || ...|||.|. . .|..|..| |.|..| | | . . |..|||.. . . |. . NYIVMTLVGKNLWDLRKNRPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWT MHN--GTIEYTSRDAHLGV-PTRRADLEILGYNLIEWLGAELPWVTQKLLAVPPKVQKAKEAFMDNIGESLKTLFPKGVPP-PIGDFMKYVSKLTHNQEP . || | .. .| | |. |.| | ..|.. .||| . . . |.| |.. .... . ....| ...|. | |.|. .. .| ACGFRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPW---RHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRP DYDKC ||... DYKFI |
|||||||||
| Kinase | ball.AA | S_TKc | 47-503 | 11 | 3.5e-11 | -12.86 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 47-503
Range on HMM: 1-231/231
Sequence Identity: 11% (55 aa)
WRIGPSIGVGGFGEIYAACKVGEKNYDAVVKCEPHGNGPLFVEMHFYLRNAKLEDIKQFMQKHGLKSLGMPYILANGSVEVNGEKHRFIVMPRYGS---D
..|. || |.||. | . ... . .|. . ... | ..| . |.| | .. .| ..|| . |
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----------------EHIRREIQILKK------HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGD
LTKFLEQNGKR-----LPEGTVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQAYLVDFGLASHFVTGDFKPDPKKMHNGTIEYTSRDAHL
| ......|.. .|| .. ... |... .|.||.| .| ||| .|||| . . ||||| .. . || .| .
LFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----------TTFCGTPWYMAPEVL-
GVPTRRADLEILGYNL------------IEWLGAELPWVTQKLLAVPPKVQKAKEAFMDNIGESLKTLFPKGVPPPIGDFMKYVSKLTHNQEPDYDKCRS
||. .| | . |. .. ...||
------------GYGKCKCDWWSCGCILYEMLCGYPPFP-------------QMQMMFKKIG--------------------------------------
WFSSALKQLKIPNNGDLDFKMKPQTSSNNNLSPPGTSKAATARKAKKIDSPVLNSSLDEKISASEDDEEEEEKSHRKKTAKKVTPSARNAKVSPLKRVAD
----------------------------------------------------------------------------------------------------
SSPPSQKRVKTEPKSTPRERATPKASPKPRSTPKASPKPQTPTAARLRTPNAK--INFSPSISLRGRPGGKTVIN-------DDLT
.| || |. . ||. . . .
------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Kinase | ball.AA | TTBK | 158-264 | 33 | 1.1e-10 | 34.04 | In-house | 97-207 (257) | Show / Hide |
Range on Protein: 158-264 Range on HMM: 97-207/257 Sequence Identity: 33% (38 aa) GTVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQAYLVDFGLASHFV--TGDFKPDPKKM--HNGTIEYTSRDAHLGVPT-RRADLEILGY .| || .|.|. . || |. | | | | .|. . |..||||| .. .|. | | . ||. | | ||. |. || | | STTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRP-PREVAGFRGTVRYASINAHRNREMGRHDDLWSLFY NLIEWLGAELPW |.| . ||| MLVEFVQGQLPW |
|||||||||
| Kinase | ball.AA | CK1-Unclassified | 163-209 | 39 | 1.2e-10 | 27.71 | In-house | 109-155 (244) | Show / Hide |
Range on Protein: 163-209 Range on HMM: 109-155/244 Sequence Identity: 39% (19 aa) LAIQMLDVYQYMHSNGYVHADLKAANILLG-LEKGGAAQAYLVDFGLA .| ||.. .|.|.....| |.| |.| | |.| . | |..||||. IADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKN-HHQVYIIDFGLS |
|||||||||
| Kinase | ball.AA | CK1 | 159-209 | 39 | 4.3e-10 | 31.13 | In-house | 106-156 (271) | Show / Hide |
Range on Protein: 159-209 Range on HMM: 106-156/271 Sequence Identity: 39% (20 aa) TVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQAYLVDFGLA || .| ||.. .|.|.....| |.| |.| |. . | |..||||| TVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLA |
|||||||||
| Kinase | ball.AA | Pkinase | 130-212 | 30 | 9.5e-09 | 32.02 | Pfam | 72-162 (293) | Show / Hide |
Range on Protein: 130-212 Range on HMM: 72-162/293 Sequence Identity: 30% (28 aa) EKHRFIVMPRY-GS----DLTKFLE-QNGKRL--PEGTVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGGA-AQAYLVDFGLASHF ..| .||. | || ... ...... .| .. . . |.| .|.||.| .| ||| .|||. ..| | . ||||| .| KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQF |
|||||||||
| Kinase | ball.AA | CK1-G | 159-264 | 33 | 6e-07 | 19.49 | In-house | 97-208 (266) | Show / Hide |
Range on Protein: 159-264 Range on HMM: 97-208/266 Sequence Identity: 33% (37 aa) TVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQA-YLVDFGLASHFVTGDFKPD----PKKMHNGTIEYTSRDAHLGVP-TRRADLEILGY || .||||.. .|.|| . | | | | | . ... ...|||.| .. . | .| || | | ||| || |.| || TVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGH NLIEWLGAELPW . | .||| MFMYFLRGSLPW |
|||||||||
| Kinase | ball.AA | TTBKL | 47-80 | 38 | 4e-06 | 16.63 | In-house | 1-34 (288) | Show / Hide |
Range on Protein: 47-80 Range on HMM: 1-34/288 Sequence Identity: 38% (13 aa) WRIGPSIGVGGFGEIYAACKVGEKNYDAVVKCEP |.| .|| ||||..| . .. |.. |..| |. WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEK |
|||||||||
| Kinase | ball.AA | TTBK | 47-64 | 61 | 5.3e-05 | 13.65 | In-house | 1-18 (257) | Show / Hide |
Range on Protein: 47-64 Range on HMM: 1-18/257 Sequence Identity: 61% (11 aa) WRIGPSIGVGGFGEIYAA |.. || ||||||| | WKVVKKIGGGGFGEIYEA |
|||||||||
| Kinase | ball.AA | TyrKc | 47-328 | 15 | 6.8e-05 | -143.47 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 47-328
Range on HMM: 1-280/280
Sequence Identity: 15% (51 aa)
WRIGPSIGVGGFGEIYAACKVGEKNYDAVVKCEPHGNGPLFVEMHFYLRNAKLEDIKQFMQ-KHGLKSL--GMPYILANGSVEVNGE------KHRFIVM
. | .| | |||.| . .. ||. .. .. ||. ...| | |.. | . .. . .|||
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVM
P--RYGSDLTKFLEQNGKRLPEGTVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQAYLVDFGLASHFVTGDFKPDPKKMHNG------TI
.| || ..| ....|. . ..| . .| ||....| || | |.|.| .. .. ||||. .. ... .
EYMPHG-DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLS------------RDIYDDDQQGESKD
EYTSR---DAHLGVPTRRADLEILGYN-----------------LIEWLGAELPWV-TQKLLAVPPKVQKAKEAFMDNIGESLKTLFPKG--------VP
|... ... .| | .| . |. . .|.. .. .|. . . . .. . |. |
YYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFT-YGQQPYPGMIQQ--------MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCP
PPIGDFMKYVSKLTHNQEPDYDKCRSWF
. . . || . .. | ... |
DEMYQIMKQCWHEDPEDRPTFSEIHECF
|
|||||||||
| Kinase | ball.AA | CK1 | 297-322 | 29 | 9.5e-05 | 12.5 | In-house | 245-271 (271) | Show / Hide |
Range on Protein: 297-322 Range on HMM: 245-271/271 Sequence Identity: 29% (8 aa) KG-VPPPIGDFMKYVSKLTHNQEPDYD || | ....|. .| ...|||. KGNFPNEFAMYLNYCRQLHFEEKPDYM |
|||||||||
| Kinase | ball.AA | Worm6 | 47-79 | 35 | 0.000391 | 11.12 | In-house | 1-34 (279) | Show / Hide |
Range on Protein: 47-79 Range on HMM: 1-34/279 Sequence Identity: 35% (12 aa) WRIGPSIGVGGFGEIYAACKVGEKN-YDAVVKCE | .. || |||| .| . . |. ..||| WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCE |
|||||||||
| Kinase | ball.AA | TTBKL | 290-328 | 25 | 0.000725 | 9.02 | In-house | 245-288 (288) | Show / Hide |
Range on Protein: 290-328 Range on HMM: 245-288/288 Sequence Identity: 25% (11 aa) SLKTLFPKG-----VPPPIGDFMKYVSKLTHNQEPDYDKCRSWF ....|| . |. ..|||... |. ...|||.. . | KDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
|||||||||
| Kinase | ball.AA | CK1-D | 47-62 | 62 | 0.001112 | 8.67 | In-house | 1-16 (261) | Show / Hide |
Range on Protein: 47-62 Range on HMM: 1-16/261 Sequence Identity: 62% (10 aa) WRIGPSIGVGGFGEIY .||| || | ||.|| YRIGRKIGSGSFGDIY |
|||||||||
| Kinase | ball.AA | CK1-G | 47-62 | 50 | 0.001531 | 7.77 | In-house | 1-16 (266) | Show / Hide |
Range on Protein: 47-62 Range on HMM: 1-16/266 Sequence Identity: 50% (8 aa) WRIGPSIGVGGFGEIY .|.|. || | |||.. YRVGKKIGCGNFGELF |
|||||||||
| Kinase | ball.AA | CK1 | 47-64 | 50 | 0.001615 | 8.21 | In-house | 1-18 (271) | Show / Hide |
Range on Protein: 47-64 Range on HMM: 1-18/271 Sequence Identity: 50% (9 aa) WRIGPSIGVGGFGEIYAA |.| || | ||.|| . YRVGRKIGQGSFGDIYLG |
|||||||||
| Kinase | ball.AA | CK1-Unclassified | 47-64 | 50 | 0.005863 | 4.59 | In-house | 1-18 (244) | Show / Hide |
Range on Protein: 47-64 Range on HMM: 1-18/244 Sequence Identity: 50% (9 aa) WRIGPSIGVGGFGEIYAA |.. || | ||||| . YRVIEKIGQGSFGEIYKC |
|||||||||
| Kinase | ball.AA | CK1-G | 297-324 | 26 | 0.014126 | 4.45 | In-house | 237-266 (266) | Show / Hide |
Range on Protein: 297-324 Range on HMM: 237-266/266 Sequence Identity: 26% (8 aa) KG--VPPPIGDFMKYVSKLTHNQEPDYDKC .. .| .. ...|| .| . .|||| QNNAFPEQFATYLRYVRRLDFFECPDYDYL |
|||||||||
| Kinase | ball.AA | TTBK | 297-324 | 28 | 0.026049 | 4.01 | In-house | 230-257 (257) | Show / Hide |
Range on Protein: 297-324 Range on HMM: 230-257/257 Sequence Identity: 28% (8 aa) KGVPPPIGDFMKYVSKLTHNQEPDYDKC | .|. . ||. .. |. ||| KHCPHEFHQFMDHIKSLNYEDRPDYQLI |
|||||||||
| Kinase | ball.AA | CK1-A | 47-69 | 34 | 0.082381 | 1.97 | In-house | 1-23 (261) | Show / Hide |
Range on Protein: 47-69 Range on HMM: 1-23/261 Sequence Identity: 34% (8 aa) WRIGPSIGVGGFGEIYAACKVGE .|. || | ||.|| . .. . YRLVRKIGSGSFGDIYLGINITN |
|||||||||
| Kinase | ball.AA | Pkinase | 47-69 | 39 | 0.409836 | 5.02 | Pfam | 1-23 (293) | Show / Hide |
Range on Protein: 47-69 Range on HMM: 1-23/293 Sequence Identity: 39% (9 aa) WRIGPSIGVGGFGEIYAACKVGE ..|| || |.||. | ....|. YHIGRKIGSGSFGCVYKCHHKGT |
|||||||||